Phase II basket trial of Dual Anti-CTLA-4 and anti-PD-1 blockade in Rare Tumors (DART) SWOG S1609: pancreatic neuroendocrine neoplasm (PNEN) cohort by Ignacio I Wistuba, Jianhua Zhang, Anup Kasi, Hong Chen, Seunghee Kim-Schulze, Holden T Maecker, Elad Sharon, Razelle Kurzrock, Sacha Gnjatic, Young Kwang Chae, Jiexin Zhang, Jianjun Zhang, Sandip Pravin Patel, Cara L Haymaker, Megan Othus, Charles Blanke, Edwin Parra, Gheath Al-Atrash, Caroline Duault, J Jack Lee, Helen X Chen, Edgar Gonzalez-Kozlova, Dzifa Yawa Duose, Luisa Solis Soto, Ganiraju Manyam, Christopher W Ryan, Jillian Fisher, Bhavana Konda, Mark Walshauser, Caddie Laberiano Fernandez, Raja Luthra, Christine M Magner

“…The most common toxicities were fatigue (47% of patients) and aspartate aminotransferase (AST) elevation (32%); the most common grade 3/4 immune-related adverse event (AE) was AST (32%) and bilirubin elevation (26%), with no grade 5 events. Programmed death-ligand 1 expression by chromogenic immunohistochemistry (N=12 patients assessed) did not associate with ORR; tumor mutation burden (TMB) was high in three patients; one of the two patients with partial remission (PFS=26 months) had high TMB (150 mutations/mb). …”
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Physical Activity and Quality of Life After Distal Femur Tumor Resection and Limb Salvage by Dimitra C. Galanis, Ioannis Zafeiris, Fotini M. Soukakou, Dimitra P. Papagelopoulos, Panayiotis Gavriil, Ioannis G. Trikoupis, Olga D. Savvidou, Konstantinos Vlasis, Vasileios A. Kontogeorgakos, Panayiotis J. Papagelopoulos

“…These findings highlight the potential benefits of tailored rehab programs to improve long-term health and QoL in sarcoma survivors, although larger studies are needed for more comprehensive insights.…”
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Systematic review of multidrug-resistant Klebsiella pneumoniae in the Arabian Peninsula: molecular epidemiology and resistance patterns by Enaam K. Idrees, Enaam K. Idrees, Marwh G. Aldriwesh, Marwh G. Aldriwesh, Marwh G. Aldriwesh, Manal M. Alkhulaifi, Majed F. Alghoribi, Majed F. Alghoribi, Majed F. Alghoribi

“…Implementing standardized methodologies and fostering molecular and genome-based AMR surveillance programs at both national and regional levels within the GHC are essential for effectively combating the spread of MDR K. pneumoniae and improving public health outcomes in the region.…”
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Assessing community antibiotic usage and adherence as per standard treatment guidelines: A potential area to enhance awareness at community pharmacy settings by Abdullah Al Masud, Ramesh Lahiru Walpola, Malabika Sarker, Alamgir Kabir, Muhammad Asaduzzaman, Md Saiful Islam, Ayesha Tasnim Mostafa, Zubair Akhtar, Holly Seale

“…Strengthening patient-physician relationships and involving community pharmacies in antimicrobial stewardship programs can improve antibiotic dispensing and counselling practices among drug-sellers.…”
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Regional variations and trends in liver transplantation practices across Europe by Tommaso Di Maira, Valérie Cailliez, Beatriz Domínguez-Gil, Beatriz Mahíllo, Marina Álvarez, Luca Saverio Belli, René Adam, Constantino Fondevila, Giacomo Germani, Hermien Hartog, Marina Berenguer

“…By identifying trends such as the expansion of Donation after Circulatory Determination of Death programs and the prioritization of model for end-stage liver disease ≥30 policies, these findings underscore the critical need for harmonized strategies to reduce waiting list mortality and improve access to transplantation. …”
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Identification of a key locus, qRL8.1, associated with root length traits during seed germination under salt stress via a genome-wide association study in rice by Peiwen Zhu, Guolan Liu, Zhihao Chen, Deyan Kong, Lijun Luo, Xinqiao Yu

