Rehabilitation effect on psycho-emotional well-being in women with surgically treated vulvar cancer: a randomised controlled trial by Blinov V. Dmitry, Antonina G. Solopova, Elena V. Gameeva, Nazim G. Badalov, Vsevolod N. Galkin, Mikhail A. Eremushkin, Alexandra M. Stepanova, Alexander E. Ivanov, Olga S. Gridasova

“…Surgical treatment of vulvar cancer (VC) entails mental and somatic disturbances due to pain, body image changes, and sexual dysfunction, which are closely associated with impaired social functioning and reduced overall quality of life. However, the results evaluating the impact of rehabilitation programmes on various components of quality of life in these patients remain limited. …”
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Building on the Translational Science Benefits Model to include team science: a practical and theory-based approach to continuous quality improvement and impact evaluation for Clin... by Kim C. Brimhall, Kim C. Brimhall, Kayla Kuhfeldt, Darrell N. Kotton, Darrell N. Kotton, Darrell N. Kotton, Matthew R. Jones, Matthew R. Jones, Matthew R. Jones

“…Qualitative data highlighted CQI strategies, such as embedding evaluation into advisory meetings to enhance program functioning. Inclusive leadership fostered a climate where diverse perspectives informed improvements. …”
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Efficiency of Therapeutic Use and Mechanisms of Therapeutic Effect of "Essentuki" and "Narzan" Mineral Waters in Various Diseases: a Review by Tatiana V. Konchugova, Tatiana V. Apkhanova, Tatyana V. Marfina, Detelina B. Kulchitskaya, Larisa A. Marchenkova, Valeriia A. Vasileva, Maxim Yu. Yakovlev, Olga M. Musaeva

“…Scientific analysis of experimental and clinical studies conducted by scientists from the Pyatigorsk Research Institute of Balneology showed that the multifaceted therapeutic effect of drinking mineral waters of the Essentuki type is realized not only due to the unique physical and chemical composition, but also due to the increase in the level of functional reserves of the body. Thus, under the influence of a single and course intake of mineral waters, an increase in the secretion of most digestive hormones (gastrin, glucagon, insulin, cholecystokinin, vasoactive intestinal polypeptide, etc.) was revealed, activating trophic processes in the digestive organs. …”
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Galectin-3 in the blood serum of patients with bone tumors by N. E. Kushlinskii, O. V. Kovaleva, P. L. Prishchep, N. N. Zybina, V. Jurisic, A. A. Alferov, Yu. B. Kuzmin, I. O. Goryacheva, I. N. Kuznetsov, I. V. Bulytcheva, S. R. Varfolomeeva, E. A. Sushentsov, E. S. Gershtein, D. V. Rogozhin, O. O. Yanushevich, I. S. Stilidi

“…Due to diversity of cancer, the functional role of galectin-3 is rather controversial; however, for many types of neoplasms, the marker acts as a tumor growth promoter.Aim. …”
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Distinct 5-methylcytosine profiles of LncRNA in breast cancer brain metastasis by Song Wang, Jianran Guo, Xinmiao Xian, Min Li, Anqi Zhang, Yujiao Liu, Yifei Zhang, Shen Chen, Guohao Gu, Xuehua Zhang, Dong Yan, Meng An, Li Pan, Bo Fu

“…Enrichment pathway analyses were through Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) to predict the potential functions of m5C in BCBM. Results The MeRIP-seq analysis identified 23,934 m5C peaks in BCBM and 21,236 m5C in BC. …”
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Optical and electron microscopy imaging of model circulating tumour cells by Марина Оленчук, Григорій Монастирський, Олена Гнатюк, А. Бойзен, Ч. Чжан, Галина Солянік, Денис Колесник, Сергій Карахім, Галина Довбешко

“…Materials and Methods: LLC cells were obtained from the National Bank of Cell Lines and Tumor Strains of the IEPOR (NAS of Ukraine) and cultured in RPMI-1640 medium under conditions of de-adhesive growth. …”
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Hemodynamic changes and their relationship with white matter hyperintensities in CSVD patients with cognitive impairment: a 4D flow study by Jiajun Cao, Chang Yuan, Zhenpeng Zhang, Xiaoying Zhao, Yukun Zhang, Peipei Chang, Qingwei Song, Bingwei Zhang, Rui Hu, Yanwei Miao

