All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs. by Andrew J Schork, Wesley K Thompson, Phillip Pham, Ali Torkamani, J Cooper Roddey, Patrick F Sullivan, John R Kelsoe, Michael C O'Donovan, Helena Furberg, Tobacco and Genetics Consortium, Bipolar Disorder Psychiatric Genomics Consortium, Schizophrenia Psychiatric Genomics Consortium, Nicholas J Schork, Ole A Andreassen, Anders M Dale

“…We applied stratified False Discovery Rate (sFDR) methods to leverage genic enrichment in GWAS summary statistics data to uncover new loci likely to replicate in independent samples. Specifically, we use linkage disequilibrium-weighted annotations for each SNP in combination with nominal p-values to estimate the True Discovery Rate (TDR = 1-FDR) for strata determined by different genic categories. …”
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Viral inhibition of the transporter associated with antigen processing (TAP): a striking example of functional convergent evolution. by Marieke C Verweij, Daniëlle Horst, Bryan D Griffin, Rutger D Luteijn, Andrew J Davison, Maaike E Ressing, Emmanuel J H J Wiertz

“…The strategies of TAP inhibition employed by viruses are very distinct and are likely to have been acquired independently during evolution. …”
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Applications of Trichoderma formulations in crop protection by Monte E, Rodriguez A, Rey M, Azpilicueta A, Gómez M I, de la Vin a G, Grondona I, Llobelt A

“…However, many other active strains have no antibiotic capacity, and these are likely to be more useful in food production systems since they have not adverse effects on important groups of beneficial soil organisms. …”
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Evaluation of a learning collaborative on team-based care: qualitative analysis of coaching calls using normalisation process theory by Kathleen Thies, Amanda Schiessl, Nashwa Khalid, Kasey Harding, Deborah Ward, Meaghan Angers

“…Similarly, the concurrence of cognitive participation and collective action likely refined each other. It took 3–4 months for most teams to establish sufficient coherence and cognitive participation, and to access actionable data. …”
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Successive increases in the resistance of Drosophila to viral infection through a transposon insertion followed by a Duplication. by Michael M Magwire, Florian Bayer, Claire L Webster, Chuan Cao, Francis M Jiggins

“…In a panel of inbred fly lines, we found that a transposable element insertion in the protein coding sequence of CHKov1 is associated with increased resistance to infection. …”
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Impacts of message sensation value and message appeal on viewer responses to YouTube anti-bullying videos by Wen-Chi Wu, Meng-Jung Lee, Hsi-Ping Nieh

“…Through quantitative content analysis, 1431 videos were coded by trained coders based on predefined coding schemes. …”
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Case report: Identification of a Chinese patient with RAG1 mutations initially presenting as autoimmune hemolytic anemia by Xin Chen, Chunxue Jiang, Wenliang Song, Tingting Sun, Jingli Yan, Wei Xu, Kai You

“…Whole exome and Sanger sequencing revealed a pathogenic recombinase-activating gene 1 mutation (c.2095C>T, p.Arg699Trp) and a likely pathogenic variant (c.2690G>A, p.Arg897Gln), resulting in a missense mutation in the amino acid sequence of the coding protein. …”
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What evidence exists on the interlinkages between ecological and societal impacts of borealisation of the arctic? A systematic map protocol by Kate Baker, Vera Helene Hausner, Jennifer Ramsay, Helen C. Wheeler

“…Borealisation occurs when the species, communities and ecological processes of the Arctic transform to resemble that of more boreal lower latitudes. Such change is likely to have profound impacts on the diverse communities and cultures of the Arctic. …”
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Lower the Flag: A Qualitative Analysis of Behavioral Alerts in the Electronic Health Record by Zoë Kopp, Irina Kryzhanovskaya, Maria E. Garcia

“…Themes were generated through open and axial coding of BAs’ free-text and thematic analysis to describe the content of BAs. …”
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Identification of a regulatory variant that binds FOXA1 and FOXA2 at the CDC123/CAMK1D type 2 diabetes GWAS locus. by Marie P Fogarty, Maren E Cannon, Swarooparani Vadlamudi, Kyle J Gaulton, Karen L Mohlke

