Adherence to benzathine penicillin prophylaxis and associated factors in patients with rheumatic heart disease attending two public hospitals in Bahir dar, Ethiopia by Gubaynew Getie Kelemu, Yohannes Tekleab Yihun, Destaw Endeshaw, Eyob Ketema Bogale

“…Abstract Background Regular intramuscular injection of benzathine penicillin every two to four weeks is a critical and cost-effective secondary prevention strategy for reducing morbidity and mortality from rheumatic heart disease (RHD), particularly in resource-limited settings like Ethiopia. However, there is limited evidence of adherence to this prophylaxis. …”
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Ultrasound-Guided High-Intensity Focused Ultrasound Combined With PD-1 Blockade in Patients With Liver Metastases From Lung Cancer: Protocol for a Single-Arm Phase 2 Trial by Chao Hu, Qiang Fu, Fei Fei Gao, Jian Zeng, Wei Xiao, Hui Li, Li Peng, Xi Huang, Li Yang, Wen Zhi Chen, Ming Yan Jiang

“… BackgroundWhile immunotherapy has revolutionized oncological management, its efficacy in lung cancer patients with liver metastases remains limited, potentially due to the unique immunosuppressive microenvironment of the liver. …”
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Immune checkpoint inhibition perturbs neuro-immune homeostasis and impairs cognitive function by Onwodi V. Ifejeokwu, An H. Do, Sanad M. El Khatib, Nhu N. Ho, Angel Zavala, Shivashankar Othy, Munjal M. Acharya

“…Abstract Background Blockade of Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and Programmed Cell Death Protein 1 (PD-1) significantly improves progression-free survival in patients with cancers, including melanoma. …”
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Principle component analysis and determining relationships between the traits of native genotypes of Russian olive in Kerman province by Javad Farrokhi Toolir, Mohammad Abedini Esfahlani

“…The presence of superior leaf traits and the subsequent improvement programs on them can expand the scope of use of elderberry from the fruit-only state. …”
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A simplified, combined protocol versus standard treatment for acute malnutrition in children 6-59 months (ComPAS trial): A cluster-randomized controlled non-inferiority trial in Ke... by Jeanette Bailey, Charles Opondo, Natasha Lelijveld, Bethany Marron, Pamela Onyo, Eunice N Musyoki, Susan W Adongo, Mark Manary, André Briend, Marko Kerac

“…Current treatments differentiate severe acute malnutrition (SAM) from moderate acute malnutrition (MAM) with different products and programs. This differentiation is complex and costly. …”
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How do focus groups of adult males in Bangladesh perceive a standard bidi pack versus existing bidi packs by Sejal Saraf, Joanna E Cohen, Lauren Czaplicki, M Shamimul Islam, A B M Rasheduzzaman, Raniyan Zaman, Sanjana Balagere

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Community-based interventions addressing multiple forms of malnutrition among adolescents in low- and middle-income countries: a scoping review by Marijana Ranisavljev, Adi Lukas Kurniawan, Elisabetta Ferrero, Sachin Shinde, Shuangyu Zhao, Uttara Partap, Ntombizodumo Mkwanazi, Noubar Clarisse Dah, Erick Agure, Hanna Y. Berhane, Christine Neumann, Deda Ogum Alangea, Shuyan Liu, Sergej M. Ostojic, Wafaie W. Fawzi, Fiona Walsh, Till Bärnighausen, ARISE-NUTRINT collaborators

“…The intervention duration ranged from 3 weeks to 2 years, with limited studies grounded in theoretical frameworks. …”
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Unveiling B7/CD28 family proteins in hepatocellular carcinoma: insights into communication and prognostic significance by Yan Cai, Xiaodi Liu, Xiaodi Liu, Tao He, Yangming Xu, Shuxian Chen, Xianliang Tan, Shouchao Wei, Zimeng Wu, Liying Xiao, Baoming Luo, Baoming Luo

