Vortioxetine alleviates motor, cognitive and emotional disorders in post-stroke rats by regulating the TLR-2/NF-κB pathway by Ziqiang Dong, Zhihui Dong, Lili Xu, Jinfeng Zhang, Lin Li, Rongjuan Wang, Xiaoyan Huang, Zhengqiang Zou, Zhengqiang Zou, Zhengqiang Zou, Zhengqiang Zou

“…Collectively, our work underscores VTX’s promising role in enhancing motor, cognitive functions, and mitigating depressive symptoms following cerebrovascular accidents, potentially through inflammation regulation. …”
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Gait analysis in a Mecp2 knockout mouse model of Rett syndrome reveals early-onset and progressive motor deficits. by Kamal K E Gadalla, Paul D Ross, John S Riddell, Mark E S Bailey, Stuart R Cobb

“…Mice harbouring knockout mutations in the Mecp2 gene display many RTT-like characteristics and are central to efforts to find novel therapies for the disorder. …”
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Hydroxyapatite microspheres encapsulated within hybrid hydrogel promote skin regeneration through the activation of Calcium Signaling and Motor Protein pathway by Shuo Liu, Lu Song, Shuwen Huang, Zhanhong Liu, Yang Xu, Zhiyuan Wang, He Qiu, Jing Wang, Zhiru Chen, Yumei Xiao, Hang Wang, Xiangdong Zhu, Kai Zhang, Xingdong Zhang, Hai Lin

“…HAp enhanced the fibroblast functionality by triggering minimal adaptive immune responses and enhancing the Calcium Signaling and Motor Protein Signaling pathways. …”
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An isolated asymmetrical AC-DC converter based brushless direct current motor drive without bridge rectifier and low pass filter by Tanmay Shukla

“…Asymmetrical converter functions as an isolated buck-boost during positive cycle (PC) and works like an isolated SEPIC during negative cycle (NC) of the source voltage. …”
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Neural Plasticity in Multiple Sclerosis: The Functional and Molecular Background by Dominika Justyna Ksiazek-Winiarek, Piotr Szpakowski, Andrzej Glabinski

“…Regardless of the numerous studies, the molecular background of neuronal plasticity in MS is still not well understood. Several factors, like IL-1β, BDNF, PDGF, or CB1Rs, have been implicated in functional recovery from the acute phase of MS and are thus considered as potential therapeutic targets.…”
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HPSE-mediated proinflammatory signaling contributes to neurobehavioral deficits following intranasal HSV-1 infection by Hemant Borase, Chandrashekhar D. Patil, Tibor Valyi-Nagy, Deepak Shukla

“…Additionally, we found that moderate activation of toll-like receptors (TLRs), particularly in Hpse+/+ mice, may contribute to the activation of the inflammasome pathway. …”
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Understanding Pathways from Cognitive Biases to the Risk of Psychosis: A Network Analysis Approach by Xi C, Wang S

“…Depressive symptom nodes serve as critical mediators between subjective cognitive problems and PLEs, underscoring their pivotal function in driving the development of PLEs among adolescents with cognitive biases. …”
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The insulin-like peptide INS-27 mediates a muscle-to-neuron feedback signal coupling muscle activity with AMPA receptor trafficking. by Bethany J Rennich, Regina M Powers, Samantha Moores, Molly Hodul, Peter Juo

“…Here, we show that the insulin-like peptide INS-27 mediates a muscle-to-neuron signal that promotes surface levels of the C. elegans AMPAR GLR-1 at synapses in pre-motor AVA interneurons that reside two synaptic layers upstream of the neuromuscular junction. …”
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Effects of subanesthetic dose of ketamine on motor and cognitive outcomes of harmaline-induced essential tremor model: a focus on Lingo-1 and inflammatory pathways by Mehran Ilaghi, Zeynab Pirmoradi, Zahra Esmaili, Shamim Hosseinalipour, Leili Rouhi, Adel Soltanizadeh, Mohsen Nakhaie, Kiana Sharififar, Moazamehosadat Razavinasab, Mohammad Shabani

“…Conclusion Our findings suggest that ketamine has limited efficacy in the harmaline ET model, showing some improvements in motor function and anxiety-like behavior but failing to address core tremor symptoms or modulate inflammatory and Lingo-1 pathways. …”
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Insulin-like growth factor 2 reduces Huntington’s disease aggregates via AKT and NF-κB signaling in huntington’s disease by Yun-Shiuan Tung, Chih-Wei Tung, Siew Chin Chan, Yi-Ching Chen, Po-Ming Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang

