Pharmacologic properties and inhibitory activity of 6-azasteroids against Mycobacterium leprae in vivo and in vitro by Thabatta L. S. A. Rosa, Maria Angela M. Marques, Tianao Yuan, Daniele F. F. Bertoluci, Joshua Werman, Fabricio da M. R. Costa, Linda A. Fischbacher, Mariana de Andrea Hacker, Ramanuj Lahiri, Márcia Bêrredo-Pinho, Patrícia S. Rosa, John T. Belisle, Nicole S. Sampson, Maria Cristina V. Pessolani

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Trends and Patterns of Antimicrobial Resistance in a Tertiary Care Hospital in Bangladesh by Sangjukta Roy, Hridika Talukder Barua, Mohammad Julhas Sujan, Akram Hossain, Shyamal Kumar Paul, Syeda Anjuman Nasreen, Salma Ahmed, Nazia Haque, Zakir Hossain Habib, Aninda Rahman, S. M. Shahriar Rizvi, Md. Abul Hasnat, Soo Young Kwon, John Stelling, Sanjay Gautam, Alina Shaw, Florian Marks, Nimesh Poudyal

“…<b>Introduction:</b> Antimicrobial resistance (AMR) is a global public health issue, particularly in resource-limited, low- to middle-income countries like Bangladesh. …”
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Safety and efficacy of the therapeutic DNA-based vaccine VB10.16 in combination with atezolizumab in persistent, recurrent or metastatic HPV16-positive cervical cancer: a multicent... by Hannelore Denys, Frederik Marmé, Frederic Forget, Lukas Rob, Pawel Blecharz, Kristina Lindemann, Peter Hillemanns, Linn Wölber, Theresa Link, Jean-Francois Baurain, Mariusz Bidziński, Linn Woelber, Michal ZikÁN, Josef Chovanec, Christian Dannecker, Stéphanie Henry, Hannelore G Denys, Velko Minchev, Anders Rosholm, Kaja C G Berg, Roberto S Oliveri, Marchela Koleva, Bozhil Robev

“…Median duration of response was not reached (n.r.) (95% CI 2.2 to n.r.), median progression-free survival was 4.1 months (95% CI 2.1 to 6.2), and median overall survival was 21.3 months (95% CI 8.5 to n.r.). In programmed death-ligand 1 (PD-L1)-positive patients (n=24), ORR was 29.2% (95% CI 12.6 to 51.1). …”
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Efficacy and safety of trastuzumab deruxtecan in gastrointestinal malignancies: a systemic review and meta-analysis by Ali Hussain, Qamar Iqbal, Sangeetha Isaac, Faisal Shariff, Ezza Tariq, Hassan Awais, Nayan Mainkar, Heidi Lynn Reis, Aakriti Arora, Akshay Deotare, Azka Tasleem, Srijan Valasapalli, Munizay Paracha, Maya Hashmi, Hamdi Battah, Mahvish Muzaffar

“…Pooled analyses were performed using the ‘meta’ package (Schwarzer et al., R programming language), and proportions with 95% confidence intervals (CIs) were calculated.ResultsWe identified 653 patients treated with T-DXd for HER2-positive GI malignancies in 10 studies. …”
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Natural lung-tropic TH9 cells: a sharp weapon for established lung metastases by Tao Chen, Hao Zhou, Shuming Li, Nong Lin, Yixuan Feng, Zhijian Cai, Chenxiao Qiao, Eloy Yinwang, Shengdong Wang, Xuehuan Wen, Xiangang Jin, Yucheng Xue, Wenkan Zhang, Xianchang Zeng, Zenan Wang, Hangxiang Sun, Lifeng Jiang, Hengyuan Li, Binghao Li, Zhaoming Ye

