Investigation of the pharmacological activity of the tetrapeptide HAEЕ, zinc, and human serum albumin in a transgenic mouse model with tau protein overexpression (P301S) by Veronika S. Shmigerova, Yulia V. Stepenko, Alexandra A. Kurbatova, Nikita S. Zhunusov, Nikita S. Lyapkalov, Maria S. Sviridova, Tatyana V. Avtina, Arkadiy V. Nesterov, Alexander A. Popov, Natalia I. Nesterova, Mariia Iu. Goltsova, Tatiana G. Pokrovskaya

“…This composition possesses properties that can potentially slow disease progression. Materials and Methods: The experiment was performed on 60 homozygous mice of both sexes from a transgenic line with the overexpression of human mutant tau protein (P301S) and on 20 mice from a wild-type C57Bl/6J background line. …”
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The Mkx- TGF-β pathway induced the development of the myodural bridge complex in SD rats by Ji-Hang Li, Ji-Hang Li, Wen-Bin Jiang, Lu Zhang, Yun-Feng Liu, Yi-Tong Sun, Hua-Xun Lai, M. Adeel Alam Shah, Wei Ma, Chan Li, Campbell Gilmore, Jian-Fei Zhang, Hong-Jin Sui

“…Studying its developmental process may offer new insights into CSF dynamics and lead to improved strategies for diagnosing and treating neurodegenerative diseases.Materials and MethodsThis study utilized utilized lentiviral plasmids to either knockdown or overexpress the Mkx gene in newborn Sprague-Dawley rats (SD) rats, establishing three groups: control, overexpression group, and interference group. …”
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Y Reverse: Modified technique in challenging airway management by Gaetana Messina, Giovanni Natale, Davide Gerardo Pica, Giuseppe Vicario, Noemi Maria Giorgiano, Rosa Mirra, Vincenzo Di Filippo, Beatrice Leonardi, Francesca Capasso, Francesco Panini D'Alba, Riccardo Vinciguerra, Alessia Caputo, Maria Antonietta Puca, Mario Pirozzi, Ciro Balbo, Sara Di Lorenzo, Stefano Farese, Giovanni Liguori, Giovanni Vicidomini, Giovanni Messina, Alfonso Fiorelli, Fortunato Ciardiello, Morena Fasano

“…We present the Y reverse technique for Y stent insertion using a combination of rigid and flexible bronchoscopy. Materials and Methods This retrospective study included 15 consecutive patients, suffering from tracheal‐carina‐lower main bronchi complex, hospitalized at the Thoracic Surgery Unit of the Vanvitelli University of Naples between October 2021 and October 2023. …”
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Resumption of Employment after Cervical Cancer Surgery: a 3-Year Follow-Up Study of Long-term Outcomes by Dmitry V. Blinov, Antonina G. Solopova, Elena V. Gameeva, Nazim G. Badalov, Mikhail A. Eremushkin, Alexandra M. Stepanova, Vsevolod N. Galkin, Alexander E. Ivanov, Saida A Akavova

“…To investigate the relationship between different rehabilitation programmes following cervical cancer surgery and return to work MATERIALS AND METHODS. The study included patients aged 18 and older with stage 1A–1B cervical cancer. …”
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Feasibility and preliminary findings of a bacterial diversity study in periodontitis: a pilot investigation from the Western Cape by Salma Kabbashi, Yvonne Prince, Ndonwi Elvis Ngwa, Haly Holmes, Glenda Mary Davison, Saarah F. G. Davids, Manogari Chetty

“…Therefore, this study was conducted to characterize the subgingival bacterial biodiversity in the periodontal pockets of patients with periodontitis in a Western Cape population.Materials & methodsPooled subgingival plaque samples were collected from the deepest pocket/crevices of five periodontitis cases and five controls using sterile paper points. …”
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Efficacy and Safety of Metastatic Directed Treatment of Oligometastatic Disease: Results of a Meta-analysis by Yael Berner-Wygoda, MA, MD, Eitan Amir, MB ChB, PhD, Philip Blumenfeld, MD, Meredith Li, MD, Diego Malon, MBA, MD, Neha Pathak, MD, Jacqueline Savil, MN-RN, Yonaton Zarbiv, MD, Vikaash Kumar, MD

