Direct conversion of urine-derived cells into functional motor neuron-like cells by defined transcription factors by Hiroaki Nagai, Masayo Saito, Hidehisa Iwata

“…Urine-derived cells (UDCs) are an alternative cell source and can be obtained via noninvasive procedures. Herein, induced motor neuron-like cells (iMNs) were generated from UDCs by transducing transcription factors involved in motor neuron (MN) differentiation. iMNs exhibited neuronal morphology, upregulation of pan-neuron and MN markers, and MN functionality, including spontaneous calcium oscillation and bungarotoxin-positive neuromuscular junction formation, when co-cultured with myotubes. …”
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Detecting cognitive motor dissociation by functional near-infrared spectroscopy by Yan Wang, Yan Wang, Yan Wang, Wentao Zeng, Wentao Zeng, Wentao Zeng, Leyao Zou, Leyao Zou, Leyao Zou, Qijun Wang, Bingkai Ren, Bingkai Ren, Bingkai Ren, Qi Xiong, Yang Bai, Yang Bai, Yang Bai, Zhen Feng, Zhen Feng, Zhen Feng

“…BackgroundBehavioral assessment based on external manifestations of consciousness fails for patients with cognitive motor dissociation (CMD). Functional near-infrared spectroscopy (fNIRS) is an emerging neuroimaging technique that can detect internal brain functional activities. …”
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Mild Zika Virus Infection in Mice Without Motor Impairments Induces Working Memory Deficits, Anxiety-like Behaviors, and Dysregulation of Immunity and Synaptic Vesicle Pathways by Jaime Alexander Chivatá-Ávila, Paola Rojas-Estevez, Alejandra M. Muñoz-Suarez, Esthefanny Caro-Morales, Aura Caterine Rengifo, Orlando Torres-Fernández, Jose Manuel Lozano, Diego A. Álvarez-Díaz

“…The infection induced mild cognitive behavioral changes, though motor and motivational functions remained unaffected. …”
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DBS in the restoration of motor functional recovery following spinal cord injury by Wen-yuan Li, Wen-yuan Li, Wen-rui Qu, Yi Li, Yi Li, Shu-ying Wang, Shu-ying Wang, Dong-ming Liu, Ling-xiao Deng, Ying Wang, Ying Wang

“…The landscape of therapeutic deep brain stimulation (DBS) for locomotor function recovery is rapidly evolving. This review provides an overview of electrical neuromodulation effects on spinal cord injury (SCI), focusing on DBS for motor functional recovery in human and animal models. …”
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Motor and balance function disorders and possibilities of their correction in patients with obesity and metabolic syndrome by L. A. Marchenkova, V. A. Vasileva

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A motor function for the DEAD-box RNA helicase, Gemin3, in Drosophila. by Ruben J Cauchi, Kay E Davies, Ji-Long Liu

“…Our findings suggest that Drosophila Gemin3 is required for larval development and motor function.…”
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Outcomes of specialist physiotherapy for functional motor disorder: the Physio4FMD RCT by Glenn Nielsen, Louise Marston, Rachael Maree Hunter, Alan Carson, Laura H Goldstein, Kate Holt, Teresa C Lee, Marie Le Novere, Jonathan Marsden, Irwin Nazareth, Hayley Noble, Markus Reuber, Jon Stone, Ann-Marie Strudwick, Beatriz Santana Suarez, Mark J Edwards

“…Future work Future work should identify or develop more suitable outcome measures for functional motor disorder research, explore who is most likely to benefit from specialist physiotherapy and identify alternative interventions for those unlikely to benefit from this treatment. …”
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Mis-localization of endogenous TDP-43 leads to ALS-like early-stage metabolic dysfunction and progressive motor deficits by Yiying Hu, Alexander Hruscha, Chenchen Pan, Martina Schifferer, Michael K. Schmidt, Brigitte Nuscher, Martin Giera, Sarantos Kostidis, Özge Burhan, Frauke van Bebber, Dieter Edbauer, Thomas Arzberger, Christian Haass, Bettina Schmid

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A Single Motor Donor Nerve for Two Functional Free Flaps in Facial Reanimation by Omar Hausien, MBBChir, MA (Cantab), MRCS, Lucia Pannuto, FEBOPRAS, Kallirroi Tzafetta, FRCS(Plast)

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REM density in Parkinson’s disease: association with motor, cognitive, autonomic function, and dopaminergic medication by Andrew Dagay, Shlomit Katzav, Noa Elisha, Jana Volkov, Riva Tauman, Nir Giladi, Jeffrey M. Hausdorff, Anat Mirelman, Jennifer Zitser

“…These findings highlight the role of motor and cognitive functions in the generation of rapid eye movements in PD. …”
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Relative improvement in language vs. motor functions with reperfusion therapies for large vessel occlusion by Zaka Ahmed, Vivek Yedavalli, Wladimir Sarmiento Gonzalez, Argye E. Hillis

