Population profile and glycemic control following initiation or switch of injectable therapies in Tianjin, China: A real‐world retrospective cohort study of adults with type 2 diab... by Qiumei Zhang, Yaqing Fan, Xixi Liu, Minlu Zhang, Jiewen Zhang, Qin Du, Lei Kang, Liming Chen

“…ABSTRACT Aims To evaluate characteristics and glycemic outcomes in individuals with type 2 diabetes using injectable therapies in real‐world clinical practice in Tianjin, China. Materials and methods Data from inpatients and outpatients receiving injectable therapies between January 2015 and December 2019 were collected from the Tianjin regional electronic medical records and retrospectively analyzed. …”
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Association of Quadratus Lumborum Muscle Stiffness with Chronic Low Back Pain Features: An Observational Study by Mónica López-Redondo, Davinia Vicente-Campos, Javier Álvarez-González, Alberto Roldán-Ruiz, Sandra Sánchez-Jorge, Jorge Buffet-García, Gabriel Rabanal-Rodríguez, Juan Antonio Valera-Calero

“…Therefore, this study aimed to explore the association between QL stiffness and multiple indicators of LBP severity. <i>Materials and Methods</i>: A cross-sectional observational study was conducted involving the participation of seventy-six patients suffering from chronic LBP. …”
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Effects of combined cyclosporin and azithromycin treatment on human mononuclear cells under lipopolysaccharide challenge by Norah Alotaibi, Aminah Alesawy, Marwa Alalshaikh, Faisal E. Aljofi, Nada Aldossary, Nada Alzahrani, Omar Omar, Marwa Madi

“…ObjectiveTo evaluate the combined effects of azithromycin and varying concentrations of cyclosporin on peripheral blood mononuclear cells (PBMCs) under lipopolysaccharide (LPS) stimulation.Materials and methodsPBMCs were isolated from four healthy donors and treated with cyclosporin at concentrations of (50, 200, and 1,000 ng/ml) either alone or in combination with azithromycin (0.4 µg/ml), with and without 100 ng ml LPS derived from Porphyromonas gingivalis. …”
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Quercetin is a foe in the heart by targeting the hERG potassium channel by Zihao Lu, Shuwen Li, Rui Wei, Wenwen Li, Yuqian Huang, Tingting Yang, Meng Yan

“…A previous study showed that quercetin can inhibit human ether-a-go-related gene (hERG, also named KCNH2) currents, which may lead to long QT syndrome, torsade de pointes (TdP), and even sudden cardiac death. This study aimed to investigate the effects of quercetin on hERG and its potential mechanism.Materials and Methods: hERG currents and action potential duration (APD) were assessed using the patch clamp technique. …”
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Minilaparoscopic Versus Conventional Laparoscopic Hysterectomy: Insights from a Single-Center Retrospective Cohort Study with Legal Considerations by Valentina Billone, Giuseppe Gullo, Eleonora Conti, Silvia Ganduscio, Sofia Burgio, Giovanni Baglio, Gaspare Cucinella, Lina De Paola, Susanna Marinelli

“…<i>Background and Objectives</i>: We compared mini-laparoscopic and laparoscopic hysterectomy in terms of surgery duration, postoperative pain, conversion rate, blood loss, postoperative complications (Clavien-Dindo classification), and the length of hospital stay. <i>Materials and Methods</i>: Patients were recruited between 1 January 2017 and 1 January 2024, at the Department of Gynecology, “Villa Sofia-Cervello” Hospital. …”
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Effectiveness of Low-Level Laser Therapy in reducing postoperative pain after dental implant surgery: A randomized clinical trial by Javier Basualdo Allende, Rodrigo Caviedes, Alfredo von Marttens, Francisca González Ramírez, Iara Vargas Piña, Milton Kuga, Eduardo Fernández

“…Background: A clinical trial was conducted to measure the effectiveness of a combined wavelength of 660 nm and 808 nm Low-Level Laser Therapy (LLLT) in reducing postoperative pain in partially and totally edentulous patients who underwent dental implant surgery. Materials and Methods: The study included 20 blinded individuals divided in a randomized split-mouth fashion; the experimental group in one hemiarch and the control group in the other hemiarch. …”
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Hemiarthroplasty in Proximal Humerus Fractures: Does Modular Metaphyseal Stem Design Lead to Better Results? An Analysis of 24 Cases by Periklis Godolias MD, Jonathan Plümer MD, Charlotte Cibura MD, Julius R Gerstmeyer MD, Maria A Bernstorff MD, Hansjörg Heep MD, Marcel Dudda PhD, Thomas A Schildhauer MD, PhD, Matthias Königshausen MD, PhD

“…Our study aims to evaluate the radiographic and clinical outcomes of patients who received a modular aHA with anatomical sizing of the tubercle-bearing metaphyseal components. Materials and Methods The medical records of thirty-nine consecutive patients were reviewed. …”
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Comparative study of the glucose and trehalose addition on the extenders for goat sperm liquid storage. by Md. Emtiaj Alam, Most. Shorifa Yeasmin, Dipak Kumar Das, Md. Shohidul Islam, Soshe Ahmed, Md. Hamidul Islam, Md. Akhtarul Islam, Md. Mostofa Kamal, Aurangazeb Kabir, Alam Khan, Md. Hakimul Haque, Md. Abdul Masum, Moizur Rahman, Mst. Ishrat Zerin Moni.

