Implications of root morphology and anatomy for water deficit tolerance and recovery of grapevine rootstocks by David Alonso-Forn, David Alonso-Forn, Ignacio Buesa, Ignacio Buesa, Luis Flor, Antoni Sabater, Hipólito Medrano, Hipólito Medrano, José M. Escalona, José M. Escalona

“…These results underscore the role of root morphology and anatomy in grapevine drought tolerance, suggesting that these traits could be incorporated as criteria for future rootstocks breeding programs. Nevertheless, field-testing under non-limiting soil conditions is essential to validate these findings.…”
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Mapping immune activity in HPV-negative head and neck squamous cell carcinoma: a spatial multiomics analysis by Bruno Gomes, Francesca Damiola, Nicolas Gadot, Jean-Philippe Foy, Pierre Saintigny, Natalie Zwing, Lena Voith von Voithenberg, Laurent Alberti, Sascha Michael Gabriel, Josep M Monné Rodriguez, Romi Feddersen

“…Despite this high immune infiltration, HNSCC often has an immunosuppressive microenvironment, which we observed as a colocalization of programmed cell death protein-1+ (PD-1+) cytotoxic T cells and cytotoxic T cells, indicating regional differences in active and exhausted cell ratios. …”
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Simultaneous occurrence of cutaneous melanocytic neoplasia in Duroc and German Saddleback pigs from three smallholder farms by Thies J. Nicolaisen, Melanie Stoff, Manon Mikic, Anna Lena Maschmeier, Johannes Buchallik-Schregel, Alexandra von Altrock, Maybrit Wirtz, Saskia Neubert, Andreas Beineke, Doris Höltig, Isabel Hennig-Pauka, Martin Ganter

“…Notably, the endangered Husum Red Pied breed maintains a limited genetic diversity, emphasizing the imperative of integrating considerations of this disease into breeding programs to mitigate the heightened risk of hereditary neoplastic afflictions in subsequent generations.…”
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Combination of two novel blocking antibodies, anti-PD-1 antibody ezabenlimab (BI 754091) and anti-LAG-3 antibody BI 754111, leads to increased immune cell responses by Markus Zettl, Melanie Wurm, Otmar Schaaf, Sven Mostböck, Iñigo Tirapu, Ilse Apfler, Ivo C. Lorenz, Lee Frego, Cynthia Kenny, Michael Thibodeau, Elisa Oquendo Cifuentes, Markus Reschke, Jürgen Moll, Norbert Kraut, Anne Vogt, Jonathon D. Sedgwick, Irene C. Waizenegger

“…Upregulation of inhibitory receptors, such as lymphocyte activation gene-3 (LAG-3), may limit the antitumor activity of therapeutic antibodies targeting the programmed cell death protein-1 (PD-1) pathway. …”
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A Galaxy with an Extremely Blue Ultraviolet Slope β = −3 at z = 9.25 Identified by JWST Spectroscopy: Evidence for a Weak Nebular Continuum and Efficient Ionizing Photon Escape? by Hiroto Yanagisawa, Masami Ouchi, Kimihiko Nakajima, Yuichi Harikane, Seiji Fujimoto, Yoshiaki Ono, Hiroya Umeda, Minami Nakane, Hidenobu Yajima, Hajime Fukushima, Yi Xu

“…We investigate UV continuum slopes β of 863 galaxies at 4 <  z  < 14 using archival JWST/NIRSpec PRISM spectra obtained from major JWST Guaranteed Time Observations (GTO), Early Release Science (ERS), and General Observers (GO) programs, including JADES, CEERS, and UNCOVER. Among these galaxies, we identify a remarkable galaxy at z  = 9.25, dubbed extremely blue galaxy 1 (EBG-1), with a significantly blue UV slope β  = −2.99 ± 0.15, unlike the rest of the galaxies that exhibit red continua or ambiguous blue continua hindered by large uncertainties. …”
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Deciphering drought response mechanism in Tibetan qingke through comprehensive transcriptomic and physiological analysis by Deyuan Jiang, Deyuan Jiang, Shuaihao Chen, Shuaihao Chen, Shuaihao Chen, Zhongmengyi Qin, Zhongmengyi Qin, Zhongmengyi Qin, La Bo, La Bo, La Bo, Liping Niu, Liping Niu, Liping Niu, Hongkang Zhou, Hongkang Zhou, Jing Wang, Jing Wang, Jing Wang, Dawa Dondup, Xin Hou, Xin Hou, Xin Hou

