Clinical significance of the phenotype of immune cells of the tumor stroma of prostate cancer by P. A. Podlesnaya, O. V. Kovaleva, M. A. Rashidova, D. V. Samoilova, A. A. Petrenko, V. V. Mochalnikova, A. N. Gratchev

“…We have shown that an increased content of CD204+ cells is associated with an older age of patients (p = 0.0026), and the number of CD163+ and CD8+ cells with no metastases to regional lymph nodes (p = 0.0067 and p = 0.0069, respectively). …”
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Refractory thrombocytopenia as a manifestation of Mycobacterium abscessus complex prosthetic valve endocarditis: a rare and fatal complication by Niladri Konar, Gaurav Gunjan

“…Positron emission tomography (PET) computed tomography (CT) showed reactive mesenteric lymph nodes. Auto-immune workup revealed antinuclear antibodies (ANA) weakly positive but ANA subtypes were negative, anti-neutrophil cytoplasmic antibodies (ANCA) immunofluorescence 2+ in 1:10 dilution (atypical pANCA), and MPO/PR3 negative. …”
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Molecular markers as predictors of response to perioperative chemotherapy in locally advanced gastric cancer by K. A. Oganyan, A. A. Musaelyan, S. V. Lapin, T. V. Kupenskaya, A. A. Sveсhkova, M. A. Belyaev, A. A. Zakharenko, S. V. Orlov

“…It was associated with low grade of differentiation (p = 0.048) and metastasis in regional lymph nodes (p = 0.037). PFS in patients with HER2-positive (HER2 – human epidermal growth factor receptor 2) GC treated with perioperative FLOT chemotherapy (4/45) was significantly lower than in patients with HER2-negative GC: the median was 156 and 317 days, respectively (hazard ratio 0.49; 95 % confidence interval 0.16–1.47; p = 0.0006). …”
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Clinical and diagnostic value of transrectal ultrasound in assessing the severity of ulcerative colitis by M.V. Stoikevych, M.V. Titova, T.S. Tarasova, O.P. Petishko

“…With their help, you can assess the state of the intestinal wall and obtain a cross-sectional image of the intestine, evaluate extraintestinal structures (lymph nodes, vessels, fatty tissue). It can be said that endoscopy and ultrasound search for the same type of information but look at different things. …”
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TREATMENT OF TRIPLE-NEGATIVE BREAST CANCER by A. D. Zikiryakhodzhaev, M. A. Frolova, E. A. Rasskazova, E. V. Glazkova

“…Grade IV treatment pathomorphosis for NAPCT per АС + Т scheme was achieved in 50.0 ± 7.9 % cases, for intensified regimen – in 62.5 ± 12.5 % cases.Median follow-up duration for this patient group was 22.1 months, and during this time disease progression was observed in 3 patients: in the 1st patient continued growth on the thoracic wall and brain metastases were diagnosed, in the 2nd patient – lung and supraclavicular lymph nodes metastases, in the 3rd patient – metastases in the cerebellum. …”
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Lymphoproliferative disorders and renal dysfunction: a case of CLL-related AKI by Akhil Tomy, Aswathi Balakrishnan, Siva Shrikanth, Cristoss Gregory, Maria Elizabeth John, Tanushree Dewan

“…Renal involvement in CLL/SLL, although uncommon, can cause kidney dysfunction through direct infiltration by neoplastic lymphocytes or immune-mediated damage.Imaging confirmed progressive lymphadenopathy, including enlarged lymph nodes in the neck, axilla and mediastinum, alongside splenomegaly, supporting systemic lymphoma progression. …”
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Efficacy and safety of cisplatin and paclitaxel (PlaTax regimen) in the neoadjuvant treatment of patients with stage II–III triple-negative breast cancer by O. O. Gordeeva, I. V. Kolyadina, L. G. Zhukova, I. P. Ganshina, G. V. Vyshinskaya, M. A. Kazantseva, M. V. Sukhova, O. E. Ryabishina, E. V. Lubennikova, D. A. Filonenko, E. I. Chichikov, I. N. Polushkina, E. I. Borisova, A. N. Lud, A. A. Meshcheryakov

