Synthesis of 2-phenyl- and 2-benzyl derivatives of 4(3Н)-quinazolinone with analgesic activity by I. P. Kodonidi, A. V. Bicherov, E. A. Manvelyan, A. A. Kolodina, A. A. Bicherov, M. M. Manvelyan, A. V. Ivchenko, N. N. Vdovenko-Martynova, A. T. Navalieva, M. M. Manvelyan

“…In this regard, a molecular design of biologically active compounds that have an analgesic activity due to the formation of ligand-receptor complexes with nociceptive and dopamine receptors, has been performed.The aim of the study was a molecular design and a subsequent targeted synthesis of 2-phenyl- and 2-benzyl derivatives of 4(3H)-quinazolinone with an analgesic activity, as well as the creation of a mathematical model in order to identify significant molecular descriptors.Materials and methods. A molecular design was carried out by a logical-structural approach using the PASS program with the identification of the biological activity of the predicted structures, as well as the energy calculation of the ligand-receptor interaction. …”
Get full text

Miniinvasive intramedullary osteosynthesis of clavicular fractures in middle one third with shifted fragments using elastic titanic compressing rod by G. I. Herzen, V. V. Kryzhevskyi, A. N. Gapon, A. S. Movchan, S. V. Dibkalyuk, A. I. Protsik, R. N. Ostapchuk

“…Materials and methods. In the Department of Orthopedics and Traumatology of Kyiv Municipal Clinical Hospital No. 6 («Medgorodok») in 38 patients ageing 18 - 67 yrs with the closed clavicular fractures in middle one third with shifted fragments the closed intramedullary osteosynthesis, using elastic titanic compressing rod, was performed. …”
Get full text

The Impact of Natural Resource Dependency and Economic Globalization on Environmental Sustainability in IRAN within the framework of the N-shaped Environmental Kuznets Curve by Abolghasem Golkhandan

“…As such, the primary aim of this research is to investigate the impact of natural resource dependency and economic globalization on environmental degradation in Iran within the framework of the N-shaped EKC.Materials and Methods: The current descriptive-analytical and applied study model is designed using time series data from 1990 to 2021 and includes the variables of GDP per capita (as an economic growth index), square and cube of GDP per capita, share of natural resource rent from GDP (as an indicator of natural resource dependency), the economic dimension of the KOF globalization index and two indicators of environmental degradation (CO2 emissions and ecological footprint). …”
Get full text

Formation of Managers’ Competencies in The Field of Project Portfolio Management of The Enterprise by H. H. Kuchmezov, S. I. Neizvestny

“…This is one of the reasons why the managers of the enterprise, when hiring yesterday’s university graduates, formulate an introductory requirement for them: - “Forget everything you were taught at the university”.Materials and methods. The study was conducted from 2019 to 2021 at the Financial University under the Government of the Russian Federation among 4th year students of the direction of study “Business Informatics”, studying in the profile “IT Management in Business”. …”
Get full text

Genetic programming-based algorithms application in modeling the compressive strength of steel fiber-reinforced concrete exposed to elevated temperatures by Mohsin Ali, Li Chen, Qadir Bux Alias Imran Latif Qureshi, Deema Mohammed Alsekait, Adil Khan, Kiran Arif, Muhammad Luqman, Diaa Salama Abd Elminaam, Amir Hamza, Majid Khan

“…This study employs independent ML methods, gene expression programming (GEP), multi-expression programming (MEP), XGBoost, and Bayesian estimation model (BES) to predict SFRC compressive strength (CS) at high temperatures. 307 experimental data points from published studies were utilized to develop the models. …”
Get full text

Cytotoxic Effects of Pulp Capping Agents on Mesenchymal Stem Cells Isolated from Human Exfoliated Deciduous Teeth by Bahareh Nazemi Salman, Ehsan Saburi, Mahtab Mohammadi Gheidari, Mahya Farsadeghi, Samira Basir Shabestari

“…Mineral trioxide aggregate (MTA), Biodentine, calcium enriched mixture (CEM) cement, and ferric sulfate (FS) are among the commonly used pulp capping agents (PCAs) for pulpotomy, and their successful application has been previously evaluated.Purpose: This study aimed to compare the cytotoxicity of PCAs against mesenchymal stem cells isolated from human exfoliated deciduous teeth (SHEDs).Materials and Method: In this in vitro study, SHEDs were exposed to MTA, Biodentine, CEM cement, and FS for 24 and 72 hours. …”
Get full text

