Decoding urinary tract infections: pathogen profiles and antimicrobial resistance in a cross-sectional study by Berun A. Abdalla, Khanda A. Anwar, Saman S. Fakhraldden, Bnar Sardar Saida, Rawa Bapir, Sasan M. Ahmed, Ayman M. Mustafa, Hiwa O. Abdullah, Rawezh Q. Salih, Hawnaz S. Abdullah, Hidayat Anwar Yaseen, Wafa A. Hamadameen, Shnya Hawre Ahmed, Rivan O. Saleem, Fahmi H. Kakamad

“…Conclusions The high prevalence of antibiotic resistance and MDR strains limits treatment options, highlighting the urgent need for updated empirical therapy guidelines, enhanced antimicrobial stewardship, and continuous surveillance programs. …”
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Scaling up tuberculosis case finding via private providers in Ghana: an impact evaluation using interrupted time series by Kenneth Mawuta Hayibor, Kenneth Mawuta Hayibor, Ernest Kenu, Gloria Ivy Mensah, Dziedzorm Awalime, Jabina Anaman, Adwoa Asante-Poku, Olena Ivanova, Bakuli Abhishek, Andrea Rachow, Andrea Rachow, Andrea Rachow, Nortey Nii Hanson-Nortey

“…The ITS analyses detected positive post-intervention trend differences in all forms of TB and bacteriologically confirmed TB notification case rates between the intervention and control areas.ConclusionExpanding free TB services through a PPM DOT model and sustained community engagement can increase TB case detection in urban areas. National TB programs should adopt and scale this approach to enhance TB surveillance and control.…”
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Bibliometric analysis of global research on PD-L1/PD-1 pathway and neurodegenerative diseases over the last two decades (2004–2023) by Jialin Wu, Jialin Wu, Chaojin Zhang, Chaojin Zhang, Qiang Cao, Wei Xuan, Xiaorong Huai, Jie Zhou, Jie Tian, Jie Tian

“…BackgroundProgrammed death receptor 1 (PD-1), encoded by the PDCD1 gene, functions as a pivotal immunosuppressive molecule. …”
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Qualitative evaluation of the multilevel influences on mental health and barriers and facilitators to care among Mozambican adolescents with HIV by Kathryn L. Lovero, Yanisa Yusuf, Joana Falcão, Allison Zerbe, Eduarda Pimentel de Gusmão, Thais Ferreira, Claude A. Mellins, Elaine J. Abrams

“…Along with informing Mozambican policy and programming, these findings may be applicable in other high HIV-burden settings to promote AWH mental health and HIV outcomes.…”
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Preclinical and clinical evaluation of intratumoral injection of an IL-12 expressing SKV-012 oncolytic virus for advanced solid tumors by Jing Jin, Zheng Jiang, Jun Liu, Hui Yang, Long Xu, Weiwei Zhang, Xingchen Peng, Nian Yang, Zongliang Zhang, Liangxue Zhou, Aiping Tong, Huaqing Lu, Yongdong Chen, Liyuan Jin

“…Based on this, we then tested the safety, efficacy and immunogenicity of SKV-012 in patients with advanced solid cancers in a phase I clinical trial (NCT06080984). No dose-limiting toxicities were observed, and adverse events were mild. …”
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Antigenic Divergence from the Seasonal Vaccine of the Influenza Virus Strains Circulating in Romania During Three Successive Seasons (2021–2024) by Ovidiu Vlaicu, Leontina Banica, Robert Hohan, Marius Surleac, Dragoş Florea, Victor Daniel Miron, Andreea Tudor, Oana Săndulescu, Anca Cristina Drăgănescu, Dan Oțelea, Simona Paraschiv

“…The viral diversity impacted vaccine efficacy, hence the need for public health programs to increase vaccine uptake and improve vaccine formulation in order to limit viral transmission.…”
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Deceased donor uterus transplantation: religious perceptions by Jana Pittman, Brigitte Gerstl, Brigitte Gerstl, Elena Cavazzoni, Natasha Mireille Rogers, Natasha Mireille Rogers, Mianna Lotz, Rebecca Deans, Rebecca Deans

