MYOCARDIAL PERFUSION ASSESSMENT IN FORECASTING EFFECT OF CORONARY ANGIOPLASTY IN PATIENTS WITH ISCHEMIC CHRONIC HEART FAILURE by A. B. Mironkov, V. V. Chestukhin, F. A. Blyakhman, T. F. Shklyar, E. N. Ostroumov, Е. D. Kotina, S. A. Sakhovsky, E. T. Asoev, B. L. Mironkov

“…To define influence of the left ventricle (LV) perfusion defects on the clinical status dynamics after coronary angioplasty in patients with the expressed myocardium dysfunction of ischemic etiology. Materials and methods. …”
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Matrix Metalloproteinases MMP-2 and MMP-9 Occupy a New Role in Severe Preeclampsia by Elena Timokhina, Alexander Strizhakov, Sapiyat Ibragimova, Evgeny Gitel, Irina Ignatko, Vera Belousova, Nikoleta Zafiridi

“…The object of the present study was to reveal the role of MMP-2 and MMP-9 in the development of severe preeclampsia. Materials and Methods. We conducted a retrospective study that included 92 pregnant women at a gestational age of 26-38 weeks, of which the principal group consisted of 61 patients with severe PE. …”
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Placental markers of miscarriage by A. A. Zhyvetska-Denysova, I. I. Vorobiova, N. Ya. Skrypchenko, S. M. Tolkach, S. M. Razdaibedin, Yu. M. Bondarenko

“…The aim of the work is to identify the markers of miscarriage and premature labor in the structures of the chorion and placenta. Materials and methods. The main group included tissue samples of the 22 chorions and 64 placentas after termination of current pregnancy from women with a history of reproductive losses. …”
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Current State of Dry Needling Practices: A Comprehensive Analysis on Use, Training, and Safety by Juan Antonio Valera-Calero, Gustavo Plaza-Manzano, Gabriel Rabanal-Rodríguez, María José Díaz-Arribas, Mateusz D. Kobylarz, Jorge Buffet-García, César Fernández-de-las-Peñas, Marcos José Navarro-Santana

“…<i>Background and Objectives</i>: Dry needling (DN) is a technique that involves inserting a thin filament needle through the skin to target myofascial trigger points for the treatment of musculoskeletal pain and dysfunction. Despite its efficacy in a broad plethora of musculoskeletal pain conditions, its safety remains a topic of debate among clinicians and researchers. …”
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Dose-dependent immunotoxic mechanisms of celastrol via modulation of the PI3K-Akt signaling pathway by Shaohui Geng, Jingqi Wen, Chunli Shen, Li Liu, Yijin Jiang, Jingyuan Fu, Yiwei Guan, Zi Ye, Yuanhao Wu, Chen Li, Guangrui Huang

“…This study investigates the mechanisms of celastrol-induced immunotoxicity, focusing on the PI3K-Akt signaling pathway, a key regulator of immune function.Materials and methodsAn integrative approach combining network toxicology, molecular docking, and experimental biology identified molecular targets in celastrol-induced immune dysfunction. …”
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Comparative analysis of cardioprotective effects of two renal denervation techniques by T. M. Ripp, S. E. Pekarskiy, A. E. Baev, T. R. Ryabova, E. I. Yaroslavskay, A. Yu. Falkovskaya, E. S. Sitkova, V. A. Lichikaki, I. V. Zubanova, M. A. Manukian, L. I. Gapon, V. F. Mordovin

“…Twelve months after distal RD, compared with the main renal artery denervation, the LV wall thickness, number of patients with LV hypertro -phy, and diastolic dysfunction decreased significantly greater. Two-dimensional STE revealed improvement of cardiac parameters. …”
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Morphological and Functional Alterations of the Cardiovascular System during Acute Clozapine Poisoning (Experimental Study) by A. S. Babkina, I. A. Ryzhkov, V. V. Antonova, Z. I. Tsokolaeva, A. R. Asanov, S. N. Kalabushev, Yu. V. Zarzhetsky

