Cerebrospinal fluid-contacting neurons are sensory neurons with uniform morphological and region-specific electrophysiological properties in the mouse spinal cord by Elysa Crozat, Edith Blasco, Jorge Ramirez-Franco, Priscille Riondel, Nina Jurčić, Riad Seddik, Caroline Michelle, Jérôme Trouslard, Nicolas Wanaverbecq

“…They express Polycystin Kidney Disease 2-Like 1 channels (PKD2L1), members of the Transient Receptor Potential superfamily, and were shown to modulate motor activity and therefore suggested to act as a novel sensory system. …”
Get full text

Binocular and Fellow Eye Acuity Deficits in Amblyopia: Impact of Fixation Instability and Sensory Factors by Yulia Haraguchi, Gokce Busra Cakir, Aasef Shaikh, Fatema Ghasia

“…These findings suggest amblyopia affects both visual sensory and motor systems, impacting binocular function and fixation stability, with potential consequences for everyday visuomotor tasks like reading.…”
Get full text

Walking reduces the risk of dementia in patients with Parkinson’s disease: a longitudinal follow-up study by Cheng-Yu Wei, Ray-Chang Tzeng, Hsu-Chih Tai, Chun-Hsien Su, Pai-Yi Chiu

“…However, such activities are less feasible for patients with Parkinson’s disease (PD) or other motor dysfunctions. Objectives: In this study, we investigated whether the minimal amount of exercise (MAE) through walking, which is practical for individuals with motor dysfunction, can reduce the risk of dementia in patients with PD. …”
Get full text

HIPSC-DIFFERENTIATED DOPAMINERGIC NEURONS ARE A USEFUL TOOL FOR STUDYING THEIR NEUROPHYSIOLOGY AND MATURATION by .O. Pavlova, L. Vandries, V. Seutin

“…Dopaminergic (DA) neurons play a crucial role in motor control, motivation, and cognition, with their degeneration in Parkinson’s disease leading to severe motor deficits. …”
Get full text

Deciphering the role of CAPZA2 in neurodevelopmental disorders: insights from mouse models by Mei Guo, Liming Liu, Xiao Mao, Manyu Xiao, Xiaobin He, Xing Pan, Yuewen Chen, Wanying Yi, Qibin Li, Xianglan Piao, Hua Wang, Yang Du, Yong Cheng

“…Behavioral assays revealed that CAPZA2+/− mice exhibited motor dysfunction and anxiety-like behaviors, along with impairments in both spatial and non-spatial memory, accompanied by deficits in social interactions. …”
Get full text

Abstract 145: Hyperacute Virtual Reality Augmented Rehabilitation (VRAR) in the Neurological ICU: A Safety and Feasibility Study by Galadu Subah, Fangyi Lin, Tiffany Ming, Kevin Clare, Akihiko Oishi, Akash Thacker, Sarah Bulbul, Anaz Uddin, Eric Feldstein, Bridget Nolan, Jose Dominguez, Sabrina Zeller, Simon Hanft, Chirag Gandhi, Fawaz Al‐Mufti

“…Introduction Virtual reality (VR) has shown great promise in stroke rehabilitation, providing interactive exercises that target motor and cognitive impairments with minimal adverse events and positive outcomes in improving motor function, balance, and patient motivation. …”
Get full text

Sinbaglustat ameliorates disease pathology in a murine model of GM1 gangliosidosis without affecting CNS ganglioside levels by Rouven Wannemacher, Lorna Jubran-Rudolf, Isabel Zdora, Eva Leitzen, Karl Rohn, Virginie Sippel, Christoph Paschen, Peter Blattmann, Wolfgang Baumgärtner, Ingo Gerhauser, Michel Alexander Steiner

“…Body weight, clinical and neurological signs, and motor function was assessed until 17–18 weeks (4 months) and 30 weeks (7 months) of age when mice were euthanized for ex vivo assessments. …”
Get full text

Neuroprotective properties of GABA and its derivatives in diabetic encephalopathy in old animals by I. N. Tyurenkov, D. A. Bakulin, A. V. Smirnov, M. R. Ekova, A. I. Bisinbekova, G. L. Snigur, Yu. I. Velikorodnaya, E. I. Morkovin, D. V. Verkholyak, O. S. Vasilyeva

“…In the animals with DM, after 6 weeks of the test substances administration, higher rates of sensory-motor and cognitive functions and a less structural damage to the sensory-motor cortex and the brain hippocampus were recorded. …”
Get full text

Drosophila neurotrophins reveal a common mechanism for nervous system formation. by Bangfu Zhu, Jenny A Pennack, Peter McQuilton, Manuel G Forero, Kenji Mizuguchi, Ben Sutcliffe, Chun-Jing Gu, Janine C Fenton, Alicia Hidalgo

“…By investigating with genetics the consequences of removing DNT1 or adding it in excess, we show that DNT1 maintains neuronal survival, as more neurons die in DNT1 mutants and expression of DNT1 rescues naturally occurring cell death, and it enables targeting by motor neurons. We show that Spätzle and a further fly neurotrophin superfamily member, DNT2, also have neurotrophic functions in flies. …”
Get full text

Probiotic treatment induces sex-dependent neuroprotection and gut microbiome shifts after traumatic brain injury by Morgan Holcomb, Austin G. Marshall, Hannah Flinn, Mariana Lozano-Cavazos, Sirena Soriano, Fernando Gomez-Pinilla, Todd J. Treangen, Sonia Villapol

