First trimester thyroid function in pregnant women residing in Saint Petersburg (Russia): reference values and risk of gestational diabetes by Polina V. Popova, Ekaterina S. Shilova, Alexandra S. Tkachuk, Alexandra V. Dronova, Anna D. Anopova, Alla E. Nikolaeva, Elena N. Grineva

“…The concept of subclinical dysfunction of the thyroid gland in pregnant women depends on the population-specific and trimester-specific reference values so fixed universal cutoff concentrations for thyroid-stimulating hormone (TSH) that were recommended earlier now are put under the question. …”
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Prioritizing FDA approved therapeutics for treating sepsis phenotypes: A network modeling approach based on neutrophil proteomics by Jordan C. Langston, Dan Liu, Qingliang Yang, Salim Merali, Carmen Merali, Narender Singh, Jennifer L. Fisher, Balabhaskar Prabhakarpandian, Laurie E. Kilpatrick, Mohammad F. Kiani, Mohammad F. Kiani

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Human neuron chimeric mice reveal impairment of DVL-1-mediated neuronal migration by sevoflurane and potential treatment by rTMS by Youyi Zhao, Ya Zhao, Lirong Liang, Andi Chen, Yuqian Li, Ke Liu, Rougang Xie, Honghui Mao, Boyang Ren, Bosong Huang, Changhong Shi, Zhicheng Shao, Shengxi Wu, Yazhou Wang, Hui Zhang

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Mediating Effects of Systemic Inflammation on the Association Between Body Roundness Index and Periodontitis in US Adults by Hui Zhang, Zhengyun Ren, Xi Peng, Tailin Guo

“…Obesity, particularly the dysfunction of adipose tissue in visceral obesity, leads to the secretion of many pro-inflammatory factors, triggering systemic inflammatory responses. …”
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Experience with conservative rehabilitation in patients with juvenile chronic arthritis by T. A. Shelepina, N. N. Kuzmina

“…Objective: to estimate a need for conservative rehabilitation treatment in patients with juvenile chronic arthritis (JCA).Material and methods. Data on the principles and procedures of rehabilitation treatment were analyzed in patients with JCA on the basis of 25- year experience. …”
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Psychology and psychopathology related to leadership by José Manuel Bertolín Guillén, Patricia De Retes Candenas

“…The mental and behavioural dysfunctions, traits and disorders of historical leaders often form a complicated web of adaptive and maladaptive behavioural characteristics. …”
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Non-immunogenic staphylokinase — a thrombolytic agent in the treatment of massive pulmonary embolism: results of the FORPE clinical trial by A. I. Kirienko, S. G. Leontyev, E. B. Yarovaya, S. I. Konstantinov, B. B. Orlov, Imad Meray, D. V. Duplyakov, V. E. Oleynikov, E. Yu. Vasilyeva, E. A. Ponomarev, S. A. Pribylov, A. G. Komarova, V. V. Bobkov, R. M. Rabinovich, G. V. Klein, Z. S. Shogenov, Yu. V. Karabach, V. N. Zolkin, V. V. Kulabukhov, V. V. Kashtalap, K. A. Linev, G. I. Stryabkova, N. V. Yasnopolskaya, V. Yu. Tolmacheva, Zh. Yu. Chefranova, Yu. A. Lykov, E. S. Panina, N. V. Solovieva, E. V. Rybin, N. V. Furman, E. V. Kulibaba, V. V. Makukhin, A. G. Koledinsky, I. S. Mullova, N. A. Cherepanova, T. V. Pavlova, P. P. Savvinova, I. A. Libov, A. S. Igoshin, I. Yu. Bogomazov, T. B. Pecherina, L. O. Lyudnev, P. N. Vlasov, I. V. Avdeeva, D. B. Maksimov, E. V. Komissarova, V. S. Ivanov, N. L. Vyazova, E. V. Vyshlov, D. S. Kurtasov, V. A. Kutsenko, O. E. Ivlev, A. G. Soplenkova, S. N. Tereshchenko, I. S. Yavelov, R. M. Shakhnovich, A. D. Erlikh, O. B. Talibov, A. M. Semenov, M. P. Semenov, S. V. Ivanov, Yu. A. Romashova, V. V. Beregovykh, A. I. Archakov, S. S. Markin

