Interconnections between the food system and antimicrobial resistance: A systems-informed umbrella review from a One Health perspective by Chloe Clifford Astbury, Catherine Hu, Krishihan Sivapragasam, Arabi Rajan, Mandy Geise, Cécile Aenishaenslin, Arne Ruckert, Kathleen Chelsea Togño, Mary Wiktorowicz, Tarra L. Penney

“…Data were extracted and summarised according to umbrella review guidelines, and a causal loop diagram (CLD) was developed to map the interrelationships between food system factors and AMR. …”
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Natural Killer Cell Activation Signature Identifies Cyclin B1/CDK1 as a Druggable Target to Overcome Natural Killer Cell Dysfunction and Tumor Invasiveness in Melanoma by Linbin Chen, Wanqian Liao, Jing Huang, Qiuyue Ding, Junwan Wu, Qiong Zhang, Ya Ding, Dandan Li, Jingjing Li, Xizhi Wen, Xiaoshi Zhang

“…Mechanistically, in melanoma cells, the CCNB1/CDK1 complex phosphorylates STAT3, activating the IL-6/STAT3 positive feedback loop, which upregulates PD-L1 and enables resistance to NK cell-mediated cytotoxicity. …”
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Orchestrated desaturation reprogramming from stearoyl‐CoA desaturase to fatty acid desaturase 2 in cancer epithelial‐mesenchymal transition and metastasis by Zhicong Chen, Yanqing Gong, Fukai Chen, Hyeon Jeong Lee, Jinqin Qian, Jing Zhao, Wenpeng Zhang, Yamin Li, Yihui Zhou, Qiaobing Xu, Yu Xia, Liqun Zhou, Ji‐Xin Cheng

“…A FADS2/β‐catenin self‐reinforcing feedback loop facilitated the degree of lipid unsaturation, membrane fluidity, metastatic potential and EMT signaling. …”
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Mechanism of SLC1A5 Regulation of Glutamine Metabolism to Promote Ferroptosis Sensitivity in Endometriosis by Hui-Yu Ma, Huan-Yu Wu, Yu-Ting Xiang, Yu-Yin Liu, Jin Xie, Peng-Yu Cai, Bin Zhang, Yu-Hang Zhang, Ming-Xiu Wu

“…Solute carrier family 1 member 5 (SLC1A5), a glutamine transporter, and c-Myc play key roles in ferroptosis, forming a “ROS/c-Myc/SLC1A5” feedback loop. The aim of this study was to investigate the regulatory role of SLC1A5 in ferroptosis. …”
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Efficacy and mechanisms underlying MRI-guided high-definition transcranial direct current stimulation for depression among university students: study protocol for a stepped wedge c... by Yuanle Chen, Rongxun Liu, Jinnan Yan, Peng Luo, Luhan Yang, Yongbin Wang, Guangjun Ji, Chuansheng Wang, Wei Zheng, Fei Wang, Yong Meng, Yange Wei

“…The central anodal electrode will be positioned over the left dorsolateral prefrontal cortex (DLPFC), and four return electrodes will be placed 3.5 cm from the central electrode to form a circular current loop. The HD-tDCS will be delivered at a current intensity of 2 mA for 30 min per day, 5 days per week. …”
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Mechanisms of Cefiderocol Resistance in Carbapenemase-Producing Enterobacterales: Insights from Comparative Genomics by Alexander Tristancho-Baró, Ana Isabel López-Calleja, Ana Milagro, Mónica Ariza, Víctor Viñeta, Blanca Fortuño, Concepción López, Miriam Latorre-Millán, Laura Clusa, David Badenas-Alzugaray, Rosa Martínez, Carmen Torres, Antonio Rezusta

“…Additionally, porin loss and loop 3 insertions (e.g., GD/TD) in OmpK36, as well as OmpK35 truncations, were more frequent in the resistant isolates, particularly in high-risk clones such as ST395 and ST512. …”
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The Impact of Digital Technology–Based Exercise Combined With Dietary Intervention on Body Composition in College Students With Obesity: Prospective Study by Chengyuan Hu, Zixin Lv, Jieping Zhu, Chunyuan Lai, Dongjuan Guo, Maolin Chen, Xiaoyan Cheng, Mingxin Rao, Xinyou Zhou, Liqiang Su

“…The effectiveness of the closed-loop monitoring-feedback behavior modification was verified by digital technology through intelligent monitoring to improve dietary compliance and a real-time feedback mechanism to enhance the effect of the intervention. …”
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Diagnostic potential of miRNA-135A1 in human papillomavirus associated cervical lesions by D. S. Elkin, M. I. Taubinskaya, N. V. Elkina, R. S. Faskhutdinov, M. D. Fedorova, A. N. Katargin, K. I. Zhordania, E. A. Mustafina, E. A. Grivachev, L. S. Pavlova, S. V. Vinokurova