“…BackgroundImmunotherapy has made remarkable achievements in cancer treatment, but it still faces the challenge of limited response rates in liver cancer therapy. Although there has been extensive research on the role of programmed cell death-ligand 1 (PD-L1) in hepatocellular carcinoma (HCC), our understanding of the effects of other inhibitory B7/CD28 family members is still limited despite advancements in prognostic tools, more specific, accurate, and robust biomarkers are required to improve HCC patient prognoses.MethodsWe acquired the single-cell sequencing data from relevant literature and selected 42 liver tissue samples, including 89,246 cells from HCC patients, to investigate the expression, localization, and intercellular communications of the B7/CD28 family in HCC. …”
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Pesticide Residues in Fruits and Vegetables from Cape Verde: A Multi-Year Monitoring and Dietary Risk Assessment Study by Andrea Acosta-Dacal, Ricardo Díaz-Díaz, Pablo Alonso-González, María del Mar Bernal-Suárez, Eva Parga-Dans, Lluis Serra-Majem, Adriana Ortiz-Andrellucchi, Manuel Zumbado, Edson Santos, Verena Furtado, Miriam Livramento, Dalila Silva, Octavio P. Luzardo

“…Food safety concerns related to pesticide residues in fruits and vegetables have increased globally, particularly in regions where monitoring programs are scarce or inconsistent. This study provides the first multi-year evaluation of pesticide contamination and associated dietary risks in Cape Verde, an African island nation increasingly reliant on imported produce. …”
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Utilizing multidisciplinary mobile outreach clinics to provide comprehensive diabetic foot care to patients experiencing homelessness by Kris M. Boelitz, MD, Jaeyoung Lee, BS, Michael D. Pepin, BS, Yiming Zhang, MS, Mallory Gibbons, MSN, NP, Frances J. Lagana, DPM, Shahida Balaparya, EdD, MBA, RVT, Lindsey Carr, Jessin Varghese, BS, NP, Caitlin Sorensen, MD, Jessica P. Simons, MD, MPH, Douglas Jones, MS, MD, Andres Schanzer, MD, Tammy T. Nguyen, MD, PhD

“…Background: Social determinants of health (SDoH) challenges can limit health care access and impose significant barriers to care, which have been amplified during the COVID-19 pandemic. …”
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First-in-human phase 1 dose-escalation results with livmoniplimab, an antibody targeting the GARP:TGF-ß1 complex, as monotherapy and in combination with the anti–PD-1 antibody budi... by Toshio Shimizu, Toshio Shimizu, John Powderly, Albiruni Abdul Razak, Patricia LoRusso, Kathy D. Miller, Steven Kao, Sarah Kongpachith, Catherine Tribouley, Michelle Graham, Brian Stoll, Maulik Patel, Mohammad Sahtout, Martha Blaney, Rachel Leibman, Talia Golan, Talia Golan, Anthony Tolcher

“…Secondary objectives were to assess safety and pharmacokinetics (PK), and exploratory objectives included evaluating preliminary efficacy.ResultsFifty-seven patients enrolled in the dose escalation: 23 in monotherapy cohorts and 34 in combination therapy cohorts. Dose-limiting toxicities were limited, no maximum tolerated dose was reached, and the maximum administered dose of 1500mg was selected for dose expansion. …”
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Exploring caregiver challenges, digital health technologies, and healthcare support: a qualitative study by Humairah Zainal, Xin Xiaohui, Julian Thumboo, Julian Thumboo, Siang Joo Seah, Low Lian Leng, Low Lian Leng, Low Lian Leng, Fong Kok Yong, Fong Kok Yong

“…Solutions proposed included caregiver-targeted training programs, streamlined digital access to care, improved DHT design, equitable access to DHTs, age-inclusive healthcare services, affordability schemes, and culturally sensitive support.DiscussionThis study highlights significant barriers to DHT adoption among informal caregivers and offers practical strategies to improve their use. …”
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Adolescent health and well‐being in sub‐Saharan Africa: Strengthening knowledge base and research capacity through a collaborative multi‐country school‐based study by Sachin Shinde, Ramadhani Abdallah Noor, Mary Mwanyika‐Sando, Mosa Moshabela, Amare W. Tadesse, Huda Sherfi, Alain Vandormael, Tara Young, Amani Tinkasimile, Roisin Drysdale, Till Baernighausen, Deepika Sharma, Wafaie W. Fawzi