FACTORS ASSOCIATED WITH D-DIMER ELEVATION IN PATIENTS WITH VENOUS THROMBOEMBOLIC EVENTS by N. M. Vorobyeva, E. P. Panchenko, A. B. Dobrovolskyi, E. V. Titaeva, O. V. Ermolina, T. V. Balakhonova, Z. B. Khasanova, A. Yu. Postnov, A. I. Kirienko

“…To study the factors associated with elevated D-dimer levels in patients with acute venous thromboembolic events (VTEE). material and methods. The study included 111 patients (76 men and 35 women aged 18–76 years) with a first or repeat episode of deep vein thrombosis (DVT) and/or pulmonary embolism (PE) in the last 2 months. …”
Get full text

Assessment of Management Effectiveness of Protected Areas for Sustainable Development (Case Study: Dez, Shimbar, Koraii) by Fakhrieh Mohseni, Gholam Reza Sabzghabaei, Soolmaz Dashti

“…These areas, which have undergone many changes in recent years, require more attention and management studies. 2-Materials and Methods The methodology of rapid assessment and prioritization of Protected Area Management (RAPPAM) is based on the process of a set of questionnaires. …”
Get full text

Valorizing pig hooves for activated carbon production with efficient Methyl green adsorption, DFT insights and bacterial removal via bio-adsorbent column by Tsenbeni N. Lotha, Rituparna Karmaker, Ketiyala, Vevosa Nakro, Lemzila Rudithongru, Imkongyanger, Francis A. S. Chipem, Latonglila Jamir

“…This research not only presents an efficient method for dye removal but also underlines the significance of repurposing waste materials, thereby supporting waste reduction and promoting eco-friendly practices for long-term environmental solutions and pollutant mitigation.…”
Get full text

Investigating the relationship between the Khami reservoir horizon in the Chilingar and Garangan oilfields in the Southern Dezful Embayment using surface geochemistry by Bahram Alizadeh, Arman Salehipour Bavarsad

“…To determine hydrocarbon content, soil samples were analyzed using acid extraction (AE) and fluorescence methods. Acid extraction showed that methane-to-ethane (C1/C2) and ethane-to-propane (C2/C3) ratios point to oil-associated hydrocarbons (Pixler 1969). …”
Get full text

Adjuvant therapy of surgical menopause symptoms in rehabilitation of patients with borderline ovarian tumors: a role of “cancer immunotherapy diet” by A. G. Solopova, A. Yu. Vlasina, E. A. Son, A. E. Ivanov, E. A. Ivanova

“…Aim: to examine intensity of surgical menopause symptoms (postovariectomy syndrome, POES) in patients with borderline ovarian tumors (BOTs) after radical surgery depending on the postoperative period management; to assess a role for “cancer immunotherapy diet”* as a standalone means in correction of surgical menopause symptoms as well as a part of patient-specific rehabilitation program.Materials and Methods. A prospective comparative study was conducted with 62 BOTs female patients aged 30 to 48 (42.0 ± 4.1) years underwent radical surgical treatment, subdivided into 3 groups: group I – “active” rehabilitation (29 subjects underwent 12 month-comprehensive personalized rehabilitation); group II – “passive” rehabilitation (17 women with standard management of the postoperative period in accordance with clinical recommendations); group III – 16 patients followed the one-year “cancer immunotherapy diet” (after being consulted by medical specialist and formulation of individual diet program). …”
Get full text

Improving the Provision of Medical Care to Patients With Stroke Using JCI Standards. First Results by R. Sh. Khasanov, A. V. Shulaev, M. F. Mukhamadeev, R. A. Dzhumabaev, Yu. S. Mukhamadieva, B. I. Zagidullin, R. M. Yakhin

“…AIM OF THE STUDY To compare the dynamics of thrombolytic therapy effectiveness in patients with stroke after the reorganization of medical care using JCI standards.MATERIAL AND METHODS In 2022, a new system for routing patients with stroke at the level of the emergency department was introduced in the Emergency Care Hospital; and 976 patients with the diagnosis of brain infarction were treated. …”
Get full text

