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661
Porcine Ovarian piRNA Dynamics: A Comparative Study During Follicular Atresia
Published 2025-05-01“…However, the underlying regulatory mechanisms remain underexplored, particularly those involving non-coding RNAs like PIWI-interacting RNAs (piRNAs). In this study, we collected single antral follicles from the ovaries of 180-day-old commercial sows, classified them as healthy (HF) and atretic (AF) based on morphological and biochemical criteria, and sequenced the RNA samples using the Illumina Hiseq 3000 system (San Diego, CA, USA). piRNAs were identified using three algorithms, and the differential expression was compared and validated by qPCR. …”
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662
Chromosome-level genome of the shining chafers Kibakoganea tamdaoensis (Coleoptera: Scarabaeidae: Rutelinae)
Published 2025-08-01“…Our annotation pipeline identified 984 noncoding RNAs and predicted 12,945 protein-coding genes in the genome (96.40% BUSCO completeness). …”
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663
LncRNAs Regulate Vasculogenic Mimicry in Human Cancers
Published 2025-04-01“…During VM, tumor cells align and organize themselves into three-dimensional (3D) channel-like structures to transport nutrients and oxygen to the internal layers of tumors. …”
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664
Unraveling LncRNA GAS5 in Atherosclerosis: Mechanistic Insights and Clinical Translation
Published 2025-06-01“…<i>GAS5</i> modulates crucial pathophysiological processes like cell proliferation, apoptosis, inflammation, lipid metabolism, and foam cell formation, primarily by acting as a competing endogenous RNA (ceRNA) and through direct protein interactions. …”
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665
Case Report: Nephrotic syndrome as the primary manifestation of Alport syndrome in a Chinese pediatric patient
Published 2025-01-01“…BackgroundAlport syndrome (AS) is a genetically heterogeneous disorder resulting from variants in genes coding for the alpha-3/4/5 chains of Collagen IV, leading to defective basement membranes in the kidney, cochlea, and eye. …”
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666
A transcriptomic analysis of Echinococcus granulosus larval stages: implications for parasite biology and host adaptation.
Published 2012-01-01“…In the context of the biology of E. granulosus, our analyses reveal: (i) a diverse group of abundant long non-protein coding transcripts showing homology to a middle repetitive element (EgBRep) that could either be active molecular species or represent precursors of small RNAs (like piRNAs); (ii) an up-regulation of fermentative pathways in the tissue of the cyst wall; (iii) highly expressed thiol- and selenol-dependent antioxidant enzyme targets of thioredoxin glutathione reductase, the functional hub of redox metabolism in parasitic flatworms; (iv) candidate apomucins for the external layer of the tissue-dwelling hydatid cyst, a mucin-rich structure that is critical for survival in the intermediate host; (v) a set of tetraspanins, a protein family that appears to have expanded in the cestode lineage; and (vi) a set of platyhelminth-specific gene products that may offer targets for novel pan-platyhelminth drug development.…”
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667
Livelihood diversification among women farmers in Nigeria’s flood-resilient drylands
Published 2025-01-01“…Women farmers diversify livelihoods by rotating fast-growing crops (e.g., beans, tomatoes, cassava), planting economic trees, raising livestock, and engaging in off-farm activities like petty trading. Enabling factors include building farmer and institutional stakeholders’ capacity, improving climate data access, supporting alternative income activities, strengthening agricultural extension, and providing infrastructural and financial support. …”
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668
Chemical circularization of in vitro transcribed RNA for exploring circular mRNA design
Published 2025-07-01“…We show that protein-coding chem-circRNAs are translationally active in cells and exhibit increased durability, like enzymatically circularized mRNAs. …”
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669
Characterization of novel human endogenous retrovirus structures on chromosomes 6 and 7
Published 2025-01-01“…While the reference genome for both regions suggests these two loci are structurally dissimilar, we found that for both loci about 5% of individuals have a unique tandem repeat-like sequence (three long terminal repeat sequences sandwiching two internal, potentially protein coding sequences), while most individuals have a standard proviral structure (one internal region sandwiched by two long terminal repeats). …”
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670
Promiscuous RNA binding ensures effective encapsidation of APOBEC3 proteins by HIV-1.
