Combined inhibition of dopamine D1/D2 receptors induces cognitive and emotional dysfunction through oxidative stress and dopaminergic neuron damage by Xue Li, Yao Zhuang, Ya Ru Zhang, Ke Ke Fan, Xin Xin Chen, Xin Xing Chen, Xuan Yi Liu, Jing Sun, Li Liu

“…The medium- and high-dose groups exhibited spatial memory impairment (longer escape latency, p < 0.05) in the water maze and more anxiety-like behavior (reduced central zone time, p < 0.01) in the open field test; however, no abnormalities in motor coordination were observed in the rotarod test (p > 0.05). …”
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Electrophysiological characterisation of intranigral-grafted hiPSC-derived dopaminergic neurons in a mouse model of Parkinson’s disease by Bérengère Ballion, Marie-Laure Bonnet, Sébastien Brot, Afsaneh Gaillard

“…Conclusions Our findings indicate that grafted mDA neurons exhibit dopaminergic-like functional properties, including intrinsic membrane potential oscillations leading to regular firing patterns. …”
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Oxidative and Excitatory Neurotoxic Stresses in CRISPR/Cas9-Induced Kynurenine Aminotransferase Knockout Mice: A Novel Model for Despair-Based Depression and Post-Traumatic Stress... by Ágnes Szabó, Zsolt Galla, Eleonóra Spekker, Mónika Szűcs, Diána Martos, Keiko Takeda, Kinuyo Ozaki, Hiromi Inoue, Sayo Yamamoto, József Toldi, Etsuro Ono, László Vécsei, Masaru Tanaka

“…Methods: In CRISPR/Cas9-induced aadat knockout (kat2-/-) mice, we examined the effects on emotion, memory, motor function, Trp and its metabolite levels, enzyme activities in the plasma and urine of 8-week-old males compared to wild-type mice. …”
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TIMP1 inhibits Rac1-mediated ROS production to ameliorate blood–spinal cord barrier disruption in amyotrophic lateral sclerosis by Jingshu Tang, Yuying Kang, Qiuyu Chen, Baodan Zhang, Nianying Shang, Jiaqi Lan, Lei Wu, Ying Peng

“…Specifically, the expression of TIMP1 or its mutant variant AlaTIMP1, which lacks MMP-inhibitory activity, in spinal cord microvascular endothelial cells (SCMECs) prior to disease onset significantly reduces BSCB leakage in mice with ALS, thereby alleviating motor function deficits and delaying disease progression. …”
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Stem cell transplantation in traumatic spinal cord injury: a systematic review and meta-analysis of animal studies. by Ana Antonic, Emily S Sena, Jennifer S Lees, Taryn E Wills, Peta Skeers, Peter E Batchelor, Malcolm R Macleod, David W Howells

“…Stem cells offer some promise in the restoration of neurological function. We used systematic review, meta-analysis, and meta-regression to study the impact of stem cell biology and experimental design on motor and sensory outcomes following stem cell treatments in animal models of SCI. …”
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Kinesiotherapeutic Possibilities and Molecular Parameters in Multiple Sclerosis by Katarzyna Wiszniewska, Małgorzata Wilk, Małgorzata Wiszniewska, Joanna Poszwa, Oliwia Szymanowicz, Wojciech Kozubski, Jolanta Dorszewska

“…Currently, in patients with MS, in addition to pharmacotherapy, neurorehabilitation is indicated to improve the motor function of the body and action in the most physiological movement patterns possible. …”
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Friction and wear characteristics of acidic phosphate ester boundary layers analyzed by near-edge X-ray absorption fine structure by Naoko Takechi-Takahashi, Kensuke Matsushima, Noritake Isomura, Satoru Kosaka, Toshihide Ohmori, Toshinari Sano, Satoru Maegawa, Fumihiro Itoigawa

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Adipose-derived stem cells in fat grafting for facial paralysis: A review of their therapeutic modality by Laurentia Fidella Averina Setia Santoso, Raoul Al Kassis, San Khasraw Mohammed, Lakshay Arora, Nancy Emmanuel, Gregory Nicolas, Juan Pablo Menendez

“…Both differentiated and undifferentiated MSCs support axonal regeneration, enhance motor function, and promote growth factor release. …”
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Tibial Nerve injury in Medial Open Wedge-High Tibial Osteotomy – A Rare Complication with 14-Year Follow-Up by Woon-Hwa Jung, Aniket Wagh, Minseok Seo

“…At the end of 14 years, the motor function was fully recovered, but the patient still had residual paresthesia. …”
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Plasticity of Corticospinal Neural Control after Locomotor Training in Human Spinal Cord Injury by Maria Knikou

