Qualitative insights into empathy in medical education: perspectives from students, doctors, and educators by Fan Yang, Fuhao Lei, Yong Li, Tao Yang

“…Cultural differences in empathy, like between Western and traditional Chinese medicine, offer new perspectives. …”
Get full text

Wood-Inhabiting Nematode, <i>Bursaphelenchus ussuriensis</i> sp. n. (Nematoda: Aphelenchoididae) from David Elm, with Molecular Phylogeny of the Genus Based on Partial Mitochondria... by Alexander Yu. Ryss, Sergio Álvarez-Ortega, Boris D. Efeykin, Ivan A. Kerchev, Kristina S. Polyanina, Anna I. Solovyeva, Sergei A. Subbotin

“…Sequences of twelve mitochondrial protein-coding genes of <i>B. cocophilus, B. fraudulentus, B. michalskii, B. ussurensis</i> sp. n., and <i>B. willibaldi</i> were obtained in this study. …”
Get full text

Cloning and Spatiotemporal Expression Analysis of <i>IGF1R</i> Gene cDNA in <i>Alopex lagopus</i> (Arctic Fox) by Wei Xu, Hualin Fu, Xiangyu Meng, Yiwen Sun, Fangyong Ning, Zhiheng Du

“…This study aimed to clarify the sequence characteristics and spatiotemporal expression patterns of the insulin-like growth factor 1 receptor (<i>IGF1R</i>) gene in <i>Alopex lagopus</i> (Arctic fox), thereby addressing the existing knowledge gap regarding <i>IGF1R</i>-mediated growth regulation in this species. …”
Get full text

Downregulated METTL3 Accumulates TERT Expression that Promote the Progression of Ovarian Endometriosis by Fang Li, Hua Tao, Yini Wei, Ru Meng, Yushan Li, Lifang Nie, Yu Zhang, Jinjun Chang

“…We found high levels of METTL3-mediated m6A modification in TERT transcripts, particularly in the coding sequence region, resulting in increased translation. …”
Get full text

Creation of gene-specific rice mutants by AvrXa23-based TALENs by Fu-jun WANG, Chun-lian WANG, Chong-ke ZHENG, Teng-fei QIN, Ying GAO, Pi-qing LIU, Kai-jun ZHAO

“…Transcription activator-like effector (TALE) nucleases (TALENs) are increasingly used as a powerful tool for genome editing in a variety of organisms. …”
Get full text

Genetic Analysis of 'PAX6-Negative' Individuals with Aniridia or Gillespie Syndrome. by Morad Ansari, Jacqueline Rainger, Isabel M Hanson, Kathleen A Williamson, Freddie Sharkey, Louise Harewood, Angela Sandilands, Jill Clayton-Smith, Helene Dollfus, Pierre Bitoun, Francoise Meire, Judy Fantes, Brunella Franco, Birgit Lorenz, David S Taylor, Fiona Stewart, Colin E Willoughby, Meriel McEntagart, Peng Tee Khaw, Carol Clericuzio, Lionel Van Maldergem, Denise Williams, Ruth Newbury-Ecob, Elias I Traboulsi, Eduardo D Silva, Mukhlis M Madlom, David R Goudie, Brian W Fleck, Dagmar Wieczorek, Juergen Kohlhase, Alice D McTrusty, Carol Gardiner, Christopher Yale, Anthony T Moore, Isabelle Russell-Eggitt, Lily Islam, Melissa Lees, Philip L Beales, Stephen J Tuft, Juan B Solano, Miranda Splitt, Jens Michael Hertz, Trine E Prescott, Deborah J Shears, Ken K Nischal, Martine Doco-Fenzy, Fabienne Prieur, I Karen Temple, Katherine L Lachlan, Giuseppe Damante, Danny A Morrison, Veronica van Heyningen, David R FitzPatrick

“…Sequence analysis of the FOXC1 and PITX2 coding regions identified two plausibly pathogenic de novo FOXC1 missense mutations (p.Pro79Thr and p.Leu101Pro). …”
Get full text

