A novel CD40LG mutation causing X‑linked hyper-IgM syndrome by Xuejing Li, Yungai Cheng, Dan Xu, Beilei Cheng, Yingchun Xu, Zhimin Chen, Lanfang Tang, Yingshuo Wang

“…The frame shift mutation led to incorrect amino acid translation and loss of β-pleated sheet and loop region, which produced a mutant dysfunctional protein. …”
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Combined strategy of α 9-integrin transduction and AEIDGIEL peptide-functionalized fibrin gel biomaterials to promote mature DRG neurite growth by Anda Cimpean, Anda Cimpean, Lars Roll, Jacqueline Reinhard, Jessica C. F. Kwok, Jessica C. F. Kwok, Andreas Faissner, Fred de Winter, James W. Fawcett, James W. Fawcett, Pavla Jendelová

“…Furthermore, we corroborate an autocrine signaling loop of α9-integrin and TN-C produced by neurons.Discussionthe proposed combination therapy of α9-integrin and fibrin gel biomaterials incorporating AEIDGIEL peptide shows promise for addressing the complex challenges of spinal cord injury and promoting effective neural regeneration, laying the foundation for further in vivo research.…”
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RNA sequencing-based profiling of differentially expressed microRNAs in endothelial cells from offspring of hypertensive pregnancies: a preliminary study by Nurul Iffah Mohd Isa, Aslah Nabilah Abdull Sukor, Saiful Effendi Syafruddin, Mohd Faizal Ahmad, Shahidee Zainal Abidin, Mohd Helmy Mokhtar, Azizah Ugusman, Azizah Ugusman, Adila A. Hamid, Adila A. Hamid

“…Therefore, this study aims to determine the miRNA expression profile of human umbilical vein endothelial cells (HUVECs) isolated from the offspring of HDP. …”
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Exploration of the mechanism underlying the impact of artificial light on guinea pig ovarian function via proteomics and acetylation analyses by Jiayu Shi, Yuliang Wang, Linfang Li, Ruxin Wang, Yao Peng, Tingting Zhou, Donglai Hu, Jie Chen, Yong Tan

“…Objective: This study aims to explore the effects of artificial light on ovarian function in female guinea pigs and the possible mechanism. …”
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Tm4sf19 inhibition ameliorates inflammation and bone destruction in collagen-induced arthritis by suppressing TLR4-mediated inflammatory signaling and abnormal osteoclast activatio... by Sujin Park, Kwiyeom Yoon, Eunji Hong, Min Woo Kim, Min Gi Kang, Seiya Mizuno, Hye Jin Kim, Min-Jung Lee, Hee Jae Choi, Jin Sun Heo, Jin Beom Bae, Haein An, Naim Park, Hyeyeon Park, Pyunggang Kim, Minjung Son, Kyoungwha Pang, Je Yeun Park, Satoru Takahashi, Yong Jung Kwon, Dong-Woo Kang, Seong-Jin Kim

“…This study aimed to investigate the role of Tm4sf19 in RA, an inflammatory and abnormal osteoclast disease, using a mouse model of collagen-induced arthritis (CIA). …”
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Nutrient availability modulates the effects of plastic leachates on the growth and community dynamics of free-living freshwater bacteria by Marius Schubert, Fazel Abdolahpur Monikh, Fazel Abdolahpur Monikh, Fazel Abdolahpur Monikh, Yuyi Yang, Yuyi Yang, Yuyi Yang, Hans-Peter Grossart, Hans-Peter Grossart

“…Our findings reveal that synthetic polymer pollution has the potential to alter microbial loop functioning and hence biochemical cycles of aquatic ecosystems.…”
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Recurrent high-grade squamous intraepithelial lesion and early-stage cervical cancer (<i>in situ</i>): predictors, long-term treatment outcomes, and opportunities for treatment and... by A. O. Shumeykina, A. G. Kedrova, E. A. Zhdanova, A. V. Tarkhov, S. E. Krasilnikov

“…Meshalkin National Medical Research Center, Novosibirsk Regional Clinical Oncology Dispensary, Federal Research and Clinical Center for Specialized Medical Care and Medical Technologies of Federal Biomedical Agency of the Russian Federation, Siberian Center of Oncology and Gynecology “AvisMed” LLC, and “Zdorovye” LLC between 2011 and 2924.All new patients with HSIL or cervical cancer in situ underwent loop radio-wave excision (conization) of the cervix and endocervical curettage. …”
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Frequency Regulation Provided by Doubly Fed Induction Generator Based Variable-Speed Wind Turbines Using Inertial Emulation and Droop Control in Hybrid Wind–Diesel Power Systems by Muhammad Asad, José Ángel Sánchez-Fernández

“…In addition, to enhance the effectiveness and smoothness of the blade pitch angle control of WTs, a pitch compensation (PC) control loop is proposed in this paper. The aim of this study was to provide optimal primary frequency regulations to hybrid wind–diesel power systems (WDPSs). …”
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Are Suggested Hiking Times Accurate? A Validation of Hiking Time Estimations for Preventive Measures in Mountains by Marco Vecchiato, Nicola Borasio, Emiliano Scettri, Vanessa Franzoi, Federica Duregon, Sandro Savino, Andrea Ermolao, Daniel Neunhaeuserer

“…<i>Materials and Methods</i>: A cross-sectional analysis was conducted using data from 25 Italian loop trails selected via the Wikiloc platform, considering user-uploaded GPS data from at least 20 users per trail. …”
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Application of Metabolomics and the Discovery of Potential Serum Biomarkers for Diuretic Resistance in Heart Failure by Yipin Yu, Qiong Yi, Chenglong Yang, Xudong Song, Duoting Tan, Qinghua Peng, Xiang Sun, Hao Liang

