A clinical case of treatment of a patient with laryngeal granular cell (Abrikossoff) tumor by Z. A.‑G. Radzhabova, M. A. Kotov, M. A. Radzhabova, O. I. Ponomareva, A. S. Artemieva, V. A. Kushnarev

“…The patient has undergone laryngectomy, thyroidectomy, and selective cervical lymph node dissection. Pathomorphological and immunohistochemical examinations of surgical material verified granular cell tumor of the larynx (Abrikosov’s tumor) that was excised within healthy tissues (R0). …”
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Role of the anatomic site in the association of HLA class I antigen expression level in metastases with clinical response to ipilimumab therapy in patients with melanoma by Timea Balatoni, Soldano Ferrone, Judit Olah, Andrea Ladányi, Eszter Papp, Anita Mohos, Anita Varga, Zsuzsanna Lengyel, Gabriella Emri

“…The aim of our study was to test human leukocyte antigen (HLA) class I and II expression in melanoma metastases as potential biomarkers of response to ipilimumab and survival in patients with metastatic melanoma, since these molecules play a crucial role in the interactions of malignant cells with host’s immune system.Materials and methods HLA class I and II antigen expression level in pretreatment surgical tissue samples (50 lymph node and 35 cutaneous or subcutaneous metastases) from 30 patients was analyzed by immunohistochemical staining with monoclonal antibodies. …”
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Correlation of P53 expression and epithelial-mesenchymal transition in non-small cell lung cancer by Xiangmei Wu, Lijiang Duan

“…Results: The positive expression rate of P53 and the incidence of EMT in NSCLC were closely linked to TNM stages, differentiation degree, and lymph node metastasis (P < 0.05). A positive association was found between P53 and EMT (r = 0.380, P < 0.05). …”
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Assessing the value of artificial intelligence-based image analysis for pre-operative surgical planning of neck dissections and iENE detection in head and neck cancer patients by Benedikt Schmidl, Cosima C. Hoch, Robert Walter, Markus Wirth, Barbara Wollenberg, Timon Hussain

“…Abstract Objectives Accurate preoperative detection and analysis of lymph node metastasis (LNM) in head and neck squamous cell carcinoma (HNSCC) is essential for the surgical planning and execution of a neck dissection and may directly affect the morbidity and prognosis of patients. …”
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Distinguishing atypical parotid carcinomas and pleomorphic adenomas based on multiphasic computed tomography radiomics nomogram: a multicenter study by Lin-Wen Huang, Jian-Chao Liang, Pei-Kun Cai, Zhi-Ping Cai, Mei-Lin Chen, Jia-Wei Pan, Yong-Feng Wen, Yun-Jun Yang, Zhen-Yu Xu, Ya-Bin Jin, Zhi-Feng Xu

“…ObjectiveThis study aimed to develop, validate, and test a comprehensive radiomics prediction model using clinical data and contrast-enhanced multiphasic computed tomography (CT) scans for differentiating between atypical parotid carcinomas (PCAs) and pleomorphic adenomas (PAs) within a multicenter cohort.Materials and methodsThe study involved 218 patients diagnosed with either PAs (n=162) or atypical PCAs (n=56) (no invasion of adjacent tissues or lymph node metastases) across three anonymized hospitals, divided into a training set (n=175) and a validation set (n=43). …”
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Magnetic Nanoparticles: Advances in Synthesis, Sensing, and Theragnostic Applications by Adeyemi O. Adeeyo, Mercy A. Alabi, Joshua A. Oyetade, Thabo T. I. Nkambule, Bhekie B. Mamba, Adewale O. Oladipo, Rachel Makungo, Titus A. M. Msagati

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SYSTEMATIC REVIEW AND METAANALYSIS OF THE RESULTS OF BREAST-CONSERVING SURGERY AFTER NEOADJUVANT CHEMOTHERAPY IN BREAST CANCER PATIENTS by A. R. Bosieva, M. V. Ermoshchenkova, A. D. Zikiryakhodzhayev, N. N. Volchenko

