Deep Learning–Based Chronic Obstructive Pulmonary Disease Exacerbation Prediction Using Flow-Volume and Volume-Time Curve Imaging: Retrospective Cohort Study by Eun-Tae Jeon, Heemoon Park, Jung-Kyu Lee, Eun Young Heo, Chang Hoon Lee, Deog Kyeom Kim, Dong Hyun Kim, Hyun Woo Lee

“…Recent advances in artificial intelligence (AI) have enabled more sophisticated analyses of full spirometric curves, including flow-volume loops and volume-time curves, facilitating the identification of complex patterns associated with increased exacerbation risk. …”
Get full text

Hypoxic glioma-derived exosomal miR-25-3p promotes macrophage M2 polarization by activating the PI3K-AKT-mTOR signaling pathway by Zhiwei Xue, Junzhi Liu, Wenchen Xing, Feiyu Mu, Yanzhao Wu, Jiangli Zhao, Xuchen Liu, Donghai Wang, Jian Wang, Xingang Li, Jiwei Wang, Bin Huang

“…As part of a feedback loop, M2-polarized macrophages can, in turn, promote malignant glioma progression. …”
Get full text

COFLEX: a novel set point optimiser and feedforward–feedback control scheme for large, flexible wind turbines by G. Lazzerini, J. Deleuran Grunnet, T. Gybel Hovgaard, F. Caponetti, V. Datta Madireddi, D. De Tavernier, S. P. Mulders

“…The current state-of-the-art control strategy is the tip-speed ratio tracking scheme, which aims to maximise power production in the partial-load region by maintaining a constant ratio between blade velocity and wind speed. …”
Get full text

Comparative in vitro immunoreactivity and protein analysis of Trimeresurus albolabris and Tropidolaemus wagleri venoms by Onrapak Reamtong, Phorutai Pearngam, Panithi Laoungbua, Siravit Sitprija, Tipparat Thiangtrongjit, Godchakorn Srisuk, Taksa Vasaruchapong, Orawan Khow, Jureeporn Noiphrom, Narongsak Chaiyabutr, Lawan Chanhome, Supeecha Kumkate

“…Structural and physicochemical analyses indicated that Loop 2 (residues 100–110) in the immunoreactive SVSP from Trimeresurus albolabris venom exhibited higher hydrophilicity and surface accessibility compared to the non-immunoreactive SVSP from Tropidolaemus wagleri venom. …”
Get full text

The microenvironment in atherosclerosis: molecular regulation mechanism and immunotherapy by Xiaoyu Teng, Qinlian Jiao, Yidan Ren, Xin Su, Zigan Li, Yuxuan Cai, Tangbin Hu, Maoxiao Feng, Xiaoyan Liu, Ming Xia, Jun Tai, Yana Zhang, Yunshan Wang, Mo Wang

“…Special attention is given to intercellular regulatory circuits such as the Th1–M1 feedback loop, the OX40L–Th17 axis, and DC–T–NK amplification loops. …”
Get full text

Synergistic thermal and surface area properties of Al2O3–TiO2/water hybrid nanofluids by Yokanan Gustino Djentoe, Farrel Yoga Widiasto, Hilbran Tama Dida Effendi, Musabbikhah, Sri Hartati, Budi Santoso, Budi Kristiawan, Agung Tri Wijayanta

“…The structural analysis of TiO2 and Al2O3 nanoparticles reveals a mesoporous structure with curve isotherm type IV that has loop hysteresis characteristics. The thermal durability of the water-based Al2O3–TiO2 hybrid nanoparticles is shown to have a strong relationship with the Moldoveanu model, confirming the trend of increasing thermal durability with a decrease in temperature as a result of increased nanoparticle mobility. …”
Get full text

Genetic Divergence and Isolation of the Green Sea Turtle (Chelonia mydas) in the Red Sea by K. Scott, S. He, R. S. Hardenstine, L. K. Tanabe, H. Barrios‐Garrido, M. P. Jensen, L. Afiq‐Rosli, N. E. Wildermann, C. M. Duarte, J. E. M. Cochran, M. L. Berumen

