SentemQC - A novel and cost-efficient method for quality assurance and quality control of high-resolution frequency sensor data in fresh waters [version 2; peer review: 1 approved,... by Sofie Gyritia Madsen van't Veen, Joachim Audet, Eti Ester Levi, Brian Kronvang, Søren Erik Larsen, Erik Jeppesen, Esben Astrup Kristensen, Anders Nielsen, Thomas Alexander Davidson, Jane Rosenstand Laugesen, Peter Mejlhede Andersen

“…The SentemQC method is computationally efficient and features a six-step user-friendly setup for anomaly detection. …”
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The relationship between the level of pig welfare and their health status by N. Yu. Krempa, O. V. Kozenko, B. V. Gutyj, I. V. Dvyliuk, N. V. Magrelo, H. V. Klym, T. V. Martyshuk, U. M. Vus, A. O. Vysotskyi, O. O. Krasnoshchok

“…According to the results of the studies, it can be concluded that the technological features of intensive pig farming, due to the influence and sometimes inconsistency with the biological, ethological, or physiological needs of pigs, have a mostly negative effect on the animal organism. …”
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[18F]FE‐PE2I PET is a diagnostic tool in dementia with Lewy bodies by Andrea Sturchio, Jonas E. Svensson, Mikael Tiger, Anton Forsberg Morén, Andrea Varrone, Per Svenningsson, Yoshiro Okubo, Amane Tateno

“…We also aimed to analyze how DAT binding correlated with clinical features, amyloid load, measured by PET, and cardiac metaiodobenzylguanidine scintigraphy (MIBG). …”
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Simulation analysis of flow characteristics in long-distance downward-inclination-dominated pipeline for multiphase mixed transportation by Yangmin HE, Quanmin YAO, Jinglin HE

“…ObjectiveThe SED oilfield is a remote block operated by PetroChina in Central Asia, located approximately 20.2 km from the pre-dehydration station FWKO6 of another oilfield. The area features significant terrain undulations that necessitate the predominance of downward inclined pipeline sections along the transport route between the two locations. …”
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RESULTS OF CLINICAL AND INSTRUMENTAL STUDY OF DIGITAL OCCLUSION INDICES DURING REGISTRATION OF INTERMAXILLARY INTERCUSPAL POSITION IN PATIENTS WITH UNILATERAL DEFECTS AND INTACT DE... by Т.R. Hlushko, Yu.V. Vovk, V.Yu. Vovk, P.S. Kryukov

“…The conducted instrumental studies demonstrate challenging opportunities to identify individualized features of static and dynamic occlusal balance at clinical registration of intermaxillary position of ICP with the help of various registration materials and techniques. …”
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Designing accessible and independent living spaces for visually impaired individuals: a barrier-free approach to interior design by Anushka Patil, Smruti Raghani

“…Optimized lighting layouts feature uniform illumination, glare reduction, and adaptive lighting to enhance visibility. …”
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Análisis numérico comparativo de fijadores para el tratamiento de fracturas proximales del fémur // Comparative numerical analysis of fixers for the treatment of proximal fractures... by Jorge Bosch-Cabrera, Roberto Estrada-Cinqualbres, Yoan Ramos-Botello

“…The results show lower values of maximum stress in the external fixer in comparison<br />with the stress that arise in the dynamic plate under the action of the acting loads on the models, so it<br />can be concluded that the first possesses best resistive features, being recommended its use in<br />patients having heavy weight or those who could make more active physical activities during their<br />postoperative recovery.…”
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A time-course comparative clinical and immune response evaluation study between the human pathogenic Orientia tsutsugamushi strains: Karp and Gilliam in a rhesus macaque (Macaca mu... by Manutsanun Inthawong, Piyanate Sunyakumthorn, Sirima Wongwairot, Tippawan Anantatat, Susanna J Dunachie, Rawiwan Im-Erbsin, James W Jones, Carl J Mason, Luis A Lugo, Stuart D Blacksell, Nicholas P J Day, Piengchan Sonthayanon, Allen L Richards, Daniel H Paris

