Serotonin receptor 5-HT2A as a potential target for HCC immunotherapy by Han Chong Toh, Olaf Rotzschke, Yi Wen Tan, Nicholas Da Zhi Ang, Wendy Lee, Ser Mei Koh, Rong En Tay, Charmaine Min Ho, Hui Chien Tay, Daniel Z Lopez, Qiao Rui Na, Kim Peng Tan, Jackwee Lim, Maichan Lau, Laurent Rénia

“…In vivo, systemic ketanserin treatment significantly prolonged survival of HCC tumor-bearing mice and was non-inferior to α-programmed death ligand 1 (PD-L1)+α-vascular endothelial growth factor A (VEGFA) combination antibody treatment. …”
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Randomized phase II study of the Bruton tyrosine kinase inhibitor acalabrutinib, alone or with pembrolizumab in patients with advanced pancreatic cancer by Al B Benson, Anirban Maitra, Milind Javle, Michael Overman, Richard E Davis, Pankaj Vats, Chandan Kumar-Sinha, Lianchun Xiao, Niharika B Mettu, Edwin R Parra, Charles D Lopez, Veerendra Munugalavadla, Priti Patel, Lin Tao, Sattva Neelapu

“…Preclinical studies in pancreatic cancer have demonstrated promising anti-tumor activity with Bruton tyrosine kinase (BTK) inhibition combined with programmed cell death receptor-1 (PD-1) blockade.Methods This was a phase II, multicenter, open-label, randomized (1:1) clinical trial evaluating the BTK inhibitor acalabrutinib, alone (monotherapy) or in combination with the anti-PD-1 antibody pembrolizumab (combination therapy). …”
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Errors Associated With Medication Administration by a Nurse During Hospitalisation: A Prospective Observational Multicentric Study by Ondrej Tesar, Martin Dosedel, Ales Antonin Kubena, Katerina Mala‐Ladova, Radka Prokesova, Iva Brabcova, Hana Hajduchova, Martin Cerveny, Ivana Chloubova, Jiri Vlcek, Valerie Tothova, Josef Maly

“…Determinants of MAE occurrence such as incorrect prescriptions or limited experience of nurses should be considered. …”
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Predicting 30-day survival after in-hospital cardiac arrest: a nationwide cohort study using machine learning and SHAP analysis by Truls Råmunddal, Mats Borjesson, Erik Andersson, Per Nordberg, Kristofer Skoglund, Johan Herlitz, Araz Rawshani, Therese Djärv, Aidin Rawshani, Peter Lundgren, Antros Louca, Vibha Gupta, Joakim Sundström, Carl Magnusson

“…This model has strong clinical utility and can be externally validated via the open-access Application Programming Interface (API) at www.gocares.se…”
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Non-consistent changes and drivers of water-sediment fluxes in the yarlung tsangpo river basin of the Tibetan plateau by Dongmei Zhao, Donghong Xiong, Kunlong He, Baojun Zhang, Fan Zhang, Han Wu, Haiyan Fang, Wenduo Zhang, Changyan Zhou, Xiaodan Wang

“…Yet, current estimates of the response of water and sediment flux remain insufficiently quantified, limited by the scarcity of long-term hydrological records in the alpine regions. …”
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Oxaliplatin, ATR inhibitor and anti-PD-1 antibody combination therapy controls colon carcinoma growth, induces local and systemic changes in the immune compartment, and protects ag... by Henri-Alexandre Michaud, Nathalie Bonnefoy, François Quenet, Julien Faget, Diego Tosi, Celine Gongora, Olivia Sgarbura, Alexandra Fauvre, Chiara Ursino, Veronique Garambois, Elodie Culerier, Louis-Antoine Milazzo, Nadia Vezzio-Vié, Laura Jeanson, Candice Marchive, Augusto Faria Andrade, Eve Combes, Salima Atis, Gérald Lossaint, Lakhdar Khellaf, Ileana Corbeau, Nadine Houede