TAp63γ is the primary isoform of TP63 for tumor suppression but not development by Xinbin Chen, Wenqiang Sun, Xiangmudong Kong, Xin Ming, Yanhong Zhang, Wensheng Yan, Shakur Mohibi, Mingyi Chen, Keith Mitchell, Jin Zhang

“…While TAp63 and ΔNp63 are expressed as three TAp63α/β/γ and ΔNp63α/β/γ due to alternative splicing, only p63α (TA and ΔN) and p63γ (TA and ΔN) proteins are found to be detectable and likely to be responsible for p63-dependent activity. …”
Get full text

Drug repurposing for Alzheimer’s disease using a graph-of-thoughts based large language model to infer drug-disease relationships in a comprehensive knowledge graph by Zhiping Paul Wang, Xi Li, Nicholas Matsumoto, Mythreye Venkatesan, Jui-Hsuan Chang, Jay Moran, Hyunjun Choi, Binglan Li, Yufei Meng, Miguel E. Hernandez, Jason H. Moore

“…ESCARGOT further enhanced performance while reducing the need for coding or advanced expertise in knowledge graph analysis. …”
Get full text

Applying the Information–Motivation–Behavioral Skills model to a video-assisted HPV intervention to promote self-screening uptake: a qualitative study in Western Kenya by Michelle Huang, Hanul Choi, Haley Dion, Laya Sathyan, Emily Herfel, Breandan Makhulo, Jeniffer Ambaka, Megan J. Huchko

“…Introduction Human papillomavirus (HPV) is the leading source of cervical cancer in Kenya. HPV, like other sexually transmitted infections, is stigmatised, which hinders efforts to address the disease. …”
Get full text

Genomic complexity and clinical significance of the RCCX locus by Vladimir V. Shiryagin, Andrey A. Devyatkin, Oleg D. Fateev, Ekaterina S. Petriaikina, Viktor P. Bogdanov, Zoia G. Antysheva, Pavel Yu Volchkov, Sergey M. Yudin, Mary Woroncow, Veronika I. Skvortsova

“…Nearly identical, repetitive elements in the genome contribute to the variability in genetic inheritance patterns, particularly in regions like the RCCX locus, where such repeats can lead to structural variations. …”
Get full text

Integrating large language models in biostatistical workflows for clinical and translational research by Steven C. Grambow, Manisha Desai, Kevin P. Weinfurt, Christopher J. Lindsell, Michael J. Pencina, Lacey Rende, Gina-Maria Pomann

“…LLMs improved productivity in coding, writing, and literature review; however, 29 of 41 respondents (70.7%) reported significant errors, including incorrect code, statistical misinterpretations, and hallucinated functions. …”
Get full text

miR-16-5p, miR-21-5p, and miR-155-5p in circulating vesicles as psoriasis biomarkers by Carlos A. Guzmán-Martín, Rogelio F. Jiménez-Ortega, María Fernanda Ortega-Springall, Mario Peña-Peña, Ana Elena Guerrero-Ponce, María Elisa Vega-Memije, Luis M. Amezcua-Guerra, Fausto Sánchez-Muñoz, Rashidi Springall

“…MicroRNAs are small, non-coding RNA molecules that play a crucial role in post-transcriptional gene regulation. …”
Get full text

Facilitators and Challenges to Adoption of a Digital Health Tool for Opioid Use Disorder Treatment in Primary Care: Mixed Methods Study by Omar Nieto, Allison D Rosen, Mariah M Kalmin, Li Li, Steven J Shoptaw, Steven P Jenkins, Zahra Zarei Ardestani, Bengisu Tulu

“…Qualitative data were analyzed using a coding reliability thematic analysis approach. …”
Get full text

Presenting the model of social entrepreneurship in the development of rural tourism in the target villages of Gilan province by Fatemeh Doozandeh Ziabari, hamed fallah tafti, Mir Mohammad Asadi, Mahdi Basouli