“…Other important prognostic factors were size of the tumor, status of regional lymph nodes, grade. Delay in surgical treatment more than a month lead to decreased 3-year progression-free survival: 87.1 % vs. 62.5 % (p = 0.047).Conclusions. …”
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Comparison of inter- and intraobserver agreement between [18F]AlF-NOTA-octreotide and [68Ga]Ga-DOTA-SSA PET/CT by Hannes Leupe, Niloefar Ahmadi Bidakhvidi, Karolien Goffin, Bliede Van den Broeck, Sander Jentjens, Annouschka Laenen, Elin Pauwels, Willem Lybaert, Eric Van Cutsem, Guy Bormans, Timon Vandamme, Frederik Cleeren, Jeroen Dekervel, Karen Geboes, Sigrid Stroobants, Chris Verslype, Christophe M. Deroose

“…Organ-specific analysis revealed strong agreement for bone and liver lesions, with slightly lower agreement for lymph nodes. Both tracers also showed excellent agreement in determining Krenning scores (0.925 for [18F]AlF-OC and 0.927 for [68Ga]Ga-DOTA-SSAs). …”
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Calcitonin testing in patients with thyroid nodules for screening medullary thyroid carcinoma: a “gray zone” by N. V. Severskaya, A. A. Ilyin, I. V. Chebotareva, N. V. Zhelonkina, P. A. Isaev, V. V. Polkin, S. A. Ivanov, A. D. Kaprin

“…However, 22 % (5/23) had metastases to the neck lymph nodes. postoperative Ctn normalization was achieved in 96 % (22/23). …”
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Mechanisms of impaired expression of p53-responsive microRNA genes in diffuse B-large cell lymphoma by E. N. Voropaeva, T. I. Pospelova, M. I. Churkina, A. A. Gurazheva, O. V. Berezina, V. N. Maksimov

“…The aim of this study was to conduct a comprehensive analysis of the methylation of the genes of the p53-responsive microRNAs MIR-34A, MIR-34B/C, MIR-203 and MIR-129-2, as well as mutations in the DNA-binding domain and destruction of the polyadenylation signal of the TP53 gene in DLBCL.Materials and methods. 136 DNA samples isolated from tumor tissue of patients with DLBCL and 11 DNA samples obtained from lymph nodes with reactive B-cell follicular hyperplasia were analyzed. …”
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RECURRENCE OF BREAST CANCER AFTER SUBCUTANEOUS MASTECTOMY WITH SIMULTANEOUS RECONSTRUCTION by A. D. Zikiryakhodzhaev, E. A. Rasskazova

“…When radical subcutaneous mastectomy keep the skin of the breast, the nipple-areola complex (NAC), submammary fold, remove the entire gland tissue together with the axillary, subclavian and subscapularis lymph nodes. Konohana mastectomy differs from subcutaneous mastectomy with removal of the nipple-areola complex. …”
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Genetic features of indolent and advanced forms of systemic mastocytosis by D. I. Shikhbabaeva, O. Yu. Vinogradova, Yu. N. Kobzev, A. L. Neverova, S. G. Malakho, M. A. Molitvina, M. M. Pankrashkina, M. V. Chernikov, V. V. Ptushkin

“…Mastocytosis is a group of diseases characterized by tumor proliferation of mast cells and their accumulation in organs and tissues, including skin, hematopoietic organs (bone marrow, spleen, lymph nodes), and the gastrointestinal tract, which is clinically manifested by symptoms of mast cell activation and organ infiltration in the form of hepatosplenomegaly, portal hypertension, ascites, and cytopenia. …”
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High-risk human papillomavirus: prevalence, association with clinical and morphological characteristics of invasive cervical cancer by L. S. Mkrtchian, V. I. Kiseleva, B. V. Boyko, L. I. Krikunova, V. A. Petrov, V. R. Gusarova, S. A. Ivanov, A. D. Kaprin, I. A. Zamulaeva

