Optimised and rapid pre-clinical screening in the SOD1(G93A) transgenic mouse model of amyotrophic lateral sclerosis (ALS). by Richard J Mead, Ellen J Bennett, Aneurin J Kennerley, Paul Sharp, Claire Sunyach, Paul Kasher, Jason Berwick, Brigitte Pettmann, Guiseppe Battaglia, Mimoun Azzouz, Andrew Grierson, Pamela J Shaw

“…We describe multiple, quantitative readouts of motor function that can be used to interrogate this early mechanism. …”
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Expression of human A53T alpha-synuclein without endogenous rat alpha-synuclein fails to elicit Parkinson's disease-related phenotypes in a novel humanized rat model. by Nicole K Polinski, Jukka Puoliväli, Leena Rauhala, Taina-Kaisa Stenius, Timo Bragge, Teija Parkkari, Anna-Maija Penttinen, Yi Chen, Omar S Mabrouk, Kelly E Glajch, Warren D Hirst, Michael Perkinton, Terina N Martinez, Mark A Frasier

“…We confirmed the aSyn A53T KI rat expresses human aSyn while lacking endogenous rat aSyn. Motor function and non-motor function remain largely unaffected in this model, and no overt nigrostriatal degeneration or brain pathology are observed up to 18 months of age. …”
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Somatosensory Plasticity in Pediatric Cerebral Palsy following Constraint-Induced Movement Therapy by Pawel J. Matusz, Alexandra P. Key, Shirley Gogliotti, Jennifer Pearson, Megan L. Auld, Micah M. Murray, Nathalie L. Maitre

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The Neuroprotective Mechanism of Low-Frequency rTMS on Nigral Dopaminergic Neurons of Parkinson’s Disease Model Mice by Qiaoyun Dong, Yanyong Wang, Ping Gu, Rusheng Shao, Li Zhao, Xiqi Liu, Zhanqiang Wang, Mingwei Wang

“…The effects of low-frequency rTMS on the motor function, cortex excitability, neurochemistry, and neurohistopathology of MPTP-induced Parkinson’s disease mice were investigated through behavioral detection, electrophysiologic technique, high performance liquid chromatography-electrochemical detection, immunohistochemical staining, and western blot. …”
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具有越障功能的输电线路除冰机器人设计 by 张屹, 韩俊, 刘艳, 丁昌鹏, 朱大林

“…By analysing the present de-icing robot design in China,a design scheme of de-icing robot with obstacle negotiation function in consideration of the structure features of the transmission line is proposed.The design scheme consists of the design of mechanical system and the design of the control system.The mechanical system is composed by the walking device,obstacle negotiating device and de-icing device,the control system includes main control module,wireless control module,motor drive module and status information feedback module.Performance tests in both laboratory and field indicate that,the mechanical system design of the de-icing robot is reasonable and the control system is of great stablity and effecitveness.…”
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Investigation of the pharmacological activity of the tetrapeptide HAEЕ, zinc, and human serum albumin in a transgenic mouse model with tau protein overexpression (P301S) by Veronika S. Shmigerova, Yulia V. Stepenko, Alexandra A. Kurbatova, Nikita S. Zhunusov, Nikita S. Lyapkalov, Maria S. Sviridova, Tatyana V. Avtina, Arkadiy V. Nesterov, Alexander A. Popov, Natalia I. Nesterova, Mariia Iu. Goltsova, Tatiana G. Pokrovskaya

“…Conclusion: The pharmaceutical composition HAEE-Zn-HSA at a dosage of 75 mg/kg, using a model of homozygous mice from a transgenic line with overexpression of human mutant tau protein P301S, demonstrated high levels of adaptive and exploratory activity and improved motor function.…”
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Distal Arthrogryposis in Newborn: Clinical Case by Vasily P. Gavrilyuk, Yana V. Evseeva, Oleg V. Cherevko, Dmitry A. Severinov

“…Child F. was hospitalized in the department of newborns and premature babies’ pathology on 6th day of life in critical condition. Spontaneous motor activity was severely decreased. He responds to the examination with little increase in motor activity and weak painful scream. …”
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Simulation and Test of a Fuel Cell Hybrid Golf Cart by Jingming Liang, Qifei Jian

“…On this basis, GUI mode of ADVISOR is used to select the rated power of vehicle motor. In line with simulation parameters, an electrical golf cart is refitted by adding a 2 kW hydrogen air proton exchange membrane fuel cell (PEMFC) stack system and test the FCHGC. …”
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Design of the Servo Control System of the Press Crimping Device based on Electronic Cam by Hui Li, Xiao Wu, Xu Wang, Xiao Qi, Liang Hua

“…Taking this as a guide， the parameters setting of the electronic cam function of servo motor are discussed， and it can be set off-line at different speeds of paper tape. …”
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Design of a Two order Active Disturbance Rejection Controller of a Stable Platform by ZHU Hai rong, LI Qi

“…In order to reduce the interference of friction, electromagnetic back EMF, carrier motion coupling, model mismatch of the stable platform to keep stable of the line of sight in the inertial space, an active disturbance rejection controller (ADRC) is designed by direct drive installation of DC torque motor. …”
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Beta, but not gamma, band oscillations index visual form-motion integration. by Charles Aissani, Jacques Martinerie, Lydia Yahia-Cherif, Anne-Lise Paradis, Jean Lorenceau

“…Electrophysiological oscillations in different frequency bands co-occur with perceptual, motor and cognitive processes but their function and respective contributions to these processes need further investigations. …”
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Impact of exposure to opioids in pregnancy on offspring developmental outcomes in the preschool years: an umbrella review by Louise Marryat, Thomas Hughes, James Boardman, Alison McFadden, Senga Robertson, Anne Whittaker