“…To evaluate the influence of sublethal dose of Clozapine on the functional and morphological parameters of the cardiovascular system in rats 4 hrs. after the drug administration.Materials and methods. The experiments were carried out on male Wistar rats weighing 200–250g (n=14). …”
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Characteristics of brain cell proliferation and migration in animals with experimental Alzheimer’s disease undergoing cognitive training by Yu. K. Komleva, Ya. V. Gorina, A. I. Chernykh, O. L. Lopatina, A. A. Shabalova, L. V. Trufanova, R. Ya. Olovyannikova, V. Yu. Endrzheevskaya-Shurygina, A. B. Salmina

“…The purpose of this paper is to study cognitive functions and their association with proliferation, survival and migration of newly-formed cells in normal adult rat brain and in the experimental Alzheimer’s disease.Materials and methods. Rats (Wistar, males, 7 months) were used. …”
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Comparative analysis of two TREC/KREC quantification methods for newborn screening of primary immunodeficiency with T- and B-lymphopenia used in Ukraine by Volodymyr Kravets, Ivanna Shymanska, Oksana Boyarchuk, Nataliya Matiytsiv, Oksana Arkhipova, Halyna Makukh

“…Severe combined immunodeficiency (SCID) is the most severe form, characterized by the absence or dysfunction of T and B cells. Without early treatment, most infants with SCID do not survive their first year. …”
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Amide Proton Transfer-Weighted MR Imaging and Signal Variations in a Rat Model of Lipopolysaccharide-Induced Sepsis-Associated Encephalopathy by Donghoon Lee, HyunJu Ryu, Yeon Ji Chae, Hind Binjaffar, Chul-Woong Woo, Dong-Cheol Woo, Do-Wan Lee

“…<b>Introduction:</b> Sepsis-associated encephalopathy (SAE) is an acute brain dysfunction secondary to systemic infection, occurring without direct central nervous system involvement. …”
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Phenotypic clusters and biomarkers profile in patients with chronic heart failure with preserved and mildly reduced left ventricular ejection fraction by Natalia A. Dragomiretskaya, Anastasia V. Tolmacheva, Alexander A. Ivannikov, Ilya I. Shvedov, Artyom V. Belyakov, Kamila R. Agalarova, Valery I. Podzolkov

“…To study the profile of cardiac biomarkers (NT-proBNP – N-terminal pro-brain natriuretic peptide, sST2 – soluble growth stimulation expressed gene 2, galectin-3, copeptin) in clusters of patients with chronic heart failure with preserved (CHFpEF) and mildly reduced (CHFmrEF) left ventricular (LV) ejection fraction (EF). Materials and methods. The study included 135 patients with CHF and LV EF40%. …”
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Early outcomes of kidney transplantation in recipients with type 1 diabetes mellitus and end‑stage kidney disease resulting from diabetic nephropathy by K. E. Lazareva, I. V. Dmitriev, A. G. Balkarov, N. V. Shmarina, N. S. Zhuravel, Yu. A. Anisimov, V. O. Alexandrova

“…Objective: to analyze early outcomes of kidney transplantation (KT) in patients with type 1 diabetes mellitus (T1D) and stage 5 chronic kidney disease resulting from diabetic nephropathy.Materials and methods. The study group included 145 T1D patients who underwent KT at the kidney and pancreas transplant department of Sklifosovsky Research Institute for Emergency Medicine between January 1, 2007 and December 31, 2023. …”
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Changes of the quality of life and efficiency criteria of coronary artery bypass grafting in patients with stable coronary artery disease and preserved left ventricular ejection fr... by Yu.A. Borkhalenko, O.J. Zharinov, K.O. Mikhaliev, O.A. Yepanchintseva, B.M. Todurov