“…C-reactive protein (CRP) plasma levels, interferon gamma (IFN-γ, interleukin-1 receptor antagonist (IL-1ra), IL-15 serum concentrations, CRP/IL10- and IFN-γ/IL-10 ratios correlated positively with bacterial load in blood, implying activation of the innate immune response and preferential development of a T helper-type 1 immune response. …”
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Exosomes enriched with miR-124-3p show therapeutic potential in a new microfluidic triculture model that recapitulates neuron–glia crosstalk in Alzheimer’s disease by Artemizia Évora, Gonçalo Garcia, Gonçalo Garcia, Ana Rubi, Eleonora De Vitis, Ana Teresa Matos, Ana Rita Vaz, Ana Rita Vaz, Francesca Gervaso, Giuseppe Gigli, Giuseppe Gigli, Alessandro Polini, Dora Brites, Dora Brites

“…We previously demonstrated that the regulation of microRNA (miR)-124 is crucial for proper neuronal function and microglia reshaping in human AD cell models.ObjectiveThe aim of this study was to develop an efficient miR-124-3p-loaded exosome strategy and validate its therapeutic potential in using a multi-compartment microfluidic device of neuron–glia that recapitulates age-AD pathological features.Methods and resultsUsing cortical microglia from mouse pups, separated from glial mixed cultures and maintained for 2 days in vitro (stressed microglia), we tested the effects of SH-SY5Y-derived exosomes loaded with miR-124-3p mimic either by their direct transfection with Exo-Fect™ (ET124) or by their isolation from the secretome of miR-124 transfected cells (CT124). …”
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From laboratory to clinic: a precise treatment strategy of mesenchymal stem cells-derived exosomes pretreated by simulating disease microenvironment by Hailian Ye, Hailian Ye, Hailian Ye, Qi He, Qi He, Qi He, Fang Qi, Fang Qi, Fang Qi, Guangchao Xu, Guangchao Xu, Guangchao Xu, Mulan Qahar, Mulan Qahar, Mulan Qahar, Chenliang Deng, Chenliang Deng, Chenliang Deng, Zairong Wei, Zairong Wei, Zairong Wei

“…These methods more accurately reflect the spatiotemporal features of the disease microenvironment, thereby improving the therapeutic potential of MSC-Exos. …”
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Mental health phenotypes of well-controlled HIV in Uganda by Leah H. Rubin, Leah H. Rubin, Leah H. Rubin, Leah H. Rubin, Kyu Cho, Jacob Bolzenius, Julie Mannarino, Rebecca E. Easter, Raha M. Dastgheyb, Aggrey Anok, Stephen Tomusange, Deanna Saylor, Maria J. Wawer, Noeline Nakasujja, Gertrude Nakigozi, Robert Paul

“…Inferential statistics compared select demographic (age, sex, education), viral load, and early life adversity between clusters.ResultsWe identified four MH phenotypes. …”
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Chondroitin Sulfate-Based Imatinib Nanoparticles Targeting Activated Hepatic Stellate Cells Against Hepatic Fibrosis by Xunzhi Liu, Changlong Fang, Hongling Yu, Lu Huang, Jiaxing Feng, Shiqin Luo, Li Song, Mengying Wu, Yulu Tan, Jianxia Dong, Tao Gong, Peihong Xiao

“…<b>Background</b>: Activated hepatic stellate cells (aHSCs) play a significant role during the onset of hepatic fibrosis, ultimately leading to excessive deposition of extracellular matrix (ECM) and other typical pathological features, and thus have become a popular target for the treatment of hepatic fibrosis. …”
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SentemQC - A novel and cost-efficient method for quality assurance and quality control of high-resolution frequency sensor data in fresh waters [version 1; peer review: 1 approved,... by Sofie Gyritia Madsen van't Veen, Joachim Audet, Eti Ester Levi, Brian Kronvang, Søren Erik Larsen, Erik Jeppesen, Esben Astrup Kristensen, Anders Nielsen, Thomas Alexander Davidson, Jane Rosenstand Laugesen, Peter Mejlhede Andersen

