Proposing a template for selecting the coordinates of laboratory standards for executive management of the country. by mohammad hasan Izadparast, ali asghar pourezzat, Alireza Amirkabiri

“…The entry of policy laboratories into the design and policy-making process is not limited to a specific stage and can be entered at any stage of the policy-making process. …”
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Progress on the Global Research Agenda for Antimicrobial Resistance in Human Health in Pakistan: Findings and Implications by Maryam S, Saleem Z, Haseeb A, Qamar MU, Amir A, Almarzoky Abuhussain SS, Imam MT, Afzal S, Meyer JC, Mudenda S, Godman B

“…Currently, research on AMR in Pakistan is primarily concentrated in major urban centers across a limited number of cities. This needs addressing going forward. …”
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SoTL in Latin America: Bridging Cultures, Transforming Teaching and Learning by Oscar Jerez Yañez, Jorge Maldonado Mahauad, Gisela Schwartzman, Carolina Rodriguez Enríquez, Sugey Montoya Sandí, Álvaro Herrera Alcaíno, Cristina Del Mastro Vecchione, Miguel Morales-Chan, Wendy Díaz Pérez, Ivory Mogollón de Lugo, Gina Camargo De Luque, Alejandra Martínez Barrientos, Fábio José Garcia dos Reis

“…These include the cultural integration of SoTL concepts, heavy faculty workloads, limited interdisciplinary programs, technological disparities, and the imperative to align educational practices with the Sustainable Development Goals (SDGs). …”
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Secondary school randomized controlled interventions with a minimum dual approach to health and the links to BMI in pupils: A systematic review and meta-analysis within the project... by Derrick R. Tanous, Gerhard Ruedl, Mohamad Motevalli, Katharina C. Wirnitzer

“…However, adults have limited capacity for adopting healthy behavior into their lifestyle (Prochaska & Velicer, 1997). …”
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Fault Diagnosis Method for Transformer Winding Based on the Load Normalized Lissajous Graphical Analysis of Leakage Magnetic Field by Bowen ZHANG, Jian FENG, Bowen WANG, Feiran YANG, Yitong XING

“…Currently, commonly used offline detection methods are limited by maintenance and operational cycles, making real-time monitoring and detecting faults impossible. …”
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Assessment of Knowledge Attitude and Practices of Rural Population Towards Infectious Diseases and Their Prevention by Saumya Shukla1, Kumar S Abhishek2, Laxmi Rathore3, Vinod Kumar Maurya1*, Vandana Upadhyay1, Pawan Kumar Dubey4, Amit Kumar Singh1

“…The weak correlation between knowledge and practice underscores the need for targeted, behavior-focused health interventions. Community-based programs, such as village workshops, school campaigns, and mobile health outreach, should be integrated with existing national disease control efforts to address the significant knowledge gaps identified and improve preventive practices. …”
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Effect of reaction styles theory-based interventions on relieving fatigue of patients with systemic lupus erythematosus (基于反应风格理论的干预方案在缓解系统性红斑狼疮患者疲劳中的应用研究)... by LI Yuwei (李雨蔚), SONG Weiting (宋炜婷), WANG Sa (王飒), QIAO Caicai (乔彩彩), LIANG Lifen (梁丽芬), MIAO Huali (苗华丽)

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Characterising the effects of displacement on gender-based violence among women living with HIV in Ukraine: a cross-sectional study by Stefan David Baral, Carrie Lyons, Althea Wolfe, Mary Anne Roach, Gnilane Turpin, Omar Syarif, Pim Looze, Katarzyna Lalak, Jean de Dieu Anoubissi, Yi-Chi Chiu, Alexandra Volgina, Sophie Brion, Keren Dunaway, Olena Stryzhak, Daria Ocheret, Laurel Sprague, Carlos Garcia de Leon Moreno, Katherine B Rucinski

“…WLHIV were recruited throughout Ukraine through limited chain referral and venue-based sampling. All participants completed a sociobehavioural questionnaire. …”
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High matrix metalloproteinase-2 expression predicts poor prognosis of colon adenocarcinoma and is associated with PD-L1 expression and lymphocyte infiltration by Yiyi Xiao, Guangming Li, Yongjie Xie, Bo Shao, Jingpeng Hao, Yanglin Zhu, Dejun Kong, Yafei Qin, Hong Qin, Shaohua Ren, Hongda Wang, Chenglu Sun, Hao Wang

“…Background Colon adenocarcinoma (COAD) is a prevalent and aggressive malignancy with limited treatment options, particularly for advanced stages. …”
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Phase I study of the safety and clinical activity of the interleukin-8 inhibitor AMY109 combined with atezolizumab in patients with advanced solid cancers by Yasutoshi Kuboki, Masafumi Ikeda, Shigehisa Kitano, Takafumi Koyama, Noboru Yamamoto, Yuki Yamaguchi, Yuki Nakagawa, Takaaki Ishida, Hidenori Mizugaki, Takatsugu Narikiyo, Ryoko Takubo, Chika Ogami, Mayuko Sekiya

“…Background Immunosuppressive conditions within the tumor microenvironment (TME) can allow tumors to evade the immune system, including by hampering programmed death ligand 1 (PD-L1) inhibitor activity. …”
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Predictive value of ENLIGHT-DP in patients with metastatic lung adenocarcinoma treated with immune checkpoint inhibitors and platinum chemotherapy directly from histopathology slid... by Eli Pikarsky, Anna Elia, Gal Dinstag, Omer Tirosh, Tuvik Beker, Ranit Aharonov, Hovav Nechushtan, Leon Gugel, Yaron Kinar, Michael Tabi, Tzivia Gottlieb, Aron Popovtzer, Johnathan Arnon, Yakir Rottenberg, Philip Blumenfeld

