Circulating tumor DNA monitoring in advanced mutated melanoma (LIQUID-MEL) by Martines Gianmarco, Palazzi Carolina, Monica Gregorio, Verzè Michela, Pluchino Monica, Giudice Giulia Claire, Maffezzoli Michele, Mazzaschi Giulia, Manuguerra Roberta, Azzoni Cinzia, Bottarelli Lorena, Tiseo Marcello, Perrone Fabiana, Minari Roberta

“…The present study aimed to evaluate the clinical utility of ctDNA dynamics in patients with metastatic melanoma receiving ICIs, while exploring its role in the oncological course. Materials and methods: The LIQUID-MEL study is a prospective, single-centre pilot study including patients with BRAF/NRAS-mutant metastatic melanoma. ctDNA was quantified using digital droplet PCR (ddPCR) at four different time points. …”
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The Effects of Dual Antiplatelet Therapy on the Occurrence of Recurrent Cardiovascular Events After Myocardial Infarction in Obese Patients by Borovyk K., Rindina N., Kravchun P., Tabachenko O., Yermak O., Romanyuk M.

“…To analyze the incidence of recurrent cardiovascular events in obese patients after myocardial infarction during a 6month followup period, depending on the combination of ticagrelor or clopidogrel with acetylsalicylic acid as part of dual antiplatelet therapy. Materials and methods. The study involved 75 patients with AMI with ST segment elevation and concomitant obesity. …”
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Global Burden of Oral Diseases in Adolescents and Young Adults Aged 10–24 Years by Wei Lu, Bing Wang, Mi Du, Shaohua Ge

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New insights in fluid monitoring for surgical patients. A concept study by Audrius Andrijauskas, Povilas Andrijauskas, Darius Dilijonas, Tomas Jovaiša, Vaidotas Marozas, Vaidotas Marozas, Edgaras Stankevičius, Axel Kerroum, Darius Čincikas, Saulė Švedienė, Giedrius Kvederas, Narūnas Porvaneckas, Christer Svensen

“…PurposeThis study evaluates the primary hypothesis of red cell mass (RCM) dependent amplitude of homeostatically acceptable limits of fluctuation in plasma dilution by exploring the correlation between RCM-specific equilibrated hematocrit (EQ_Hct) and amplitude of plasma dilution during perioperative mini Volume Loading Test (mVLT).Materials and methodsWe retrospectively analyzed data from our previous RCTs, including 1,651 invasive arterial plasma dilution (aPD), 1,645 noninvasive “capillary” plasma dilution (cPD) and 236 estimates of EQ_Hct from 236 perioperative mVLT sessions. …”
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Prognostic significance of cardiac dysfunction markers in comorbid patients with chronic heart failure by E. V. Kovalenko, L. I. Markova, O. L. Belaya, V. N. Oranzhereeva

“…Purpose of the study was to prediction of the unfavorable course of chronic heart failure in comorbid patients who have undergone COVID-19.Materials and methods. The study included 181 patients with verified cardiovascular pathology and chronic heart failure with preserved ejection fraction of NYHA functional class 1-3, suffering from type 2 DM and CKD, which were divided into two groups: group 1 included 135 patients who had suffered COVID-19 not earlier than 3-6 months ago, in group 2 (n = 46) COVID there was no history of-19. …”
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The efficacy and safety of divozilimab in patient with systemic sclerosis: 48-week results of the randomized double-blind placebo-controlled phase III clinical study LIBERIUS by L. P. Ananyeva, M. N. Starovoytova, I. Z. Gaydukova, G. V. Lukina, E. V. Zonova, L. V. Eliseeva, G. F. Fatkhullina, D. I. Abdulganieva, D. G. Krechikova, T. V. Kropotina, O. B. Nesmeyanova, I. B. Vinogradova, E. S. Zhugrova, L. V. Ivanova, N. E. Nikulenkova, O. R. Ziganshin, T. V. Plaksina, M. V. Zlobin, Yu. Yu. Grabovetskaya, N. F. Soroka, O. B. Ershova, T. V. Povarova, O. N. Anoshenkova, A. A. Lutckii, A. V. Zinkina-Orikhan, Yu. N. Linkova, E. A. Fokina, A. A. Porozova, P. S. Pukhtinskaia, A. V. Eremeeva

“…The aim of the study is to evaluate the efficacy, safety and immunogenicity of divozilimab (DIV), anti-CD20 monoclonal antibody, in patients with systemic sclerosis (SS).Materials and methods. Patients with SS according to ACR/EULAR (American College of Rheumatology/ European Alliance of Associations for Rheumatology) 2013 criteria with modified Rodnan skin score (mRSS) ≥10 and ≲20 and forced vital capacity (FVC) ≥40% from the due took part in the study. …”
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Comparison of Serenoa repens, lycopene, and selenium versus dutasteride for the treatment of LUTS/BPH: an Italian multicenter case-control prospective study (COMP study) by Giuseppe Morgia, Arturo Lo Giudice, Sebastiano Cimino, Giulio Reale, Gaetano Larganà, Enza La Manna, Massimo Madonia, Alessandro Tedde, Francesco Santaniello, Giuseppe Vespasiani, Stefano Zaganelli, Salvatore Arnone, Nicola Cruciano, Maurizio Carrino, Francesco Persico, Carlo Terrone, Rafaela Malinaric, Andrea Minervini, Marco Carini, Giorgio Ivan Russo

