LRP6 regulates growth in Litopenaeus vannamei via the Wnt/β-catenin signaling pathway by Sheng Wang, Xiaodi Wang, Hao Yang, Xuanzheng Di, Haoyang Li, Bin Yin, Ziwei Liu, Chaozheng Li, Jianguo He

“…Additionally, LvTcf was found to induce the expression of LvLRP6 and a number of Wnt ligands, thus amplifying Wnt/β-catenin pathway activation and reinforcing the growth-promoting feedback loop. The present investigation demonstrated the importance of LRP6 in shrimp growth, which contributes to our knowledge of the molecular processes that underlie crustacean growth and offers a theoretical basis for breeding and genetic enhancement initiatives aimed at enhancing shrimp aquaculture growth performance.…”
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Delivery of miR-26a-5p by Subcutaneous Adipose Tissue-Derived Extracellular Vesicles Alleviates Acute Lung Injury in Mice Through CHUK/NF-κB Pathway by Xie Y, Ran L, Yue C, Wang C, Chen F, Su Y, Qin Y, Zhang Q, Liu J, Du N, Zhang L, Jiang Y, Liu G

“…Notably, SAT-EVs transferred miR-26a-5p to alveolar macrophages, which directly targeted conserved helix-loop-helix ubiquitous kinase (CHUK), a key regulator of the NF-κB pathway. …”
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Advances in studies and applications of thick diamond films prepared by microwave plasma chemical vapor deposition by Fucheng LIU, Guanjie MA, Jiangtao HUANG, Zongyan ZHANG, Peigang HAN, Bin HE

“…The evolution of MPCVD chambers has seen a transition from quartz tubes and quartz bell jars to cylindrical resonance chambers, loop antennas, and ellipsoidal resonance chambers. …”
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A Review of Multidisciplinary Evidence on the Role of Urban Green Space in Improving the Sleep Quality of the Elderly by Ning KANG, Han XIE, Tao JIANG

“…In summary, future research should establish a complete closed loop of “scientific research − prescription development − design implementation − effect evaluation”, grounded in deepened mechanistic understanding. …”
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Real‐world data on Empagliflozin and Dapagliflozin use in patients with HEART failure: The RED–HEART study by Umut Kocabas, Isil Ergin, Veysel Yavuz, Cihan Altın, Mehmet Kaplan, Gülsüm Meral Yılmaz Öztekin, Mustafa Doğduş, Selda Murat, Bektaş Murat, Tarık Kıvrak, Dilay Karabulut, Ersin Kaya, İbrahim Halil Özdemir, Cennet Yıldız, Fatma Özge Salkın, Emre Özçalık, Şeyda Günay Polatkan, Fahri Çakan, Taner Şen, Umut Karabulut, Sinem Çakal, Ersan Oflar, Ümit Yaşar Sinan, Mustafa Yenerçağ, Uğur Önsel Türk

“…Abstract Aims We aimed to determine the use of sodium–glucose cotransporter 2 inhibitors (SGLT2is) and to identify clinical factors associated with their use in patients with heart failure (HF) in a real‐life setting. …”
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Patterns of inflammation and immune activation by coreceptor use in people living with HIV-1 by Francisco Xavier Guerra-Castillo, Francisco Xavier Guerra-Castillo, Sandra Pinto-Cardoso, Santiago Ávila-Ríos, Monserrat Chávez-Torres, Amy Peralta-Prado, Carolina González-Torres, Javier Gaytán-Cervantes, Brenda Requena-Benitez, Dafne Díaz-Rivera, Carmen Alaez-Verson, María Concepción Hernández-García, Vilma Carolina Bekker-Méndez

“…Logistic regression was used to evaluate associations between immune activation profiles and the presence of X4-tropic viruses.ResultsNinety-eight individuals had high-quality V3 loop sequences, 81.6% harbored only R5 variants (R5 group), while 18.4% had mixed R5/X4 populations (X4 group). …”
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Experimental Study on The Mechanical Properties of Novel Viscous Mass Damper by CAI Yijie, XU Weizhi, WANG Shuguang, DU Dongsheng, SUN Yue

“…However, the development of the device itself remains relatively limited. This paper aims to design and develop a novel viscous mass damper (NVMD). …”
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NDRG1 enhances the sensitivity to Cetuximab by promoting Stat1 ubiquitylation in colorectal cancer by Guang Yang, Chengsheng Ding, Xiao Yang, Jiang Jiang, Shiyuan He, Yanfei Shao, Enkui Zhang, Xiaodong Fan, Xueliang Zhou, Ling Huang, Cindy Xinyu Zhang, Jing Sun, Yu Wang, Lu Zang, Minhua Zheng, Junjun Ma

“…Importantly, this novel NDRG1-dependent regulatory loop also enhanced CTX sensitivity both in vitro and in vivo. …”
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Optimal control strategies supported by system dynamics modelling: a study on hookworm disease in China by Huihui Zhu, Jinxin Zheng, Jilei Huang, Mizhen Zhang, Changhai Zhou, Tingjun Zhu, Hongchun Tian, Xiaohong Wu, Yang Liu, Bo Zhong, Hong Xie, Liping Zhang, Lei Tie, Jingwen Luo, Xiaoqin Mao, Bin Zhang, Xiu Deng, Suping Zhang, Menbao Qian, Shizhu Li, Xiaonong Zhou

