WDJ-S4, a standardized herbal formula, promotes gastrointestinal motility via modulation of the acetylcholine pathway in a loperamide-induced functional dyspepsia mice by Seung-Ju Hwang, Chang-Seob Seo, Dong-Cheol Baek, Tae-Wook Woo, Jing-Hua Wang, Jin-Seok Lee, Yu-Jin Choi, Ji-Yeon Gu, Dong-Seon Kim, Chang-Gue Son

“…Context WDJ-S4, a standardized herbal formula, has been prescribed for refractory functional dyspepsia (FD) in Korea, but the detailed mechanisms are lacking.Objective The present study investigates the acceleration of gastrointestinal (GI) motility by WDJ-S4 and its potential mechanisms.Materials and methods For five days, WDJ-S4 (50, 100 and 200 mg/kg) or mosapride (3 mg/kg) was orally given to BALB/c mice. …”
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Redo inferior pubectomy for failed anastomotic urethroplasty in pelvic fracture urethral injury by Lin Wang, Wenxiong Song, Xufeng Peng, Rong Lyu, Jijian Wang, Chongrui Jin, Chao Feng, Xiangguo Lyu, Yinglong Sa, Yidong Liu

“…The incidence of erectile dysfunction reached 77.4% (24/31). Normal continence was achieved in 27 (87.1%) patients. …”
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A 5-year single-center experience in heart transplantation in Rostov oblast by V. L. Korobka, M. Yu. Kostrykin, A. A. Duzhikov, V. D. Shamkhanyants, D. K. Lobachev, O. V. Kotov, A. A. Kartashov, A. V. Sumin, M. V. Gusnay, A. I. Trapeznikova, E. A. Kudryashova, R. V. Korobka

“…Objective: to evaluate the outcomes of heart transplants performed at Rostov Regional Clinical Hospital within five years.Materials and methods. Between 2017 and 2022, 29 orthotopic heart transplants (HT) were performed in our clinic. …”
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The effect of coal-derived humic substances and their silver-containing bionanocomposites on arginine balance in peritoneal macrophages of intact mice by E. S. Trofimova, M. V. Zykova, M. G. Danilets, A. A. Ligacheva, E. Yu. Sherstoboev, I. O. Grigorieva, D. A. Mikhalev, A. V. Tsupko, L. A. Logvinova, I. V. Perminova, M. V. Belousov

“…Antigen-presenting cells (APCs), especially macrophages, play an important role in the body defense against various pathogens. Their dysfunction and polarization are associated with most inflammatory and autoimmune diseases. …”
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Evaluating Quality of Life and Cognitive Impairment in Post-cardiac Operation by Fatemehshima Hadipourzadeh, Ali Sadeghi, Rasool Ferasatkish, Rasoul Azarfarin, Maryam Ghadimi, Yasmin Chaibakhsh, Maryam Ghanbari, Roxana Rastravan, Javad Jamalian, Fatemeh Eftekhari

“…Materials & Methods: This descriptive cross-sectional study was conducted on 183 patients who underwent cardiac operation. …”
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Free fatty acid-induced DDX3 inhibits autophagy via miR-141 upregulation in diet-induced MASLD mice model system by Md. Musa Hossain, Amit K. Mishra, Ajay K. Yadav, Md. Ismail, Teja Naveen Sata, Amrendra K. Sah, Arnab Banik, Gopal Sharma, Senthil K. Venugopal

“…Introduction and Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is one of the primary causes of chronic liver disease and may lead to liver cirrhosis and hepatocellular carcinoma. …”
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Rosuvastatin mitigates blood–brain barrier disruption in sepsis-associated encephalopathy by restoring occludin levels by Qin Shen, Qian Yu, Taojiang Chen, Lijuan Zhang

“…However, its potential neuroprotective role in SAE remains unclear. Materials and methods SAE models were established using the cecal ligation and puncture (CLP) method. …”
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Recombinant human urinary trypsin inhibitor improves the immunological function of splenic dendritic cells in mice with acute lung injury by Tong Wang, Wenna Liu, Jun Li, Yongli Wan, Hang Su, Anlong Qi

“…Materials and methods RhUTI was administered to mice, and splenic CD11c + DCs were isolated and assessed using flow cytometry for apoptotic or phenotypic analysis. …”
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The length of the warm ischemic interval in lung donation after circulatory death does not impact post-transplantation outcomes by Amer Alzahrani, MD, Kentaro Noda, PhD, Ernest G. Chan, MD, John P. Ryan, PhD, Masashi Furukawa, MD, PhD, Pablo G. Sanchez, MD, PhD

“…There were no observed associations between agonal or warm ischemic times and post-transplant outcomes, including primary graft dysfunction, ventilator dependency, and acute rejection. …”
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Alterations in the gut microbiome and metabolism with doxorubicin-induced heart failure severity by Qian Wang, Meihua Liu, Meihua Liu, Tianpei Liu, Tianpei Liu, Long Li, Chenyang Wang, Xiaolin Wang, Shuling Rong, Xuedong Zhou

“…ObjectiveThis study aimed to explore the changes in gut microbiota and its metabolites in different pathophysiological stages of doxorubicin (DOX)-induced heart failure (DIHF) and the relationship between gut microbiota and metabolites in various degrees of DIHF.Materials and methodsC57BL/6 J mice were injected intraperitoneally with 5 mg/kg of DOX once a week for 5 consecutive weeks. …”
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Uricase-Expressing Engineered Macrophages Alleviate Murine Hyperuricemia by Yu-Zhong Feng, Hao Cheng, Guo-Qing Xiong, Jia-Zhen Cui, Zhi-Li Chen, Yuan-Yuan Lu, Zhi-Xin Meng, Chen Zhu, Hao-Long Dong, Xiang-Hua Xiong, Gang Liu, Qing-Yang Wang, Hui-Peng Chen

