Discovery and development of ANV419, an IL-2/anti-IL-2 antibody fusion protein with potent CD8+ T and natural killer cell-stimulating capacity for cancer immunotherapy by Patrizia Murer, Barbara Brannetti, Jean-Michel Rondeau, Laetitia Petersen, Nicole Egli, Simone Popp, Catherine Regnier, Kirsten Richter, Andreas Katopodis, Christoph Huber

“…Its anti-tumor efficacy was enhanced when combined with programmed cell death protein 1 (PD-1) or cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) checkpoint inhibitors. …”
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Current status of vocational delay of gratification among practicing nursing students and its influencing factors: a cross-sectional study by Tianyu Chu, Xian Chen, Qian Zhang, Juanjuan Yang, Hui Zhou, Yibo Wu, Jie Jiao

“…The study conducted in three hospitals in Anhui Province may limit the generalizability of the results due to regional differences in education and practice. …”
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Strategies for the Prevention and Management of Respiratory Infections in Patients at High Risk in the UAE: A Cross-Disciplinary Position Paper by Abdullah Shehab, Huda Al Dhanhani, Omar Alhammadi, Mohamed Badi Hassan, Mohamed Farghaly, Ahmed Hassoun, Bassam Mahboub, Mona Tahlak, Reem Faisal Abutayeh, Hammam Haridy, Ashraf Hassanien, Jean Joury, Humaid O. Al-Shamsi

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A Confidence Scoring Procedure for eDNA Metabarcoding Records and Its Application to a Global Marine Fish Dataset by Andrea Polanco F., Romane Rozanski, Virginie Marques, Martin Helmkampf, David Mouillot, Stéphanie Manel, Camille Albouy, Oscar Puebla, Loïc Pellissier

“…The polar regions notably displayed high proportions of low confidence scores, probably due to the limited completeness of the regional reference databases and the taxonomic resolution of the teleo marker. …”
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New Geological and Structural Facts under the Lateritic Cover in Garga Sarali, Ndokayo (East Cameroon) Area, from Audiomagnetotellurics Soundings by Pepogo Man-mvele Augustin Didier, Ndougsa-Mbarga Théophile, Meying Arsène, Ngoh Jean Daniel, Mvondo-Ondoua Joseph, Ngoumou Paul Claude

“…Using Imagem software, coherency of data has been evaluated and only the data with a coherency below or equal to 0.7 have been considered. Two programs were used to map the subsurface. The pseudosections were obtained using IPI2WIN-MT, while geoelectrical sections were obtained using Stratagem Resistivity Plotter. …”
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Novel Application of Quantum Computing for Routing and Spectrum Assignment in Flexi-Grid Optical Networks by Oumayma Bouchmal, Bruno Cimoli, Ripalta Stabile, Juan Jose Vegas Olmos, Carlos Hernandez, Ricardo Martinez, Ramon Casellas, Idelfonso Tafur Monroy

“…Additionally, we conducted a comparative analysis between QAOA, integer linear programming, and deep reinforcement learning methods to evaluate the performance of the quantum-based approach relative to classical techniques. …”
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Intestinal microbiota as biomarkers for different colorectal lesions based on colorectal cancer screening participants in community by Gairui Li, Gairui Li, Dan Zhao, Binfa Ouyang, Yinggang Chen, Yashuang Zhao

“…The intestinal microbiota markers identified may serve as valuable tools in community-based CRC screening programs.…”
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Post-marketing safety concerns with Tislelizumab: a disproportionality analysis of the FDA adverse event reporting system by Chen Li, Chen Li, Yi Ding, Shanshan Cai, Bai Cheng Liu, Xiufeng Wang

“…BackgroundTislelizumab is an anti-programmed cell death protein 1(anti-PD-1) monoclonal antibody, which was approved by the Food and Drug Administration(FDA) on March 14, 2024. …”
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Socioeconomic Determinants of Over-Indebtedness of Microfinance Borrowers: Insights for Client Protection against Modern Financial Challenges by Bharat Singh Thapa, Moti Ram Paudel, Alberto Lanzavecchia, Durga Datt Pathak

“…The findings suggest that financial literacy programs, improved income-generating opportunities, and responsible loan usage can mitigate over-indebtedness and promote sustainable financial inclusion. …”
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Prevalence of cervical dysplasia and its relationship with socio-demographic characteristics in a low-resource setting by Babatunde Enoch Adewumi, Julius kolajo Dare, Rita Omobosola Alabi, Rosemary Oluwatosin Komolafe, Sonnen Atinge, Enoch Olaoluwa Olatoye, Halimat Eyitayo Issa, Bethrand Ozioma Chukwu, Emmanuel Kokori, Alexander Idu Entonu

