Validation of the ABC Method for Gastric Cancer Risk Stratification Across Helicobacter pylori Infections With Diverse CagA Status and Subtypes in Brazil by Luis Masuo Maruta, Asuka Furukawa, Heinrich Bender Kohnert Seidler, Aloisio Felipe‐Silva, Keisuke Uchida, Daisuke Kobayashi, Kurara Yamamoto, Junko Minami, Masaki Sekine, Minako Takagi, Renato Takayuki Hassegawa, Eduardo Koji Marchi Ogawa, Rodrigo Barbosa Villaça, Tecio deAraujo Couto, Jorge Alberto Capra Biasuz, Edmar Tafner, Ana Luiza Werneck‐Silva, Simone Perez Pilli, José Guilherme Nogueira daSilva, Leonard Medeiros daSilva, Ricardo Ambrosio Fock, Chinatsu Ogura, Yumi Mizuguchi, Keiko Miura, Kouhei Yamamoto, Yoshinobu Eishi, Kenichi Ohashi

“…Conclusions These findings demonstrate the clinical relevance of CagA diversity for gastric cancer risk assessment. Although limited to an endoscopy‐referred cohort, the ABC method reliably identified low‐risk individuals (Group A) and may help reduce unnecessary endoscopies in screening programs, regardless of CagA status and subtypes. …”
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Combination cancer immunotherapy targeting TNFR2 and PD-1/PD-L1 signaling reduces immunosuppressive effects in the microenvironment of pancreatic tumors by Yi Duan, Wen Chen, Jian Xu, Xiaoyu Zhang, Xiaozhen Zhang, Tingbo Liang, Xueli Bai, Mengyi Lao, Hanshen Yang, Muchun Li, Honggang Ying, Lihong He, Kang Sun, Chengxiang Guo, Haitao Jiang

“…The in vitro mechanism that TNFR2 regulates programmed cell death 1 ligand 1 (PD-L1) was investigated using immunofluorescence, immunohistochemistry, flow cytometry, western blotting, and chromatin immunoprecipitation (ChIP). …”
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Adopting drone technology for blood delivery: a feasibility study to evaluate its efficiency and sustainability by Pammi Gauba, Anita Nangia, Shalini Bahadur, Sangeeta Pahuja, Shweta Dang, Rambha Pathak, Kiran Agarwal, Sunita Sharma, Deepti Ambalkar, Manoj Jha, Ranju Singh, Priyanka Virdi, Rakesh Gupta, Shambhavee Singh, Ravindra Pandey, Bhuvan Adhlakha, Pragati Agarwal, Kuldeep Nigam, Sumit Aggarwal

“…Blood and its components are critical for life-saving transfusions, however, their availability at the point of care is often limited. Moreover, the logistical challenges associated with blood product transport are substantial and maintaining the cold chain throughout the supply route is crucial to sustain their functional integrity as the temperature fluctuations can compromise its oxygen-carrying capacity. …”
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Intermittent hypoxia-hyperoxia therapy in medical rehabilitation: Effects on body composition in patients with metabolic syndrome by Andreea-Bianca Uzun, Andreea-Dalila Nedelcu, Mădălina-Gabriela Iliescu, Liliana-Elena Stanciu, Adina Petcu, Lucian Cristian Petcu, Bogdan Obada, Doina-Ecaterina Tofolean

“…MS represents a major public health challenge and current intervention methods have limitations in effectiveness and long-term adherence. …”
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Mangrove composition and anthropogenic marine debris survey in Camotes Group of Islands, Philippines by Maximino III Abejo, Arnel Nudalo, Martha Joyce Garciano, Ian Paul Bayon, Chembelyn Gella Bayon, Marvin Guinocor, Jesrael Linao, Althea Mae Guevara, Christine Caya, Sylvester Tan Cortes

“…These include establishing community-based monitoring programs, launching plastic waste reduction campaigns, restoring debris-impacted mangrove areas, and aligning local actions with national marine litter policies. …”
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Improving contraceptive agency through peer social support: findings from a longitudinal qualitative evaluation of the I-CAN intervention in Uganda by Erica Sedlander, Beth Phillips, Isabelle Thapar, Catherine Birabwa, Lauren Suchman, Madeline Griffith, Dinah Amongin, Ronald Wasswa, Lynn Atuyambe, Jenny Liu, Peter Waiswa, Kelsey Holt

“…BackgroundSexual and reproductive health organizations have been advocating for a human rights-based approach to contraceptive programming for many years, but progress has been slow. …”
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Genome-wide association analysis of grain iron and zinc in rice grown under agroclimatic sites with contrasting soil iron status by Sonu, Amit Kumar, Vikram Jeet Singh, Prolay Kumar Bhowmick, Shekharappa Nandakumar, Sunaina Yadav, Subbaiyan Gopala Krishnan, Ranjith Kumar Ellur, Haritha Bollinedi, Ashok Kumar Singh, Kunnummal Kurungara Vinod

