Exploring the mechanism of triptolide inhibiting the motility of fibroblast-like synoviocytes in rheumatoid arthritis via RhoA/Rho-associated kinase axis, based on network pharmaco... by Jiacheng Shen, Jiacheng Shen, Jiacheng Shen, Yuxuan Fang, Yuxuan Fang, Nan Xu, Nan Xu, Hongyi Chen, Hongyi Chen, Miao Zhu, Miao Zhu, Dan Li, Dan Li, Zewen Chu, Masataka Sunagawa, Yanqing Liu, Yanqing Liu, Haibo Wang, Haibo Wang, Guoqing Li, Guoqing Li

“…The aim of this study was to investigate TPL-regulated effects on RA-FLS skeleton and reveal the specific mechanism of TPL-inhibition of RA-FLS migration and invasion.Materials and methodsIn vitro experiments were performed using RA-FLS cell line. …”
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Artificial intelligence analysis of thermal energy for convectively heated ternary nanofluid flow in radiated channel considering viscous dissipations aspects by Hamid Qureshi, Amjad Ali Pasha, Muhammad Asif Zahoor Raja, Zahoor Shah, Salem Algarni, Talal Alqahtani, Waqar Azeem Khan, Moinul Haq

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Inhibition of carbohydrate digestive enzymes by a complementary essential oil blend: in silico and mixture design approaches by El Hassania Loukili, Mouhcine Fadil, Amal Elrherabi, Mohammed Er-rajy, Mohamed Taibi, Khalil Azzaoui, Khalil Azzaoui, Rachid Salghi, Rachid Sabbahi, Mohammed M. Alanazi, Larbi Rhazi, Aleksandar Széchenyi, Aleksandar Széchenyi, Mohamed Siaj, Belkheir Hammouti

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The impact of a hazardous external environment on the quality of life, physical activity, and health of students in Ukraine, Poland, and Romania by Vladimir Potop, Igor Vypasniak, Iryna Ivanyshyn, Vasyl Lutskyi, Iryna Kryventsova, Lyudmila Shesterova, Krzysztof Prusik

“…In Romania, men showed better results in the psychological health component (42.79±8.61) compared to women (39.67±8.70) and higher physical functioning scores. Conclusions. The results of the analysis highlight that the war in Ukraine significantly impacts the physical and mental health of Ukrainian students. …”
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Immunohistochemical Assessment of Maspin, β-Catenin, and MMP-14 in Oral Potentially Malignant Lesions and Oral Squamous Cell Carcinoma: A Retrospective Observational Study by Oana Mihaela Condurache Hrițcu, Delia Gabriela Ciobanu Apostol, Ștefan Vasile Toader, Carmen Solcan, Daciana Elena Brănișteanu, Mihaela Paula Toader, Victor-Vlad Costan

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ANALYTICAL APPROACH IN EVALUATING THE RELATIONS OF ODONTOMETRIC INDICATORS AND LINEAR PARAMETERS OF DENTAL ARCS IN PEOPLE WITH VARIOUS FACE TYPES by D. A. DOMENYUK, S. V. DMITRIENKO, E. G. VEDESHINA, M. P. PORFYRIADIS, G. M.-A. BUDAYCHIEV

“…Interpretation of these indices can be used to characterize physiological occlusion, to determine the correspondence of the base dimensions of the dental arches of both jaws, and also to predict the shape and size of the dental arches in the treatment of patients with anomalies of occlusion in order to achieve an optimal functional and aesthetic result.…”
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Imaging techniques for diffuse myocardial fibrosis as a marker of high cardiovascular risk in young patients with type 1 diabetes mellitus by Oksana I. Vengrzhinovskaya, Irina Z. Bondarenko, Olga A. Shatskaia, Natalia V. Tarbaeva, Anastasya Iu. Korneluk, Victor Iu. Kalashnikov, Marina V. Shestakova, Natalia G. Mokrysheva

“…To assess the CVS structural and functional state in young patients with DM 1 without CVD according to echocardiography and MRI of the heart using T1 mapping. …”
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Investigation of Tongqiao Huashuan Granules’ effect on hippocampal neuron autophagy in vascular dementia rats via the PI3K/Akt-mTOR signaling pathway using network pharmacology and... by Xiaoqu Jiang, Shuyao Yu, Shuaifeng Yao, Sikai Wang, Jing Cai, Zhongsheng Tang, Shijie Zhu

“…The Gene Ontology (GO) functional enrichment analysis yielded a total of 569 items (BP: 366, CC: 97, MF: 106). …”
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Influence of pyridyl nitrogen’s position and hydrogen bonding interactions on antibacterial activities investigated by in vitro and in silico by Suma Ramachandra Gopady, Thripthi Nagesh Shenoy, Abdul Ajees Abdul Salam, Srikrishna Herga Damodar Kedlaya, Shashanka Puranika Kota, Anusha Prabhu, Yegneswaran Prakash Peralam, Srinivasulu Maddasani

“…Schiff’s base compounds are known for their diversified applications / functionalities. A Schiff base with a pyridine moiety in its molecular structure is anticipated with potential biological activity. …”
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Optimising the Timing of Health Resort Treatment in Patients with Arterial Hypertension and Increased Meteosensitivity: a Prospective Study by Tatyana A. Knyazeva, Irina A. Grishechkina, Maxim Yu. Yakovlev, Elena A. Valtseva, Mikhail V. Nikitin, Bertha Yu. Abramova, Alexey V. Chernov