“…Non-detection of HPV HR in cervical cancer is associated, including with a false negative result of the study.The literature analysis showed the presence of an association between HPV status and age, morphological form of the tumor, viral load, high oncogenic risk HPV genotype, presence of deep stromal invasion, and metastatic involvement of lymph nodes. With regard to such molecular genetic parameters of HPV HR as viral load and HPV DNA integration, associative relationship with prognostic important clinical indicators of cervical tumor – the stage of the disease, the loco-regional prevalence of the tumor process, the histological type of tumor – remains the subject of discussion.Conclusion. …”
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Prospective Phase II Trial of Definitive Chemoradiation and Concurrent Nivolumab in Locally Advanced p16+ Oropharynx Cancer by Samuel Nicholas Regan, MD, Jennifer Shah, MD, Krithika Suresh, PhD, Krystal A. Morales, MD, PhD, Yue Cao, PhD, Madhava Aryal, PhD, Benjamin S. Rosen, PhD, Heather Walline, PhD, Choonik Lee, PhD, Jessica Aldous, BS, Paul L. Swiecicki, MD, Keith A. Casper, MD, Steven B. Chinn, MD, Kelly M. Malloy, MD, Mark E.P. Prince, MD, Chaz L. Stucken, MD, Andrew G. Shuman, MD, Molly Heft-Neal, MD, Teresa H. Lyden, MA, CCC-SLP, Anna Blakely, MA, CCC-SLP, Madison Ambrose, MA, CCC-SLP, John Chad Brenner, PhD, Francis P. Worden, MD, Michelle L. Mierzwa, MD

“…Purpose: We conducted a prospective, single-institution phase II trial to test the hypothesis that the addition of nivolumab to definitive chemoradiation would improve the progression-free survival (PFS) among patients with high-risk p16+ oropharyngeal squamous cell carcinoma (OPSCC). Methods and Materials: Patients with previously-untreated locoregionally advanced, p16+ OPSCC (clinical T4/N3, matted lymph nodes, and/or retropharyngeal lymphadenopathy) were enrolled. …”
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Artificial intelligence in automatic image segmentation system for exploring recurrence patterns in small cell carcinoma of the lung by Jing Shen, Shaobin Wang, Hui Guan, Mingyi Di, Zhikai Liu, Qi Chen, Mei Li, Jie Shen, Ke Hu, Fuquan Zhang

“…The initial region of the primary tumor or metastatic lymph nodes was identified as a critical recurrence area, with a 100% recurrence rate in patients whose initial tumor region included 10 specific regions. …”
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Predicting the outcome of cytoreductive surgery in patients with advanced ovarian cancer by M.  G.  Yakovleva, T.  V.  Gorodnova, Kh.  B.  Kotiv, O.  A.  Smirnova, O.  E.  Lavrinovich, N.  A.  Mikaya, Yu.  N.  Trifanov, K.  D.  Guseynov, E.  V.  Bakhidze, I.  E.  Meshkova, A.  S.  Khadjimba, K.  S.  Kozyreva, М.  А.  Shagal, S.  А.  Тyatkov, D.  V.  Okonechnikova, E.  A.  Ulrich, A.  F.  Urmancheeva, I.  V.  Berlev

“…The main cause of non-optimal interventions (n = 52) were: diffuse carcinomatosis of the small bowel and its mesentery – 73 % (38 / 52), carcinomatosis of the hepatoduodenal zone – 9 % (5 / 52) and a total of 16 % (9 / 52) were other non-resectable tumors (paraaortal, intrathoracic lymph nodes, invasion of the pancreas or pleura, lung metastases). …”
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Tumores neuroendocrinos gastroenteropancreáticos: un estudio retrospectivo en el suroccidente colombiano by J.C. Bravo-Ocaña, N. López-Moreno, E.D. Salazar-Cardona, A.F. Mejía-Hurtado, V. Gutiérrez-Aragón, M. Gonzáles-Hurtado, L.A. Satizabal-Mayor, J.F. Lbasseauny-Morales, N. Rojas-Rojas, C.A. Rojas-Rodríguez

“…Early tumors are mainly located in the stomach and advanced tumors in the small intestine, with metastases in the liver and regional lymph nodes. The present study suggests the importance of disease awareness in the early detection of GEP-NETs; said factor, combined with timely interdisciplinary management, could significantly impact patient outcomes.…”
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