“…We analysed 710 bp of the mtDNA d‐loop from five Red Sea rookeries. Five haplotypes, grouped into two highly divergent haplogroups, were identified. …”
Get full text

Revolutionising young adult diabetes care: a patient-centred transformation to improve access, engagement and outcomes in one of England's most deprived areas by Tala Balafshan, Heather Sullivan, Suzanne Keigan, Amanda Wilson, Ifeoluwa Oyedeji

“…Introduction: The transformation of our Young Adult Diabetes Service was driven by a patient-centred approach aimed at improving clinical outcomes and patient experience in one of the most deprived areas in England. …”
Get full text

The cyclic di-GMP receptor YcgR links the second messenger with the putrescine quorum sensing system in modulation of Dickeya oryzae motility by Weihan Gu, Yufan Chen, Congcong Xie, Zhongqiao Chen, Huagui Gao, Yaping Zhu, Lian-hui Zhang, Lisheng Liao

“…Critically, this facilitative effect was inhibited by c-di-GMP molecules; thus, SpeA, YcgR, and c-di-GMP constitute a regulatory loop modulating D. oryzae motility by controlling the rate of putrescine biosynthesis. …”
Get full text

Development of a prognostic risk stratification model for HER2-positive breast cancer brain metastasis and its implications in guiding treatment decisions by Jiaxin Chen, Yuan Sh, Danfeng Dong, Huicui Yan, Huiqiang Zhang, Zisheng Wu, Jinmei Zhou, Xuexue Wu, Fei Chu, Zefei Jiang, Shanhu Li, Jin Yang, Ling Xu, Tao Wang

“…Despite improved prognosis, survival remains limited. This study aims to investigate the clinicopathological characteristics of HER2-positive breast cancer brain metastasis (BCBM) patients and their prognostic associations, to identify personalized treatment strategies to enhance survival. …”
Get full text

Toward a circular carbon economy: Production of green C1 compounds through high-temperature CO2 electrolysis by Nan Zheng, Jing Zhu, Haitao Zhu, Jin Xuan, Haoran Xu, Meng Ni

“…Broader context: The carbon cycle economy is an approach that focuses on managing and reducing carbon emissions through a loop system that encompasses reducing, reusing, recycling, and removing. …”
Get full text

The Investigation of the Prospects for Using NS4A Antigen of Hepatitis C Virus for the Development of Recombinant Mosaic Vaccines with Self-Adjuvant Properties by V. V. Koupriyanov, L. I. Nikolaeva, A. A. Zykova, P. I. Makhnovskiy

“…The aim of this study was to design promising variants of recombinant proteins based on NS4A antigen of hepatitis C virus (HCV) for subsequent work on the creation of a mosaic recombinant vaccine against hepatitis C. …”
Get full text

Safety and Efficacy of Modular Digital Psychotherapy for Social Anxiety: Randomized Controlled Trial by Mona M Garvert, Jessica McFadyen, Stuart Linke, Tayla McCloud, Sofie S Meyer, Sandra Sobanska, Paul B Sharp, Alex Long, Quentin J M Huys, Mandana Ahmadi

“…We developed a novel digital adaptation of CBT for social anxiety that is both modular and fully digital without a therapist in the loop and implemented it in the smartphone app Alena. …”
Get full text

Molecular characterization of VP1 gene during the foot and mouth disease virus outbreak in East Java, Indonesia, in 2022 by Zayyin Dinana, Suwarno Suwarno, Imam Mustofa, Jola Rahmahani, Kusnoto Kusnoto, Aussie Tahta Maharani, Anisa Lailatul Fitria, Adiana Mutamsari Witaningrum, Firdausy Kurnia Maulana, Nur Saidah Said, Deka Uli Fahrodi, Fedik Abdul Rantam

“…Background and Aim: Foot and mouth disease (FMD) is highly contagious in cloven-hoofed animals, and it causes outbreaks in Indonesia and several countries worldwide. …”
Get full text

