A self-regulated expiratory flow device for mechanical ventilation: a bench study by Lianye Yang, Ubbo F. Wiersema, Shailesh Bihari, Roy Broughton, Andy Roberts, Nigel Kelley, Mark McEwen

“…The effectiveness of the device was evaluated for reduction in peak expiratory flow, expiratory time, mean airway pressure, and the reduction of tidal dissipated energy (measured as the area within the airway pressure–volume loop). …”
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Gut microbiome and plasma metabolome alterations in ileostomy and after closure of ileostomy by Liang Xu, Xiaolong Li, Lang Chen, Haitao Ma, Ying Wang, Wenwen Liu, Anyan Liao, Liang Tan, Xiao Gao, Weidong Xiao, Hua Yang, Guangyan Ji, Yuan Qiu

“…ABSTRACT A temporary loop ileostomy is a routine procedure for protecting the anastomosis in patients undergoing radical resection of rectal cancer. …”
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The N-degron pathway mediates the autophagic degradation of cytosolic mitochondrial DNA during sterile innate immune responses by Chan Hoon Jung, Yoon Jee Lee, Eun Hye Cho, Gee Eun Lee, Sung Tae Kim, Ki Sa Sung, Daeho Kim, Dong Hyun Kim, Yeon Sung Son, Jin-Hyun Ahn, Dohyun Han, Yong Tae Kwon

“…Thus, cytosolic mtDNA activates the N-degron pathway to facilitate its own degradation and form a negative feedback loop, by which the cell can turn off sterile immune responses at the right time.…”
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Revolutionising young adult diabetes care: a patient-centred transformation to improve access, engagement and outcomes in one of England's most deprived areas by Tala Balafshan, Heather Sullivan, Suzanne Keigan, Amanda Wilson, Ifeoluwa Oyedeji

“…Materials and methods: We implemented data-driven, multidisciplinary interventions to optimise care delivery and reduce healthcare burdens1,2: • Reducing DNA rates: pre-appointment outreach by healthcare assistants reduced DNA rates from 50% to 18.1%, while follow-up waiting times decreased from 5.5 months to 3 months, boosting engagement and clinic efficiency. • Improving access: a dedicated email service and urgent access clinic allowed patients to bypass traditional appointment barriers, ensuring timely advice and intervention. • Preventing emergency admissions: early identification and personalised management plans reduced recurrent diabetic ketoacidosis (DKA) admissions by 80%, improving patient safety. • Expanding diabetes technology: 87.8% of patients now use continuous glucose monitoring (CGM), with most insulin pump users transitioning to hybrid closed-loop systems, improving glycaemic control and autonomy. • Continuous quality improvement: annual audits of nine key care processes maintained high standards, achieving a median HbA1c of 63 mmol/mol, among the best nationally. …”
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A CNN-LSTM Phase Compensation Method for Unidirectional Two-way Radio Frequency Transmission System by Jiahui Cheng, Zhengkang Wang, Yaojun Qiao, Hao Gao, Chenxia Liu, Zhuoze Zhao, Jie Zhang, Baodong Zhao, Bin Luo, Song Yu

“…In addition, compared to the phase locked loop (PLL) PCM, the proposed CNN-LSTM PCM can reduce the root-mean-square (RMS) phase jitter of the received signal from 219 ps to 19.72 ps, and improve the frequency stability of the system at 10,000 s by 84.5%. …”
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In Vitro and In Silico Analysis of Entrainment Characterization in Injection Jet-Assisted Fontan Circulation by Arka Das, Ray O. Prather, Anthony Damon, Michael Farias, Alain Kassab, Eduardo Divo, William DeCampli

“…This study describes a mock flow loop model (MFL) designed to quantitatively estimate pulmonary flow entrainment induced by continuous and pulsed flow injections. …”
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Research Progress on Wet Recovery of Zinc Metal from Blast Furnace Smelting Dust by Lijuan JIA, Shaoxiang YANG, Linjie YANG, Jiayu FENG, Shuo CUI, Fang WANG, Yanzhang LIU, Ping NING

“…In the future, efforts should integrate the design of mineral phase reconstruction with the development of green leaching agents. A closed-loop recycling process should be established, along with the construction of a multi-technology synergy and intelligent control system. …”
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The role of multiple high‐risk human papillomavirus infection on the persistence recurrence of high‐grade cervical lesions after standard treatment: A systematic review and a meta‐... by Chiara Cassani, Mattia Dominoni, Marianna Francesca Pasquali, Barbara Gardella, Arsenio Spinillo

“…A total of 8321 subjects treated (loop electrosurgical excision, laser or surgery) because of HSIL were followed‐up and included in the meta‐analysis. …”
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Using GPS and accelerometer data to precisely record egg laying, incubation and chick hatching of Cinereous Vultures (Aegypius monachus) in-situ by Cornel Cotorogea, Emilian Stoynov, Atanas Grozdanov, Simeon Marin, Hristo Valeriev Peshev, Ivelin Ivanov, Georgi P. Stoyanov

“…Its application can enhance conservation programs by enabling timely interventions, improving breeding success rates, and contributing to a deeper understanding of Cinereous Vulture reproductive biology. …”
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Quantifying Plasmodium falciparum infections clustering within households to inform household-based intervention strategies for malaria control programs: An observational study and... by Gillian Stresman, Charlie Whittaker, Hannah C Slater, Teun Bousema, Jackie Cook

“…Combining these detection strategies with presumptively treating residents of index households over a sustained time period could contribute to malaria elimination efforts.…”
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Decentralized Consensus Protocols on <i>SO</i>(4)^<i>N</i> and <i>TSO</i>(4)^<i>N</i> with Reshaping by Eric A. Butcher, Vianella Spaeth