“…Additionally, PP treatment improved motor recovery in males and alleviated depressive-like behaviors in females. …”
Get full text

PTEN deficiency in postnatally developing Purkinje cells disrupts metabolic signaling, leading to dendritic abnormalities and sex-specific behavioral deficits by Lindsay J. Walsh, Izabella M. Espinal-San Miguel, Ana V. Rodriguez, Ursula M. Peña, Kiley E. Flynn, Will C. Remillard, Siena R. Brazier, Natalia I. Anderson, Aidan J. Clark, Tiffany A. De Varona, Ileana Soto

“…Abstract Conditional deletion of the Pten gene in cerebellar Purkinje cells (PCs) results in cellular hypertrophy, neurodegeneration, and autism-like behaviors in adult mice. Here, we investigated the effects of PTEN conditional deficiency on PC dendritic development and early postnatal motor, spontaneous, and social behaviors. …”
Get full text

La actividad física y la psicomotricidad en las personas mayores: sus contribuciones para el envejecimiento activo, saludable y satisfactorio = The physical and psychomotor activit... by Menéndez Montañés, María Concepción, Kist, Rosane Bernardete Brochier

“…The demographic aging of the population at world-wide level has caused an alert one on the importance of guaranteeing that the people majors can live better and with greater independence from the maintenance of its functional capacities. In this article we present the bio-psycho-social benefits of the physical activity for the promotion of the active and healthful aging, and the importance of Psychomotricity like a technique of corporal intervention appear that can influence of positive way in the personnel competence and efficiency motor, the cognition, the affectivity, the well-being and the socialization of the aged people, reducing the risks of deterioration and social marginalization…”
Get full text

Overview of Binocular Diplopia: Etiology, Assessment Methods, and Treatment Strategies by Yasir Adil Shakor, Razieh Bahreini, Ali Majdi

“…This study emphasizes the complexity of diplopia, distinguishing between monocular and binocular types, and motor and sensory forms. Management involves functional therapies, prismatic correction, and if needed, botulinum toxin or surgery. …”
Get full text

Designing and modeling an intelligent system for managing the distribution and scheduling of farmed fish feed using the Arduino Uno microcontroller by Shayesteh Tabatabaei

“…By the Arduino output components, the system injects feed into the aquaculture environment using mechanisms like servo motors. Additionally, the system has the capability to adjust the feeding schedule based on the nutritional needs of the fish, enhancing efficiency and minimizing the need for human intervention. …”
Get full text

PINK1 deficiency rewires early immune responses in a mouse model of Parkinson’s disease triggered by intestinal infection by Sherilyn Junelle Recinto, Alexandra Kazanova, Lin Liu, Brendan Cordeiro, Shobina Premachandran, Hicham Bessaiah, Alexis Allot, Elia Afanasiev, Sriparna Mukherjee, Jessica Pei, Adam MacDonald, Moein Yaqubi, Heidi M. McBride, Diana Matheoud, Louis-Eric Trudeau, Samantha Gruenheid, Jo Anne Stratton

“…We previously developed a model system in PINK1 KO mice displaying PD-like motor symptoms at late stages following intestinal infections. …”
Get full text

Effects of nicotine on catecholaminergic neurotransmission in a premotor stage model of Parkinson’s disease by Cristina Cosi, Agnes Auclair, Veronique Ravailhe, Nathalie Malfetes, Veronique N’Guyen

“…A partial 6-hydroxydopamine (OHDA) bilateral lesion of the dorsal striatum (DS) in rats induces impairments in cognitive functions, social behavior, and depressive-like behavior, with little effect on locomotor activity, whether spontaneous or forced. …”
Get full text

Disruption of axonal transport in Parkinson’s disease: the role of pathological α-Syn and AMPK/p38 MAPK signaling by Xiaoman Yang, Zhuoran Ma, Piaopiao Lian, Yi Wu, Ke Liu, Zhaoyuan Zhang, Zhicheng Tang, Yan Xu, Xuebing Cao

“…Mechanisms by which PFFs caused axonal transport defects of dopamine neurons in PD-like models. (A) Shows normal axonal transport. (B) Demonstrates how PFFs increase ?…”
Get full text

Application of Nanobiosensor engineering in the diagnosis of neurodegenerative disorders by Thikra S. Dhahi, Alaa Kamal Yousif Dafhalla, A. Wesam Al-Mufti, Mohamed Elshaikh Elobaid, Tijjani Adam, Subash C.B. Gopinath

“…They are characterised by progressive loss of neuronal function and structure leading to crippling cognitive, motor and psychiatric impairments. …”
Get full text

Comprehensive behavioural study of senescence-accelerated mouse prone 8 and senescence-accelerated mouse prone 10 by Hiroshi Ueno, Yu Takahashi, Shinji Murakami, Kenta Wani, Tetsuji Miyazaki, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara

“…These differences may underlie variations in anxiety-like behaviours and locomotor activity. Conclusion: Together, these findings highlight the utility of SAMP8 and SAMP10 mice as models for studying age-related functional decline in the brain.…”
Get full text

Brain network and energy imbalance in Parkinson’s disease: linking ATP reduction and α-synuclein pathology by Hirohisa Watanabe, Sayuri Shima, Kazuya Kawabata, Yasuaki Mizutani, Akihiro Ueda, Akihiro Ueda, Mizuki Ito, Mizuki Ito

“…This model emphasizes how ATP deficits drive pathological protein aggregation, impaired autophagy, and the degeneration of key brain networks, contributing to both motor and non-motor symptoms.…”
Get full text