“…With the intensification of global warming, drought stress has become a major abiotic factor limiting qingke productivity. However, the molecular mechanisms underlying its drought response remain largely unexplored. …”
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Postural imbalance without visual input is associated with specific neuropsychological deficits in older adults – results from the LIFE-adult study by Eva Grill, Andreas Zwergal, Andreas Zwergal, Dorothee Saur, Julian Klingbeil, Christopher Fricke, Florian Schöberl, Karim Felfela, Karim Felfela, Andrea Zülke, Steffi Riedel-Heller, Joseph Classen

“…Romberg’s ratios were not significantly associated with executive functions, procedural speed or memory functions.DiscussionIt may be worthwhile to examine in the future whether inclusion of balance testing enhances the value of screening programs for cognitive impairment. Inversely, it may be appropriate to apply routine cognitive tests when balance problems are detected in older patients.…”
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Discriminant analysis of occupational performance characteristics in patients with major depressive disorders and healthy individuals by Tomonari Hayasaka, Izumi Nagashima, Miku Hoshino, Koji Teruya, Yasuyuki Matumoto, Masami Murao, Taku Maruki, Masako Watanabe, Takeshi Katagiri, Yayoi Imamura, Mariko Kurihara, Yuki Oe, Yoshikazu Takaesu, Takashi Tsuboi, Koichiro Watanabe, Hitoshi Sakurai

“…Methods Baseline data were collected from medical records and activity programs. Three occupational therapists conducted content analysis to assess occupational performance characteristics. …”
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RC48-ADC monotherapy or in combination with immunotherapy for locally advanced or metastatic urothelial carcinoma with HER2 low and null expression: a multicenter, real-world, retr... by Daining Wang, Manming Cao, Yijun Zhang, Liangkuan Bi, Meiting Chen, Mengqian Ni, Qiufan Zheng, Kai Yao, Zhuowei Liu, Xia Yang, Yanxia Shi, Zhiming Wu, Xin An

“…Abstract Background Approximately half of urothelial carcinoma (UC) patients exhibit low or null HER2 expression. Limited data are available on the efficacy of anti-HER2 RC48-ADC (Disitamab Vedotin) in HER2 low and null advanced UC. …”
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Divergent trends in the burden of esophageal, gastric, and liver cancers in China by Yongjie Xu, Changfa Xia, Jiachen Wang, Yujie Wu, Wanqing Chen

“…Future efforts should intensify existing prevention measures while expanding screening programs, particularly for aging populations. These findings offer valuable insights for regions undergoing similar epidemiological transitions.…”
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The efficacy and safety of a novel PD‐1/CTLA‐4 bispecific antibody cadonilimab (AK104) in advanced non‐small cell lung cancer: A multicenter retrospective observational study... by Hongxin Li, Wen Zhao, Chengming Li, Hongchang Shen, Meiying Li, Chengjun Wang, Chunyan Han, Cuihua Yi, Jun Wang, Xue Meng, Lian Liu, Shuwen Yu, Jisheng Li

“…Abstract Background For patients with advanced non‐small cell lung cancer (NSCLC) who have received frontline immunochemotherapy, subsequent treatment options are limited. As the first dual programmed cell death‐1 (PD‐1)/cytotoxic T lymphocyte‐associated antigen‐4 bispecific antibody approved globally, cadonilimab demonstrated potential antitumor activity in advanced NSCLC patients resistant to anti‐PD‐1/PD‐L1 antibodies. …”
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The second victim phenomenon among German emergency medical technicians: a cross-sectional study based on the SeViD questionnaire (SeViD-VIII) by Hartwig Marung, Victoria Klemm, Reinhard Strametz, Thomas Neusius, Matthias Raspe, Hannah Roesner, Harald Karutz, Klaus Runggaldier, Rainer Petzina, Luis Teichmann, Stefan Bushuven