“…However, the neural mechanisms underlying restoration of lost voluntary motor function are not well understood and translational neuroscience research is needed so patient-orientated rehabilitation protocols to be developed.…”
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Effectiveness of Photobiomodulation Therapy in the Management of Fibromyalgia Syndrome: A Systematic Review by Sebastián Eustaquio Martín Pérez, Joel Rodríguez Niebla, Loanne Giraud Pérez, Raquel Campo León, Alejandro López Mejías, David Morales Tejera, Isidro Miguel Martín Pérez

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Impact of Exercise Training in Patients with Diabetic Peripheral Neuropathy: An Umbrella Review by Alba Gracia-Sánchez, Adriana López-Pineda, Rauf Nouni-García, Sara Zúnica-García, Esther Chicharro-Luna, Vicente F. Gil-Guillén

“…Management typically involves preventive strategies like patient education, risk stratification, and regular foot screenings. …”
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Disease‐modifying effects of ganglioside GM1 in Huntington's disease models by Melanie Alpaugh, Danny Galleguillos, Juan Forero, Luis Carlos Morales, Sebastian W Lackey, Preeti Kar, Alba Di Pardo, Andrew Holt, Bradley J Kerr, Kathryn G Todd, Glen B Baker, Karim Fouad, Simonetta Sipione

“…Treatment with GM1 slows down neurodegeneration, white matter atrophy and body weight loss in R6/2 mice. Motor functions are significantly improved in R6/2 mice and restored to normal in Q140 mice, including gait abnormalities that are often resistant to treatments. …”
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Adipose tissue-derived mesenchymal stem cells have better restorative capacity than bone marrow-derived cells in a cerebellar ataxic rat model by Rasha M. Att, Angie M. Ameen, Horeya Erfan Korayem, Noha Abogresha, Yasser El-Wazir

“…We assessed the following: 1) cerebellar motor functions in vivo (by Rotarod test, open-field test, and Quantitative gait analysis); 2) cerebellar histological architecture; and 3) cerebellar immunohistochemical examination of the Bax/Bcl-2 ratio as in indicator of apoptosis, and the levels of vascular endothelial growth factor (VEGF) and insulin-like growth factor-1 (IGF-1) as neuroprotective factors. …”
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Separate brainstem circuits for fast steering and slow exploratory turns by Lulu Xu, Bing Zhu, Zhiqiang Zhu, Xingyu Tao, Tianrui Zhang, Abdeljabbar El Manira, Jianren Song

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Computing with electromagnetic fields rather than binary digits: a route towards artificial general intelligence and conscious AI by Johnjoe McFadden

“…According to the theory, non-conscious brain processing occurs solely within the EM field-insensitive digital neuronal network, enabling fast, parallel computations, but cannot form complex, integrated concepts, so it is limited to specialised functions necessary for tasks like motor coordination. …”
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Autism spectrum disorder related phenotypes in a mouse model lacking the neuronal actin binding protein profilin 2 by Walter Witke, Marina Di Domenico, Laura Maggi, Alessia Di Nardo, Valentin Stein, Pietro Pilo Boyl

“…Lastly, we study anatomical features of the cerebellum using immunofluorescence stainings.ResultsWe show that PFN2 deficiency reproduces a number of autistic-like phenotypes in the mouse, such as social behavior impairment, stereotypic behavior, altered vocal communication, and deficits in motor performance and coordination. …”
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Distinct features of the Leishmania cap-binding protein LeishIF4E2 revealed by CRISPR-Cas9 mediated hemizygous deletion. by Nofar Baron, Nitin Tupperwar, Irit Dahan, Uzi Hadad, Geula Davidov, Raz Zarivach, Michal Shapira

“…Overall, LeishIF4E2 does not behave like a general translation factor and its function remains elusive. …”
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Machine Learning and Statistical Analyses of Sensor Data Reveal Variability Between Repeated Trials in Parkinson’s Disease Mobility Assessments by Rana M. Khalil, Lisa M. Shulman, Ann L. Gruber-Baldini, Sunita Shakya, Jeffrey M. Hausdorff, Rainer von Coelln, Michael P. Cummings

“…Mobility tasks like the Timed Up and Go test (TUG), cognitive TUG (cogTUG), and walking with turns provide insights into the impact of Parkinson’s disease (PD) on motor control, balance, and cognitive function. …”
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Evaluating the Potential of Portulaca oleracea L. for Parkinson’s Disease Treatment Using a Drosophila Model with dUCH-Knockdown by Huynh Kim Thoa Truong, Man Anh Huynh, My Dung Vuu, Thi Phuong Thao Dang

“…Parkinson’s disease (PD), which is characterized by the decreased motor function and the loss of dopaminergic neurons, is a common neurodegenerative disorder in elders. …”
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