“…BackgroundUterus transplant now offers an alternative deceased donation treatment option for women with uterine infertility. Limited research exists on religious opinions that may impact the addition of the uterus to current multi-organ deceased donor programsObjectiveTo explore the acceptability of uterus transplantation and deceased uterus donation across different religious groups.DesignA cross-sectional survey of 2,497 participants was conducted between October 2022 and January 2023 in NSW Australia. …”
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Species‐Specific Epigenetic Signature Associates With Heat Stress Tolerance in the Perennial Tree Species Populus by Biruk A. Feyissa, Jun Hyung Lee, Dana Carper, Nancy L. Engle, Timothy J. Tschaplinski, Paul E. Abraham, David J. Weston, Wellington Muchero, Gerald A. Tuskan, Jin‐Gui Chen

“…Our study has demonstrated that priming‐based stress adaptation is species‐specific but can be attained through crossbreeding, indicating its potential use in breeding programs.…”
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The link between amyloid β and ferroptosis pathway in Alzheimer’s disease progression by Naďa Majerníková, Alejandro Marmolejo-Garza, Casandra Salinas Salinas, Minh D. A. Luu, Yuequ Zhang, Marina Trombetta-Lima, Tamara Tomin, Ruth Birner-Gruenberger, Šárka Lehtonen, Jari Koistinaho, Justina C. Wolters, Scott Ayton, Wilfred F. A. den Dunnen, Amalia M. Dolga

“…Recent evidence suggests that ferroptosis, a type of programmed cell death caused by iron accumulation and lipid peroxidation, contributes to AD pathogenesis. …”
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Most prominent challenges in translational neuroscience and strategic solutions to bridge the gaps: Perspectives from an editorial board interrogation by Dirk M. Hermann, Marco Bacigaluppi, Claudio L. Bassetti, Gabrio Bassotti, Johannes Boltze, Andrew Chan, Turgay Dalkara, Adam Denes, Exuperio Diez-Tejedor, Richard Dodel, Thorsten R. Doeppner, Egor Dzyubenko, Ayman ElAli, Tamas Fulop, Alexander Gerhard, Bernd Giebel, Janine Gronewold, Matthias Gunzer, Thomas Heinbockel, Kaibin Huang, Marcello Iriti, Hans-Otto Karnath, Kasteleijn-Nolst Trenite, Ertugrul Kilic, Giuseppe Lanza, Arthur Liesz, Tim Ullrich Magnus, Jessica Mandrioli, Ayan Mohamud-Yusuf, Thomas Müller, Suyue Pan, Luca Peruzzotti-Jametti, Stefano Pluchino, Ryszard Pluta, Aurel Popa-Wagner, Ameneh Rezayof, Mohamed L. Seghier, Xinhua Shu, Vikram Singh, Jussi Sipilä, Mark Slevin, Yamei Tang, Georgios Tsivgoulis, Giustino Varrassi, Chen Wang, Bayram Yilmaz, Maha S. Zaki, Jinwei Zhang

“…Significant barriers remain in the funding of investigator-driven clinical trials through public research programs, as well as the education of translational and clinician scientists dedicated to clinical translation. …”
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Overview of female healthcare providers’ outlooks on cervical cancer screening: a narrative review by Wubishet Gezimu, Ababo Demeke, Firomsa Bekele, Solomon Seyife Alemu, Lema Fikadu, Addisalem Workie Demsash, Geleta Nenko Dube, Gemeda Wakgari Kitil, Elias Ezo

“…Given that healthcare providers are on the frontlines (act as role models) in increasing the community’s cervical cancer screening uptake, we suggest concerned bodies increase screening access and implement staff training programs. In addition, further mixed studies should be considered to deeply understand the possible attributes ingrained in individual and social belief systems.…”
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Barriers to healthcare access: a multilevel analysis of individual- and community-level factors affecting female youths’ access to healthcare services in Senegal by Hailu Aragie, Habtu Kifle Negash, Mihret Getnet, Winta Tesfaye, Yibeltal Yismaw Gela, Tseganesh Asefa, Maru Mandefro Woldeyes, Hiwot Tezera Endale

“…Special emphasis should be placed on addressing the unique challenges faced by unmarried female youth through tailored support programs. Furthermore, community-wide interventions to reduce poverty and enhance overall socioeconomic conditions are essential for creating a sustainable and equitable healthcare environment.…”
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A data-driven approach exploring the entrepreneurial-managerial spectrum by Alexa Booras, Jan Auernhammer, Katerina Monlux, Jennifer Bruno, Sahar Jahanikia, Hua Xie, Neeraj Sonalkar, Manish Saggar