“…We then unblinded the clinical outcomes and evaluated the predictive value of ENLIGHT-DP in comparison to programmed death ligand (PD-L)-1 and tumor mutational burden (TMB).Results ENLIGHT-DP is predictive of response to treatment with receiver operating characteristic (ROC) area under the curve (AUC) of 0.69 (p=0.01) and outperforms both TMB and PD-L1 expression with ROC AUC of 0.52 and 0.46, respectively. …”
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Selective activation of interleukin-2/interleukin-15 receptor signaling in tumor microenvironment using paired bispecific antibodies by Camilla Jandus, Walter Ferlin, Sébastien Calloud, Alizée Viandier, Pauline Malinge, Nicolas Fischer, Limin Shang, Krzysztof Masternak, Julien Montorfani, Eric Hatterer, Laurence Chatel, Adeline Lesnier, Bruno Daubeuf, Lise Nouveau

“…Nonetheless, their wider therapeutic application has been hampered by severe dose-limiting toxicities including systemic cytokine release and organ edema for IL-2, and inconvenient intratumoral administration for IL-15. …”
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Modeling the effects of climate change scenarios on the potential distribution of Vespa crabro Linnaeus, 1758 (Hymenoptera: Vespidae) in a Mediterranean biodiversity hotspot by Erika Bazzato, Arturo Cocco, Emanuele Salaris, Ignazio Floris, Alberto Satta, Michelina Pusceddu

“…Future projections indicate a distribution range contraction by the 2040s and 2060s, primarily driven by extreme variability in precipitation and rising temperatures approaching the species' thermal tolerance limits.Our study demonstrates the value of integrating citizen science data, high-resolution climate data, and advanced modeling techniques to understand and manage alien species in the context of climate change. …”
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Inhibitory Fcγ receptor deletion enhances CD8 T cell stemness increasing anti-PD-1 therapy responsiveness against glioblastoma by Won Hyung Park, In Kang, Keun Bon Ku, Chae Won Kim, Yumin Kim, Byeong Hoon Kang, Jeongwoo La, Stephen Ahn, Sung Ki Lee, Heung Kyu Lee

“…In this study, we investigate a target that triggers stem-like properties in CD8 T cells to enhance the response to ICB in a murine GBM model.Methods Using Fcgr2b−/− mice and a murine GL261 GBM model, we confirmed the efficacy of anti-programmed cell death protein-1 (PD-1) immunotherapy, observing improved survival. …”
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Effect of bright light therapy combined with five-element music therapy on negative emotions and sleep quality of pregnant women (强光联合五音疗法对孕妇负面情绪及睡眠质量的影响)... by ZHANG Caixia (张彩霞), ZHANG Ping (张萍), CAI Donglin (蔡东林), AN Rongrong (安溶溶)

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Prognostic Value of KRAS/TP53 Status for Overall Survival in First-Line Monoimmunotherapy and Chemoimmunotherapy Treated Patients With Nonsquamous NSCLC in the Netherlands: A Brief... by Vincent D. de Jager, MD, Léon C. van Kempen, PhD, Betzabel N. Cajiao Garcia, MSc, T. Jeroen N. Hiltermann, MD, PhD, Anthonie J. van der Wekken, MD, PhD, Ed Schuuring, PhD, Stefan M. Willems, MD, PhD

“…Introduction: Programmed death-ligand 1 (PD-L1) is the main predictive biomarker used to identify patients with NSCLC who are eligible for treatment with immune checkpoint inhibitors. …”
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Subcutaneous checkpoint inhibition is equivalent to systemic delivery when combined with nelitolimod delivered via pressure-enabled drug delivery for depletion of intrahepatic myel... by Diwakar Davar, Yujia Liu, Jason Laporte, Prajna Guha, Steven C Katz, Chandra C Ghosh, Lauren Cournoyer, Alizee Ballarin, Ilan B Layman, Molly Morrissey, Kayla Fraser, Shriya Perati, Bryan F Cox, Evgeny Yakirevich, Diana O Treaba, Timothy D Murtha

“…After a week, fluorescently labeled nelitolimod (10 µg/mouse) was delivered via PEDD and co-administered anti-programmed cell death-1 (α-PD-1) either via Sys or SQ. …”
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Investigation on research innovation ability and training demand of clinical nursing staff (临床护理人员科研创新能力及培训需求现况调查) by YAN Xin (闫欣), QI Lixia (祁丽霞), WANG Zheng (王征), WEI Rui (卫蕊), LI Bin (李斌)

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Safety and efficacy of PD-1 inhibitor (sintilimab) combined with transarterial chemoembolization as the initial treatment in patients with intermediate-stage hepatocellular carcino... by Lei Yu, Lan Zhang, Xin Xu, Zheng Wang, Jian Zhou, Jia Fan, Wentao Wang, Zhenggang Ren, Lixing Li, Peiran Huang

“…Background Numerous studies have demonstrated limited survival benefits of transarterial chemoembolization (TACE) alone in the treatment of intermediate-stage hepatocellular carcinoma (HCC) beyond up-to-seven criteria. …”
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Durable antitumor response via an oncolytic virus encoding decoy-resistant IL-18 by Yu Liu, Yichi Zhang, Yayi Hou, Yan Cheng, Mengyu Zhang, Yuanhui Zhao, Dongge Xu, Weikang Sun, Yuqing Miao, Susu He, Dwayne Stupack, Erguang Li

“…Antitumor memory and synergistic effect with an anti-programmed cell death protein-1 (PD-1) antibody was evaluated. …”
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