“…Two marker-trait associations (MTAs), qGFe12.1ADT and qGZn12.1BPN-N, were validated in an F2:3 population using linked SSR markers.DiscussionThese validated MTAs provide valuable genetic resources for biofortification breeding programs aimed at increasing Fe and Zn concentrations in rice grains, addressing micronutrient deficiencies among rice-dependent populations.…”
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Smartphone pregnancy apps: systematic analysis of features, scientific guidance, commercialization, and user perception by Michael Nissen, Shih-Yuan Huang, Katharina M. Jäger, Madeleine Flaucher, Adriana Titzmann, Hannah Bleher, Constanza A. Pontones, Hanna Huebner, Nina Danzberger, Peter A. Fasching, Bjoern M. Eskofier, Heike Leutheuser

“…Previous studies have only conducted a limited analysis of pregnancy app functionalities, expert involvement/evidence-based content, used commercialization techniques, and user perception. …”
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Fine mapping genetic variants affecting birth weight in sheep: a GWAS of 3007 individuals using low-coverage whole genome sequencing by Ran Li, Yuheng Bai, Maqiang Zhao, Xinyue Zhang, Haiyan Wang, Bo Feng, Shuo Zhang, Huanhuan Zhang, Gang Ren, Xihong Wang, Yu Jiang

“…However, its genetic architecture remains poorly understood due to historical limitations in sample size and reliance on low-density SNP arrays. …”
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Efficacy of the spatial repellent SC Johnson Mosquito Shield™ against anophelines in free-flight chambers, semi-field systems, experimental huts, and in-home tests by Johnson K. Swai, Johnson K. Swai, Johnson K. Swai, Watson S. Ntabaliba, Hassan A. Ngonyani, Noely O. Makungwa, Antony P. Mseka, Saphina H. Ngoyani, Ibrahim S. Kibwengo, Ahmadi B. Mpelepele, Ahmadi B. Mpelepele, Jason D. Moore, Jason D. Moore, Madeleine R. Chura, Thomas M. Mascari, Sarah J. Moore, Sarah J. Moore, Sarah J. Moore, Sarah J. Moore

“…The findings highlight the strengths and limitations of free-flight chambers, semi-field systems, experimental huts, and in-home tests in generating efficacy data for new spatial repellent products. …”
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A novel missense single-nucleotide polymorphism (c.149G>A) in the bovine leptin gene and its association with growth traits in Madura cattle by Kuswati Kuswati, Irida Novianti, Rizki Prafitri, Wike Andre Septian, Rafika Febriani Putri, Chairdin Dwi Nugraha, Ahmad Furqon

“…Genetic polymorphisms in this gene can influence phenotypic traits and may serve as molecular markers for selection in breeding programs. However, comprehensive characterization of LEP gene variants in local Indonesian breeds, such as Madura cattle, remains limited. …”
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CHIVID: A Rapid Deployment of Community and Home Isolation During COVID-19 Pandemics by Parpada Piamjinda, Chiraphat Boonnag, Piyalitt Ittichaiwong, Seandee Rattanasonrerk, Kanyakorn Veerakanjana, Khanita Duangchaemkarn, Warissara Limpornchitwilai, Kamonwan Thanontip, Napasara Asawalertsak, Thitikorn Kaewlee, Theerawit Wilaiprasitporn

“…Background: CHIVID is a telemedicine solution developed under tight time constraints that assists Thai healthcare practitioners in monitoring non-severe COVID-19 patients in isolation programs during crises. It assesses patient health and notifies healthcare practitioners of high-risk scenarios through a chatbot. …”
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The Association of Immune Cell Infiltration with Metastasis Location in De Novo Metastatic Triple Negative Breast Cancer: A Multicenter Cross-Sectional Study in Indonesia by Jeffry Beta Tenggara, Andhika Rachman, Joedo Prihartono, Lisnawati Lisnawati, Sonar Soni Panigoro, Didik Setyo Heriyanto, Ricci Steven, Kevin Tandarto, Samuel Juanputra, Aru Wisaksono Sudoyo

“…Background: Triple-negative breast cancer (TNBC) is an aggressive cancer subtype, with limited treatments and a high metastasis risk. The varying location of metastasis in TNBC patients often leads to in prognosis in breast cancer. …”
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Dollar store policy opportunities in Baltimore City: community member and policy maker perspectives by Samantha M. Sundermeir, Sydney R. Santos, Emma C. Lewis, Sara John, Karen Gardner, Emily Friedman, Lisa Poirier, Shuxian Hua, Sevetra Peoples-Brown, Sevetra Peoples-Brown, Sara E. Benjamin-Neelon, Sara E. Benjamin-Neelon, Joel Gittelsohn