“…Background: Diuretic resistance (DR) is characterized by insufficient fluid and sodium excretion enhancement despite maximum loop diuretic doses, indicating a phenotype of refractory heart failure (HF). …”
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Overlapping genes connect rheumatoid arthritis and head and neck cancer: coincidence or shared immune pathophysiology? by Ran Wang, Haiyang Li, Haiyang Li, Yifan Yang, Yifan Yang, Meng Lian, Meng Lian

“…IntroductionDespite advances in understanding the pathophysiology of rheumatoid arthritis (RA) and head and neck cancer (HNC) individually, their shared genetic and molecular mechanisms remain poorly defined.MethodsThis study aimed to explore gene-level connections between RA and HNC. …”
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Contribution of efflux pump hyperactivity to the resistance to new β-lactam-β-lactamase inhibitor combinations including ceftazidime-avibactam, aztreonam-avibactam, and imipenem-re... by Sung Pin Tseng, Tsung Ying Yang, Pu He, Yu Cin Deng, Po Liang Lu

“…AIM: To investigate the resistance mechanisms of new β-lactam-β-lactamase inhibitor (β+βi) combinations in Enterobacterales isolates from Taiwan. …”
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Performance of a six-methylation-marker assay in predicting LEEP specimen histology results of cervical HSIL patients: a retrospective study by Ruolan Wu, Yingting Wei, Anyue Wu, Jinhua Huang, Ruiju He, Liying Gu, Zubei Hong, Lihua Qiu

“…Abstract Background Discrepancies have been found between preoperative colposcopic biopsy results and histology results of loop electrical excision procedure (LEEP) specimens. …”
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Rationale and design of the THIRST Alert feasibility study: a pragmatic, single-centre, parallel-group randomised controlled trial of an interruptive alert for oral fluid restricti... by Yang Chen, Anoop Shah, Folkert W Asselbergs, R Thomas Lumbers, Daniel Higgins, Yogini Jani, Nausheen Saleem, Kris Chafer, Matthew Robert Sydes

“…A restriction in oral fluid intake is commonly imposed on patients as an adjunct to pharmacological therapy with loop diuretics, but there is a lack of evidence from traditional randomised controlled trials (RCTs) to support the safety and effectiveness of this intervention in the acute setting.This study aims to explore the feasibility of using computer alerts within the electronic health record (EHR) system to invite clinical care teams to enrol patients into a pragmatic RCT at the time of clinical decision-making. …”
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Pharmacoepidemiological analysis of routine management of heart failure patients in the Russian Federation. Part I by Yu. M. Lopatin, S. V. Nedogoda, M. V. Arkhipov, A. S. Galyavich, N. A. Koziolova, N. G. Lozhkina, E. V. Reznik, A. S. Salasyuk, M. Yu. Frolov, A. I. Chesnikova, E. V. Chumachek, L. A. Shpagina

“…Aim. To assess the healthcare system costs for the management of patients with heart failure (HF) based on a retrospective analysis of primary medical documentation.Material and methods. …”
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Micropollution of rainwater collected from roof surfaces in the context of sustainable water management by Monika Zdeb, Dorota Papciak, Wojciech Strojny, Monika Kwapniewska

“…The rainwater harvesting system is seen as an alternative source based on green technology, a closed loop economy, environmentally friendly and sustainable. …”
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MICRORNA IN MONITORING OF THE EVOLUTION OF GLIAL CEREBRAL TUMORS by R. Yu. Seliverstov, M. I. Zaraiskiy, R. V. Tyurin, A. G. Naryshkin, V. G. Valerko, V. V. Semiglazov, Ch. Takahachi

“…The study of miRNA-21, -128, and -342 expressions was carried out according to the semiquantitative StemLoopRealTime protocol, using small U6 RNA as a reference gene. …”
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Thermodynamic Work of High-Grade Uterine Prolapse Patients Undergoing Transvaginal Mesh Repair with Total Hysterectomy by Hui-Hsuan Lau, Cheng-Yuan Lai, Ming-Chun Hsieh, Hsien-Yu Peng, Dylan Chou, Tsung-Hsien Su, Jie-Jen Lee, Tzer-Bin Lin

“…The objective benefit of transvaginal mesh with concomitant total hysterectomy (TVM-HTX) repair to high-grade uterine prolapse (UP) patients has not been fully established. This study aimed to clarify the impact of TVM-HTX on the voiding function of high-grade UP patients by comparing pre- and post-operatively measured pressure–flow and pressure–volume investigations. …”
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Whole exon screening of SLC2A4 gene and the association of rs5435 with type 2 diabetes in a Bangladeshi case-control study by Mohammad Mamunur Rashid, Mohammad Sayem, Maisha Adiba, Abdullah Al Saba, A.H.M. Nurun Nabi, Tahirah Yasmin

“…This study, therefore, aims to identify and analyze genetic variants within the SLC2A4 gene and determine their association with T2D risk through a Bangladeshi case-control study. …”
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Cell-free plasma miRNAs analysis for low invasive lung cancer diagnostics by M. Yu. Konoshenko, P. P. Laktionov, Yu. A. Lancuhaj, S. V. Pak, S. E. Krasilnikov, O. E. Bryzgunova

“…Expression of 17 miRNAs most characteristic for the development of LC according to our and literature data in the above-mentioned blood plasma fractions was analyzed by stem-loop reverse transcription polymerase chain reaction.Results. 29 and 10 miRNA pairs were differentially expressed in plasma extracellular vesicles and plasma of lung cancer patients and donors. …”
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