“…ObjectiveTo observe the hemodynamics of intracranial arteries and veins in patients with cerebral small vessel disease (CSVD) with cognitive impairment (CI), and to explore the association between these flow features and white matter hyperintensities (WMH).Materials and methodsA total of 53 patients with CSVD were included in the study, comprising 30 patients with CI (CI group) and 23 patients with non-CI (NCI group); Meanwhile, 25 age-matched cognitively healthy volunteers were recruited. …”
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Efficacy and safety of combination therapy with lenvatinib and pembrolizumab in elderly patients with advanced endometrial cancer by M. V. Volkonskiy, A. A. Akopyan, T. A. Zhelezkova, R. S. Zhikhorev, E. P. Krasnorutskaya, N. R. Abidova, T. A. Makarkina, M. O. Skorina, V. M. Filippova, I. A. Luev, Yu. V. Vasilyeva, G. D. Malina, L. P. Veshkina, B. L. Nersesyan

“…Additional studies are required to evaluate the efficacy and safety of the combination therapy of lenvatinib and pembrolizumab in patients with a more severe functional status.…”
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Establishment and molecular characterization of novel luminal A and luminal B canine mammary cancer cell lines for comparative oncology by Juthathip Jurutha, Yanika Piyasanti, Kornkanok Sritabtim, Suparat Chaipipat, Kannika Siripattarapravat, Sukumal Prukudom, Usuma Jermnak, Rungthiwa Sinsiri, Kakanang Wongsuppabut, Charuwan Wongsali, Nutawan Niyatiwatchanchai, Wijit Sutthiprapa, Napachanok Swainson, Wachiraphan Supsavhad

“…Immunohistochemistry (IHC) was used to assess expression of estrogen receptor alpha (ERα), progesterone receptor (PR), ErbB2, Ki-67, vimentin, and multi-cytokeratin. Functional assays (wound-healing and transwell migration) assessed metastatic behavior. …”
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Diagnostic Effectiveness of Transforming Growth Factor Beta 1 in Assessing the Risk of Developing Graft Dysfunction in Liver Recipient Children by R. M. Kurabekova, O. M. Tsiroulnikova, I. E. Pashkova, A. G. Olefirenko, O. E. Gichkun, L. V. Makarova, R. A. Monakhov, P. O. Shevchenko

“…Materials and methods. 95 children aged 3 to 73 months with liver cirrhosis of various etiologies were surveyed. …”
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Results of a study of the effectiveness of direct coronary oxygen persufflation as a donor heart conditioning method by M. O. Zhulkov, D. A. Sirota, I. S. Zykov, A. K. Sabetov, K. A. Agaeva, А. G. Makaev, D. M. Osintsev, A. P. Nadeev, V. Е. Kliver, E. E. Kliver, A. M. Volkov, A. R. Tarkova, А. V. Fomichev, A. M. Chernyavsky

“…Objective: to evaluate the technical feasibility as well as functional, metabolic and structural integrity of donor heart myocardium after 4 hours of direct intracoronary oxygen persufflation in an experiment. …”
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Mitigation of mycotoxin residues and activation of endogenous stem cells in broiler chickens using a toxin binder: Implications for meat safety and performance enhancement by Erma Safitri, Hery Purnobasuki, Tita Damayanti Lestari, Suzanita Utama, Rimayanti Rimayanti, Mirni Lamid, Mutmainah Wardatul Jannah, Siti Darodjah, Goo Jang, Mitsuhiro Takagi

“…These findings support the dual functional role of toxin binders in enhancing broiler meat safety and physiological resilience.…”
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Deciphering the anticoccidial mechanism of Qinghao Changshan formula through network pharmacology and molecular docking by Dong Tian, Hui Fu, Hongxia Tao, Miaolan Li, Qinghua Zhang, Weidong Deng

“…Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were conducted to explore relevant biological functions and pathways. Molecular docking was used to validate interactions between selected active compounds (isorhamnetin, kaempferol, quercetin) and key targets (epidermal growth factor receptor [EGFR], estrogen receptor 1 [ESR1], progesterone receptor [PGR]). …”
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The hormonal status of male combatants depending on the volume of body wounding by I.A. Lurin, E.M. Khoroshun, N.Yu. Seliukova, M. Rekhviashvili, V.V. Makarov, M.O. Boiko, V.V. Nehoduiko, K.V. Misiura

“…The metabolic response which occurs in human body independently of trauma severity is associated with necessity of the functioning of all organs and systems at the highest level in order to save lives of victims. …”
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COMPARATIVE ANALYSIS OF QUALITY OF LIFE AFTER THORACIC ENDOVASCULAR AORTIC REPAIR AND OPTIMAL MEDICAL THERAPY IN PATIENTS WITH UNCOMPLICATED TYPE B AORTIC DISSECTION by Anna Yu. Shkandala, Oleh V. Zelenchuk, Serhii M. Furkalo, Borys M. Todurov, Andrii V. Khokhlov, Nataliia O. Yashchenko, Serhii M. Sudakevych