“…Background Lung metastasis remains the primary cause of tumor-related mortality, with limited treatment options and unsatisfactory efficacy. …”
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Development of a Customizable Web-Based Dashboard for Remote Blood Pressure Monitoring: Feasibility and Usability Implementation Study by Joshua Wollen, Thuy Nguyen, Charles Coton, Gina DeWildt, Gabretta Cooksey, Audrey Cohen, Nicholas Hoang, Munachi Okpala, Michael Gonzalez, Mengxi Wang, Chigozirim Izeogu, Elmer Bernstam, Charles Green, Sean Savitz, Jose-Miguel Yamal, Anjail Sharrief

“…ResultsSeventeen BP monitors were evaluated, and the BlipcareBlip BP800 was selected based on its cellular connectivity, ergonomic design, and application programming interface compatibility. The EDC system successfully linked patient data to the dashboard, enabling real-time visualization of BP trends and provider alerts. …”
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Seed germination of plants grown in coal mine wastes in response to copper, lead, and cadmium stress by Nateq Lashkari Sanami, Jamshid Ghorbani, Seyed Mohammad Hodjati, Ghorban Vahabzadeh Kebria, Babak Motesharezadeh

“…Abandoned mine wastes from mining activities limit the growth of plants due to unfavorable conditions and the concentration of a wide range of heavy metals. …”
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Mothers Practices and Factors Affecting Sunlight Exposure of Their Infants in Adami Tulu Jido Kombolcha District, East Shoa Zone, Oromia Region, Ethiopia, 2022: A Community Based C... by Abdulhakim Hora Hedato MPH, Abdissa Alemu Dibaba MPH, Ephrem Lejore Sibamo MPH, Wondwosen T/Silasie Kidane MSc, Beriso Furo Wengoro PhD, Fikiru Yigezu Jaleta MSc, Abdulkerim Hassen Moloro MSc

“…To address these issues, healthcare providers, local health offices, and mass media should focus on educational programs and strengthening advice during health visits. …”
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Progress on implementation of the World Health Organization global antimicrobial resistance surveillance system recommendations on antimicrobial resistance surveillance in Africa:... by Dr Mackline Hope, Dr Reuben Kiggundu, Mr Dickson Tabajjwa, Mr Fahad Lwigale, Mr Herman Mwanja, Dr Conrad Tumwine, Dr Jonathan Mayito, Dr Dathan M Byonanebye, Dr Andrew Kambugu, Dr Francis Kakooza

“…Conclusion: Gaps exist in AST for AMR surveillance with priority pathogen-antibiotic combinations not routinely tested in most surveillance programs. A full report from this study will be published by June 2024.…”
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Assisted partner notification as a strategy to enhance Pre-Exposure Prophylaxis (PrEP) screening and uptake – results from a prospective cohort study in Lilongwe, Malawi by Tapiwa Munthali, Angella Masano, Jane S. Chen, Wiza Kumwenda, Claire Pedersen, Kenneth Chinthenga, Edward Jere, Esther Mathiya, Beatrice Ndalama, Naomi Nyirenda, Naomi Bonongwe, Maganizo B. Chagomerana, Mina C. Hosseinipour, Irving F. Hoffman, Mitch Matoga, Sarah E. Rutstein

“…This study explored the feasibility and outcomes of integrating aPN into PrEP programs at an STI clinic in Malawi. Methods Between March 2022 and January 2023, this prospective cohort study enrolled men and women presenting for STI services who were initiating PrEP (index PrEP user) and their referred sexual partners. …”
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Impact of differentiated service delivery models on quality of life among people living with HIV in Uganda– a quasi-experimental study by Benson Nasasira, Grace Banturaki, Nelson Kalema, Joseph Musaazi, Aidah Nanvuma, Stephen Okoboi, Nancy Gathoni Kiarie, Joash Ntenga Moitui, Damazo Kadengye, Jonathan Izudi, Barbara Castelnuovo

“…These findings support the broader adoption of DSD models in delivering ART across HIV programs to enhance the QoL and clinical outcomes among PLHIV.…”
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Transcriptome analysis of historic olives reveals stress-specific biomarkers by Hamad A. Alkhatatbeh, Monther T. Sadder, Nizar Haddad, Nizar Haddad, Ibrahim Al-Amad, Mohammad Brake, Nawal A. Alsakarneh, Abdulsalam M. Alnajjar