“…Many of the type 2 diabetes loci identified through genome-wide association studies localize to non-protein-coding intronic and intergenic regions and likely contain variants that regulate gene transcription. …”
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One step on the QI journey: team perspectives on surveys for improvement by Julie E Reed, Julie K Johnson, Marjorie M Godfrey, Cassandra B Iroz

“…Data were analysed through multiple rounds of coding and inductive thematic analysis.Results Collaborative participants viewed surveys positively as an improvement tool. …”
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Colectomy Rates for Ulcerative Colitis Differ between Ethnic Groups: Results from a 15-Year Nationwide Cohort Study by Ravi Misra, Alan Askari, Omar Faiz, Naila Arebi

“…Indian patients were 21% more likely to require colectomy for UC compared with WE group (OR: 1.21, 95% CI: 1.04–1.42, and p=0.001). …”
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Interpersonal relationships in patients suffering from chronic musculoskeletal pain: a case-control study analyzing core conflictual relationship themes and interpersonal problems by Pernilla Abrahamsson, Bo Vinnars, Annika Lindgren

“…Controlling for these variables, components of CCRT were significantly more likely to be disharmonious in patients with CMP compared to patients with OA. …”
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What percentage of secondary school students do their homework with the help of artificial intelligence? - A survey of attitudes towards artificial intelligence by Mátyás Turós, Róbert Nagy, Zoltán Szűts

“…Although women have more positive attitudes toward using AI for learning purposes, they are less likely to use it to complete their homework assignments. …”
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ABRAXAS (FAM175A) and Breast Cancer Susceptibility: No Evidence of Association in the Breast Cancer Family Registry. by Anne-Laure Renault, Fabienne Lesueur, Yan Coulombe, Stéphane Gobeil, Penny Soucy, Yosr Hamdi, Sylvie Desjardins, Florence Le Calvez-Kelm, Maxime Vallée, Catherine Voegele, Breast Cancer Family Registry, John L Hopper, Irene L Andrulis, Melissa C Southey, Esther M John, Jean-Yves Masson, Sean V Tavtigian, Jacques Simard

“…To determine if ABRAXAS could be a breast cancer susceptibility gene in other populations, we conducted a population-based case-control mutation screening study of the coding exons and exon/intron boundaries of ABRAXAS in the Breast Cancer Family Registry. …”
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Temporal response patterns of Layer 4 rat barrel cortex neurons across various naturalistic whisker motions. by Dinh K Tang, Mark B Flegg, Ramesh Rajan

“…A central topic in neuroscience is the neural coding problem which aims to decipher how the brain signals sensory information through neural activity. …”
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“It's almost a life and death sentence”: Stakeholder perspectives on determinants of substance use risks and treatment access for individuals convicted of sexual offenses by Ruth T. Shefner

“…There are strong theoretical and anecdotal reasons to believe that SORN policies likely increase substance-use-related harms for registrants. …”
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Comprehensive Analysis of Rodent-Specific <i>Probasin</i> Gene Reveals Its Evolutionary Origin in Pseudoautosomal Region and Provides Novel Insights into Rodent Phylogeny by Stephan Maxeiner, Lukas Walter, Samuel Luca Zeitz, Gabriela Krasteva-Christ

“…During evolution of the Muroidea lineages, <i>probasin</i> recombined to the X-specific region of the X-chromosome in mice and hamster species. This event likely saved the gene from events that other pseudoautosomal genes suffered, namely displaying an increase in G and C nucleotide composition or accumulation of repetitive elements. …”
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Tessere il tempo. Bolzaneto tra autobiografia, romanzo e storie in cerchio by Ilaria Bracaglia

“…A style in which traces of memory can come to life and inhabit places and landscapes like the scenes of a drama: the novel.…”
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Transmedia a sztuka Roberta Wilsona by Agnieszka Jelewska

“…The intermedial model of arts has been exhausted and there has appeared the problem of transmediality, as well as such issues like transcegenity, transinstrumentality, transperception and even transcompetence of art. …”
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