Mechanism of immune escape mediated by T cell depletion induced by TOX signaling pathway in cervical cancer microenvironment by LIU Dan, ZHANG Guxiang, XIE Dan, XU Yan, XIE Chengfang, TANG Yuxi

“…A total of 24 mice were randomly assigned to the following four groups: immunoglobulin G (IgG) group, Anti-SNX9 group, Anti-programmed death-1 (PD-1) group and Anti-SNX9+Anti-PD-1 group, with 6 mice in each group. …”
Get full text

Life on the Edge: Challenges to Beginning Successful Aging by Fattaneh Hajilou, Tavakkol Aghayari Hir, Ali Pilvari

“…In nations grappling with economic difficulties and the declining value of individual properties and assets, the elderly face heightened vulnerabilities due to limited access to resources and opportunities that enhance their quality of life. …”
Get full text

Assessing the Feasibility of Persistent Scatterer Data for Operational Dam Monitoring in Germany: A Case Study by Jonas Ziemer, Jannik Jänichen, Carolin Wicker, Daniel Klöpper, Katja Last, Andre Kalia, Thomas Lege, Christiane Schmullius, Clémence Dubois

“…For implementation into operational monitoring programs, greater effort must be spent on near-real-time updates of BBD datasets.…”
Get full text

Investigating waste management strategies in the extended producer responsibility in Iran by Hassan Passandideh Tashakori, Parvin Farshchi, Dariush Karimi, Seyed Masoud Monavari

“…Introduction: In many developed countries, Extended Producer Responsibility (EPR), which is among the successful waste management programs, has been adopted and implemented as a policy approach. …”
Get full text

TV-communication as compulsory scenario of continuous imitation / ТВ-коммуникация как принудительный сценарий непрерывной имитации... by GAMALEYA G.N. / ГАМАЛЕЯ Г.Н.

“…But who and how cultivates this sacrificial heroism on our TV? By special programs and veterans of special broadcasts: why, what for and how? …”
Get full text

Obstetric, foetal and neonatal outcomes in adolescent pregnancy in sub-Saharan Africa: Systematic review and meta-analysis protocol. by Anthony Danso-Appiah, Eric Behene, Joan Naadu Hazel, Shirley Abanga

“…<h4>Expected outcomes</h4>This systematic review will inspire countries in Sub-Saharan Africa to implement innovative and context-sensitive programs that will improve the health and outcomes of adolescent pregnancy. …”
Get full text

Assessment of relationship between chickpea genotypes from ICARDA with a western Iranian landrace (Bivanij) by farhad Nazarian Firouzabadi, Mahin Rahimi, Ahmad Ismaili

“…Introduction Despite the fact that Iran is one of the major chickpea (Cicer arietinum L.) center of origins, limited information is available regarding chickpea genetic variation and diversity. …”
Get full text

The forecasted prevalence of comorbidities and multimorbidity in people with HIV in the United States through the year 2030: A modeling study. by Keri N Althoff, Cameron Stewart, Elizabeth Humes, Lucas Gerace, Cynthia Boyd, Kelly Gebo, Amy C Justice, Emily P Hyle, Sally B Coburn, Raynell Lang, Michael J Silverberg, Michael A Horberg, Viviane D Lima, M John Gill, Maile Karris, Peter F Rebeiro, Jennifer Thorne, Ashleigh J Rich, Heidi Crane, Mari Kitahata, Anna Rubtsova, Cherise Wong, Sean Leng, Vincent C Marconi, Gypsyamber D'Souza, Hyang Nina Kim, Sonia Napravnik, Kathleen McGinnis, Gregory D Kirk, Timothy R Sterling, Richard D Moore, Parastu Kasaie

“…<h4>Background</h4>Estimating the medical complexity of people aging with HIV can inform clinical programs and policy to meet future healthcare needs. …”
Get full text

Evaluation of HIV treatment outcomes with reduced frequency of clinical encounters and antiretroviral treatment refills: A systematic review and meta-analysis. by Noelle Le Tourneau, Ashley Germann, Ryan R Thompson, Nathan Ford, Sheree Schwartz, Laura Beres, Aaloke Mody, Stefan Baral, Elvin H Geng, Ingrid Eshun-Wilson

“…<h4>Background</h4>Global HIV treatment programs have sought to lengthen the interval between clinical encounters for people living with HIV (PLWH) who are established on antiretroviral treatment (ART) to reduce the burden of seeking care and to decongest health facilities. …”
Get full text

Evaluation of Various Traits of some Bean (Phaseolus vulgaris L.) Genotypes in Ilam Climatic Conditions by Fatemeh Kamari, Zahra Tahmasebi

“…Introduction Common bean (Phaseolus vulgaris L.) is a vital legume, rich in protein and nutrients, that is significantly impacted by the two-spotted spider mite (Tetranychus urticae), leading to substantial economic losses in agricultural fields. Given the limitations of chemical control and its environmental consequences, the identification and utilization of resistant cultivars represent a sustainable approach to pest management. …”
Get full text

Cardiotoxicity of Chemotherapeutic Drugs (Literature Review and Clinical Case Description) by Avagimyan Ashot A., Mkrtchyan Lusine G.