“…Here, we report a meta-analysis of randomized controlled trials (RCTs) aimed to evaluate the efficacy and safety of adding stereotactic radiation to metastases versus the standard of care (SOC) in treating OMD. Methods and Materials: A meta-analysis was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. …”
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Contrast-enhanced US Bosniak Classification: intra- and inter-rater agreement, confounding features, and diagnostic performance by Dong-dong Jin, Bo-wen Zhuang, Ke Lin, Nan Zhang, Bin Qiao, Xiao-yan Xie, Xiao-hua Xie, Yan Wang

“…Purpose To explore intra- and inter-rater agreement for US features, identify confounding features, and assess the diagnostic performance of CEUS Bosniak classification. Materials and methods This retrospective study included patients with complex CRMs who underwent CEUS examination from January 2013 to August 2023. …”
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The Role of Leu-Enkephalin Synthetic Analogue in Regulation of Systemic Inflammatory Response and Prevention of ARDS in Severe Combined Injury by A. Y. Ryzhkov, V. V. Antonova, R. A. Cherpakov, E. A. Chernevskaya, A. K. Shabanov, D. A. Ostapchenko, M. A. Magomedov, O. A. Grebenchikov

“…To study the effect of ley-enkephalin synthetic analogue on the dynamics of inflammatory response markers and organ dysfunction in patients with severe combined trauma.Materials and methods. A prospective clinical study with historical control from two clinical centers — N. …”
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Pulmonary cysts as a diagnostic indicator of Birt-Hogg-Dubé syndrome in patients with renal neoplasm by Amreen Shakur, Grant D. Stewart, Timothy J. Sadler, Judith L. Babar, Anne Y. Warren, Stephen Scullion, Abhishekh H. Ashok, Sumit Karia, Igor Chipurovski, James Whitworth, Stefan J. Marciniak, Eamonn R. Maher, Maria TA Wetscherek

“…Abstract Objectives To assess the presence and CT features of pulmonary cysts (PCs) in patients with renal neoplasms (RN) as a hallmark of Birt-Hogg-Dubé syndrome (BHDS). Materials and methods Single institution retrospective study of all patients with histological RN between May 2014 and May 2020. …”
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Identification of WRKY gene family and analysis of drought stress expression in Poncirus polyandra by ZHANG Shanshan, RUAN Sunmei, YANG Wenzhong

“…The purpose of this study is to analyse the function of WRKY genes and screen out the genes with potential drought resistances in P. polyandra. [Methods] Based on the genome-wide data of P. polyandra, WRKY genes were identified by HMMER, NCBI-CDD and SMART searches. …”
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Focal liver lesions: multiparametric microvasculature characterization via super-resolution ultrasound imaging by Qian-Qian Zeng, Shi-Zhe An, Chao-Nan Chen, Zhen Wang, Jia-Cheng Liu, Ming-Xi Wan, Yu-Jin Zong, Xiao-Hua Jian, Jie Yu, Ping Liang

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Russian Non-Interventional Study of the Efficacy and Tolerability of Rifaximin-α Therapy in Patients with Uncomplicated Diverticular Disease under the Conditions of Outpatient Prac... by O. S. Shifrin, E. A. Poluektova, A. V. Korolev, T. I. Semenova, M. V. Shein, G. N. Leksikova, O. A. Tokareva, O. E. Davydova, P. S. Andreev, S. E. Katorkin, A. A. Chernov, A. V. Zhuravlev, O. S. Sek, A. A. Kopina, N. Yu. Samokhina, Yu. V. Gorozhankina, M. F. Samigullin, V. S. Groshilin, E. N. Borisova, T. A. Petrova, I. Yu. Pirogova, S. V. Mednikov, N. V. Smagin, A. S. Sarsenbaeva, N. V. Smirnova, L. G. Kirsanova, N. M. Malyutina, M. A. Smirnova, E. N. Shleikova, V. T. Ivashkin

“…This observational (non-interventional) study was aimed at obtaining data on practitioners’ commitment to prescribing rifaximin-α therapy to patients with uncomplicated diverticular disease (UDD), to assess patients’ adherence to such prescriptions, as well as to assess physicians’ and patients’ satisfaction with this drug under the conditions of outpatient practice.Materials and methods. 27 research physicians in 22 research centres located in 15 Russian cities and 250 patients participated in an open, prospective multicentre observational study. …”
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Non-Cognitive Behavioral Therapy Psychological Interventions May Not Make the Difference in Children and Adolescents With Chronic Pain by Perlman L, Malka N, Terry O, Nguyen A, Guimarães Ferreira Fonseca L, Ingelmo JI, Ingelmo P