“…It is a global health concern, particularly in low-resource countries with limited healthcare services and preventive measures. …”
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Why and how should we simulate platform trials? Learnings from EU-PEARL by Elias Laurin Meyer, Tobias Mielke, Marta Bofill Roig, Michaela Maria Freitag, Peter Jacko, Pavla Krotka, Peter Mesenbrink, Tom Parke, Sonja Zehetmayer, Dario Zocholl, Franz König

“…We addressed the functionality limitations of existing software as well as the unavailability of the coding therein by developing a suite of open-source software to use in simulating platform trials based on the R programming language. …”
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A versatile HPLC method collaborated with NaDES-ultrasound-assisted LLE and machine learning for purity testing and trace analysis of 1,4-benzodiazepines in crime scene evidence, h... by Walaa Nabil Abd-AlGhafar, Rasha Abo Shabana, Rania El-Shaheny, Manar M. Tolba

“…The method showed excellent linearity and a high sensitivity with detection limits of 0.34, 0.18, and 0.04 µg mL−1 for CDP, ALP, and DZP, respectively. …”
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Assessing mentoring: A scoping review of mentoring assessment tools in internal medicine between 1990 and 2019. by Yong Xiang Ng, Zachary Yong Keat Koh, Hong Wei Yap, Kuang Teck Tay, Xiu Hui Tan, Yun Ting Ong, Lorraine Hui En Tan, Annelissa Mien Chew Chin, Ying Pin Toh, Sushma Shivananda, Scott Compton, Stephen Mason, Ravindran Kanesvaran, Lalit Krishna, Lalit Krishna

“…<h4>Background</h4>Mentoring's success in enhancing a mentee's professional and personal development, and a host organisations' reputation has been called into question, amidst a lack of effective tools to evaluate mentoring relationships and guide oversight of mentoring programs. A scoping review is proposed to map available literature on mentoring assessment tools in Internal Medicine to guide design of new tools.…”
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POC CD4 Testing Improves Linkage to HIV Care and Timeliness of ART Initiation in a Public Health Approach: A Systematic Review and Meta-Analysis. by Lara Vojnov, Jessica Markby, Caroline Boeke, Lindsay Harris, Nathan Ford, Trevor Peter

“…<h4>Background</h4>CD4 cell count is an important test in HIV programs for baseline risk assessment, monitoring of ART where viral load is not available, and, in many settings, antiretroviral therapy (ART) initiation decisions. …”
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Challenges and Obstacles in Providing Healthcare Services to the Nomadic Populations, with a Focus on Strengthening the Network System in Khouzestan Province, Iran: A Qualitative A... by Hojjat Rahmani, Sadegh Moradi, Nayeb Fadaei Dehcheshmeh

“…Decision-makers and managers, considering the unique conditions of life in the design and implementation of health programs, decision-makers and managers should prioritize strengthening healthcare networks in hard-to-reach areas. …”
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Continental Assessment of Work-Related Musculoskeletal Disorders Prevalence Among Surgeons: Systematic Review and Meta-Analysis by Philippe Gorce, Julien Jacquier-Bret

“…<b>Methods</b>: Three open databases were scanned without a date limit until 31 December 2024 to select relevant studies. …”
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Into the wild: a mixed-methods pilot study of the mental health benefits of a nature summer camp for urban children with psychological needs by Snimer Nagi, Samantha Kempe, Sophie Barriault, Lara Masri, Sara Dyyat, Caitlin Muhl, Susan Bennett, Nicole Racine

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Research on the Flame-Retardant Performance of Antioxidant Gel Foam in Preventing Spontaneous Coal Combustion by Hu Wen, Ziqi Wang, Maoxia Liu

“…Multi-scale experiments, including FTIR, leakage air testing, programmed temperature rise, and small-scale fire extinction, were conducted to evaluate its performance. …”
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Optimizing sustainable multiple biomass-to-biofuel conversion network with integrated water resource management utilizing data-driven robust planning by Hani Gilani, Hadi Sahebi

“…The third challenge is managing operational risks, such as uncertainty in biofuel demand, which leads to conservative planning and underscores the need for realistic uncertain programming approaches. To address these challenges, the proposed study designs a biofuel conversion network that utilizes third-generation feedstocks and non-edible seed sources, sourcing necessary water from wastewater resources. …”
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Rethinking: Timely Access to Comprehensive Sexual and Reproductive Health Education within the Context of Seasonal Migration in the Urban Slum of the Greater Accra Region, Ghana—A... by Ransford Kwaku Afeadie, Emmanuel Ayetey Appiah

“…Results Migrant adolescents face limited access to SRH education because of their absence in communities, resulting in a lack of confidence in SRH decision-making, leading to low confidence in SRH decision-making. …”
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