“…Abstract Background Salt stress is a major abiotic constraint limiting rice (Oryza sativa L.) production worldwide, particularly in saline-affected regions. …”
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Combination of HDAC inhibition and cytokine enhances therapeutic HPV vaccine therapy by Jeffrey Schlom, James L Gulley, Caroline Jochems, Sofia R Gameiro, Wiem Lassoued, Daniel Burnett, Lisa K Poppe, Nicholas Roller, Miriam Marlene Medina-Enríquez, Katherine E Lothstein, Asma S Khelifa, Masaya Miyamoto

“…Standard therapies offer limited benefit to patients with advanced-stage disease. …”
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Deep learning and genomic best linear unbiased prediction integration: An approach to identify potential nonlinear genetic relationships between traits by F. Shokor, P. Croiseau, H. Gangloff, R. Saintilan, T. Tribout, T. Mary-Huard, B.C.D. Cuyabano

“…For individual traits, this oversight may minimally affect prediction accuracy, but it can limit genetic progress when selection involves multiple traits. …”
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Identification of a novel InDel locus within the <i>ACSL5</i> gene and its association with body measurement traits in goats by A. Wang, A. Wang, A. Wang, X. Wu, X. Wu, Q. Xu, B. Wang, T. Xiao, Y. Liu, W. Li

“…These findings suggest that InDel mutations in the goat <i>ACSL5</i> gene may serve as a valuable molecular genetic marker for breeding programs aimed at improving production traits.</p>…”
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Digital strategies to promote crowdsourcing open calls for co-creating HIV interventions: a youth community-based participatory approach by Olaoluwaposi Ogunlana, Peter Kalulu, Ucheoma Nwaozuru, Olufunto A. Olusanya, Oluwayemisi T. Olaoluwa, Temitope Ojo, Titilola Gbaja-Biamila, Chiyere Arinze, Lateef Akeem, Lauren Fidelak, Chisom Obi-Jeff, Oliver C. Ezechi, Joseph D. Tucker, Joseph D. Tucker, Juliet Iwelunmor

“…IntroductionThe HIV epidemic disproportionately affects adolescents and young adults (AYA), yet their engagement in HIV programming remains limited. Digital strategies, such as social media campaigns, engage a diverse range of AYA to co-create HIV interventions, but their effectiveness is less known. …”
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Carboplatin, etoposide, atezolizumab, and bevacizumab in the first-line treatment of patients with extensive stage small-cell lung cancer: the GOIRC-01-2019 CeLEBrATE study by Marcello Tiseo, Corrado Ficorella, Andrea Ardizzoni, Carlo Genova, Francesca Mazzoni, Giuseppe Lamberti, Luca Boni, Ida Colantonio, Alessandro Leonetti, Saverio Cinieri, Andrea Bonetti, Michele Tognetto, Federica Bertolini, Alessandro Follador, Elisa Andrini, Antonio Frassoldati, Francesco Gelsomino, Giulia Pasello, Karim Rihawi, Ferdinando Riccardi, Donatella Giardina, Matteo Brighenti

“…Background The addition of a programmed death-ligand 1 (PD-L1) inhibitor, either atezolizumab or durvalumab, to platinum-etoposide prolonged survival in a limited subset of patients with extensive-stage small-cell lung cancer (ES-SCLC). …”
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Real‐world experience of adjuvant immunotherapy for stages III–IV melanoma: A monocentric observational study by Manon Blaise, Eric Fontas, Barbara Seitz‐Polski, Laura Troin, Alexandra Picard, Perrine Rousset, Elodie Long‐Mira, Micheline Razzouk‐Cadet, Madleen Chassang, Thierry Passeron, Henri Montaudié

“…Median time to first recurrence from starting adjuvant programmed cell death 1 was 6.5 months (range, 1–35). …”
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Acceptability of intermittent preventive treatment of malaria in pregnancy with sulfadoxine-pyrimethamine plus dihydroartemisinin-piperaquine in Papua New Guinea: a qualitative stu... by Elvin Lufele, Sophie Pascoe, Alice Mengi, Alma Auwun, Nalisa Neuendorf, John W. Bolnga, Moses Laman, Stephen J. Rogerson, Kamala Thriemer, Holger W. Unger

“…Results Women expressed positive feelings and attitudes towards SP plus DP/DP-placebo; reported limited side effects; and found the size, number, colour, and taste of study medicines acceptable. …”
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Exploring the relationship between predicted negative energy balance and its biomarkers of Holstein cows in first-parity early lactation by Hongqing Hu, Sébastien Franceschini, Pauline Lemal, Clément Grelet, Yansen Chen, Hadi Atashi, Katrien Wijnrocx, Hélène Soyeurt, Nicolas Gengler