“…One of the main advantages of NACT is the reduction of the tumor size and regression of lymph node metastasis.The aim of the study was to analyze the outcomes of breast-conserving surgery after NACT compared to adjuvant chemotherapy, including the examination of the width of resection margins and the frequency of re-operations, the volume of tissue removed and cosmetic outcomes.Material and Methods. …”
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THE USE OF THE PROPELLER FLAP FOR COVERING SKIN DEFECT AFTER AXILLARY LYMPHADENECTOMY FOR BREAST CANCER by I. V. Reshetov, V. A. Khiyaeva, K. G. Kudrin, A. S. Fatyanova

“…The purpose of the study was to assess the feasibility of using the propeller flap to cover a large axillary fossa defect following lymph node dissection in breast cancer patients.Material and Methods. …”
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Predicting the hypoxic volume of head and neck tumors from fluorodeoxyglucose positron emission tomography images using artificial intelligence by Wei Zhao, Milan Grkovski, Heiko Schoder, Aditya P. Apte, John Humm, Nancy Y. Lee, Joseph O. Deasy, Harini Veeraraghavan

“…Hence, we tested the hypothesis that an artificial intelligence (AI) model could synthesize 18F-FMISO-like images from routinely acquired 18F-fluorodeoxyglucose (18F-FDG) PET images in order to predict primary tumor or metastatic lymph node hypoxic volumes. Materials and methods: One hundred and thirty-four (training = 84, validation = 13, testing = 21, additional testing = 16) HN carcinoma patients, treated with chemoradiotherapy between 2011 and 2018 and scanned at treatment baseline with 18F-FDG PET/computed tomography (CT) and 18F-FMISO dynamic PET/CT, were analyzed. …”
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THE ROLE OF BRAF MUTATION STATUS IN SURGICAL TREATMENT OF WELL-DIFFERENTIATED THYROID CANCER by A. P. Polyakov, N. N. Volchenko, E. N. Slavnova, A. V. Kudryavtseva, M. V. Ratushnyy, V. V. Ratushnaya, M. M. Filyushin, I. V. Rebrikova, P. A. Nikiforovich

“…At the same time neither multicentricity nor metastases in regional lymph nodes were associated with BRAF-mutation (p &gt; 0.05). …”
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The role of thoracoscopic pneumonectomy in surgical treatment of lung diseases by V. A. Porkhanov, V. V. Danilov, V. B. Kononenko, N. V. Naryzhnyi, A. L. Kovalenko, V. V. Shtraub, V. A. Zhikharev

“…The number of removed lymph nodes during lymphadenectomy in group 1 was (19±10) nodes (from 6 to 40), in group 2 – (18±9) nodes (from 6 to 38). …”
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ONCOLOGICAL RESULTS OF SURGICAL TREATMENT EFFECTIVENESS OF STAGE I AND II ORAL CAVITY CANCER by A. V. Karpenko, R. R. Sibgatullin, A. A. Boyko, N. S. Chumanikhina, M. G. Kostova, O. M. Nikolaeva, L. D. Roman

“…However, these data can be explained by older age of patients who didn’t undergo neck lymph node dissection (65.2 vs. 57.6 years), and presence of a more severe concomitant pathology.Conclusion. …”
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Long-Term Outcomes of Patients Undergoing Conversion Surgery After Induction Chemotherapy: Turkish Oncology Group Study by Furkan Ceylan, Selin Aktürk Esen, Olçun Ümit Ünal, Ferit Aslan, İlknur Deliktaş Onur, Öztürk Ateş, Erkut Demirciler, İlkay Tuğba Ünek, Ahmet Gülmez, Esra Özen Engin, Semra Taş, Gamze Gököz Doğu, Melih Şimşek, Hacı Mehmet Türk, Ali İnal, Gökhan Şahin, Haydar Çağatay Yüksel, Ateş Kutay Tenekeci, Mutlu Hızal, Mehmet Ali Nahit Şendur, Doğan Uncu

“…Factors associated with shorter PFS included advanced tumor stage (ypT3-T4), lymph node metastasis, and multiple metastases, while shorter OS was linked to advanced tumor stage and lack of objective response. …”
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Survival Impact of Postoperative Primary Area Radiotherapy on De Novo Metastatic Breast Cancer: A Retrospective Study by Pingchuan Li MD, Lineng Wei MS, Yinan Ji MD, Huawei Yang MD