“…Additionally, a desk review of health and school meal policies and programs and a qualitative investigation into health and food environments in schools were conducted with students, administrators, and food vendors. …”
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Utilization of Smartphone Applications by Anesthesia Providers by Michael S. Green, Johann J. Mathew, Archana Gundigi Venkatesh, Parmis Green, Rayhan Tariq

“…Smartphone app stores were searched, and a survey was sent to 416 anesthesia providers at 136 anesthesiology residency programs querying specific facets of application use. …”
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Integrative analysis of immunogenic PANoptosis and experimental validation of cinobufagin-induced activation to enhance glioma immunotherapy by Yonghua Cai, Heng Xiao, Shuaishuai Xue, Peng Li, Zhengming Zhan, Jie Lin, Zibin Song, Jun Liu, Wei Xu, Qixiong Zhou, Songtao Qi, Xi’an Zhang, Ziyi Luo

“…Abstract Background Glioma, particularly glioblastoma (GBM), is a highly aggressive tumor with limited responsiveness to immunotherapy. PANoptosis, a form of programmed cell death merging pyroptosis, apoptosis, and necroptosis, plays an important role in reshaping the tumor microenvironment (TME) and enhancing immunotherapy effectiveness. …”
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Development of a controlled-release mosquito RNAi yeast larvicide suitable for the sustained control of large water storage containers by Keshava Mysore, James D. Oxley, Craig Duckham, Clarissa Castilla-Gutierrez, Akilah T. M. Stewart, Nikhella Winter, Rachel Shui Feng, Satish Singh, Lester D. James, Azad Mohammed, David W. Severson, Molly Duman-Scheel

“…Increasing concerns for insecticide resistance and larvicide safety are limiting the successful treatment of large household water storage containers, which are among the most productive habitats for Aedes juveniles. …”
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Exploring the perceptions and requirements of exergames for adolescents with depression: a qualitative study by Yuqi Chen, Xiaolong Huang, Wei Luo, Haiyan Liu, Yaqin Gao, Muyao Wang, Yan Zhang, Jingjing Liu, Changyan Zhong, Aixiang Xiao, Yu Chen

“…Exergames hold the potential to provide a positive entertainment experience, yet their utilization among adolescents with depression remains limited. This study aims to investigate the perceptions and requirements regarding exergames in adolescents with depression, with the goal of designing tailored exergame intervention programs for clinical applications. …”
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A Multicenter Study on the Challenges and Real-World Utilization of Immune Checkpoint Inhibitors in Resource-Constrained Settings: Insights and Implications from India by Ashwin Oommen Philips, Sunu Cyriac, P. Unnikrishnan, Anil T. Jose, Krishnakumar Rathnam, S.V. Saju, Smita Kayal, Soumya Surath Panda, Lalatendu Moharana, Sindhu Kilaru, Amit Sehrawat, Deepak Sundriyal, Puneet Dhamija, Deepak Jain, Pamela Alice K., Jaineet Sachdeva, Nishant Batta, Raman Arora, Yogesh Arora, Harpreet Singh, Mridul Anand, Ishu Sharma, Prasanth Ganesan

“…Ninety-one patients were analyzed; lung cancer (39.6%) and renal cancer (11%) were the main indications for ICI use. Programmed death ligand 1 expression was tested in 40.7% and tumor mutational burden in 3.3%. …”
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Unveiling the qualities of a ‘good doctor’: family carers’ and healthcare professionals’ perspective on dementia healthcare in India by Upasana Baruah, Rachita Rao, Josefine Antoniades, Santosh Loganathan, Mathew Varghese, Claudia Cooper, Mike Kent, Briony Dow, Bianca Brijnath

“…Conclusion Findings highlight a need for training programs for healthcare professionals to foster the values inherent to delivery of person-centered care.…”
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Cost-Effective Detection of SNPs and Structural Variations in Full-Length Genes of Wheat and Sunflower Using Multiplex PCR and Rapid Nanopore Kit by Ekaterina Polkhovskaya, Evgeniy Moskalev, Pavel Merkulov, Ksenia Dudnikova, Maxim Dudnikov, Ivan Gruzdev, Yakov Demurin, Alexander Soloviev, Ilya Kirov

“…Although current high-throughput genotyping methods are efficient in detecting known polymorphisms, they are limited when multiple variant sites are scattered along the gene. …”
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