“…This is due to the drastic changes caused by technology innovation; like entrepreneurship through the sharing economy, which leads to direct interaction of people with tourism services (Yu & Wang, 2019). …”
Get full text

Conceptual Model of Factors Affecting Mathematics Literacy Based on the Perspective of 9th Grade Students: A Qualitative Research by Narges Yaftian, Maryam Shayan

“…Research Methodology The present study employed a qualitative approach, with data analyzed using open, axial, and selective coding methods. Participants were selected from among ninth-grade students in Isfahan city. …”
Get full text

Psychometric Hepatic Encephalopathy Tests and Electroencephalogram Results Among Cirrhotic Patients by Alaa Aboud Mohamed, Mostafa M. Elkholy, Ola O. Mangoud, Ahmed R. N. Ibrahim, Marwa O. Elgendy, Ali M. Abdel Fattah

“…In the Letter Cancellation Test (LCT) (total error), 80% of patients had organic disorders, and 24% showed affections with (LCT) (completion time). The Digit Symbol Coding Test results showed affection in 28% of patients. …”
Get full text

Acceptability of the ePOWER intervention: Managing previvors' cancer-related uncertainty and supporting decision making by Marleah Dean, Bethany Jowers, Claire Conley, Erica Camacho, Whitney Espinel, Kimberly A. Kaphingst

“…Objective: Previvors—unaffected individuals who have increased risk of cancer due to a pathogenic or likely pathogenic variant in a gene—experience high levels of uncertainty, which is associated with negative outcomes. …”
Get full text

Effects of digital and non-digital parental distraction on parent-child interaction and communication by Souhir Chamam, Souhir Chamam, Alexia Forcella, Alexia Forcella, Nadia Musio, Nadia Musio, Florence Quinodoz, Florence Quinodoz, Nevena Dimitrova

“…Interactive quality was assessed at Time 1 and Time 2 using the Coding Interactive Behavior scale. Communication was assessed by coding the number of word tokens and types during Time 1 and Time 2; child gestures were also coded. …”
Get full text

Demethylase FTO mediates m6A modification of ENST00000619282 to promote apoptosis escape in rheumatoid arthritis and the intervention effect of Xinfeng Capsule by Fanfan Wang, Fanfan Wang, Jianting Wen, Jianting Wen, Jian Liu, Jian Liu, Ling Xin, Yanyan Fang, Yanyan Fang, Yue Sun, Mingyu He, Mingyu He

“…IntroductionThe pathological mechanisms of rheumatoid arthritis (RA) are closely associated with the apoptosis escape of fibroblast-like synoviocytes (FLS). The m6A modification of long non-coding RNAs (lncRNAs) plays a critical regulatory role in RA pathogenesis. …”
Get full text

The role of major and minor structural proteins of porcine reproductive and respiratory syndrome virus in induction of protective immunity by Dan Li, Dan Li, Laixu Zhu, Laixu Zhu, Chenchen Cui, Chenchen Cui, Zhenchun Wu, Zhenchun Wu, Pengkai Qing, Pengkai Qing, Qiongqiong Zhou, Qiongqiong Zhou, Peng Gao, Peng Gao, Yongning Zhang, Yongning Zhang, Lei Zhou, Lei Zhou, Xinna Ge, Xinna Ge, Xin Guo, Xin Guo, Jun Han, Jun Han, Hanchun Yang, Hanchun Yang

“…IntroductionPorcine reproductive and respiratory syndrome virus (PRRSV), an economically significant threat to the world pork production, is notoriously known for its heterogeneity, and therefore the current vaccines often fail to provide efficient cross-protection against diverse PRRSV strains.MethodsBy making chimeric viruses using HP-PRRSV-2 lineage 8 (JXwn06) and lineage 1 NADC30-like strains (CHsx1401) as model organisms, the recently results have shown that the viral structural protein-coding region is critical for induction of homologous immunity. …”
Get full text