“…Consensus protocols for a multi-agent networked system consist of strategies that align the states of all agents that share information according to a given network topology, despite challenges such as communication limitations, time-varying networks, and communication delays. …”
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Starting a synthetic biological intelligence lab from scratch by Md Sayed Tanveer, Dhruvik Patel, Hunter E. Schweiger, Kwaku Dad Abu-Bonsrah, Brad Watmuff, Azin Azadi, Sergey Pryshchep, Karthikeyan Narayanan, Christopher Puleo, Kannathal Natarajan, Mohammed A. Mostajo-Radji, Brett J. Kagan, Ge Wang

“…They can be trained in a feedback loop to perform tasks similar to deep artificial neural networks that are trained on big data. …”
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Advance of DAM-like genes in bud dormancy of deciduous fruit trees in Rosaceae family by ZHAO Yalin, WANG Lirong

“…Dormancy is highly dependent on external environment, and seasonal variations in bud break and flowering time have been reported in the context of global warming. …”
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Tracking an Eruptive Intermediate Prominence Originating from the Farside of the Sun by Qingmin Zhang, Wenwei Pan, Beili Ying, Li Feng, Yiliang Li, Xiaoli Yan, Liheng Yang, Ye Qiu, Jun Chen, Suli Ma

“…The apex of the prominence changes from a smooth loop to a cusp structure during the rising motion, and the northwest leg displays a drift motion after 04:30 UT, implying a writhing motion. …”
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Implantable continuous-flow total artificial heart for newborns and small pediatric patients: First report of working modelCentral MessagePerspective by Jamshid H. Karimov, MD, PhD, Chihiro Miyagi, MD, PhD, Taiyo Kuroda, MD, Anthony R. Polakowski, BS, MEng, Christine R. Flick, BS, Barry D. Kuban, BS, Kiyotaka Fukamachi, MD, PhD, Tara Karamlou, MD, Munir Ahmad, MD, Hani Najm, MD

“…The pump flow range (0.5-1.5 L/min) was confirmed in a mock circulatory testing loop. Within the tested flow range, the I-CFTAH can support small patients that could benefit from the intended cardiac output. …”
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Ultra-high dose rate radiotherapy overcomes radioresistance in head and neck squamous cell carcinoma by Hong-Shuai Li, Ruo Tang, Hua-Shan Shi, Zi-Jian Qin, Xiao-Yang Zhang, Yun-Fei Sun, Zhi-Gong Wei, Chao-Fan Ma, Liu Yang, Ye Chen, Zhe-Ran Liu, Li-Li Zhu, Wen Yang, Li Yang, Ai-Ning Xu, Zhuo Zhang, Shu-Qing Liao, Jin-Shui Shi, Jian-Jun Deng, Xiao-Zhong He, Xing-Chen Peng

“…Mechanistically, UHDR-RT activated CD8+ T cells, which stimulated M1 macrophages through paracrine IFN-γ signaling, thereby enhancing TiME activation. Furthermore, the activated M1 macrophages secreted CXCL9, which in turn reactivated CD8+ T cells, forming a feedforward loop that amplified TiME activation. …”
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A 7 day Multiwavelength Flare Campaign on AU Mic. II. Electron Densities and Kinetic Energies from High-frequency Radio Flares by Isaiah I. Tristan, Rachel A. Osten, Yuta Notsu, Adam F. Kowalski, Alexander Brown, Graeme L. White, Carol A. Grady, Todd J. Henry, Eliot Halley Vrijmoet

“…Here, we present high-time-resolution light curves from the Karl G. Jansky Very Large Array (VLA) Ku band (12–18 GHz) and the Australia Telescope Compact Array (ATCA) K band (16–25 GHz), which observe gyrosynchrotron radiation and directly probe the action of accelerated electrons within flaring loops. …”
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Development of a superheated water chromatography method for the sustainable determination of preservatives in foods and cosmetics by Roberta La Tella, Danilo Donnarumma, Francesca Rigano, Paola Donato, Patrik Appelblad, Paola Dugo, Luigi Mondello, Alice Mondello

“…The use of higher temperatures allowed to perform analyses at higher flow rates in reduced analysis time and was also in terms of peak bandwidth resulting to increased efficiency for the most retained compound. …”
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Clinical outcome of adding injection of freeze-dried platelet-derived factor concentrate to operative treatment accompanied by an early rehabilitation for Achilles tendon rupture i... by Shota Morimoto, Futoshi Morio, Yuta Matsumae, Masashi Nakamura, Yoshitaka Nakao, Toshiya Tachibana, Tomoya Iseki

“…In all patients, surgery was performed using the modified side-locking loop suture technique, and an early rehabilitation protocol was implemented postoperatively. …”
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Cost-effectiveness of different tuberculosis diagnostic approaches in Nigeria based on decision analytical modelling by Muktar H Aliyu, Hafsat U Ibrahim, Rayyan M Garba, Jameel I Ahmad, Kabiru Abdulsalam, Yasir N Jibril, Faisal S Dankishiya, Abdullahi Ibrahim, Ibrahim U Garzali, Aisha A Galadanci, Abdullahi K Suleiman, Abdulgafar L Olawumi, Umar F Abdullahi, Fatima M Mahmud, Amina A Umar, Olive Asafu- Adjaye, Lukman F Owolabi, Baba M Musa

“…These ICERs are consistent with willingness-to-pay thresholds set at three times Nigeria’s gross domestic product (GDP) and remained robust over a wide range of costs and epidemiological parameter inputs.Conclusion Among PLWH in Nigeria, the TB-LAM algorithm represents the most cost-effective diagnostic strategy. …”
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