Trim21 deficiency alleviates osteoporosis by inhibiting osteoclast differentiation through regulating Txnip by Ya-Chen Peng, Yong-Sheng Ye, Qin-Xiao Hu, Zhi-Quan Hao, Zhen-Yan Li, Luo-Yong Jiang, Hao-Ran Peng, Ri-Xu Liu, Zhen-Gang Zha, Huan-Tian Zhang

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Menin facilitates the cell proliferation of bladder cancer via modulating the TFAP2C/β-catenin axis by Qing Shi, Xiang Pan, Shiheng Zhang, Mengyuan Wu, Meiqi Xu, Yun-Qi Li, Li Zhong, Zi-Qi Wang, Wanhai Xu, Yakun Luo

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An extract from the culture of a thermophilic <i>Staphylococcus aureus</i> strain suppresses allergic inflammation in the airways <i>in vivo</i> and degranulation of mast cells and... by O. V. Kalyuzhin, O. V. Proskurina, S. A. Sukhanova, N. V. Novikova, N. A. Kolganova

“…To study the anti-allergic effects of ruzam, an extract from the culture of a thermophilic Staphylococcus aureus strain, in an in vivo model of asthma and its influence on degranulation of mast cells and basophils in vitro.Materials and methods. Allergic asthma in guinea pigs was reproduced by two intraperitoneal injections of ovalbumin followed by a series of inhalations of this antigen for 1.5 months. …”
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Predictive Value of Resistin in Acute Coronary Syndrome Patients with and without Type 2 Diabetes Mellitus by Istabraq shehap, Hazim Ghazzay, Khalid Abdulghafoor

“…Also, resistin is an effector molecule of the inflammatory response that contributes to ACS.…”
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Sufficiently activated mature natural killer cells derived from peripheral blood mononuclear cells substantially enhance antitumor activity by Chuanling Liu, Yingying Li, Yanrong Li, Meng Hu, Haiyan Wang, Shasha Lu, Zhao Li, Dilinuer Dilimulati, Shunchang Jiao, Shelian Lu, Weihong Zhao

“…Thus, strengthening the cytotoxic effector function of PBNK cells and improving NK cell expansion in vitro for a convenient allogeneic therapy are essential. …”
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Enhancement of systemic and lung-localized CD4⁺ T-cell immune responses by truncation of NS1 protein of a seasonal live influenza vaccine strain by Polina I. Prokopenko, Ekaterina A. Stepanova, Victoria A. Matyushenko, Alexandra Ya. Rak, Anna K. Chistyakova, Arina D. Kostromitina, Tatyana S. Kotomina, Igor V. Kudryavtsev, Artem A. Rubinstein, Alexey S. Komlev, Larisa G. Rudenko, Irina N. Isakova-Sivak

“…Truncation of NS1 protein of the LAIV strain significantly increased the levels of virus-specific CD4+ effector memory T cells in spleens and the levels of CD4+ tissue-resident memory T cells in lungs of mice after two-dose immunization, indicating a higher potential for protection against influenza infection of the LAIV NS126 vaccine strain compared to the classical variant of LAIV. …”
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An organotypic human melanoma-in-skin model as an in vitro tool for testing Vγ9Vδ2-T cell-based immunotherapy by E. Michielon, L.A. King, T. Waaijman, M. Veth, S.W. Spiekstra, H.J. van der Vliet, S. Gibbs, T.D. de Gruijl

“…Materials and methods: Vγ9Vδ2-T cells were introduced into Mel-RhS via intradermal injection and cultured within the tissue microenvironment for up to 3 days. …”
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Membrane and Soluble CD137 in Systemic Lupus Erythematosus: Role as Biomarkers for Disease Activity by Fulvia Ceccarelli, Francesco Natalucci, Alessandra Di Filippo, Giulio Olivieri, Chiara Napoletano, Aurelia Rughetti, Marianna Nuti, Ilaria Grazia Zizzari, Fabrizio Conti