“…The SentemQC method is computationally efficient and features a six-step user-friendly setup for anomaly detection. …”
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Real-time detection of Chinese cabbage seedlings in the field based on YOLO11-CGB by Hang Shi, Hang Shi, Changxi Liu, Changxi Liu, Miao Wu, Miao Wu, Hui Zhang, Hui Zhang, Hang Song, Hang Song, Hao Sun, Hao Sun, Yufei Li, Yufei Li, Jun Hu, Jun Hu

“…This module focuses on the distinctive features of Chinese cabbage seedlings. Additionally, a simplified Bidirectional Feature Pyramid Network (BiFPN) is incorporated into the neck network to bolster feature fusion efficiency. …”
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The boundaries between PML and PML-IRIS: difficult to define, pathology may predict by Jiamin Chen, Yanni Du, Lei Sun, Yuyang Dai, Liang Zhang, Xinghuan Ding, Ting Liu, Kun Yang, Xiaoyi Han, Man Li, Xingang Zhou, Xingang Zhou

“…Myelin architecture was evaluated through Luxol fast blue staining, complemented by molecular diagnostics incorporating quantitative JC viral load PCR and metagenomic next-generation sequencing (mNGS).ResultsNotably, 63.2% (12/19) of them had blood CD4+ T-cell counts &lt; 200 cells/μl, and 36.8% (7/19) had ≥ 200 cells/μl. 52.9% (9/17) of the patients had elevated CSF protein, 5.3% (1/19) had decreased CSF glucose. …”
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Ferroptosis-related genes participate in the microglia-induced neuroinflammation of spinal cord injury via NF-κB signaling: evidence from integrated single-cell and spatial transcr... by Siqiao Wang, Li Yang, Zhourui Wu, Chen Li, Shaoke Wang, Zhihui Xiao, Bei Ma, Rongrong Zhu, Liming Cheng

“…Cell subclusters and unique features of microglia in SCI were identified by single-cell transcriptomic analysis, which were validated in GSE226286. …”
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Low CD4 count was characterized in recent HIV CRF01_AE infection and it rapidly increased to reach a peak in the first year since ART initiation by Xue-Ying Zhang, Li Wang, Yue Jiang, Si-Miao Huang, Hong-Rui Zhu, Wei Liu, Jia-Ye Wang, Xiang-Hui WEI, Yi-Lin Zhao, Wen-Juan Wei, Teng Fei, Xiao-Hong Chen, Dan Wang, Jin-Liang Li, Hong Ling, Min Zhuang

“…Subtype-specific virological and immunological features of recently infected PLWH have not yet been elucidated. …”
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Methodology for the Positive Voices 2022 Survey of People With HIV Accessing Care in England, Wales, and Scotland: Cross-Sectional Questionnaire Study by Janey Sewell, Carole Kelly, Adamma Aghaizu, Hannah Kitt, Annegret Pelchen-Matthews, Veronique Martin, Amal Farah, Colette Smith, Alison Brown, Clare Humphreys, Alex Sparrowhawk, Valerie Delpech, Alison Rodger, Fiona Lampe, Meaghan Kall

“…ObjectiveThis paper aimed to describe the methodology, recruitment strategies, and key sociodemographic features of participants recruited for the second national round of Positive Voices (PV2022). …”
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Suppression and control of unbalanced and misalignment coupler vibration of a double-rotor permanent magnet drive by Yongcun GUO, Xin MA, Shuang WANG, Deyong LI, Tun YANG

“…Under starting and braking conditions or non-uniform load conditions of large belt conveyors, the double-rotor permanent magnet drive system is susceptible to large vibrations caused by periodic excitations and perturbations. …”
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Development of a new data management system for the study of the gut microbiome of children who are small for their gestational age by Felix Manske, Magdalena Durda-Masny, Norbert Grundmann, Jan Mazela, Monika Englert-Golon, Marta Szymankiewicz-Bręborowicz, Joanna Ciomborowska-Basheer, Izabela Makałowska, Anita Szwed, Wojciech Makałowski

“…Since different users will have different demands regarding features, data security, and web environments, we provide our implementation of the web interface as a visual example. …”
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