“…In terms of safety, engineered macrophages did not cause liver or kidney dysfunction in mice, nor did they induce systemic immune response. …”
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Treatment of vascular complications following orthotopic liver transplantation. The experience of a regional cente by V. L. Korobka, M. Yu. Kostrykin, M. V. Malevanny, O. V. Kotov, R. V. Korobka, E. S. Pak, Yu. V. Khoronko, N.  G. Sapronova, I. A. Sukhanov, R. Yu. Khoronko

“…The aim of this study is to evaluate the incidence, treatment and outcome of VCs in patients after orthotopic LT at the Center for Surgery and Donor Coordination, Rostov Regional Clinical Hospital.Materials and methods. Between July 2015 and April 2023, 100 orthotopic LTs were performed. …”
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Non-selective laryngeal reinnervation in thyroid surgery by V. O. Palamarchuk, O. A. Tovkai, V. V. Voitenko, N. V. Solomennikova

“…To evaluate the results of the voice disorders correction in unilateral abduction paralysis of larynx by the anastomosis “ansa cervicalis – recurrent laryngeal nerve” during primary and repeated thyroid surgery. Materials and methods. Surgical non-selective laryngeal reinnervation (primary, delayed) by anastomosis “ansa cervicalis – recurrent laryngeal nerve” was performed in 49 patients with abduction paralysis of larynx, 45 of whom had ipsilateral and 4 contralateral anastomosis. …”
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Impact of chronic opioid on cognitive function and spermatogenesis in rat: An experimental study by Hamid Norioun, Seyed Jamal Moshtaghian, Firoozeh Alavian, Maryam Khombi Shooshtari, Golnaz Alipour, Saeedeh Ghiasvand

“…Conclusion: Prolonged exposure to methadone and morphine resulted in memory dysfunction, chronic stress, hormonal disturbances, altered gene expression, and fertility complications. …”
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Phthalate exposure from plastics and cardiovascular disease: global estimates of attributable mortality and years life lostResearch in context by Sara Hyman, Jonathan Acevedo, Chiara Giannarelli, Leonardo Trasande

“…Phthalates are commonly used in the production of plastic materials and have been linked to increased oxidative stress, metabolic dysfunction, and cardiovascular disease. …”
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Sexual differences in the clinical features of antipsychotic-induced hyperprolactinemia in patients with schizophrenia by E. G. Kornetova, V. V. Tiguntsev, A. N. Kornetov, A. A. Goncharova, O. A. Lobacheva, A. A. Davydov, S. A. Khardikova, S. A. Ivanova, A. V. Semke

“…The goal was to identify gender differences in the clinical features of antipsychotic-induced hyperprolactinemia in patients with schizophrenia.Materials and methods. 98 patients from the Department of Endogenous Disorders of the Research Institute of Mental Health Clinic in Tomsk were examined. …”
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Characterizing outcomes in a large cohort of latinx patients with autoimmune hepatitis by Eleanor Belilos, Jessica Strzepka, Ethan Ritz, Nancy Reau, Costica Aloman

“…Latinx patients were more likely to have metabolic dysfunction-associated steatotic liver disease (MASLD) (p = 0.004), and had higher Fibrosis-4 (FIB-4) (p = 0.0279) and AST-to-Platelet-Ratio-Index (APRI) (p = 0.005) at one year. …”
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Exploring the Link Between Vitamin K and Depression: A Systematic Review by Mohamad Hisham Hashim, Nik Nasihah Nik Ramli, Siti Nur Atiqah Zulaikah Nasarudin, Maisarah Abdul Mutalib, Muhammad Najib Mohamad Alwi, Aswir Abd Rashed, Rajesh Ramasamy

“…<i>Background and Objectives:</i> Depression is a multifactorial mental health disorder involving inflammation, oxidative stress, neuroplasticity deficits, and metabolic dysfunction. Emerging research suggests that vitamin K, beyond its classical roles in coagulation and bone metabolism, may influence neurobiological processes relevant to mood regulation. …”
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Body Image Concern and Sexual Function Relationship in the Postpartum Period: The Mediating Role of Sexual Self-esteem by Mahin Noroozi Dashtaki, Mohammad Sadegh Zamani Zarchi, Ali Hosseinzadeh Oskouei, Mona Baghbani Nader, Amir Sam Kianimoghadam

“…Thus, mental health professionals are recommended to consider body image concerns and sexual self-esteem to select the most appropriate treatment for sexual dysfunction in women.…”
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Predictors of the Severity and Duration of Treatment of Sepsis-Associated Delirium by N. A. Rezepov, Yu. V. Skripkin, O. N. Ulitkina, O. A. Grebenchikov, V. V. Likhvantsev

“…At present, the causes of these disorders are adequately explained by the theory of neuroinflammation that takes into account the pathogenic influence of the systemic inflammatory reaction and related endothelial dysfunction on the central nervous system function.The purpose of the study was to evaluate the relevance of the severity of the systemic inflammatory response, the intensity of oxidative stress and the severity of patient's general state to prediction of the duration of delirium and therapy outcomes in patients with sepsis-associated delirium.Materials and methods. …”
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