“…Non-immunogenic staphylokinase is a modified recombinant staphylokinase with low immunogenicity, high thrombolytic activity and fibrin selectivity.Material and methods. This multicenter, open-label, randomized, comparative clinical trial FORPE in two parallel groups was conducted in 23 clinical centers in Russia. …”
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Rare Presentation of Pulmonary Alveolar Proteinosis Causing Acute Respiratory Failure by Ryan R. Kroll, Sameer Kumar, Ronald F. Grossman, Charles Price, John R. Srigley

“…Pulmonary alveolar proteinosis (PAP) is a rare condition characterized by dysfunctional alveolar macrophages, which ineffectively clear surfactant and typically cause mild hypoxemia. …”
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Pediatric Sjögren’s Syndrome: Focus on Ocular Involvement and Diagnostic Challenges by Emanuela Del Giudice, Maria Carmela Saturno, Maria Grazia Fiorino, Danilo Iannetta, Luca Spadea, Vanessa Martucci, Alessia Marcellino, Mariateresa Sanseviero, Angela Mauro, Sandra Cinzia Carlesimo, Nicola Nante, Giovanni Guarducci, Leopoldo Spadea, Riccardo Lubrano, Maria Pia Paroli

“…Slit-lamp examination revealed inhomogeneous tear films in all patients and blepharitis in 66.7%, consistent with Meibomian gland dysfunction. Systemic features included arthralgia, Raynaud’s phenomenon, fatigue, and frequent seropositivity for ANA and anti-SSA/Ro antibodies. …”
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Co-occurrence of myositis and neuropathy after anti-CD30 therapy in a late-adolescent Hodgkin lymphoma patient by Adela Della Marina, Lydia Rink, Andreas Hentschel, Michael M. Schündeln, Christopher Nelke, Heike Kölbel, Calvin Tucht, Vera Dobelmann, Tobias Ruck, Tim Hagenacker, Teresinha Evangelista, Ulrike Schara-Schmidt, Andreas Roos

“…MRI confirmed myositis, and biopsy revealed neurogenic and inflammatory changes with complement deposition and mitochondrial dysfunction. Proteomics showed upregulation of inflammatory relevant proteins, with HPRT1 (749.43-fold) being the most increased one. …”
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Subclinical Changes in Type 2 Diabetes Patients with Heart Failure Stage A and B Treated with Oral Semaglutide by Larissa Dăniluc, Adina Braha, Oana Elena Sandu, Carina Bogdan, Loredana Suhov, Lina Haj Ali, Alexandra-Iulia Lazăr-Höcher, Alexandra Sima, Adrian Apostol, Mihaela Viviana Ivan

“…<i>Conclusions:</i> These findings show that improved subclinical left ventricular systolic dysfunction is associated with improved glycemic control, visceral adiposity, and reduced insulin resistance, respectively, with improved lipid profiling.…”
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A Comprehensive Safety Assessment of <i>Ralstonia eutropha</i> H16 for Food Applications: Integrating Genomic, Phenotypic, and Toxicological Analyzes by Xiaoyan You, Shuxia Song, Bing Li, Hui Wang, Le Zhang, Xiangyang Li, Junliang Chen, Zhiguang Zhu, Guoping Zhao

“…While its capabilities in synthesizing single-cell proteins and biodegradable materials are well documented, comprehensive strain-level safety evaluations remain insufficient for food-grade applications. …”
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Controlled expansion stent grafts versus legacy stent grafts for transjugular intrahepatic portosystemic shunt: a single-centre retrospective study on the incidence of hepatic ence... by Afonso Fonseca, Rui Ramos, Élia Coimbra, António Caetano, Teresa Neves, Rafaela Pereira, Inês Conde Vasco, Marta Alves, Tiago Bilhim

“…Conclusion VCX stent grafts induce an immediate lower PPG reduction, which might lead to more stent dysfunctions, but also to a reduction in post-TIPS HE.…”
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Increasing prevalence of thyroid autoimmunity in childhood type 1 diabetes in the pre-COVID but not during the COVID era by Vivien Herczeg, Eszter Muzslay, Diána Czipó, Lili Terkovics, Johanna Takács, Réka Garai, Réka Garai, Fanni Kovács, Andrea Luczay, Anna Körner, Péter Tóth-Heyn