“…Because deep and motor areas often infarct relatively early in acute stroke, we hypothesized that reperfusion therapies improve predominantly cortical functions more than motor function. …”
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Association of Chronic Pain with Motor Symptom Severity in Parkinson’s Disease: An Exploratory Cross-Sectional Analysis by Niels Pacheco-Barrios, Vivian D. B. Gagliardi, Roberta R. Grudtner, Iloba Gabriel Njokanma, Ben Illigens, John D. Rolston, Felipe Fregni, Kevin Pacheco-Barrios

“…Background: Parkinson’s disease (PD) is a neurodegenerative disorder characterized by motor symptoms like bradykinesia, tremor, rigidity, and postural instability. …”
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Simplified cerebellum-like spiking neural network as short-range timing function for the talking robot by Vo Nhu Thanh, Hideyuki Sawada

“…In the human brain, the cerebellum plays a key role in the coordination, precision and timing of motor responses. We have developed a talking robot, which generates human-like vocal sounds using a simplified cerebellum-like neural network model as the timing function. …”
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Cognitive functions and their relation to balance and agility in athletes from different sports branches by Dilara Özen Oruk, Kılıçhan Bayar, Özcan Saygın, Banu Bayar

“…Successful performance in each sport requires high ability in various features, including motor and perceptual-cognitive skills. The aim of this study was to compare balance and agility in athletes from several sports branches in order to find out how cognitive functions relate to these parameters. …”
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C. elegans dopaminergic D2-like receptors delimit recurrent cholinergic-mediated motor programs during a goal-oriented behavior. by Paola Correa, Brigitte LeBoeuf, L René García

“…Calcium imaging and optogenetics suggest that heightened DA-expressing ray neuron activities coincide with the cholinergic cloacal ganglia function during spicule insertion attempts. D2-like receptor signaling also attenuates the excitability of additional mating circuits to reduce the duration of mating attempts with unproductive and/or inappropriate partners. …”
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Cognitive and motor disturbances in depression: insights from comprehensive behavioral assessments by Ioanna Douka, Marit F. L. Ruitenberg, Marit F. L. Ruitenberg, Kamile Weischedel, Carlos Phouthavongsay, Sara L. Weisenbach, Jos N. van der Geest, Brian J. Mickey, Vincent Koppelmans

“…Patients with severe psychomotor retardation often respond poorly to SSRIs but benefit from neurostimulation like ECT. However, comprehensive assessments of cognitive and motor domains in the same depression sample are rare.MethodsThis pilot study compared 20 depressed patients and 22 controls across multiple tests of cognitive and motor functions. …”
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Green tea silver nanoparticles improve physiological motor and cognitive function in BALB/c mice during inflammation by Herbert Izo, Ninsiima, Ejike, Daniel Eze, Kenneth, Ssekatawa, Halima, Nalugo, Caroline, Asekenye, David, Onanyang, Edson Ireeta, Munanura, Moses, Ariong, Kevin, Matama, Gerald, Zirintunda, Ngala Elvis, Mbiydzenyuy, Fred, Ssempijja, Adam Moyosore, Afodun, Ibe Michael, Usman, Oscar Hilary, Asiimwe, Julius, Tibyangye, Keneth Iceland, Kasozi

“…Concen- trations of green tea AgNPs modulated basic sensory and motor behaviors in BALB/c male mice demonstrating their importance in complementary and integrative medical practice.…”
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Cognitive and Motor Function Effects of Antipsychotics in Traumatic Brain Injury: A Systematic Review of Pre-Clinical Studies by Gabrielle Cataford, Laurie-Anne Monton, Stephanie Karzon, Camille Livernoche-Leduc, Mar Saavedra-Mitjans, Marie-Julie Potvin, Francis Bernard, Lisa Burry, Caroline Arbour, David R. Williamson

“…The analysis revealed no consistent effect of haloperidol on motor functions, but risperidone was associated with a significant impairment in motor function on day 5 post-injury (7.05 sec; 95% confidence interval [CI]: 1.47, 12.62; I2 = 92%). …”
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Effect of low-energy extracorporeal shock wave on vascular regeneration after spinal cord injury and the recovery of motor function by Wang L, Jiang Y, Jiang Z, Han L

“…After SCI, the Basso, Beattie, and Bresnahan (BBB) scale was used to evaluate motor function over a period of 42 days at different time points. …”
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The gain-of-function UBE3A Q588E variant causes Angelman-like neurodevelopmental phenotypes in mice by Kellan P. Weston, Anna M. Gunelson, Susan E. Maloney, Xia Ge, Jalin A. Stelzer, Kwang-Soo Kim, Shylyn Collier, Marissa M. Mindt, Megan J. Agajanian, Michael B. Major, Dennis Goldfarb, Kevin K. Noguchi, Jason J. Yi

“…Abstract Mutations in the E3 ubiquitin ligase UBE3A that cause enzymatic gain-of-function result in disease phenotypes which differ from classic Angelman syndrome. …”
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