Prognostic value of high-resolution electrocardiography parameters, heart rate variability, and QT interval dynamics in patients with chronic heart failure by A. E. Radzevich, V. V. Popov, N. A. Bulanova, M. Yu. Knyazeva

“…To study prognostic value of high-resolution electrocardiography (HR-ECG), heart rate variability (HRV), QT interval dispersion and duration parameters, for assessing the risk of chronic heart failure (CHF) decompensation, atrial fibrillation (AF), and sudden cardiac death (SCD) in coronary heart disease (CHD) patients. Material and methods. In total, 70 patients with various CHD forms, Functional Class II-III CHF (NYHA), and documented AF paroxysms in anamnesis, were examined. …”
Get full text

Features of arterial stiffness in preschool children by A. E. Nosov, O. Yu. Ustinova

“…The aim of the study was to identify the characteristics of arterial stiffness and develop criteria for increased and decreased (supernormal) arterial stiffness in preschool children. Material and methods. Twenty-four preschool children (10 boys and 14 girls) aged 62.3 ± 11.5 months were examined. …”
Get full text

Postoperative analgesic effect of adding neostigmine to levobupivacaine in ultrasound-guided spermatic cord block for testicular sperm extraction surgery by Amr Samir Wahdan, Ahmed Abdelhady Moussa, Mohamed Abdel Fattah Farag, Hasan Abdullah Alayyaf, Mennatallah Magdi Mohamed

“…This study targeted assessing the results of combining neostigmine with levobupivacaine in US-SCB for providing perioperative analgesia in patients undergoing testicular sperm extraction (TESE) surgery. Material and Methods: This double-blind, randomized controlled study was performed for 112 subjects undergoing TESE operation using general anesthesia. …”
Get full text

Evaluation & Criticism by Ahmed Benbernou, Alessandra Como, Olga Harea, Uta Pottgiesser, Kritika Singhal, Luisa Smeragliuolo Perrotta

“…The comparison was built by using different methods intersecting multiple points of view and following specific thematic tracks that seek to deconstruct the complexity of the middle-class mass housing topic into singular aspects. …”
Get full text

Problems of domestic school natural science education, patriotism promotion and their influence on the training of medical professionals by N. A. Bogdanov, A. P. Aniskina

“…To identify problems of domestic natural science education and patriotism promotion (as a motivational personality component), which negatively affect the professional training of health professionals.Material and methods. When working on the article, we used the following methods: theoretical — analysis of modern legal documents of secondary general education, analysis of recommended educational literature on subjects, and empirical — analysis of the experience of biology teachers in modern conditions according to the recommended programs of disciplines and standards; analysis of the results of the Unified State Exam (USE) for 2021-2022 and scientific generalization.Results. …”
Get full text

Three-Dimensional Evaluation of the Effects of Kinesio Taping on Postoperative Swelling and Pain after Surgically Assisted Rapid Palatal Expansion by Murat Ulu, Özgür Gözlüklü, Çiğdem Kaya, Nuri Ünal, Hüseyin Akçay

“…Objectives: The purpose of the present study was to evaluate the effects of kinesio taping on pain and swelling after surgically assisted rapid palatal expansion. Material and Methods: A total of 21 (12 male and 9 female) patients with transverse maxillary deficiency were enrolled in the study. …”
Get full text

Gender differences for myocardial infarction in ACS outcome with ST elevation in the Republic of Buryatia by L. B. Sodnomova, N. O. Bulutova

“…Study material and methods: 84 medical records of patients with myocardial infarction - 50 male and 54 female patients admitted in the emergency cardiac care department. …”
Get full text

Determination of spray-drying parameters for Limosilactobacillus reuteri and Lactiplantibacillus plantarum to include them in ice cream formulated with sweet whey by J.F. Ceron-Cordoba, L.C. Muñoz-Domínguez, J.U. Sepulveda Valencia, D.A. Restrepo-Molina

“…Spray drying, a protective method used to address this issue, employs prebiotics such as inulin and maltodextrin as wall materials, due to their selective fermentation by LAB and intestinal microbiota. …”
Get full text