“…IntroductionWater scarcity and soil salinization are increasingly becoming limiting factors in food production, including olives, a major fruit crop in several parts of the world. …”
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Assessment of The Potential Interference and Conflict of Artificial Intelligence With Human Rights and Citizenship: Challenges and Solutions by Hossein Khazaei, Mojtaba Hemmati

“…Thus, when AI systems learn and evolve independently or exhibit behaviors outside of their programming, this issue becomes even more complicated. …”
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Development and application of intelligent auxiliary diagnosis system in the Traditional Chinese Medicine nursing clinic (智能辅诊系统在中医护理门诊中的开发与应用)... by ZHANG Jing (张敬), TANG Ling (唐玲)

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The Impact of Digital Technology–Based Exercise Combined With Dietary Intervention on Body Composition in College Students With Obesity: Prospective Study by Chengyuan Hu, Zixin Lv, Jieping Zhu, Chunyuan Lai, Dongjuan Guo, Maolin Chen, Xiaoyan Cheng, Mingxin Rao, Xinyou Zhou, Liqiang Su

“… BackgroundLifestyle interventions are a critical component of weight loss programs, yet digital, personalized, and theory- and evidence-based lifestyle interventions remain limited. …”
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Parenting interventions to promote early child development in the first three years of life: A global systematic review and meta-analysis. by Joshua Jeong, Emily E Franchett, Clariana V Ramos de Oliveira, Karima Rehmani, Aisha K Yousafzai

“…Subgroup analyses revealed significantly greater effects on child cognitive, language, and motor development, and parenting practices in low- and middle-income countries compared to high-income countries; and significantly greater effects on child cognitive development, parenting knowledge, parenting practices, and parent-child interactions for programs that focused on responsive caregiving compared to those that did not. …”
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Digitalisasi Model Sistem Akuntansi Terintegrasi Bagi Usaha Bersama Simpan Pinjam di Kota Kupang by Yustina Alfira Nay, Selfiana Goetha, Maria Goreti Malut

“…The system development method used is the System Development Life Cycle (SDLC) model, consisting of system analysis, conceptual design, system selection, detailed design, testing and programming, and implementation. The design stage uses Data Flow Diagrams (DFD) levels 0 and 1, Entity Relationship Diagram (ERD) database design, flowcharts, and black box methods to test the suitability of system specifications with UBSP functional requirements. …”
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Exploring the effects of curiosity and anxiety on Mathematics teaching efficacy beliefs in primary school teachers by Veysel Göçer, Ender Özeren

“…Abstract Backround In the mathematics education literature, there is a limited number of comprehensive studies that examine the dynamic relationship between teacher efficacy beliefs and psychological variables such as curiosity and anxiety within the context of primary education. …”
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Effectiveness of Telemedicine Interventions on Motor and Nonmotor Outcomes in Parkinson Disease: Systematic Review and Network Meta-Analysis by Jiejie Dou, Junyu Wang, Xianqi Gao, Guotuan Wang, Ying Bai, Yixin Liang, Kunyi Yang, Yong Yang, Lin Zhang

“…These findings highlight the importance of tailoring telemedicine programs to address specific therapeutic needs in PD management. …”
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Quantitative Proteomic Study Reveals Amygdalin Alleviates Liver Fibrosis Through Inhibiting mTOR/PDCD4/JNK Pathway in Hepatic Stellate Cells by Huang H, Ru SJ, Chen JM, Liu W, Fang SH, Liu Q, Meng Q, Liu P, Zhou H

“…Histology and immunohistochemistry as well as serum biochemical analysis were performed to evaluate amygdalin efficacy in mice. The key gene programmed cell death protein 4 (PDCD4) was overexpressed or knocked down in human hepatic stellate cells (HSCs). …”
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