“…The aim of this retrospective cohort study with secondary retrospective matched case–control analysis was to evaluate the impact of interruption of non-CBT psychological interventions, namely psychoanalysis and psychodynamic psychotherapy, on children and adolescents with chronic pain conditions during the SARS-CoV-2 pandemic.Materials and Methods: We included pediatric patients with primary and secondary chronic pain conditions evaluated by our team during the SARS-CoV-2 pandemic. …”
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CLINICAL AND BIOCHEMICAL INDICATORS IN WHITE RATS IN THE TREATMENT OF EXPERIMENTAL GENERALIZED PARODONTITIS by Yu.I. Silenko, M.V. Khrebor, Y.M. Silenko, O.A. Pisarenko

“…The aim of the research is to examine the clinical parameters and the state of free radical oxidation in blood and periodontal tissues of white rats in the treatment of spontaneous generalized periodontitis with the use of polypeptides. Materials and methods of the research. Experiments were performed on 280 six-month-old of rats Wistar line of both sexes weighing 120-130 g. …”
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Ultrasound of muscles for the diagnosis of sarcopenia in patients with inflammatory bowel diseases by Olga E. Akchurina, Dilyara D. Mukhametova, Alfiya K. Odintsova, Diana I. Abdulganieva

“…To assess the muscle mass of patients with inflammatory bowel disease (IBD) using ultrasound. Materials and methods. 102 IBD patients hospitalized in gastroenterology department of Republican Clinical Hospital (Kazan) were involved in the study. …”
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Effectiveness of scaffolded case-based learning in anesthesiology residency training: a randomized controlled trial by LongYuan Zhou, Chang Cai, RuiLan Wu, Yong Qi

“…Methods This prospective randomized controlled trial encompassed 12 anesthesiology residents, systematically randomized into an experimental cohort (receiving scaffolding teaching integrated with case-based discussion) and a control cohort (receiving traditional lecture-based instruction utilizing the same clinical case). …”
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Clinical Effectiveness of Bilateral Extended ESP Block in Cardiac Surgery Patients with Median Sternotomy under Conditions of Artificial Blood Circulation by Ruslan M. Taran, Vyacheslav V. Osaulenko, Karina O. Chmul, Serhii I. Vorotyntsev

“…To evaluate the clinical effectiveness of bilateral extended blockade of the plane of the extensor back muscles (ESPB) as a component of multimodal analgesia in cardiosurgical operations with median sternotomy under conditions of artificial blood circulation. Materials and methods. A single-center retrospective-prospective observational study included 123 patients who underwent cardiac surgery on the heart with a median sternotomy with artificial blood circulation. …”
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Dexmedetomidine versus Dexamethasone as an Adjuvant to Ropivacaine in Transversus Abdominis Plane Block in Infraumbilical Surgeries for Postoperative Analgesia: A Randomised Clinic... by Anupama Kumari, Aarjvi Patel, Payal Berawala, Sara Mary Thomas

“…The secondary objective was to compare postoperative haemodynamic changes and side effects. Materials and Methods: In this randomised double-blinded prospective clinical study, conducted in the Department of Anaesthesia, Shrimati Bhikhiben Kanjibhai Shah Medical Institute and Research Centre (SBKS MIRC), Piparia, Vadodara, Gujarat, India from March 2023 to September 2024. 80 patients of American Society of Anaesthesiologists (ASA) I and II, aged 18-60 years, undergoing elective infraumbilical surgeries (open abdominal hysterectomy and open bilateral inguinal hernia repair) under spinal anaesthesia were randomly allocated into two groups of 40 patients each. …”
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Evaluation of Blood Lactate Level as a Predictor of In-hospital Morbidity and Mortality in Patients Undergoing Surgery for Bowel Perforation: A Prospective Cohort Study by Anish Kumar Singh23, Sandeep Kumar, Nityasha, Mamta Jain, Mamta Jain, Teena Bansal, Amanpreet Singh

“…Aim: To evaluate perioperative lactate levels and their clearance as predictors of in-hospital M&M in bowel perforation surgery. Materials and Methods: The present prospective cohort study was conducted in the Department of Anaesthesiology and Critical Care, Pt. …”
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The effects of normal and interrupted sleep combined with acute caffeine supplementation on some immune system indices and anaerobic power in male athletes by Mohammad hossein Hashemzadeh, Farhad Rahmaninia, Payam Saidie

“…In the current study, the effects of normal and interrupted sleep combined with acute caffeine supplementation on some immune system indices and anaerobic power in male athletes were examined.Materials and Methods: This semi-experimental study was conducted using a randomized design. …”
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