Nopal and Pirfenidone Ameliorate Epididymal Fat Weight and Anthropometric Parameters in a Mouse Obesity Model with Diethylnitrosamine by Jorge Gutiérrez-Cuevas, Daniel López-Cifuentes, Ana S. Sandoval-Rodríguez, Juan Armendariz-Borunda

“…Mexico has a high prevalence of obesity and metabolic dysfunction-associated steatotic liver disease (MASLD). …”
Get full text

An Assessment of Endothelial Markers in Patients with Uncomplicated Malaria in Jazan Province, Saudi Arabia by Madkhali A, Dobie G, Mobarki AA, Essawi K, Hakami W, Hakami AR, Nahari MH, Matari YH, Alhazmi R, Alkurbi M, Musawi S, Alyahyawi Y, Alhakami FA, Akhter MS, Saboor M, Hakamy A, Hamali HA

“…This study aimed to assess circulating endothelial cell markers and their correlation with routine laboratory parameters and parasite density in malaria patients compared to matched healthy controls.Materials and Methods: This study included 34 patients with non-severe P. falciparum malaria and 34 matched-healthy controls from the Jazan region. …”
Get full text

Epidemiological Analysis of Outcomes of Small Obstetric Operations by I. V. Taranenko, A. V. Lubimova

“…Many patients are afraid to address and ask questions about personal feelings and sexual life at the reception. Sexual dysfunction may be formed after performing obstetric benefits or injuries to the soft tissues of the birth canal, actually should be regarded as maternal morbidity. …”
Get full text

Features of short-term heart rate variability in internally displaced people with type 2 diabetes mellitus by V.A. Serhiyenko, V.B. Sehin, V.I. Pankiv, A.A. Serhiyenko

“…Anxiety and depression inherent in IDP predict slow recovery and increase the risk of post-traumatic stress disorder and mortality. Dysfunction of the autonomic nervous system is often combined with type 2 diabetes mellitus (T2DM) and cardiac autonomic neuropathy (CAN). …”
Get full text

The aspirin resistance and platelets` receptors expression in chronic heart failure patients with type 2 diabetes mellitus by M. Yu. Kolesnyk, V. V. Syvolap

“…The presence of DM in CHF patients can dramatically increase platelet dysfunction. The problem is much complicated by high level of aspirin resistance in diabetic patients. …”
Get full text

AAV8 gene therapy for mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) in a patient's liver maintained ex situ for 9 days by Teresa Brevini, Lisa Swift, Helen Reynolds, John Ong, Richard Stopforth, Yogeshkumar Malam, Harry Spiers, AnnaPaterson, Adam Duckworth, Arthur Kaser, Vassillis Kosmoliaptsis, Ramon Marti, Jelle van den Ameele, Gwilym Webb, Christopher Watson, Andrew Butler, Fotios Sampaziotis

“…Introduction: Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare genetic disorder caused by mutations in TYMP.1 This results in nucleoside accumulation, mitochondrial damage and progressive gastrointestinal and neurological dysfunction leading to cachexia and death before 40 years. …”
Get full text

The Functional State of the Myocardium in Patients with Ischemic Heart Disease, Diabetes Mellitus Type 2 and Cardiac Insufficiency by Horb Yu., Strona V., Komir I.

“…The earliest sign of myocardial damage in type 2 diabetes is the appearance of diastolic dysfunction of the left ventricle with subsequent dilatation of its cavity and the development of progressive heart failure and heart rhythm disorders. …”
Get full text

An Engineered Hierarchical Hydrogel with Immune Responsiveness and Targeted Mitochondrial Transfer to Augmented Bone Regeneration by Wenjin Cai, Shihua Mao, Ying Wang, Bicong Gao, Jiaying Zhao, Yongzheng Li, Yani Chen, Dong Zhang, Jintao Yang, Guoli Yang

Get full text

Hepatoprotective Therapy Efficacy in Obstructive Hepatobiliary Diseases: A Prospective Randomized Study by Mykhailo Maksymenko, Olexii Kulivets, Roman Havryliuk, Walery Zukow

“…Despite significant advances in interventional and surgical approaches, liver dysfunction associated with these disorders continues to substantially impact patient morbidity and mortality. …”
Get full text

Integrated Single-Cell and Spatial Transcriptomic Analysis Identifies ISR-Related Genes Driving Immune Regulation in Parkinson’s Disease by Jiang H, Zhang X, Feng S, Feng W

“…The integrated stress response (ISR), a conserved mechanism activated by cellular stress, has been linked to several neurological diseases, but its role in PD and the key ISR-related genes involved are still poorly understood.Materials and Methods: We used publicly available transcriptomic data from GEO, including single-cell RNA sequencing and spatial transcriptomics, to identify ISR-related genes involved in PD progression. …”
Get full text

The Role of qSOFA, Derived Neutrophil-to-Lymphocyte Ratio, MEWS, and PIRO Scores in Predicting the Severity of Odontogenic Infections in Young and Adult Patients by Serban Talpos Niculescu, Robert Avramut, Tareq Hajaj, Raluca Maracineanu, Antonis Perdiou, Roxana Talpos Niculescu, Marius Pricop, Horatiu Urechescu, Florin Urtila, Roxana Radu, Nicoleta Nikolajevic Stoican, Malina Popa