“…Patients of group A had significantly higher total values of the physical component of quality of life compared to group B (51.0 (41.5; 54.5) points versus 42.0 (38.0; 47.0) points, p=0.032 ), while patients of group A were characterized by significantly higher values of the parameter "Physical functioning" (59.5; 75.0) points versus 64 (51.0; 68.0) points, p=0.043 and "Pain" (89 ( 71.5;95) points against 77(61.0;91.0) points, p=0.038) in comparison with patients of group B. …”
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Insights into De Quervain’s Tenosynovitis as an Unintended Consequence of Problematic Smartphone Usage: A Cross-sectional Observational Study by Aswin Sugumaran, Dilip Kumar Naidu, Madhan Raju, Sabari Vaasan Lakshmikanthan, S Karthikeyan, Kevin Dhas, Vamsi Krishna, Praveen Raja

“…Pain intensity was assessed using the VAS, while functional disability was measured using the quick DASH and PRWE questionnaires. …”
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Identification of novel molecular subtypes and construction of a prognostic signature via multi-omics analysis and machine learning in lung adenocarcinoma by Ke Ma, Jie Xu, Jie Xu, Congyue Wang, Congyue Wang, Xu Cao, Xu Cao, Wenjie Yu, Jingjing Xi, Xuan Zhang, Jiamin Zhan, Yang Liu, Aoyang Yu, Aoyang Yu, Shuhan Liu, Yanhua Liu, Yanhua Liu, Chong Chen, Chong Chen, Xiaoli Mai, Xiaoli Mai

“…This study aimed to identify novel molecular subtypes and construct a prognostic signature to enhance the stratification of LUAD prognosis.Materials and methodsNovel molecular subtypes of LUAD patients were identified by applying 10 distinct clustering algorithms on multi-omics data. …”
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History and development direction of iterative upgrading of deep coalbed methane reservoir reconstruction technology：Taking the Daji Block in the eastern margin of the Ordos Basin... by Fengyin XU, Huaibin ZHEN, Shuguang LI, Feng WANG, Lei ZHANG, Yubin WANG, Weichu YU, Weiping ZHU, Borui XU, Yun YANG, Haifeng ZHAO, Kunsen BAI

“…Practical application of finely tailored fracturing designs based on geological characteristics has yielded remarkable results.However, the paper identifies five key challenges and areas for improvement in deep coal reservoir stimulation: High water consumption and difficulties in managing flowback fluids during ultra-large-scale fracturing; The need for breakthroughs in intelligent fracturing technologies; Immaturity of collaborative fracturing methods; The urgent requirement to establish fracturing technology systems for deep, medium-to-low-rank coal seams; Incomplete functionality of fracturing fluids.To address these challenges, six development directions are proposed:① Advancing water-reducing fracturing techniques; ② Conducting research on fishbone horizontal wells combined with matrix acidizing for large-scale water-reduction and production enhancement; ③ Expanding the application of artificial intelligence in intelligent fracturing and post-fracturing evaluation; ④ Developing and implementing collaborative fracturing techniques to optimize well-to-fracture network integration; ⑤ Strengthening research and development and application of stimulation technologies for deep, medium-to-low-rank coal reservoirs; ⑥ Innovating new fracturing materials to further reduce costs, improve efficiency, and enhance recovery rates for deep CBM.…”
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The first generic tirzepatide GP30931: physicochemical and biological similarity to the reference drug by I. A. Lugovik, A. V. Babina, S. S. Arutyunyan, D. О. Ermolaeva, V. B. Saparova, T. N. Kobeleva, P. G. Zaikin, A. D. Mikushina, A. S. Bukatin, I. E. Eliseev, B. Ts. Zajchik, Y. S. Keruchenko, I. S. Ohrimenko, E. V. Bocharov, A. Kh. Taldaev, V. A. Lushpa, I. E. Makarenko, R. V. Drai

“…Conducting a physicochemical and biological characterization of the drug Sejaro® (GP30931) in comparison with the original drug Mundjaro® to establish their comparability.Materials and methods. Three batches of each drug (solution for subcutaneous administration, 25 mg/ml) were studied. …”
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Knee-Sparing Resection and Reconstruction Surgery for Bone Sarcoma Using 3D-Surgical Approach: Average of 5-Year Follow-Up by Amit Benady, Noy Yehiel, Ortal Segal, Omri Merose, Amir Sterenheim, Osnat Sher, Ben Efrima, Eran Golden, Yair Gortzak, Solomon Dadia

“…This study aims to evaluate the effectiveness of a precise 3D-based surgical approach for knee-sparing tumor resections, assessing its feasibility and its impact on surgical, oncological, and functional outcomes. <i>Materials and Methods</i>: This single-center retrospective study presents the surgical and oncological outcomes of knee-sparing surgeries following bone sarcoma resections. …”
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