“…The implementation of structured peer support programs may help mitigate the impact of SVP.…”
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A pH/MMP-9 smart dual-responsive liposome GBE@LP co-delivers and controls the release of GB1107/BMS1166/Enzalutamide for liver cancer immunotherapy by Shijia Lu, Chenxiao Zhang, Huiru Wu, Junjie Wang, Jinglong Wang, Limei Zhao, Tianyang Ren, Guofei Li

“…CD8+ T cell-based immunotherapy is the most promising option for the treatment of liver cancer, but its application is severely limited by low infiltration and functional exhaustion of CD8+ T cells in liver cancer tissues. …”
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Adherence to Mediterranean diet in Moroccan school-age adolescents: sociodemographic, socioeconomic and lifestyle determinants by Halima Belaoufi, Sanaa El-Jamal, Khadija Sahel, Abdelghani Aboukhalaf, Firdaous Friki, Hamid Chamlal, Jamila Elbiyad, Soumaya Atouife, Abdellah El Habazi, Rekia Belahsen

“…Targeted nutritional intervention programs should be implemented to improve adherence to the MD among Moroccan adolescents, by promoting healthy eating habits.…”
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Fecal microbiota transplantation alleviates cognitive impairment by improving gut microbiome composition and barrier function in male rats of traumatic brain injury following gas e... by Xinwen Dong, Yaguang Su, Zheng Luo, Cuiying Li, Jie Gao, Xiaofeng Han, Sanqiao Yao, Weidong Wu, Linqiang Tian, Yichun Bai, Guizhi Wang, Wenjie Ren

“…Furthermore, GE markedly elevated the levels of regulatory T cell (Tregs)-related factors interleukin-10, programmed death 1, and fork head box protein P3 in the brains of rats. …”
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Assessment of Long-Read Sequencing-Based Congenital Adrenal Hyperplasia Genotyping Assay for Newborns in Fujian, China by Xudong Wang, Xingxiu Lu, Faming Zheng, Kun Lin, Minjuan Liao, Yi Dong, Tiantian Chen, Ying He, Mei Lu, Jing Chen, Yanfang Li, Yulin Zhou

“…Such a combined screening strategy is worthy to be recommended for NBS programs in the future.…”
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PD-L2 glycosylation promotes immune evasion and predicts anti-EGFR efficacy by Min Li, Yiqi Xu, Yuqing Wang, Xuan Zhou, Mei Mei, Jingxuan Yang, Zhenyue Gao, Ruxin Hu, Yuhong Wang, Zheng Su, Xiaoyue Zhang, Yu Ren

“…Background Combination therapy has been explored for advanced head and neck squamous cell carcinoma (HNSCC) owing to the limited efficacy of anti-epidermal growth factor receptor (EGFR) therapy. …”
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Evaluating implementation preparedness for suicide screening and referral in a Nepali emergency department: A mixed-methods study by Anmol P Shrestha, Roshana Shrestha, Ajay Risal, Renu Shakya, Kripa Sigdel, Riya Bajracharya, Pratiksha Paudel, Divya Gumudavelly, Emilie Egger, Sophia Zhuang, Lakshmi Vijayakumar, Ashley Hagaman

“…Results Qualitatively, clinicians expressed hopelessness and reservations surrounding ED programs to prevent suicide given important system and social barriers. …”
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IBERBIRDS: A dataset of flying bird species present in the Iberian PeninsulaZenodo by Paula Rodríguez, Rubén Parte, Guillermo A. González, Alejandra Gacho, Darío Santos, Rubén Usamentiaga, Oscar D. Pedrayes

“…Despite these advancements, robust AI-driven solutions for avian species recognition remain limited, primarily due to the scarcity of high-quality annotated datasets. …”
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CONCEPTUAL MODEL OF ENTERPRISE DIGITAL TRANSFORMATION MANAGEMENT FOR ENSURING SUSTAINABLE REGIONAL DEVELOPMENT by Костянтин Завражний, Ірина Сотник, Анжеліка Кулик

“…Based on empirical and secondary data, the study identifies critical challenges including limited access to finance, a shortage of digital and «green» skills, resistance to change, lack of institutional support, and underdeveloped digital infrastructure in certain regions. …”
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