“…The improvement of diastolic dysfunction and heart failure might also play an important role. …”
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Diagnostic value of anti-HLA antibody monitoring in the diagnosis of immunological complications following kidney transplantation by V. O. Aleksandrova, I. V. Dmitriev, N. V. Borovkova, A. G. Balkarov, N. A. Mushta, N. V. Shmarina, N. V. Doronina, K. E. Lazareva

“…However, DSA synthesis statistically significantly increased the incidence of acute rejection, kidney graft dysfunction and increased the time of recovery of nitrogen excretory function.…”
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Evaluation and Management of Urological Complications Following Pediatric Kidney Transplantation: Experience from a Single Tertiary Center by Maria Sangermano, Enrico Montagnani, Serena Vigezzi, Marco Moi, Alessandro Morlacco, Nicola Bertazza Partigiani, Elisa Benetti

“…Early complications were often detected due to acute graft dysfunction, while late ones were mainly identified during routine clinical, laboratory, or ultrasound follow-up. …”
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Effects of virtual reality with different modalities on upper limb recovery: a systematic review and network meta-analysis on optimizing stroke rehabilitation by Jiali Zhang, Mingxiu Liu, Junlin Yue, Jinmei Yang, Yan Xiao, Jie Yang, Enli Cai

“…BackgroundAs a major cause of disability worldwide, stroke affects about 80% of survivors with upper limb (UL) motor dysfunction, significantly impairing their quality of life. …”
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Sepsis Course and Outcome Depends on the Genetic Variant in the 3`-Region of Aquaporin 4 Gene <i>AQP4</i> and Comorbidities by A. G. Chumachenko, E. K. Grigoriev, R. A. Cherpakov, I. N. Tyurin, V. M. Pisarev

“…The aim of the study was to determine the effects of region 3` polymorphism in the AQP4 gene on the clinical course and outcome of sepsis.Materials and methods. The prospective study included 290 ICU patients from three clinical hospitals in Moscow aged 18–75 years with clinical signs of sepsis (SEPSIS-3, 2016).Results. …”
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Tumour lysis syndrome: modern aspects of the problem by N. V. Matinyan, T. T. Valiev, L. A. Martynov, V. P. Akimov, E. A. Kovaleva, Yu. V. Buidenok

“…To summarize the literature and our own clinical experience in the diagnosis and treatment of ATLS in pediatric oncohematology.Materials and methods. The literature data on the diagnosis and treatment of ATLS in children with oncohematological diseases were analyzed. …”
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Sex hormones influence on epilepsy in young men by T.A. Litovchenko, O.A. Goncharova, A.O. Voitiuk, O.P. Zavalna, V.A. Florikian, O.Yu. Sukhonosova

“…Сhanges in sex hormones in men have hardly been studied, despite the possible significant impact of epilepsy on the hormonal spectrum in general and on sex hormones in particular. Hormonal dysfunction is also a known factor in worsening the clinical course of epilepsy. …”
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Comparative evaluation of SGLT-2i and GLP-1RA neuroprotective properties in type 2 diabetic patients by A. V. Murasheva, T. L. Karonova, O. S. Fuks, N. V. Timkina, A. D. Fedotova, E. N. Grineva, E. V. Shlyakhto

“…BACKGROUND: Chronic brain dyscirculation (CBD) is a common type 2 diabetes mellitus (DM) complication that leads to the cognitive dysfunction. Glucagon-like peptide-1 receptor agonists (GLP-1RA) and sodium-glucose cotransporter type 2 inhibitors (SGLT-2i) can reduce the stroke risk but their effect on CBD is not fully studied.AIM: To study and to compare the effect of SGLT-2i of various selectivity and GLP-1RA on the biochemical and functional parameters of CNS damage in patients with type 2 DM.MATERIALS AND METHODS: Type 2 diabetic patients with target HbA1c level on metformin monotherapy were included in “MET” group (n=43), with non-target HbA1c were divided into groups: “MET+EMPA”, n=47, (empagliflozin therapy), “MET+CANA”, n=41, (canagliflozin therapy), “MET+GLP-1RA”, n=66 (therapy with injectable GLP-1RA). …”
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