“…This study demonstrates the utility of MIR-predicted traits for understanding the genetic mechanisms of NEB and its potential for integration into breeding programs, while emphasizing cautious interpretation of these results due to limitations of MIR-predictions of studied traits to represent directly measured traits.…”
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Clinical factors influencing retreatment with anti-PD-(L)1 therapies after treatment in early-stage cancers: a modified Delphi consensus study by Christos Chouaïd, Lajos Pusztai, Federico Cappuzzo, Phillip Parente, Robert Jones, Vernon K Sondak, Masayoshi Nagata, Raquel Aguiar-Ibáñez, Yosuke Hirasawa, Ryuichi Mizuno, Smita Kothari, Carmel Spiteri, Alexander Sun, Chris Elder, Masaru Ishida, Seung Hyeun Lee, David Okonji, Bhavesh Shah, Dominihemberg Ferreira, Andrea Lauer, Amrit Kaliasethi, Carol Kao, Jan McKendrick

“…Anti-programmed death (ligand) 1 (anti-PD-(L)1) therapies were first introduced in the metastatic setting and have since been approved and reimbursed for treating early-stage cancers in the adjuvant, perioperative, and neoadjuvant settings in many cancer types. …”
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Phase I dose escalation study of IO-108, an anti-LILRB2 antibody, in patients with advanced solid tumors by Ying Zhu, Tao Huang, John Powderly, Aung Naing, Manish R Patel, Matthew H Taylor, Rong Deng, Kyu Hong, Luke Chung, Hongyu Tian, Wen Hong Lin, Paul Woodard, Nathan Siemers, Hong Xiang, Donna Valencia, X Charlene Liao, Xiao Min Schebye

“…IO-108 was well-tolerated up to the maximally administered dose of 1,800 mg every 3 weeks (Q3W) as monotherapy and in combination with pembrolizumab. No dose-limiting toxicity was observed, and a maximum tolerated dose was not reached. …”
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BRCA cascade counselling and testing in Italy: current position and future directions by Silvia Costanzo, Lea Godino, Simona De Summa, Tommaso Maria Marvulli, Maurizio Genuardi, Maria Luisa Di Pietro, Emanuela Lucci Cordisco, Daniela Turchetti, Sara Miccoli, Giuseppe Deledda, Giovanna Fantoni, Valeria Viassolo, Oronzo Brunetti, Raffaele De Luca, Maria Digennaro, Francesca Romito, Maria Campanella, Margherita Patruno

“…Abstract Background Genetic testing has led to a considerable enhancement in the ability to identify individuals at risk of Hereditary Breast and Ovarian Cancer syndrome related to BRCA1/2 pathogenic variants, thus necessitating personalised prevention programs. However, barriers related to intrafamilial communication, privacy regulations, and genetic information dissemination hinder preventive care, particularly in Italy, where legal constraints limit the disclosure of genetic risks to at-risk relatives. …”
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The effect of technology stress on knowledge concealment with the mediating role of job fatigue and moderating work autonomy by Hossein Jamali, Mehdi Kabirinaeini, Zeynab Elahi

“…This issue can ultimately limit organizations' ability to create effective communities of practice and organizational learning. …”
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Navigating Ethical Dilemmas Of Generative AI In Medical Writing by Qurrat Ulain Hamdan, Waleed Umar, Mahnoor Hasan

“…Privacy and Security Concerns The innate programming of generative AI chatbots to store the information that is provided to them also raises concerns regarding their safety and security. …”
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L’ITALIANO L2 TRA LAVORO DI CURA E PLURALITÀ IDENTITARIA: UN’INDAGINE SUI BISOGNI FORMATIVI DELLE ASSISTENTI FAMILIARI DALL’EST EUROPA ATTRAVERSO L’AUTOBIOGRAFIA LINGUISTICA... by Edith Cognigni, Tatiana Borisova, Elena Michelini

“…Communicative competence is shown to be a crucial dimension of caregiving, although participants report significant challenges related to sociolinguistic variation and intercultural dynamics. Limited access to formal language instruction has led many to rely on autonomous learning practices, underscoring the urgent need for tailored L2 educational programs that integrate linguistic, professional, and intercultural competencies. …”
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