“…Based on these premises, the aim of this Italian multicenter case-control prospective non-randomized study is to compare the therapy with SeR-Se-Ly alone versus Dutasteride alone against BPH, in order to research a good therapeutic alternative with limited side effects.Materials and methodsFrom April 2021 to April 2022, 269 consecutive patients from 21 Italian centers were enrolled in this case-control study. …”
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Sexual Quality of Life in Postmenopausal Women: A Comparative Randomized Controlled Trial of Intravaginal PRP Therapy Versus Local Hormonal Treatments by Geanina Sacarin, Ahmed Abu-Awwad, Nitu Razvan, Marius Craina, Bogdan Hogea, Bogdan Sorop, Simona-Alina Abu-Awwad, Mircea Diaconu, Nicolae Ciprian Pilut, Madalina-Ianca Suba

“…This study aimed to compare the effectiveness and safety of intravaginal platelet-rich plasma (PRP) therapy versus local hormonal treatment in improving sexual function and vaginal health in postmenopausal women. <i>Materials and Methods</i>: A prospective, controlled clinical trial was conducted between January 2023 and December 2024 across three private gynecology clinics in Timișoara, Romania. …”
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Elevated prolactin levels before endometrial transformation negatively impact reproductive outcomes in frozen embryo transfer cycles under hormone replacement therapy by Yaxin Wang, Fei Sheng, Li Cao, Jiaying Ni, Meishan Wang, Yan Yang, Jiating Wang, Jingyi Lu, Jian Zhou, Hongfang Shao

“…This study aimed to examine the relationship between PRL levels and reproductive outcomes in frozen embryo transfer (FET) cycles under hormone replacement therapy (HRT). Materials and methods A total of 1212 FET cycles under HRT were included from a single center in Shanghai between March 2013 and June 2023. …”
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Body composition as a potential imaging biomarker for predicting the progression risk of chronic kidney disease by Zhouyan Liao, Guanjie Yuan, Kangwen He, Shichao Li, Mengmeng Gao, Ping Liang, Chuou Xu, Qian Chu, Min Han, Zhen Li

“…Abstract Purpose To investigate whether the body composition parameters can be employed as potential biomarkers for predicting the progression risk of chronic kidney disease (CKD). Materials and methods Four hundred sixteen patients diagnosed with CKD were included in this retrospective study. …”
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Prognostic significance of right ventricular dysfunction in heart failure with preserved ejection fraction: a meta-analysis of reconstructed time-to-event data by Roozbeh Narimani-Javid, Mehrdad Mahalleh, Kiyarash Behboodi, Kasra Izadpanahi, Alireza Arzhangzadeh, Reza Nikfar, Seyed Ali Hosseini, Ehsan Amini-Salehi, Sasan Shafiei, Hamed Vahidi, Kaveh Hosseini, Hamidreza Soleimani

“…However, there are still gaps in understanding how right ventricular dysfunction (RVD) affects long-term outcomes in patients with heart failure with preserved ejection fraction (HFpEF). Materials and methods In this systematic review and meta-analysis, a comprehensive search was conducted to identify studies investigating RVD as the predictor of the composite outcome of All-cause death, cardiac death, and hospitalization for HF in patients with HFpEF published until October 2024. …”
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Association of dietary cholesterol intake with the risk of fatal cardiovascular events in individuals with type 2 diabetes by A. K. Kuntsevich, O. D. Rymar, S. V. Mustafina, G. I. Simonova, L. V. Shcherbakova, E. G. Verevkin, A. O. Shchetinina, S. K. Malyutina

“…To date, there is no unequivocal answer about the presence of a relationship between cholesterol consumption and the risk of cardiovascular diseases, which determines the relevance of the study of this issue.AIM: To study the association of dietary cholesterol with the risk of fatal outcomes from cardiovascular disease (CVD) in individuals with type 2 diabetes mellitus (DM2).MATERIALS AND METHODS: The baseline study was carried out within the framework of the HAPIEE project in 2003-2005. …”
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Impaired right atrial function preceding right ventricular systolic dysfunction: clinical utility and long-term prognostic value in pulmonary hypertension by Fan Yang, Yan Yan, Wang Jiang, Zhouming Wang, Caixin Wu, Qian Wu, Yuanlin Deng, Yamin Du, Zhenwen Yang, Zhang Zhang, Dong Li