“…In vivo studies in R6/2 HD transgenic mice reveal that IGF2 administration improves motor functions and decreases mHTT levels. Conclusions Collectively, our findings elucidate the multifaceted role of IGF2 in HD, highlighting its therapeutic potential through modulation of AKT and NF-κB signaling pathways.…”
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Phosphodiesterase inhibition and Gucy2C activation enhance tyrosine hydroxylase Ser40 phosphorylation and improve 6-hydroxydopamine-induced motor deficits by Erik H. Douma, Jesse Stoop, Matthijs V. R. Lingl, Marten P. Smidt, Lars P. van der Heide

“…Conclusions This study underscores the therapeutic potential of enhancing tyrosine hydroxylase Ser40 phosphorylation to improve motor function in Parkinson’s disease. Both PDE inhibition and GUCY2C activation represent promising non-invasive strategies to modulate endogenous dopamine biosynthesis and address motor deficits. …”
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Clinic and pathophysiology of false sensory perceptions in the scientific views of Viktor Kandinsky by E. V. Snedkov, A. E. Veraksa, P. Y. Muchnik

“…Kandinsky was the first in the world to present a detailed differentiation of clinical forms of false sensory perceptions, specificating simple hallucinations, dream-like hallucinations and two varieties of pseudohallucinations. …”
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Changes in the miRNA-mRNA Regulatory Network Precede Motor Symptoms in a Mouse Model of Multiple System Atrophy: Clinical Implications. by Simon Schafferer, Rimpi Khurana, Violetta Refolo, Serena Venezia, Edith Sturm, Paolo Piatti, Clara Hechenberger, Hubert Hackl, Roman Kessler, Michaela Willi, Ronald Gstir, Anne Krogsdam, Alexandra Lusser, Werner Poewe, Gregor K Wenning, Alexander Hüttenhofer, Nadia Stefanova

“…Analysis was performed at a time point when α-synuclein accumulation was already present in oligodendrocytes at neuropathological examination, but no neuronal loss nor deficits of motor function had yet occurred. Our data provide a first evidence for the leading role of gene dysregulation associated with deficits in immune and inflammatory responses in the very early, non-symptomatic disease stages of MSA. …”
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Effects of Mental Fatigue on Gait Performance and Variability by Ali Zardosht, Jessie Daw, Lee T Atkins, C Roger James, Hyung Suk Yang

“…OBJECTIVES Mental fatigue has been shown to negatively impact physical performance, including motor skills and neuromuscular function. This study aimed to investigate the effects of mental fatigue on gait performance and variability in healthy young male adults. …”
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Modulation of NMDA receptor signaling and zinc chelation prevent seizure-like events in a zebrafish model of SLC13A5 epilepsy. by Deepika Dogra, Van Anh Phan, Sinan Zhang, Cezar Gavrilovici, Nadia DiMarzo, Ankita Narang, Kingsley Ibhazehiebo, Deborah M Kurrasch

“…Here, we used CRISPR/Cas9 to create loss-of-function mutations in slc13a5a and slc13a5b, the zebrafish paralogs to human SLC13A5. slc13a5 mutant larvae showed cognitive dysfunction and sleep disturbances, consistent with SLC13A5 individuals. …”
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Regulation of cochlear hair cell function by intracellular calcium stores by Ghanshyam P. Sinha, Gregory I. Frolenkov

“…IntroductionMammalian hearing depends on the dual mechanosensory and motor functions of cochlear hair cells. Both these functions may be regulated by Ca2+ release from intracellular stores. …”
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Process Industry Undergoing Electrification: New Challenges in Functional Safety by Angela Lotti, Diego Maporti, Martin Baumgaertl, Paolo Mocellin, Gianluca Pauletto

“…It was found that the Safe Torque Off (STO) function, commonly used in inverters, could provide a reliable and compact method for safely powering off thyristors. …”
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Longitudinal associations between physical performance and cognition in individuals with Parkinson’s disease by Andrew J. Petkus, Ryan P. Foreman, Matthew Pilgrim, Aram Kim, Elise Hong, Beth E. Fisher, John D. Van Horn, David Wing, Michael W. Jakowec, Dawn M. Schiehser, Giselle M. Petzinger

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An fMRI Study of Intra-Individual Functional Topography in the Human Cerebellum by Catherine J. Stoodley, Eve M. Valera, Jeremy D. Schmahmann

“…Neuroimaging studies report cerebellar activation during both motor and non-motor paradigms, and suggest a functional topography within the cerebellum. …”
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Experimental Investigation and Simultaneous Optimisation of Honing Parameters of Dry Cast Iron Cylinder Relining Sleeves of Motor Vehicle Engine Blocks for Surface Finish and Energ... by Nicholas Tayisepi, Lameck Mugwagwa, Albert Mnkandla, Innocent Mapindu, Takudzwa Muhla

“…Honing operations, are vital machining manufacturing operations, utilised in the motor vehicles engine block cylinders internal surfaces super-finishing process, for improving many functional attributes of the machined cylinders. …”
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