Published 2015-01-01“…The apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3) proteins are cell-encoded cytidine deaminases, some of which, such as APOBEC3G (A3G) and APOBEC3F (A3F), act as potent human immunodeficiency virus type-1 (HIV-1) restriction factors. …”
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671
Analysis of Polymorphisms on GH-MspI and IGF1-SnaBI Loci in Five Turkish Native Cattle Breeds
Published 2018-10-01“…Growth Hormone (GH) and Insulin like Growth Factor-I (IGF1) are members of somototrophine axis pathway. …”
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672
Enhancing the effectiveness of interprofessional education in health science education: a state-of-the-art review
Published 2024-12-01“…Study features were evaluated using a coding scheme, and qualitative analysis of the included studies was performed. …”
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673
Number of ICD-10 diagnosis fields required to capture sepsis in administrative data and truncation bias: A nationwide prospective registry study.
Published 2025-01-01“…<h4>Background</h4>In observational studies that use administrative data, it is essential to report technical details such as the number of International Classification of Disease (ICD) coding fields extracted. This information is crucial for ensuring comparability between studies and for avoiding truncation bias in estimates, particularly for complex conditions like sepsis. …”
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674
Melbournevirus encodes a shorter H2B-H2A doublet histone variant that forms structurally distinct nucleosome structures
Published 2025-07-01“…This viral histone variant has a truncated H2B portion and its amino acid sequence deviates from that of the main viral H2B-H2A throughout the entire coding region. It is less abundant than the main H2B-H2A doublet, is likely essential for melbournevirus fitness, and is conserved in all Marseilleviridae. …”
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675
Experiences of dental students in virtual education: A qualitative study
Published 2024-11-01“…MAXQDA version 11 software was used for open coding and categorizing codes. Results: Two main categories (themes) were obtained under the headings of perceived disadvantages and perceived advantages of virtual education. …”
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676
Exploring the Putative Involvement of MALAT1 in Mediating the Beneficial Effect of Exendin-4 on Oleic Acid-Induced Lipid Accumulation in HepG2 Cells
Published 2025-02-01“…<b>Background/Objectives</b>: The reduction of oleic acid (OA)-induced steatosis in HepG2 cells observed upon treatment with the glucagon-like peptide-1 receptor agonist (GLP-1RA) Exendin-4 (Ex-4) is associated with the modulation of the expression of several microRNAs, long non-coding RNAs (lncRNAs), and mRNAs. …”
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677
The Transcription of Transposable Elements Differentially Regulated by SVAs in the Major Histocompatibility Complex Class I Region of a Parkinson’s Progression Markers Initiative C...
Published 2025-01-01“…The SVA-regulated TE RNAs in blood cells appear to function as enhancer-like elements, differentially influencing the expression of HLA class I genes, non-HLA genes, and noncoding RNAs. …”
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678
Urban snow and ice removal and storage: A systematic literature review
Published 2025-08-01“…The pertinent research was thoroughly synthesized using content analysis by manual coding in ATLAS.ti software (to assist textual analysis), network visualization, and co-occurrence analyses (including temporal and geographical distributions). …”
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679
Diversification and recurrent adaptation of the synaptonemal complex in Drosophila.
Published 2025-01-01“…The synaptonemal complex (SC) is a protein-rich structure essential for meiotic recombination and faithful chromosome segregation. Acting like a zipper to paired homologous chromosomes during early prophase I, the complex is a symmetrical structure where central elements are connected on two sides by the transverse filaments to the chromatin-anchoring lateral elements. …”
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680
The potential of miR-29 in modulating tumor angiogenesis: a comprehensive review
Published 2025-04-01“…Abstract MicroRNAs (miRNAs) are a class of short non-coding RNAs that play a crucial role in the post-transcriptional regulation of gene expression. …”
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