“…Key concerns included policy enforcement, given the additional funding required, and current limited capacity at the city government level. Strategies to address such challenges were generated including implementing business licenses at the city level, linking new ordinances to dollar store leases and permits, and encouraging dollar store participation in federal and local programs to more feasibly stock healthier food items (e.g., fresh produce). …”
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Phase I study of intratumoral administration of CV8102 in patients with advanced melanoma, squamous cell carcinoma of the skin, squamous cell carcinoma of the head and neck, or ade... by Lucie Heinzerling, Michael Fluck, Caroline Robert, Celeste Lebbe, Erika Richtig, Sven D Koch, Ulrike Gnad-Vogt, Tobias Seibel, Thomas Eigentler, Juan Martin-Liberal, Sebastian Ochsenreither, Peter Mohr, Patrick Terheyden, Carsten Weishaupt, Michael Erdmann, Lukas Koch, Ainara Soria, Igor Samoylenko, Jürgen Krauß, Peter Brossart, Franz Georg Bauernfeind, Marina Gonzalez, Peter Wengenmayer, Ioannis Thomas, Artem Poltoratskiy, Marina Sekacheva, Beate Schmitt-Bormann, Gianluca Quintini, Martin Falk, Paula Codó, Arjun Oberoi, Jana Hess, Yulia Semiletova, Casilda Llacer Perez, Oliver Schönborn-Kellenberger

“…One patient had Grade 3 aspartate transaminase/alanine aminotransferase elevation which met dose-limiting toxicity (DLT) criteria. Another patient experienced Grade 3 immune-mediated pneumonitis. …”
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Engineered Mycobacterium smegmatis expressing anti-PD-L1/IL-15 immunocytokine induces and activates specific antitumor immunity by Lin Li, Yang Yang, Baorui Liu, Jie Shen, Jie Shao, Fangcen Liu, Yi Mei, Junmeng Zhu, Xiaoxuan Sha, Rutian Li

“…Background Immune checkpoint inhibitors and cytokines have revolutionized tumor treatment but are still limited by dose-dependent toxicity and efficacy. In situ vaccine platforms based on intelligent microbes are promising therapeutic strategies that sustainably deliver drugs locally without causing severe systemic risks.Methods In this study, we have innovatively engineered a non-pathogenic, adjuvant-acting Mycobacterium smegmatis (M. smegmatis) that co-expresses a programmed cell death-ligand 1 (PD-L1) inhibitor and an interleukin-15 (IL-15) cytokine complex containing the interleukin-15 receptor alpha (IL-15Rα) sushi domain (Ms-PDL1scfv-IL15).Results We demonstrate that the fusion protein of PD-L1 inhibitor and IL-15 cytokine systemically binds mouse or human PD-L1 and maintains IL-15 stimulatory activity. …”
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Objective assessment tools in laparoscopic or robotic‐assisted gynecological surgery: A systematic review by Freweini Martha Tesfai, Jasleen Nagi, Iona Morrison, Matt Boal, Adeola Olaitan, Dhivya Chandrasekaran, Danail Stoyanov, Anne Lanceley, Nader Francis

“…Future research should prioritize filling these gaps while integrating advanced technologies like kinematic data and AI for robust, objective surgical skill assessment within gynecological advanced surgical training programs.…”
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Digital competence and digital entrepreneurial intention: A social cognitive approach by Bao Quoc Lam, Hao Yen Tran, Kiet Anh Nguyen, Kiet Tuan Nguyen, Minh Pham

“…Implications & Recommendations: The study’s limitations include a relatively small sample size and a focus on the role of entrepreneurial education without exploring the mediating effects of cognitive structures like self-efficacy and outcome expectations. …”
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Addressing knowledge, attitude and practice gaps for effective dengue management strategies in Indonesia by Ari Prayitno, Mei Neni Sitaresmi, Bachti Alisjahbana, Bachti Alisjahbana, Carolina Halim, Fauchil Wardati, Mentari Yudiansyach, Sri Rezeki Hadinegoro

“…However, comprehensive assessments of Knowledge, Attitudes, and Practices (KAP) regarding dengue in the Indonesian adult population are limited. This study provides one of the first comprehensive evaluations of KAP in Indonesia, aiming to inform integrated dengue management programs.MethodsThis study utilized data from the larger GEMKAP study, which covered seven countries, including Indonesia. …”
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Peritoneal dialysis catheter insertion in patients with obesity: a cohort study and single centre approach to increasing uptake by Walker Andrew, Corr Michael, Conroy Daniel, McDaid James, McGrogan Damian, Fogarty Damian, O’Neil Stephen

“…These findings challenge the traditional reluctance to offer PD to obese patients and advocate for the expansion of PD programs to include this growing demographic. Clinical Trial Number Not Applicable…”
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