“…Developmental outcomes associated with prenatal opioid exposure included visual function, motor skills, externalising problems and language difficulties. …”
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Novel paradigm enables accurate monthly gestational screening to prevent congenital toxoplasmosis and more. by Ying Zhou, Karen Leahy, Andrew Grose, Joseph Lykins, Maryam Siddiqui, Nicole Leong, Perpetua Goodall, Shawn Withers, Kevin Ashi, Stephen Schrantz, Vera Tesic, Ana Precy Abeleda, Kathleen Beavis, Fatima Clouser, Mahmoud Ismail, Monica Christmas, Raphael Piarroux, Denis Limonne, Emmanuelle Chapey, Sylvie Abraham, Isabelle Baird, Juliette Thibodeau, Kenneth M Boyer, Elizabeth Torres, Shannon Conrey, Kanix Wang, Mary Allen Staat, Nancy Back, Coralie L'Ollivier, Caroline Mahinc, Pierre Flori, Jorge Gomez-Marin, Francois Peyron, Sandrine Houzé, Martine Wallon, Rima McLeod

“…Thus, ICT enables well-accepted gestational screening programs that facilitate rapid treatment saving lives, sight, cognition and motor function. This reduces anxiety, delays, work, and cost at point-of-care and clinical laboratories.…”
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Effective Protection Against Status Epilepticus Caused by Lithium–Pilocarpine: Combination of Midazolam and Lacosamide by Cumaali Demirtas, Metehan Akca, Ugur Aykin, Yunus Emre Surmeneli, Hava Yildirim, Mehmet Yildirim

“…Additionally, it was observed that LEV, LCM, and VPA administered together with MDZ did not negatively affect both cognitive and motor functions.…”
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Phase II open label study of valproic acid in spinal muscular atrophy. by Kathryn J Swoboda, Charles B Scott, Sandra P Reyna, Thomas W Prior, Bernard LaSalle, Susan L Sorenson, Janine Wood, Gyula Acsadi, Thomas O Crawford, John T Kissel, Kristin J Krosschell, Guy D'Anjou, Mark B Bromberg, Mary K Schroth, Gary M Chan, Bakri Elsheikh, Louise R Simard

“…Exploratory outcome measures included assessment of gross motor function via the modified Hammersmith Functional Motor Scale (MHFMS), electrophysiologic measures of innervation including maximum ulnar compound muscle action potential (CMAP) amplitudes and motor unit number estimation (MUNE), body composition and bone density via dual-energy X-ray absorptiometry (DEXA), and quantitative blood SMN mRNA levels. …”
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‘Time is of the essence’: upper-body aerobic exercise to improve cardiovascular health during inpatient rehabilitation within the first year following spinal cord injury – protocol... by Samuel J E Lucas, Tom E Nightingale, Naveen Kumar, Shin-Yi Chiou, Afroditi Stathi, Manish Kalla, Daniel D Hodgkiss, Shane J T Balthazaar, Aheed E F Osman, Srinivasa C Budithi, Joy Roy Chowdhury

“…Secondary outcomes include assessments of (1) blood biomarkers linked to CVD, (2) cardiac structure and function, (3) extracranial vasculature, (4) HRQOL, (5) cognitive function, (6) physical activity level, (7) cardiorespiratory fitness, (8) motor function and (9) feasibility outcomes. …”
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Does Transcranial Direct Current Stimulation Improve Gait Performances in Healthy Older Adults? A Meta-Analysis by Beom Jin Choi, Hajun Lee, Nyeonju Kang

“…Results: During single-task walking, the random-effects meta-analysis showed improvements in stride time variability (SMD = 0.203; p = 0.005) and functional mobility (SMD = 0.595; p < 0.001). Moreover, single-task walking performances were improved when the tDCS protocols targeted the primary motor cortex (SMD = 0.424; p = 0.005) and used off-line stimulation (SMD = 0.168; p = 0.008). …”
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Longitudinal Treatment Patterns of Chorea in North American Patients with Huntington’s Disease: Data from Enroll-HD by Erin Furr Stimming, Daniel O. Claassen, Ginny P. Sen, Olga Klepitskaya, Michael Serbin, Hyunwoo Kim, Sean C. Hinton, Dietrich Haubenberger

“…Mean Unified Huntington’s Disease Rating Scale scores for Total Maximal Chorea, Total Motor Score, and Total Functional Capacity were 9.6, 39.5, and 7.8, respectively. …”
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Experimental Implementation of Automatic Control of Posture-Dependent Stimulation in an Implanted Standing Neuroprosthesis by Brooke M. Odle, Lisa M. Lombardo, Musa L. Audu, Ronald J. Triolo

“…To this end, a feedback controller, named the “Posture Follower Controller”, was developed to aid in task-dependent posture shifting by individuals with spinal cord injury standing with functional neuromuscular stimulation. In this experimental feasibility study, the controller modulated activation to the paralyzed lower extremity muscles as a function of the position of overall center of pressure (CoP), which was prescribed to move in a straight line in forward and diagonal directions. …”
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A Randomized Controlled Double Blind Trial of Ciclosporin versus Prednisolone in the Management of Leprosy Patients with New Type 1 Reaction, in Ethiopia. by Saba M Lambert, Digafe T Alembo, Shimelis D Nigusse, Lawrence K Yamuah, Stephen L Walker, Diana N J Lockwood

“…Improvements in nerve function both, new and old, sensory (66% vs 49%) and motor (75% vs 74%) loss were higher (but not significantly so) in the patients on CnP. …”
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