“…Materials. We enrolled SLE patients and sex/age-matched healthy subjects (HS). …”
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EFFECT OF GLYPROLINES ON THE LEVEL OF APOPTOTIC AND NEUROTROPHIC FACTORS UNDER CONDITIONS OF “SOCIAL” STRESS by A. L. Yasenyavskaya, A. A. Tsibizova, L. A/ Andreeva, N. F. Myasoedov, O. A. Bashkina, M. A. Samotrueva

“…Thus, the administration of glyproline neuropeptide compounds Thr–Lys–Pro–Arg–Pro–Gly–Pro (Selank), Pro–Gly–Pro and Pro–Gly–Pro–Leu under stress conditions, contributes to the restoration of the initiating and effector caspases level, as well as of neurotrophic factors. …”
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TIGIT immunosuppressive role in female reproductive system malignant neoplasms: from mechanism to therapy by A. U. Khamadyanova, A. I. Romanova, A. N. Sklyar, A. P. Yamilova, M. G. Miranda Planas, G. D. Galeeva, S. R. Khakimov, A. A. Yakubov, S. K. Bikinyaev, Sh. M. Mammaev, A. A. Vardanyan, P. A. Kantaeva, T. R. Algirieva

“…TIGIT blockade, especially in combination with PD-1/PD-L1 (programmed cell death ligand 1), restores effector cell function and enhances antitumor immunity in preclinical and clinical studies.Conclusion. …”
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A combination of PD-1 and TIGIT immune checkpoint inhibitors elicits a strong anti-tumour response in mesothelioma by Huaikai Shi, Ta-Kun Yu, Ben Johnson, Sakthi Priya Selvamani, Ling Zhuang, Kenneth Lee, Sonja Klebe, Samuel Smith, Kirby Wong, Kate Chen, Georgina Clark, Emma M. Rath, Holly Pearson, David Gallego Ortega, Anthony Linton, Steven Kao, Pablo Silveira, Yuen Yee Cheng

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Structural and functional characteristics of the T helpers 17 subpopulation in allergic diseases of the respiratory organs in children by E. V. Prosekova, N. G. Plekhova, A. I. Turyanskaya, V. A. Sabynych

“…The purpose of the present study was to analyze the subpopulations of Th17 lymphocytes and IL-17A, IL-17F interleukins in children with atopic asthma and allergic rhinitis. Materials and methods: a comprehensive assessment of structural and functional characteristics of T helper cells was carried out in 60 children aged 3-11 years with a verified diagnosis of atopic asthma. …”
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Radiation-Based Multi-Modal Therapy Combining with Immunotherapy to Develop a Vaccine-Like Effective Treatment for Triple-Negative Breast Cancer by Dai M, Tian Z, Xu F, Yao B, Liang H, Li D, Wang J, Rong J, Liu T, Tang H, Lu H, Zhang W

“…The synergistic therapy exerts a powerful vaccine-like long-term immune memory function to prevent tumor recurrence with the elevated level of effector memory T (Tem) cells (from 12.8% to 33.3%, P &amp;lt; 0.05).Conclusion: Based on the 4T1 mouse model, developed an effective vaccine-like therapeutic strategy combining X-PDT with Anti-CTLA4, which can effectively ablate tumors, inhibit metastasis, and prevent tumor recurrence. …”
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Anti-tumor effects of NK cells and anti-PD-L1 antibody with antibody-dependent cellular cytotoxicity in PD-L1-positive cancer cell lines by Bhumsuk Keam, Miso Kim, Tae Min Kim, Dong-Wan Kim, Dae Seog Heo, Ha-Ram Park, Soyeon Kim, Ji-Eun Park, Seong-Eun Kim, Junsang Doh

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Influence of stress on cellular immunity in patients with autoimmune thyroid pathology by Yu.I. Karachentsev, O.A. Goncharova, V.M. Dubovyk, L.V. Gerasymenko, K.O. Pobelensky

“…The purpose of the study was to establish the features of the cellular link of the immune response to stress in patients with autoimmune thyroiditis and diffuse toxic goiter. Materials and me­thods. Sixty patients with AITDs were examined in the clinic of V. …”
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