“…Objectives: The objective of this study was to assess the effects of varying glucose and trehalose concentrations on tris-citric acid-egg yolk-fructose (TCEF) diluents for the short-term cold storage of goat semen. Materials and Methods: The semen sample was collected, unwashed, and divided into the following groups: control (TCEF without glucose and trehalose), TCEF + glucose (75, 150 mm), and TCEF + trehalose (75, 150 mm). …”
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Colorectal cancer mortality in persons with severe mental illness: a scoping review with meta-analyses of observational studies by Paula R. Pop, Gitte S. Larsen, Mette K. Thomsen, Christoffer Johansen, Robert Zachariae, Bolette Skjødt Rafn

“…The aim of this scoping review was to describe and quantify CRC mortality for persons with SMI compared with the general population. Patients/materials and methods: We followed the JBI Manual for Evidence Synthesis and PRISMA guidelines in a systematic search of four databases from inception until April 29th, 2024. …”
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The efficacy and safety of nusinersen within the expanded access program in Russia by S. B. Artemieva, L. M. Kuzenkova, E. S. Ilyina, Yu. A. Kursakova, L. M. Kolpakchi, E. Yu. Sapego, A. A. Golenko, S. G. Popovich, D. V. Parshin, O. A. Shidlovskaya, Yu. O. Papina, A. V. Monakhova, D. V. Vlodavets

“…The aim of the study was to assess the safety and efficacy of nusinersen therapy in patients with type 1 spinal muscular atrophy for 6 months as part of an expanded access program at federal and regional healthcare facilities. Materials and methods. Patients with type 1 spinal muscular atrophy received nusinersen therapy under the expanded access program (NCT02865109). …”
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Genetic Marker Detection of Natural-Focal Infectious Disease Pathogens in Samples of Ixodidae Ticks, Collected on the Territory of the Republic of Guinea by E. V. Naidenova, K. S. Zakharov, M. Yu. Kartashov, D. A. Agafonov, A. M. Senichkina, A. D. Katyshev, M. A. Diallo, M. B. Bah, S. Boumbaly, V. V. Kutyrev

“…Current epidemiological and epizootiological situation on natural-focal infectious diseases on the territory of the Republic of Guinea is not entirely clarified.The aim of this work was to identify genetic markers (RNA/DNA) of natural-focal infectious disease agents in samples of Ixodidae ticks collected in the Republic of Guinea, and to determine the spectrum of pathogens circulating in various landscape-geographical zones of the country.Materials and methods. To conduct research on the territory of all landscape-geographical zones of the Republic of Guinea, 4695 specimens of Ixodidae ticks of 11 species were collected. …”
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The Arabic Version of Injury-Psychological Readiness to Return to Sport Scale: Translation and Psychometric Validation by Osama R. Abdelraouf, Amr A. Abdel-Aziem, Nouf H. Alkhamees, Zizi M. Ibrahim, Mohamed A. Elhosiny, Shaza E. Ibrahim, Amal A. Elborady

“…So, this cross-cultural validation study was carried out to translate and validate the Injury-Psychological Readiness to Return to Sport Scale (I-PRRS) into the Arabic language. <i>Materials and Methods</i>: One hundred twenty athletes with lower extremity injuries (95 males and 25 females) completed the Arabic I-PRRS twice with a one-week time interval. …”
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Bilateral Rectus Sheath Block with Continuous Bupivacaine Infusions After Elective Open Gastrectomy: A Randomized Controlled Trial by Janis Opincans, Igors Ivanovs, Aleksejs Miscuks, Janis Pavulans, Katrina Deja Martinsone, Agris Rudzats, Zurabs Kecbaja, Olegs Gutnikovs, Aleksejs Kaminskis

“…We conducted a clinical trial to investigate the effectiveness of bilateral rectus sheath block (RSB) with continuous bupivacaine infusion in comparison with placebo following elective open gastrectomy. <i>Materials and Methods:</i> Patients indicated for elective open gastrectomy were screened, enrolled, and randomised between October 2021 and September 2023. …”
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Analysis of Drug and Health Resource Use Before and After COVID-19 Lockdown in a Population Undergoing Treatment for Depression or Anxiety by Ana Lear-Claveras, Ana Clavería, Ana Clavería, Ana Clavería, Sabela Couso-Viana, Sabela Couso-Viana, Patrice Nabbe, Bárbara Oliván-Blázquez, Bárbara Oliván-Blázquez, Bárbara Oliván-Blázquez