“…MiRNA expression in clinical samples was assessed by both next generation sequencing and quantitative stem-loop polymerase chain reaction (sl-qPCR). Plasma miRNAs from patients with precancerous and cancerous lesions and healthy donors were analyzed using sl-qPCR. …”
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Profiling of blood miRNAomes revealed the potential regulatory role of miRNAs in various lameness phenotypes in feedlot cattle by Zhe Pan, Wentao Li, Sonja Bialobzyski, Yanhong Chen, Eoin O’Hara, Hui-zeng Sun, Karen Schwartzkopf-Genswein, Le Luo Guan

“…However, different lameness phenotypes share similar clinical symptoms and there is a limited understanding of potential biomarkers relating to such disease for further molecular diagnosis. This study aimed to identify blood miRNA profiles of feedlot cattle with various lameness phenotypes and whether they could be potential diagnostic markers to differentiate lameness phenotypes and predictive lameness recovery. …”
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Balancing LncRNA H19 and miR‐675 Bioconversion as a Key Regulator of Embryonic Myogenesis Under Maternal Obesity by Yao Gao, Md Nazmul Hossain, Liang Zhao, Xiangdong Liu, Yanting Chen, Jeanene Marie Deavila, Mei‐Jun Zhu, Gordon K. Murdoch, Min Du

“…H19 contains a G‐rich loop, and KH‐type splicing regulatory protein (KHSRP) mediates the biogenesis of pre‐miRNAs containing G‐rich loops, which depends on its phosphorylation by AKT, a key mediator of IGF2 signalling. …”
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Research progress of Ni-rich ternary cathode materials by Xueyi GUO, Haiyan CAI, Gaoqiang MAO, Wanjing YU, Hui TONG, Shuo YIN

“…Subsequently, the main modification strategies for Ni-rich ternary cathode materials, including ion doping (such as of anions/cations), surface and interface modification (such as using electrochemically inert materials, ionic/electronic conductive materials, and a lithium residue compound), single-crystal structural design, concentration-gradient application, and core–shell structure design, which all aim to improve the overall performance of the materials, are summarized systematically. …”
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Differential directional effects between insomnia symptoms and suicidal ideation across trait depression levels: a cross-lagged network analysis among Chinese medical undergraduate... by Jingxuan Zhang, Xiaolin Zhang, Xiaolin Zhang, Xiaolin Zhang, Feng Hu, Kuiliang Li, Mengjie Luo, Mengjie Luo, Yang Yu, Yang Yu, Zhengzhi Feng, Zhengzhi Feng

“…Personalized interventions targeting specific insomnia symptoms (e.g., AIS6, AIS7 or AIS8) and suicidal emotional factors (e.g., OPT or DSP) are crucial disrupting feedback loops or critical connections to reduce suicide risk, particularly in individuals with varying levels of trait anhedonia. …”
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Diagnostic and therapeutic practice for HFpEF across continents and regions: An international survey by Inga J. Ingimarsdóttir, Julie K.K. Vishram‐Nielsen, Hafsteinn Einarsson, Sidney Goldfeder, Nathan Mewton, Anders Barasa, Carmen Basic, Marish I.F.J. Oerlemans, David Niederseer, Anastasia Shchendrygina, Finn Gustafsson, Frank Ruschitzka, Keisuke Kida, Dania Mohty, Rolland R. Rakotonoel, Han Naung Tun, Thórdís J. Hrafnkelsdóttir, Clara Saldarriaga

“…Abstract Aims This study aims to evaluate the worldwide variations in the diagnosis and treatment of heart failure with preserved ejection fraction (HFpEF), using an HF survey distributed internationally to physicians, including both cardiologists and non‐cardiologists. …”
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Standardization and Evaluation of the LAMP Technique for the Diagnosis of Canine Visceral Leishmaniasis in Conjunctival Swab Samples Using DNA Extracted by a Silica Column and Boil... by Isabela C. S. Santos, Daniel M. Avelar, Luciana F. C. Miranda, Cintia X. de Mello, Lucas Keidel, Maria Inês F. Pimentel, Luanna S. Ventura, Aline Fagundes, Fernanda N. Santos, Liliane F. A. Oliveira, Shanna A. Santos, Sandro Antonio Pereira, Rodrigo C. Menezes, Andreza P. Marcelino