“…Previous research has individually examined specific aspects of entrepreneurial (vs. managerial) work, but limited studies have examined their effects holistically. …”
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Effects of home-based slow-paced breathing on functional performance in middle-aged women: A randomized controlled trial study by Karama Masmoudi, Fatma Chaari, Haithem Rebai, Sonia Sahli

“…Given the low adherence to traditional exercise programs among this population, home-based slow-paced breathing (SPB) presents a promising accessible alternative. …”
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Serplulimab combined with gemcitabine, nab-paclitaxel and stereotactic body radiotherapy as the first-line treatment for patients with metastatic pancreatic adenocarcinoma in China... by Dan Cao, Ke Cheng, Chenyan Zhang, Deying Kang, Ruizhen Li, Chen Chang, Heqi Yang, Junjie Xiong, Du He, Xi-Jiao Liu

“…Introduction Patients with pancreatic ductal adenocarcinoma (PDAC) remain a poor prognosis despite the development of chemotherapy. Although programmed cell death 1 (PD-1) blockade has shown great efficacy in various solid tumours, its application in treating PDAC is limited. …”
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Stigma measurement in health: a systematic reviewResearch in context by Sara Malone, Lara Counts, Luke Zabotka, Anneliese Williams, Nele Loecher, Kayla Wynja, Gemma Bryan, Robin Tanner, Ana Cáceres-Serrano, Gia Ferrara, Lucia Fuentes, Tharwa Bilbeisi, Marissa Maheu, Benjamin K. Oelkers, Muna Ogwo, Lauren Yaeger, Asya Agulnik, Dylan Graetz, Shayla Lawrence, Jocelyn Rivera, Farris Abutineh, Doris Maldonado

“…Funding: Components for the programs involved in this work have been funded by St. …”
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The effects of decentralisation on patient and service outcomes: a case of the 2018 decentralisation of multidrug-resistant tuberculosis in Zambia by Tulani Francis L. Matenga, Malizgani Paul Chavula, Joseph Mumba Zulu, Adam Silumbwe, Patricia Maritim, Margarate N. Munakampe, Batuli Habib, Namakando Liusha, Jeremiah Banda, Ntazana N. Sinyangwe, Chris Mweemba, Angel Mubanga, Patrick Kaonga, Mwiche Musukuma, Henry Phiri, Hikabasa Halwiindi

“…Limited evidence exists on the effects of decentralisation on the quality of TB care provided through public sector decentralisation. …”
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Romidepsin Enhances the Killing Ability of NKG2D-CAR-T Cells through Enhanced Expression of NKG2DL against Ovarian Cancer Cells by Liang Wang, Xite Lin, Lirui Yu, Pengming Sun

“…Levels of interleukin-2 (IL-2) and Pore-forming protein (PFP) were statistically significant at a low target ratio but programmed cell death protein 1 (PD-1) remained unaffected (p ≥ 0.05). …”
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Exploring the health benefits of outdoor exercise for cancer survivors: a systematic review of more than 700 individuals by Sonia Ortega-Gómez, Luca Di Bartolo, Joanna Velissari, Beatriz Gomes, Susanna Pusa, Joshua Thaller, Sofia Papakonstantinou, Musa Kirkar, Ennio Iannitto, Nádia Moura, Carmen Nogueira, Jesús Gustavo Ponce-González, Rebecca Baxter, Paula Tavares, Apostolos Vantarakis, Antonino Bianco, Ana Carbonell-Baeza, David Jiménez-Pavón, the OACCUs consortium

“…Health practitioners should consider incorporating outdoor activities into cancer rehabilitation programs. Systematic review registration PROSPERO CRD42024545392.…”
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Behavioral Drivers Influencing Women’s Decision to Use Self-Injectable Contraception Provided by Community Health Surveillance Assistants in Rural Malawi by Martha Kamanga, Dilys Walker, Address Malata, Mandaachepa Nyando, Jessie Salamba, Alaizi Nkhoma, Innocencia Mtalimanja, Tamanda Jumbe, Emas Potolani, Alfred Maluwa, Chifundo Zimba, Josophine Changole, Rabecca Bika, Emily Himes, Lauren Suchman, Janelli Vallin, Beth Phillips, Jenny Liu, Kelsey Holt

“…However, utilization of SI remains limited, especially in rural areas where access challenges persist. …”
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