“…Children with AIT had a significantly elevated risk of thyroid dysfunction compared to those with only thyroid autoantibody positivity (p&lt;0.001).ConclusionOur results show a rise in the prevalence of thyroid autoimmunity among T1D children over the past decade, but our data do not support the assumed role of SARS-CoV-2 in the development of the disease.…”
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Plasma cytomegalovirus DNA load predicts outcomes in liver transplant recipients by Hao‐Chien Hung, Po‐Jung Hsu, Jin‐Chiao Lee, Yu‐Chao Wang, Chih‐Hsien Cheng, Tsung‐Han Wu, Ting‐Jung Wu, Hong‐Shiue Chou, Kun‐Ming Chan, Wei‐Chen Lee, Chen‐Fang Lee

“…Higher qPCR was associated with more severe CMV disease, early allograft dysfunction, major posttransplant complications, longer ICU stays, and lower 2‐year overall survival (OS; all p < .05). …”
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Early markers of renal damage in type 2 diabetes: role of vitamin D-binding protein by V.M. Yerokhovych, O.V. Karpenko, Ye.I. Ilkiv, N.M. Kobyliak, I.A. Paliienko, I.V. Dumka, Yu.I. Komisarenko

“…Materials and methods. A total of 123 patients with type 2 diabetes participated in the study. …”
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Imaging techniques for diffuse myocardial fibrosis as a marker of high cardiovascular risk in young patients with type 1 diabetes mellitus by Oksana I. Vengrzhinovskaya, Irina Z. Bondarenko, Olga A. Shatskaia, Natalia V. Tarbaeva, Anastasya Iu. Korneluk, Victor Iu. Kalashnikov, Marina V. Shestakova, Natalia G. Mokrysheva

“…One of the earliest manifestations of cardiovascular system dysfunction is myocardial remodeling. In patients with DM 1, myocardial remodeling is diagnosed using echocardiography. …”
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Resveratrol targeting MDM2/P53/PUMA axis to inhibit colonocyte apoptosis in DSS-induced ulcerative colitis mice by Rui Tang, Rui Tang, Ling Jiang, Quan Ji, Pengyuan Kang, Yuan Liu, Pengyu Miao, Xiaofan Xu, Mingxi Tang, Mingxi Tang, Mingxi Tang

“…Targeting apoptosis is a critical therapeutic strategy for UC.Aim of the studyThis study aims to investigate the therapeutic potential of Resveratrol in ulcerative colitis (UC) by targeting excessive colonocyte apoptosis and intestinal barrier dysfunction. Specifically, we seek to elucidate the mechanisms through which Resveratrol modulates apoptosis-related pathways and evaluate its efficacy in restoring intestinal homeostasis and mitigating UC progression in both in vivo and in vitro models.Materials and MethodsWe used dextran sulfate sodium (DSS) to induce UC in a mouse model. …”
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Imaging and Biomarkers: The Assesment of Pulmonary Embolism Risk and Early Mortality by Alexandru Gratian Naum, Irina Jari, Liliana Moisii, Andra Mara Ursu, Paloma Moisii

“…A second objective of the research was to investigate the relationship between imaging by PAOI and these biomarkers in different etiologies of PE. <i>Materials and Methods</i>: This study comprised 109 patients with PE, hospitalized and treated between February 2021 and August 2022. …”
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Characteristics and Features of the Circulatory System Status in Patients with Liver Cirrhosis as a Disease of Multiple Organ Lesions: Pathogenesis; Diagnostics; Principles of thei... by Farmaha M., Abrahamovych M., Ferko M.

“…To analyze the studies on frequency, pathogenesis, clinics, diagnostics and treatment of polymorbid syntropic extrahepatic lesions of the cardiovascular system in patients with liver cirrhosis published until now. Materials and methods. We have worked on clinical research data for previous years and have analyzed a case of the disease of a particular patient who was under our observation. …”
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