“…However, their use is limited by the emergence of resistance mechanisms, including to oxaliplatin. …”
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Prevalence and Predictors of Diabetic Retinopathy in Saudi Arabia: Insights from a Systematic Review and Meta-Analysis by Ali Mohammed Alshahrani, Alaa Mohammed Alshahrani, Beshayer Abdullah H. Al-Boqami, Alwaleed Abdulhadi Alqahtani, Bassam Alzahrani, Yousef Bassi, Mohammed Yousef Almohaimeed, Abeer Mohammed Alalmaai, Ariana Saraiva, Bandar Naffaa Alhumaidi, Najla A. Albaridi, Maria João Lima, Conrado Carrascosa, António Raposo

“…To minimize the effects of DR, early intervention, routine DR screening programs, and optimal diabetes control are essential. …”
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Prevalence and factors associated with resilience in Peruvian adolescent schoolchildren during the early post-pandemic context: a cross-sectional study by Mario J. Valladares-Garrido, Luis E. Cueva-Cañola, Pamela Grados-Espinoza, Luz A. Aguilar-Manay, Jassmin Santin Vásquez, Danai Valladares-Garrido, Danai Valladares-Garrido, César J. Pereira-Victorio, César J. Pereira-Victorio, Víctor J. Vera-Ponce, Víctor J. Vera-Ponce

“…However, evidence on the prevalence and associated factors of resilience in adolescents remains limited in Latin America, particularly in school settings and the post-pandemic context. …”
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Mitochondrial genome of Lonicera macranthoides: features, RNA editing, and insights into male sterility by Zhong Chen, Wei Zhuo, Yuqi Wang, Junpeng Qi, Li Liu, Sheng’E. Lu, Han Wang, Tao Sun, Liqiang Wang, Fengming Ren, Fengming Ren

“…Overall, our study provides a complete mitogenome of L. macranthoides, which will aid in its genetic marker exploration, evolutionary relationship analysis, and breeding programs.…”
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Comparative assessment of line probe assays and targeted next-generation sequencing in drug-resistant tuberculosis diagnosisResearch in context by Giovanna Carpi, Marva Seifert, Andres De la Rossa, Swapna Uplekar, Camilla Rodrigues, Nestani Tukvadze, Shaheed V. Omar, Anita Suresh, Timothy C. Rodwell, Rebecca E. Colman

“…These findings provide critical evidence to guide updates in DR-TB diagnostic programs. Funding: Support for the Seq&Treat project was provided through funding from Unitaid (2019-32-FIND MDR).…”
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Tislelizumab plus concurrent chemoradiotherapy versus concurrent chemoradiotherapy for elderly patients with inoperable locally advanced esophageal squamous cell carcinoma: a multi... by Ke Zhang, Qifeng Wang, Jianzhong Cao, Chengcheng Fan, Wenbin Shen, Qin Xiao, Xiaolin Ge, Tian Zhang, Xiao Liu, Xi Chen, Jie Dong, Zewei Li, Zhunhao Zheng, Cihui Yan, Ping Wang, Qingsong Pang, Wencheng Zhang

“…However, the 3-year overall survival (OS) is limited to approximately 40%. Tislelizumab is the first- and second-line standard treatment for advanced ESCC with tolerable toxicity. …”
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Myt1l haploinsufficiency leads to obesity and multifaceted behavioral alterations in mice by Markus Wöhr, Wendy M. Fong, Justyna A. Janas, Moritz Mall, Christian Thome, Madhuri Vangipuram, Lingjun Meng, Thomas C. Südhof, Marius Wernig

“…Molecularly, we found it to repress many non-neuronal gene programs, explaining its supportive role to induce and safeguard neuronal identity in combination with proneural bHLH transcriptional activators. …”
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IL-4-STAT6-induced high Siglec-G/10 expression aggravates the severe immune suppressive tumor microenvironment and impedes the efficacy of immunotherapy in head and neck squamous c... by Ming Yan, Wenyi Yang, Zhaoyang Guo, Houyu Ju, Yusheng Lu, Yifan Fei, Yuanchen Yin, Guoxin Ren, Chaofeng Han, Jingzhou Hu