“…Optimized control strategies are needed. This study aims to optimize intervention strategies for hookworm disease in China. …”
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SGLT2 inhibitor with and without ALDosterone AntagonIst for heart failure with preserved ejection fraction: Design paper by João Pedro Ferreira, Francisco Vasques‐Nóvoa, Francisca Saraiva, Ana C. Oliveira, Jorge Almeida, Ana Beatriz Batista, Arsénio Barbosa, Ana Filipa Ferreira, Cátia Costa, Diogo Santos‐Ferreira, Fernando Friões, Cândida Goncalves, João Tiago Guimarães, Marta Leite, Pedro Marques, Joana Mascarenhas, Maria Inês Matos, Catarina Pereira, Pedro Rodrigues, Abhinav Sharma, Gualter Silva, Inês Pereira‐Sousa, Carla Sousa, Faiez Zannad, Joana Pimenta, Ricardo Fontes‐Carvalho, Adelino Leite‐Moreira

“…Most patients were treated with renin–angiotensin blockers (68%), beta‐blockers (70%) and loop diuretics (69%). Compared to other HFmr/pEF trials, SOGALDI‐PEF patients were older, were more frequently women, had a high prevalence of atrial fibrillation, and had more often a preserved ejection fraction. …”
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Increase in colonic propionate as a method of preventing weight gain in adults aged 20–40 years: iPREVENT, a multicentre, double-blind, randomised, parallel-group trial by Gary Frost, Joana C Vasconcelos, Jennifer E Pugh, Aisha Anjum, Katerina Petropoulou, George Thom, Louise McCombie, Martina Tashkova, Sumayya Alshehhi, Daphne Babalis, Leah Holroyd, Christina Prechtl, Tom Preston, Mike J Lean, Waljit Dhillo, A Toby Prevost, and Douglas Morrison

“…Limitations This study aimed to explore the efficacy of enhanced propionate production above background fermentation. …”
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A Dermatoglyphic Study of Primary Fingerprints Pattern in Relation to Gender and Blood Group Among Residents of Kathmandu Valley, Nepal by Sushma Paudel, Sushmita Paudel, Samikshya Kafle

“…Fingerprint patterns (loops, whorls, and arches) were analyzed and compared with participants’ ABO-Rh blood groups. …”
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Optimal Robust Motion Controller Design Using Multiobjective Genetic Algorithm by Andrej Sarjaš, Rajko Svečko, Amor Chowdhury

“…The RIC approach is presented in the form with internal and external feedback loops, in which an internal disturbance rejection controller and an external performance controller must be synthesised. …”
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Splicing to keep splicing: A feedback system for cellular homeostasis and state transition by Zhonghao Guo, Xurui Zhang, Yachen Li, Yule Chen, Yungang Xu

“…Increasing evidence has highlighted the regulation for pre‐mRNA splicing of the splicing factors (SFs). This review aims to examine featured mechanisms and examples of SF regulation by AS, focusing on paradigmatic feedback loops and their biological implications. …”
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Optimisation of Water Distribution Networks Design by Minimizing the Total Length by Y. LAHIOUEL, K. CHAOUI, L. KHEZZAR, A. HADDAD, Z. AZARI

“…The aim of the present work is to establish a new algorithm for the optimization of the design of water distribution networks. …”
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INCREASING THE RELIABILITY OF HEATING SYSTEMS by R. A. Shershenov, A. Yu. Efimov, V. Yu. Shmakov

“…Objectives. The study was aimed at improving the reliability of heat supply systems. …”
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Underwater fiber laser removal of synthetically cultured Caulobacter crescentus biofilms on aluminium using response surface methodology by Hawa Ringkai, Khairul Fikri Tamrin, Ngieng Ngui Sing, Abdullah Yassin, Awang Ahmad Sallehin Awang Husaini, Jamil Musel

“…A response surface methodology was applied to optimize three laser processing parameters: laser power, laser speed, and repetition loops. The aim was to maximize biofilm removal efficiency while minimizing substrate damage. …”
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Investigation of dermatoglyphic patterns for mandibular retrognathism or maxillary prognathism as a novel diagnostic approach for skeletal Class II malocclusion by Naela Mohamed Al-Mogahed, Khalid Aldorae, Amourah Rashad Alfakhri, Maram Abdullah Taleb, Wafa’a Al-Sharaeai, Ahmad Mostafa Kahoul

“…Dermatoglyphic patterns, including Whorls, Loops, Tented Loops, Central Pockets, and Arches, were analyzed for all 10 fingers using the ink-and-stamp method. …”
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Acute presentation of cocoon abdomen as septic peritonitis mimicking with strangulated internal herniation: a case report by Sabah Uddin Saqib, Rimsha Farooq, Omair Saleem, Sarosh Moeen, Tabish Umer Chawla

“…Abstract Background Abdominal cocoon syndrome is a rare cause of intestinal obstruction in which loops of small bowel get entrapped inside a fibro-collagenous membrane. …”
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Addressing the Limitations of the Futures Cone: Introducing the Adaptive Futures Mesh by Alireza Hejazi

“… This paper aims to address the limitations of traditional strategic foresight methodologies, specifically the Futures Cone (FC), by introducing and evaluating a novel framework called the Adaptive Futures Mesh (AFM). …”
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