“…The available tests have low sensitivity. This study aimed to standardize and evaluate the loop-mediated isothermal amplification technique with K26 target (K26-LAMP) for diagnosis of CVL in conjunctival swab (CS) DNA samples extracted through a silica column commercial kit (SW-kit) and boiling (SW-DB) and to compare sensitivity with conventional PCR (kDNA-cPCR) and quantitative real-time PCR (18S-qPCR). …”
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Regulation of plant gene expression by tsRNAs in response to abiotic stress by Chunmei Li, Jing Zhu, Han Jin, Haotian Feng, Haimin Zhuang, Zijun Du, Guolin Zhu, Haiyang He, Fuyang Ye, Zhaohui Mo, Qingtao Hu, Zhenbang Chen, Kai Liu, Xiaorong Wan

“…Results tsRNAs are categorized into two main types: tRNA-derived stress-induced RNAs (tiRNAs; 29–50 nt) and tRNA-derived fragments (tRFs; 14–40 nt). tiRNAs arise from anticodon loop cleavage by RNase A/T2, while tRFs are generated via Dicer-dependent or -independent pathways. …”
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Blocking ITGA5 potentiates the efficacy of anti‐PD‐1 therapy on glioblastoma by remodeling tumor‐associated macrophages by Rongrong Zhao, Ziwen Pan, Jiawei Qiu, Boyan Li, Yanhua Qi, Zijie Gao, Wei Qiu, Weijie Tang, Xiaofan Guo, Lin Deng, Gang Li, Hao Xue

“…Fully understanding the cellular heterogeneity and immune adaptations in response to anti‐PD‐1 therapy is necessary to design more effective immunotherapies for GBM. This study aimed to dissect the molecular mechanisms of specific immunosuppressive subpopulations to drive anti‐PD‐1 resistance in GBM. …”
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Insight into rifampicin resistance behind discordant mutations in RpoB of Mycobacterium tuberculosis: A molecular dynamics simulations study by Muhammad Tahir Khan, Elise Dumont, Jialou Zhu, Kashif Iqbal Sahibzada, Madeeha Shahzad Lodhi, Mehmood Qadir, Dongqing Wei

“…Based on DCCM and PCA, highest negatively-correlated motion was found for L430 > P/C701 > W followed by S428T/D435G, H445W/L452, and S428/H445Y. The role of the loop 431–447 of RpoB flexibility was found to be correlated to RIF binding. …”
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Determinants and Experiences of Care‐Seeking for Childhood Pneumonia in a Rural Indian Setting: A Mixed‐Methods Study by Barsha Gadapani Pathak, Sarmila Mazumder, Yasir Bin Nisar, Aditya Bhatt, Mandeep Singh, Tarun Madhur, Ingvild Fossgard Sandøy

“…Patient or Public Contribution This study is part of an ongoing implementation research (IR) aimed at improving the effective coverage of childhood pneumonia management in a low‐resource setting. …”
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A Pentavalent HIV-1 Subtype C Vaccine Containing Computationally Selected gp120 Strains Improves the Breadth of V1V2 Region Responses by Xiaoying Shen, Bette Korber, Rachel L. Spreng, Sheetal S. Sawant, Allan deCamp, Arthur S. McMillan, Ryan Mathura, Susan Zolla-Pazner, Abraham Pinter, Robert Parks, Cindy Bowman, Laura Sutherland, Richard Scearce, Nicole L. Yates, David C. Montefiori, Barton F. Haynes, Georgia D. Tomaras

“…Background: HIV-1 envelope (Env) variable loops 1 and 2 (V1V2) directed non-neutralizing antibodies were a correlate of decreased transmission risk in the RV144 vaccine trial. …”
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Retinoblastoma-binding Protein 9 Suppresses Intestinal Inflammation and Inflammation-induced Tumorigenesis in MiceSummary by Kensuke Hamada, Yuki Nakanishi, Yu Muta, Mayuki Omatsu, Kosuke Iwane, Munehiro Ikeda, Jiayu Chen, Yoko Masui, Naoki Aoyama, Nobukazu Agatsuma, Go Yamakawa, Takahiro Utsumi, Hiroki Kitamoto, Makoto Okabe, Yoshiro Itatani, Takumi Adachi, Koubun Yasuda, Shuji Yamamoto, Akihisa Fukuda, Etsushi Kuroda, Masaki Ohmuraya, Kazutaka Obama, Seiichi Hirota, Hiroki Ikeuchi, Kenji Nakanishi, Hiroshi Seno

“…Background & Aims: Retinoblastoma-binding protein 9 (RBBP9) was initially reported as cell cycle regulator via RB/E2F. …”
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