“…Conclusion RT may improve disease control in selected dnMBC patients undergoing surgery, particularly those with lymph node metastasis. …”
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Decision-Making for Ablation of Colorectal Liver Oligometastases Patients: A 10-Year Retrospective Study of Survival Outcomes Based on Right-Versus Left-Sided Primary Tumor Locatio... by Xiao-Guang Qi MD, PHD, Jian-Ming Li MD, PHD, Jian-Ping Dou MD, PHD, Fang-Yi Liu MD, PHD, Zhen Wang MD, PHD, Zhao-He Zhang MD, PHD, Ping Liang MD, PHD, Jie Yu MD, PHD

“…Independent predictors of OS were identified, including multiple liver metastases ( P = .0085), right-sided colon cancer ( P = .0210), tumor size ≥2 cm ( P = .0273), and lymph node metastasis of primary colorectal cancer ( P = .0302), termed as the “MRSL” score. …”
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Factors Predicting Postoperative Quality of Life among Rectal Cancer Patients in Thailand: A Retrospective Cohort Study by Cherdsak Iramaneerat, Natthida Owattanapanich, Woramin Riansuwan, Varut Lohsiriwat, Siriluck Prapasrivorakul

“…The QoL measures were found to be negatively impacted by age and lymph node status. Gender, the type of operation, presence of ostomy, location of the tumor, preoperative radiation, adjuvant chemotherapy, laparoscopic approach, duration after surgery, proximal and distal margins, tumor size, metastasis, and recurrence showed no impact on the QoL. …”
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Clinical and laboratory differences between primary acute and reactivation of chronic Epstein-Barr viral infection in children (systematic review and meta-analysis) by M. M. Kulikova, T. V. Solomay, T. A. Semenenko

“…Distinctive signs of primary acute EBV infection are fever, generalized lymphadenopathy, enlargement of cervical lymph nodes, acute tonsillitis, exanthema, excess of ALT reference values, leukocytosis, the presence of atypical mononuclears. …”
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Efficacy and safety of thermal ablation for T1N0M0 papillary thyroid cancer in pediatric and adolescent patients - a preliminary multicenter retrospective study by Zhenlong Zhao, Shurong Wang, Shengnan Huo, Jinke Li, Lu Zhou, Lihong Liu, Songsong Wu, Zhibin Cong, Ying Wei, Jie Wu, Shiliang Cao, Na Yu, Yan Li, Ming’an Yu

“…The tumor progression rate was 4.0%, with one case of lymph node metastasis at the 24-month follow up. …”
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Improving the Anti-Tumor Effect of Indoleamine 2,3-Dioxygenase Inhibitor CY1-4 by CY1-4 Nano-Skeleton Drug Delivery System by Hui Li, Junwei Liu, Jingru Wang, Zhuoyue Li, Jianming Yu, Xu Huang, Bingchuan Wan, Xiangbao Meng, Xuan Zhang

“…In this study, the mesoporous silica nano-skeleton carrier material Sylysia was selected as the carrier to load CY1-4, and then the CY1-4 nano-skeleton drug delivery system (MSNM@CY1-4) was prepared by coating the hydrophilic polymer material Hydroxypropyl methylcellulose (HPMC) and the lipid material Distearoylphosphatidyl-ethanolamine-poly(ethylene glycol)₂₀₀₀ (DSPE-PEG₂₀₀₀) to improve the anti-tumor effect of CY1-4. …”
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Phase 2 Trial of Ultrahypofractionated Image-guided Partial Breast Irradiation Following Lumpectomy with Optional Oncoplastic Reconstruction for Early-stage Breast Cancer by Vani Gupta, BS, Andrew T. Wong, MD, Rachel Radigan, MPH, Michelle Sahagian, DO, Sophia L. Fu, MD, MS, Austin Barney, CMD, Jeffrey Pettit, MS, Rishi Shah, BS, Shridevi Singh, MD, Jana Deitch, MD, Johnny Kao, MD

“…All patients were locally controlled, but there were 2 ipsilateral breast events consisting of an intramammary lymph node failure and second primary triple-negative breast cancer outside the radiation field, both successfully salvaged with further local and systemic therapy. …”
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