“…This study assessed the characteristics of right atrial (RA) function using cardiac magnetic resonance feature tracking (CMR-FT) before RVSD onset and evaluated the long-term prognostic significance of these characteristics. Materials and methods A total of 96 PH patients, including 36 without RVSD (PH-nonRVSD) and 60 with RVSD (PH-RVSD), were compared to 20 healthy controls (HCs). …”
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Ultra-low dose dual-layer detector spectral CT for pulmonary nodule screening: image quality and diagnostic performance by Li Ding, Mingwang Chen, Xiaomei Li, Yuting Wu, Jingxu Li, Shuting Deng, Yikai Xu, Zhao Chen, Chenggong Yan

“…Abstract Objectives To investigate the image quality and diagnostic performance with ultra-low dose dual-layer detector spectral CT (DLSCT) by various reconstruction techniques for evaluation of pulmonary nodules. Materials and methods Between April 2023 and December 2023, patients with suspected pulmonary nodules were prospectively enrolled and underwent regular-dose chest CT (RDCT; 120 kVp/automatic tube current) and ultra-low dose CT (ULDCT; 100 kVp/10 mAs) on a DLSCT scanner. …”
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Trends and hotspots in targeted therapy resistance research for renal cell carcinoma: a bibliometric and visualization analysis by Ziqian Wang, Xiaodu Xie, Ze Wang, Peng Tang, Jian Chen, Jing Xu, Junying Zhang, Haiyang Xiao, Chongliang Zheng, Jun Jiang, Qiuli Liu, Weihua Lan

“…Despite extensive research on resistance mechanisms, there is a lack of comprehensive bibliometric studies examining the overall characteristics of targeted therapy resistance in renal cell carcinoma. Materials and methods Publications on resistance to targeted therapy in renal cell carcinoma were identified from the Web of Science Core Collection (WoSCC) from June 2004 to November 2024. …”
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Efficacy and predictors of response to somatostatin analogues in patients with ectopic ACTH syndrome by Olga O. Golounina, Zhanna E. Belaya, Alla A. Markovich, Liudmila Y. Rozhinskaya, Galina A. Mel`nichenko, Natalia G. Mokrysheva, Ivan I. Dedov

“…To study the immediate efficacy, tolerability and predictors of response to prolonged-acting somatostatin analogues (SSAs) in patients with ectopic ACTH syndrome (EAS). Materials and methods. A multicenter, observational study with a retrospective analysis. …”
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Development and validation of a model based on preoperative dual-layer detector spectral computed tomography 3D VOI-based quantitative parameters to predict high Ki-67 proliferatio... by Dan Zeng, Jiayan Zhang, Zuhua Song, Qian Li, Dan Zhang, Xiaojiao Li, Youjia Wen, Xiaofang Ren, Xinwei Wang, Xiaodi Zhang, Zhuoyue Tang

“…Abstract Objective To develop and validate a model integrating dual-layer detector spectral computed tomography (DLCT) three-dimensional (3D) volume of interest (VOI)-based quantitative parameters and clinical features for predicting Ki-67 proliferation index (PI) in pancreatic ductal adenocarcinoma (PDAC). Materials and methods A total of 162 patients with histopathologically confirmed PDAC who underwent DLCT examination were included and allocated to the training (114) and validation (48) sets. 3D VOI-iodine concentration (IC), 3D VOI-slope of the spectral attenuation curves, and 3D VOI-effective atomic number were obtained from the portal venous phase. …”
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The influence of hepatic arterial blood flow rate on holmium microsphere distribution: an MRI study in perfused porcine livers by Tess J. Snoeijink, Anne van den Brekel, Jan L. van der Hoek, Jaap G. M. Greve, H. Remco Liefers, Milou Boswinkel, Simon J. S. Ruiter, Joey Roosen, Erik Groot Jebbink, J. Frank W. Nijsen

“…To examine the impact of HA blood flow rate and high microsphere dosages on microsphere distribution in normal liver parenchyma, ex vivo magnetic resonance imaging (MRI)-guided machine perfusion experiments were conducted in porcine livers. Materials and methods Porcine livers were subjected to oxygenated normothermic machine perfusion at three HA flow rates (0.02, 0.15, and 0.22 mL/min/g liver tissue; n = 3 per condition). …”
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Comparison of Quadratus Lumborum Block and Rectus Sheath Block for Postoperative Analgesia in Single-Port Laparoscopic Adnexal Surgery: A Randomized Controlled Trial by Dongju Kim, Seunguk Bang, Jihyun Chung, Youngin Lee, Hyun-Jung Shin, Yoonji Park

“…This study aimed to compare the analgesic efficacy of quadratus lumborum block (QLB) and rectus sheath block (RSB) in this surgical context. <i>Materials and Methods</i>: In this randomized controlled trial, 68 patients undergoing single-port laparoscopic adnexal surgery were randomly assigned to receive either QLB or RSB at the end of surgery. …”
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Establishment of a New Equation for Ultrasonographic Estimated Foetal Weight in Chongqing: A Prospective Study by Chenhuizi Wu, Jianfeng Sun, XiaoJing Dong, Liuyun Cai, Xinru Deng, Fenglan Zhang, Yang Shu, Maochao Zhang, Xiaodong Luo

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