“…However, in our country there is still no coordination of scientific research in this area, as a result – there are no multifaceted studies, manuals and recommendations, scientific and practical programs for the prevention, diagnosis and treatment of various manifestations of cardiotoxicity. …”
Get full text

Effects of Computer-Assisted Working Memory Training Programme on Working Memory Ability and Mathematical Performance of Children at Risk of Mathematical Learning Difficulties by Kamyar Azimi, Manijeh Shehniyailagh, Alireza Hajiyakhchali, Maneli Shehni Karamzadeh

“…Data were analyzed using AMOS (version 24) and SPSS (version 26) programs. FindingsThe descriptive data for the control and the experimental groups is discussed. …”
Get full text

Estimation and evaluation of iron reserves in the eastern area of Eileh1 mine, Razavi Khorasan province by Hamid Esmati Daroneh, Maryam Gholamzadeh

“…As anticipated, the figure demonstrates that as the limit grade increases, the deposit amount decreases while the average grade rises. …”
Get full text

Development and Validation of a Critical Thinking Questionnaire: A Case Study of the Lived Experience of Students from the University of Isfahan and Isfahan University of Medical S... by Esmaeil Kashef, Maghsod Farasatkhah, Vahid Ghasemi, Mozhgan Mohammadi Naeni

“…Ultimately, the findings of this study could aid educational administrators and policymakers in designing academic programs and policies that fostered environments conducive to the effective development of critical thinking. …”
Get full text

The EORTC QLQ-F17 as a shortened version of the EORTC QLQ-C30 to assess self-reported functioning in cancer patients: investigating equivalence and psychometric properties in a ran... by Florian Zeman, Johannes M. Giesinger, Tobias Pukrop, Morten Aa Petersen, Mogens Groenvold, Sandra Nolte, Dagmara Kuliś, Sunil Shrestha, Laurence Leysen, Kim Cocks, Corneel Coens, Georgios Ioannidis, Cecilia Pompili, Michael Koller

Get full text

Enhanced B7-H4 expression in gliomas with low PD-L1 expression identifies super-cold tumors by Yan Zhang, Di Chen, Qiqi Lu, Yu Yao, Gaopeng Li, Chunxia Ji, Ying Qi, Chao Tang, Ji Xiong, Jian Hu, Fatma Betul Aksoy Yasar, Dave S B Hoon, Liangfu Zhou

“…Our study was performed to determine coexpression levels of two major B7 immune regulatory molecules programmed death ligand 1 (PD-L1) and B7-H4, both of which have been demonstrated to inhibit antitumor host immunity in gliomas.Methods We assessed tumor tissues from stage II–IV primary gliomas (n=505) by immunohistochemistry (IHC) for protein levels of both PD-L1 and B7-H4. …”
Get full text

PD-L1 targeting high-affinity NK (t-haNK) cells induce direct antitumor effects and target suppressive MDSC populations by Jeffrey Schlom, James W Hodge, Clint T. Allen, Shahrooz Rabizadeh, Patrick Soon-Shiong, John H. Lee, Renee N. Donahue, Kristen Solocinski, Michelle R Padget, Kellsye P Fabian, Yvette Robbins

“…Background Although immune checkpoint inhibitors have revolutionized cancer treatment, clinical benefit with this class of agents has been limited to a subset of patients. Hence, more effective means to target tumor cells that express immune checkpoint molecules should be developed. …”
Get full text

Genetic diversity of cultivated Gayo Arabica Coffee (Coffea arabica L.) based on morphological and microsatellite markers by Rita Andini, Ahmad Zaelani, Muhammad Ikhsan Sulaiman, Enny Rimita Sembiring, Rachman Jaya, Meenakshi Gusain, Deepak Bhanot, Roma Sarnaik Morghade, Abdel-Rhman Z. Gaafar, Abdul Azis, Heru Prono Widayat

“…Conclusion This work will be of particular relevance to breeding programs and conservation initiatives aimed at ensuring the sustainability of arabica coffee cultivation in Indonesia and other tropical highland regions. …”
Get full text

Mesenchymal stem cells derived from hPSC via neural crest attenuate chemotherapy-induced premature ovarian insufficiency by ameliorating apoptosis and oxidative stress in granulosa... by Xinran Li, Jinrong Liao, Youhong Zheng, Wei Cai, Jie Chen, Yu Liang, Yuanmei Chen, Xiaoxuan Li, Jiamao Luo, Jiaxin Xie, Manping Zhou, Lilin Hang, Xiujuan Sun, Xin Yue, Xuefeng Wang, Yifeng Wang, Huiyan Wang

“…However, research on hPSC-MSC-based treatments for POI remains limited, particularly in the characterization of the intermediate differentiation stages from hPSC to MSC. …”
Get full text

Proportion of good oral hygiene and mean value oral hygiene index among children with cerebral palsy in Africa and Asia: a systematic review and meta-analysis by Ermias Sisay Chanie, Kalkidan Sisay Chanie, Natnael Moges, Denekew Tenaw Anley, Zufan Alamrie Asmare, Melkamu Aderajew Zemene, Natnael Atnafu Gebeyehu, Misganaw Asmamaw Mengstie, Mohammed Abdu Seid, Endeshaw Chekol Abebe, Molalegn Mesele Gesese, Yenealem Solomon Kebede, Berihun Bantie, Sefineh Fenta Feleke, Tadesse Asmamaw Dejenie, Natnael Amare Tesfa, Anteneh Mengist Dessie, Habtamu Shimels Hailemeskel, Tsiyereda Sisay Chanie, Sewunet Sisay Chanie

“…Abstract Background Children with cerebral palsy face various challenges, including oral hygiene, which is crucial for their overall well-being and quality of life. However, limited research investigates oral hygiene among children with cerebral palsy. …”
Get full text