“…Background Immune checkpoint blockade therapy has shown limited efficacy in head and neck squamous cell carcinoma (HNSCC). …”
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Inheritance of Some Salt Tolerance-Related Traits in Bread Wheat (<i>Triticum aestivum</i> L.) at the Seedling Stage: A Study of Combining Ability by Toka Hadji, Mouad Boulacel, Awatef Ghennai, Maroua Hadji, Fethi Farouk Kebaili, Chermen V. Khugaev, Olga D. Kucher, Aleksandra O. Utkina, Alena P. Konovalova, Nazih Y. Rebouh

“….), a staple crop of paramount importance worldwide, encounters significant production limitations due to abiotic stressors, particularly salinity. …”
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Clinical activity of durvalumab for patients with advanced mismatch repair-deficient and repair-proficient endometrial cancer. A nonrandomized phase 2 clinical trial by Linda Mileshkin, Elizabeth Barnes, Tarek Meniawy, Kristy Robledo, Michael Friedlander, Geraldine Goss, Jermaine Coward, Yoland Antill, Michelle Cummins, Sally Baron-Hay, Martin R Stockler, Catherine Shannon, Philip Beale, Peey-Sei Kok, Deborah Smith, Sonia Yip, Amanda Spurdle, Yeh Chen Lee, Janine Lombard, John Andrews

“…Background In this study, we assessed the activity of durvalumab, an antibody to programmed death ligand-1, in two cohorts of women with advanced endometrial cancers (AEC)—mismatch repair proficient (pMMR) and mismatch repair deficient (dMMR).Methods A multicenter phase two study was performed in women with AEC with pMMR tumor progressing after one to three lines of chemotherapy and women with AEC with dMMR tumor progressing after zero to three lines of chemotherapy. …”
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Smartphone addiction and sleep quality among nursing students in Meknes, Morocco: A cross-sectional study by Abdelhadi El Haddaouy, Youssef Miyah, Mohammed Benjelloun, Aziz Mengad, Hicham Blaak, Hayat Iziki, Fatima El Omari

“…However, research on this subject in Morocco remains limited. Objective: This study aimed to examine the impact of smartphone addiction on sleep quality and identify risk factors that moderate this relationship among nursing students. …”
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Study on the efficacy of IFN-γ- and sPD-1-overexpressing BMSCs in enhancing immune effects for the treatment of lung adenocarcinoma by Yahui Xie, Zhen Lv, Yubin Wang, Jin Ma, Xingmin Wei, Guisen Zheng, Jianjun Wu

“…BackgroundSoluble programmed cell death receptor-1 (sPD-1) blocks the PD-1/PD-L1 pathway, reverses tumor immune suppression, and inhibits tumor growth. …”
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Systematic review and meta-analysis of effectiveness of robotic therapy in the recovery of motor functions after stroke by Mariyam Amirbekova, Tokzhan Kispayeva, Tokzhan Kispayeva, Ausra Adomaviciene, Laura Eszhanova, Inna Bolshakova, Zhanna Ospanova

“…The findings support early stratification and personalization of rehabilitation programs based on stroke timing, age, and intervention intensity. …”
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Healthcare workers’ knowledge, attitudes, and practices on catheter-associated UTI prevention: influencing factors in an OB/GYN hospital by Fei Qu, Yanyu Pang, Mei Wang, Xiaojie Liu, Jing Wang, Jing Wang, Li Li

“…The ultimate aim is to provide evidence for improving targeted training programs and infection control measures.Methods and participantsA cross-sectional study was conducted in an OB/GYN hospital in Shanghai, China. …”
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Physician burnout, associated factors, and their effects on work performance throughout first-year internships during the COVID-19 pandemic in Thailand: a cross-sectional study by Vithawat Surawattanasakul, Penprapa Siviroj, Wuttipat Kiratipaisarl, Wachiranun Sirikul, Vitchayut Phetsayanavin, Chantarateera Pholvivat, Natcha Auernaruemonsuk, Chanon Lamlert

“…To address these issues, mentorship programs and buddy support systems, along with adherence to recommended work-hour guidelines, are crucial to mitigate burnout and improve work performance.…”
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