“…The aim of this study is to determine the changes in these parameters, between the 6 months prior to the lockdown (09/14/2019 to 03/15/2020) and the 6 months following its end (05/03/2020 to 11/04/2020), in a population undergoing active treatment for depression or anxiety, according to the electronic clinical record.Materials and MethodsReal world data observational study of 110,694 individuals aged &gt;16 years suffering from active or undergoing treatment for depression or anxiety according to the electronic medical records of the Aragon Regional Health Service (Spain). …”
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Ocrelizumab – a monoclonal antibody – in the treatment of adult patients with multiple sclerosis: a systematic review by D. L. Klabukova, M. E. Holownia-Voloskova, M. V. Davydovskaya, T. N. Ermolaeva, K. I. Polyakova, A. G. Fisun, K. A. Kokushkin

“…Aim: To analyze the efficacy, safety and pharmacoeconomic aspects of using ocrelizumab in adult patients with relapsing/remitting multiple sclerosis (R/R MS).Materials and Methods. We used the commonly accepted PICo(S) questionnaire with the following specifics: the population – patients with R/R MS; the intervention – ocrelizumab; the comparators – all disease-modifying treatments for MS; the outcomes – the annualized relapse rate, confirmed disability progression, MRI results, quality-adjusted years of survival (QALYs), adverse events, and other clinical outcomes. …”
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Effect of Transcranial Direct-Current Stimulation and Task-Oriented Training on Electroencephalography-Based Motor Recovery Chronic Stroke: A Randomized Clinical Trial by Maryam Zolghadr, Shohreh Noorizadeh Dehkordi, Javad Sarrafzadeh, Saeed Talebian, Hassan Haddadzade Niri, Marzieh Yassin

“…This study aims to determine the effect of motor cortical transcranial direct-current stimulation (tDCS) as a top-down approach combined with task-oriented training (TOT) as a bottom-up intervention on changes in electroencephalography (EEG) spectral power in chronic stroke patients. Materials and Methods: Thirty chronic hemiparetic stroke survivors were randomly assigned to receive real or sham stimulation targeting the primary motor cortex (C3/C4) at 2 mA for 20 minutes and TOT daily over 15 sessions. …”
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Diagnostic and prognostic laboratory criteria for the development of sepsis in purulent-inflammatory diseases of soft tissues by G. S. Golobokov, V. V. Tsvetkov, I. I. Tokin, S. D. Shejanov, A. B. Levashova, D. A. Lioznov

“…Identification of laboratory parameters that are used in routine practice and can serve as diagnostic and prognostic criteria for the development of sepsis and its outcomes in patients with purulent-inflammatory diseases of soft tissues.Materials and methods. The study included 48 patients with purulent-inflammatory diseases of soft tissues. …”
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Videoconference-Delivered Acceptance and Commitment Therapy for Family Caregivers of People With Dementia: Pilot Randomized Controlled Trial by Areum Han, Robert Oster, Hon Yuen, Jeremy Jenkins, Jessica Hawkins, Lauren Edwards

“…ObjectiveThis pilot randomized controlled trial, conducted in the United States, aims to assess the effects of a videoconference-delivered, therapist-guided ACT program on reducing depressive symptoms and improving other mental health outcomes among family caregivers with depression who give care to individuals with dementia, compared to a control group that received psychoeducation materials only. MethodsThis 2-arm, parallel-group pilot randomized controlled trial randomly assigned 33 family caregivers to either a 10-week videoconference-delivered ACT program (n=16, 48%) or a control group that received psychoeducation materials alone (n=17, 52%). …”
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Genomic diversity of toxigenic <i>Vibrio cholerae</i> O1 biovar El Tor strains isolated during three waves of the 7th cholera pandemic by Nina I. Smirnova, D. A. Rybal’chenko, Yu. V. Lozovsky, Ya. M. Krasnov, E. Yu. Shchelkanova, A. V. Fedorov, V. V. Kutyrev

“…The aim of the work was to analyze the dynamics of changes in pathogenicity, epidemicity as well as drug resistance and phylogeny in toxigenic strains of V. cholerae El Tor isolated in Russia and endemic regions during three waves of ongoing pandemic. Materials and methods. We used whole-genome nucleotide sequences of 155 strains, obtained by us (42) and taken from the NCBI Genbank (113). …”
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Comparative Analysis of Three Pain Scales for Evaluation of Procedural Pain in Neonates: A Cross-sectional Study by Preethi Subramanian, Sudharshan Raj Chitgupikar, Shreya Jalapu, Takreem Ilyas

“…Aim: To compare the validity and internal consistency of Neonatal Infant Pain Scale (NIPS), Premature Infant Pain Profile Assessment Revised (PIPP-R), Douleur Aigue Nouveau-né (DAN) scale, for assessing procedural pain in neonates before, during and after a heel prick procedure. Materials and Methods: A cross-sectional study was conducted among 60 term neonates in a rural teaching hospital. …”
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