Wildlife policy, the food system and One Health: a complex systems analysis of unintended consequences for the prevention of emerging zoonoses in China, the Democratic Republic of... by Zhuoyu Wang, Tarra L Penney, Mala Ali Mapatano, Chloe Clifford Astbury, Janielle Clarke, Kathleen Chelsea Togño, Shital Desai, Anastassia Demeshko, Russel Aguilar, Angran Li, Zhilei Shi, Cary Wu, Marc K Yambayamba, Hélène Carabin, Valentina De Leon, Eduardo Gallo-Cajiao, Kirsten Melissa Lee, Krishihan Sivapragasam, Mary Wiktorowicz

“…We combined evidence from a rapid literature review with key informant interviews to develop causal loop diagrams (CLDs), a form of systems map representing causal theory about system factors and interconnections. …”
Get full text

Outcomes of patients after successful left ventricular assist device explantation: a EUROMACS study by Christiaan F.J. Antonides, Felix Schoenrath, Theo M.M.H. deBy, Rahatullah Muslem, Kevin Veen, Yunus C. Yalcin, Ivan Netuka, Jan Gummert, Evgenij V. Potapov, Bart Meyns, Mustafa Özbaran, David Schibilsky, Kadir Caliskan, the EUROMACS investigators

“…Abstract Aims Sufficient myocardial recovery with the subsequent explantation of a left ventricular assist device (LVAD) occurs in approximately 1–2% of the cases. …”
Get full text

Evaluation of blaOXA-48-like point mutation carbapenemase-producing Enterobacterales in Prapokklao Hospital, Thailand by Sirijan Santajit, Witawat Tunyong, Thida Kong-Ngoen, Weewan Arsheewa, Woranich Hinthong, Pornpan Pumirat, Nitat Sookrung, Nitaya Indrawattana

“…Multiple-sequence alignment and in silico analysis revealed variation of R214 located in the β5–β6 loop. This study identified blaOXA-48-like point mutation groups and carbapenemase production, predominantly metallo-β-lactamases, among CRE isolates, especially K. pneumoniae and E. coli. …”
Get full text

Predictive analysis of B-cell antigenic epitopes in phospholipase D toxins from Loxosceles spiders by Alejandro Catalán, Carolina García, Valentina Sambra, Nicole Cadena, José Rojas, Tomás Arán-Sekul, Juan San Francisco, Valeria Vásquez-Saez, Christian Muñoz, Abel Vásquez, Jorge E. Araya

“…Finally, the catalytic loop was identified as a common discontinuous epitope in the PLDs independently of the cluster or the class it belongs to. …”
Get full text

Structural insights into prolactin-releasing peptide receptor signaling and G-protein coupling selectivity by Zhangsong Wu, Chen Qiu, Yiming Liu, Xiaoyi Yan, Qiaohui Li, Shirui Jiang, Jun Xu, Xin Pan, Fang Ye, Zhiyi Zhang, Peiruo Ning, Binghao Zhang, Lezhi Xu, Bangning Cheng, Xufu Xiang, Chungen Qian, Yang Du, Geng Chen

“…Furthermore, structural and functional analysis indicates that conformational alterations in the intracellular loops (ICLs), along with the “wavy hook” of Gα, may explain the selective coupling of G proteins in PrRPR signaling.…”
Get full text

Crosstalk Between Autophagy and Oxidative Stress in Hematological Malignancies: Mechanisms, Implications, and Therapeutic Potential by Antonio José Cabrera-Serrano, José Manuel Sánchez-Maldonado, Carmen González-Olmedo, María Carretero-Fernández, Leticia Díaz-Beltrán, Juan Francisco Gutiérrez-Bautista, Francisco José García-Verdejo, Fernando Gálvez-Montosa, José Antonio López-López, Paloma García-Martín, Eva María Pérez, Pedro Sánchez-Rovira, Fernando Jesús Reyes-Zurita, Juan Sainz

“…We discuss how oxidative stress triggers autophagy, creating a feedback loop that promotes tumor survival, and how autophagic dysregulation leads to increased ROS accumulation, exacerbating tumorigenesis. …”
Get full text