“…To develop programs for restoring the functional state and adaptive capabilities of patients with arterial hypertension and increased weather sensitivity in order to optimize the duration of their spa treatment. …”
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Magnesium ions regulate the Warburg effect to promote the differentiation of enteric neural crest cells into neurons by Qiongqian Xu, Xixi He, Yaru Mou, Dong Sun, Xintao Zhang, Jichang Han, Xiaoyang Liu, Xingjian Liu, Xue Ren, Dongming Wang, Jian Wang, Chuncan Ma, Qiangye Zhang, Aiwu Li

“…This study explores how magnesium ions regulate the glycolytic pathway to enhance ENCCs differentiation into neurons. Materials and methods We used polymerase chain reaction, western blot, immunofluorescence, and multielectrode array techniques to assess magnesium ions' impact on ENCCs differentiation. …”
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Green Synthesis, Characterization and Pharmaceutical Applications of Biocompatible Zinc Oxide Nanoparticles Using <i>Heliotropium rariflorum</i> Stocks by Noor Ul Uza, Ghulam Dastagir, Syed Tanveer Shah, Elitsa Pavlova, Aftab Jamal, Mahmoud F. Seleiman, Jakub Černý

“…These NPs are used in food packaging materials, self-cleaning glass, ceramics, deodorants, sunscreens, paints, coatings, ointments, lotions, and as preservatives. …”
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Evaluation of lymphangiogenesis in acellular dermal matrix by Mario Cherubino, Igor Pellegatta, Federico Tamborini, Michele Cerati, Fausto Sessa, Luigi Valdatta

“…Special attention was given to lymphangiogenic aspects. Materials and Methods: Among 57 rats selected to analyse the role of ADM in lymphangiogenesis, we created four groups. …”
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Construction of DF-1 Cell Line of Stably Expressing Cas9 Protein Mediated by Lentivirus and Verification of Its Activity by Xiaojiao LI, Xinyu ZHU, Xian ZOU, Xia YAN, Yanhua HE, Chenglong LUO

“…【Conclusion】The DF-1 cell line of stably expressing Cas9 protein with cleavage activity was successfully established, which could provide basic materials for the subsequent research on chicken functional genes on the DF-1 cell line of stably expressing Cas9 protein.…”
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Feasibility, Added Value, and Radiation Dose of Combined Coronary CT Angiography and Stress Dynamic CT Myocardial Perfusion Imaging in Moderate Coronary Artery Disease: A Real-Worl... by Marco Fogante, Enrico Paolini, Fatjon Cela, Paolo Esposto Pirani, Liliana Balardi, Gian Piero Perna, Nicolò Schicchi

“…Conclusion: The combined CCTA and dynamic CT-MPI protocol is feasible in real-world clinical practice and offers a comprehensive morphological and functional assessment of moderate CAD, with a manageable radiation dose and examination time.…”
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WEB SERVICE OF WORKS PLANNING USING NETWORK GRAPH by Інна Грод, Надія Балик, Ярослав Василенко, Сергій Мартинюк, Василь Олексюк, Ольга Барна

“…A brief description of the functionality and user interface of the proposed web application is provided. …”
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Effects of Prostaglandin E1 and Balloon Atrial Septostomy on Cerebral Blood Flow and Oxygenation in Newborns Diagnosed with Transposition of the Great Arteries by Manuela Cucerea, Maria-Livia Ognean, Alin-Constantin Pinzariu, Marta Simon, Laura Mihaela Suciu, Dana-Valentina Ghiga, Elena Moldovan, Mihaela Moscalu

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Increasing cisplatin exposure promotes small-cell lung cancer transformation after a shift from glucose metabolism to fatty acid metabolism by Qiu-yu Zhao, Wen-jun Liu, Jian-guang Wang, He Li, Jia-lu Lv, Yumeng Wang, Chun Wang

“…RNAseq analyses identified TP53 and RB1 gene mutations. Comprehensive functional assays were performed to characterize A549/DDP1 μg/mL and A549/DDP3 μg/mL cells, focusing on proliferation and migratory capabilities. …”
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Pathway-based cancer transcriptome deciphers a high-resolution intrinsic heterogeneity within bladder cancer classification by Zhan Wang, Zhaokai Zhou, Shuai Yang, Zhengrui Li, Run Shi, Ruizhi Wang, Kui Liu, Xiaojuan Tang, Qi Li

“…Results Four BLCA intrinsic subtypes with different molecular, functional and phenotypic characteristics were successfully identified. …”
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Intraoperative Three-dimensional Imaging for Detection of Malreduction during Tibiofibular Syndesmosis Reconstruction—Evaluating Fibula–Tibia Positional Accuracy and Outcomes: Case... by Adriaan L Franx, Corné Kanters, Inger B Schipper, Pieta Krijnen, Jochem M Hoogendoorn, Sander M Verhage

“…Aims and background: Distal tibiofibular syndesmosis injuries often require stabilization to prevent osteoarthritis (OA) and functional impairment. Malreduction rates up to 52% have been reported after fluoroscopy-guided fibula–tibia (fib–tib) positioning screw placement, and malreduction is associated with poor outcomes, including chronic pain, instability, and posttraumatic arthritis. …”
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