Get full text

Common Ɣ-chain cytokine receptors as functional phenotype markers of PD-1and TIM-3-positive T cells in multiple myeloma by E. V. Batorov, V. A. Aristova, G. Yu. Ushakova, S. A. Sizikova, V. V. Denisova, E. Ya. Shevela, A. A. Ostanin, E. R. Chernykh

“…PD-1+ and/or TIM-3+ levels of activated, dysfunctional, and regulatory T cells can potentially be used to predict the safety and efficacy of targeted immunotherapy.…”
Get full text

DIAGNOSTIC SIGNIFICANCE OF NOVEL MARKERS FOR ASSESSMENT OF MYOCARDIUM CONDITION IN OBSTRUCTIVE DIFFUSE-GENERALIZED FORM OF HYPERTROPHIC CARDIOMYOPATHY by Yu. V. Frolova, O. V. Dymova, M. A. Babaev, S. Yu. Kim, E. Yu. Van, V. E. Sinitsin, E. A. Mershina, S. L. Dzemeshkevich

“…To evaluate informativity and relation of changes of galectin-3 (G3) and natriuretic brain peptide (BNP) in diagnostics of myocardium dysfunctions during analysis of surgical intervention in HCMP patients.Material and methods. …”
Get full text

The Association between Allergies and Hematologic Tumors — A Review by Aleksandra Hrapkowicz, Joanna Szydziak, Kinga Janowska, Olga Szeidl, Dominika Rehan, Julia Wołoszczak, Agnieszka Mioskowska , Daria Dąbkowska

“… Introduction: Dysfunctions of the immune system in allergic diseases and hematological malignancies are the subject of many studies due to the mechanisms that link them. …”
Get full text

Advancing offline magnetic resonance-guided prostate radiotherapy through dedicated imaging and deep learning-based automatic contouring of targets and neurovascular structures by Philipp Schubert, Matthias May, Daniel Höfler, Hans-Peter Fautz, Jana Hutter, Ricarda Merten, Sina Mansoorian, Thomas Weissmann, Lisa Deloch, Miriam Schonath, Nathalia Belmas, Felix Grabenbauer, Benjamin Frey, Udo Gaipl, Bernd-Niklas Axer, Juliane Szkitsak, Michael Uder, Christoph Bert, Rainer Fietkau, Florian Putz

“…Background and Purpose: Erectile dysfunction (ED) affects quality of life following radiotherapy for prostate cancer. …”
Get full text

Pathomorphological parameters of sepsis-associated encephalopathy in deceased septic patients without purulent lesions to the brain by T. V. Shulyatnikova, L. M. Tumanska

“…The obtained data indicate that the delirious state, loss of consciousness and other manifestations of SAE are associated with ischemic-hypoxic and ammonia-induced ischemic and apoptotic changes of the brain neurones; small foci of encephalolysis; adaptive remodeling and dystrophic changes of astrocytes; microglial reactiveness with increased proportion of phagocytic microgliocytes; brain edema and dysfunctional glymphatics.…”
Get full text

Electrophysiological markers of advanced stages of glaucomatous optic neuropathy by V. I. Kotelin, M. V. Zueva, I. V. Tsapenko, S. Yu. Petrov, A. N. Zhuravleva

“…Purpose: to determine the changes in electrophysiological parameters reflecting specific dysfunctions of retinal ganglion cells (RGCs) at advanced stages of glaucomatous optic neuropathy (GON).Material and methods. …”
Get full text

Restoration of the functional state of military personnel after gunshot wounds to the upper limb using physical therapy measures based on the principles of neuroplasticity by Nataliia Shestopal, Helen Bismak, Olena Lazarieva

“…MG patients experienced significantly fewer limitations associated with upper limb dysfunctions compared to CG, which had a positive effect on the ability to perform exercises related to professional activity according to the results of the military questionnaire. …”
Get full text

Attention deficit hyperactivity disorder symptoms among medical students at the University of Belgrade: Detection and association with sociodemographic characteristics, academic ac... by Kojović Natalija, Joković Nikola, Mandić-Maravić Vanja, Marić Nađa P.

“…Mental disorders, social difficulties and dysfunctionality are maintained in adulthood, but they can also be resolved. …”
Get full text

Efficacy of osmotic laxative polyethylene glycol 4000 in treatment of constipation in pediatrics by S. I. Erdes, B. O. Matsukatova, S. A. Revyakina, Ye. V. Casanave

“…To evaluate the dynamics of clinical symptoms of constipation at children and parameters of peripheral electrogastroenterography (PEGEG) on treatment with osmotic laxative polyethylene glycol 4000 (PEGs).Material and methods. For treatment of constipation in 15 children aged 5 to 17 years (average – 9,9±3,9 year) 14-day's course of intake of osmotic laxative PEG (Forlax®, «Beaufour Ipsen Pharma», France) was prescribed. …”
Get full text