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601
Developing a Technology-Mediated EFL Teacher Program Based on Critical Pedagogy: The Context of Iran in Focus
Published 2024-11-01“…With a view to the recent educational developments in addition to the increasing adoption of critical pedagogy (CP) in educational systems worldwide (Grassini, 2023), taking critical digital pedagogy (CDP) in the field of teacher education within the context of Iran offers numerous benefits, like encouraging critical thinking, fostering creativity, building community, and empowering students. …”
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602
Hand position fields of neurons in the premotor cortex of macaques during natural reaching
Published 2025-04-01“…Our findings suggest field-like positional coding may be a mechanism shared across brain regions for spatial representation in goal-directed movements, including body navigation and forelimb reaching.…”
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603
TikTok flipped classroom method in folk art courses: an investigation of teachers and learners’ perceptions
Published 2025-03-01“…Through these insights, the research contributes to a better understanding of how social media platforms like TikTok can enhance engagement and learning outcomes in creative courses.…”
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604
Mechanisms and Emerging Regulators of Neuroinflammation: Exploring New Therapeutic Strategies for Neurological Disorders
Published 2024-12-01“…The therapeutic landscape is evolving, with traditional anti-inflammatory drugs like NSAIDs and corticosteroids offering limited efficacy in chronic conditions. …”
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605
CRISPR/dCas12a-mediated activation of SlPAL2 enhances tomato resistance against bacterial canker disease.
Published 2025-01-01“…Alternative strategies to pesticides include breeding resistant crop varieties, biological control, and utilizing genome-editing tools like CRISPR/Cas. However, the application of epigenome editing, particularly CRISPR activation (CRISPRa), in plants remains underexplored. …”
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606
Is Oral Communication Apprehension Reasonable?: A Study on Sociocultural Factors Among Indonesian EFL Learners
Published 2023-12-01“…Data analysis involved Ethnomethodological Conversation Analysis (ECA) and thematic coding. The findings indicate that factors like interruption, overlap, self-correction, self-monitoring, and reliance on the first language (L1) during oral communication contribute to apprehension. …”
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607
Rewriting Viral Fate: Epigenetic and Transcriptional Dynamics in KSHV Infection
Published 2024-11-01“…Kaposi’s sarcoma-associated herpesvirus (KSHV), a γ-herpesvirus, is predominantly associated with Kaposi’s sarcoma (KS) as well as two lymphoproliferative disorders: primary effusion lymphoma (PEL) and multicentric Castleman disease (MCD). Like other herpesviruses, KSHV employs two distinct life cycles: latency and lytic replication. …”
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608
Taxonomic status and phylogenetic analyses based on complete mitochondrial genome and microscopic ossicles: Redescription of a controversial tropical sea cucumber species (Holothur...
Published 2025-04-01“…The mitogenome contained 13 protein-coding genes (PCGs), 2 ribosomal RNAs (rRNAs), and 22 transfer RNA (tRNA) genes, with a sequence length of 15,797 bp. …”
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609
Meta-analysis and in-silico functional characterization of the SNCA variant rs356220 in Parkinson’s disease
Published 2025-07-01“…This research emphasizes the need for holistic study approaches to explore the intricacies of complex disorders like PD.…”
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610
Fine-mapping and molecular characterisation of primary sclerosing cholangitis genetic risk loci
Published 2024-11-01“…In this work, colocalisation analyses nominate likely primary sclerosing cholangitis effector genes and biological mechanisms at five non-coding (UBASH3A, PRKD2, ETS2 and AP003774.1/CCDC88B) and one coding (SH2B3) primary sclerosing cholangitis loci. …”
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611
Chromosome‐level genome assembly of Iodes seguinii and its metabonomic implications for rheumatoid arthritis treatment
Published 2025-03-01“…Metabolite analysis identified 84 active components in I. seguinii, including the discovery of luteolin, with 119 targets predicted for RA treatment, including core targets like AKT1, toll‐like receptor 4 (TLR4), epidermal growth factor receptor (EGFR), tumor necrosis factor (TNF), TP53, NFKB1, janus kinase 2 (JAK2), BCL2, mitogen‐activated protein kinase 1 (MAPK1), and spleen‐associated tyrosine kinase (SYK). …”
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612
Is postoperative cognitive dysfunction a disease of microglial inflammatory memory? A state-transition model from metabolic stress to epigenetic lock-in
Published 2025-08-01“…These events engage epigenetic machinery—including HDAC3, DNMT3a, and long non-coding RNAs like MEG3—which reinforce transcriptional programs that lower activation thresholds and amplify cytokine output. …”
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613
Lower frequency of TLR9 variant associated with protection from breast cancer among African Americans.
Published 2017-01-01“…<h4>Introduction</h4>Toll-like receptor 9 (TLR9) is an innate immune system DNA-receptor that regulates tumor invasion and immunity in vitro. …”
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614
Mitochondrial Dysfunction: The Silent Catalyst of Kidney Disease Progression
Published 2025-05-01“…Disrupted mitochondrial dynamics, such as excessive fission mediated by Drp1, exacerbate tubular apoptosis and inflammation in AKI models like ischemia–reperfusion injury. In CKD, persistent mitochondrial dysfunction drives oxidative stress, fibrosis, and metabolic reprogramming, with epigenetic mechanisms (DNA methylation, histone modifications, non-coding RNAs) regulating genes critical for mitochondrial homeostasis, such as <i>PMPCB</i> and <i>TFAM</i>. …”
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615
Chromosome-level genome assembly reveals adaptive evolution of the invasive Amazon sailfin catfish (Pterygoplichthys pardalis)
Published 2025-04-01“…Several expanded genes are associated with immune functions, including antigen recognition domains like the Ig-v-set domain and the tandem expansion of the CD300 gene family. …”
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616
A qualitative descriptive analysis on generative artificial intelligence: bridging the gap in pedagogy to prepare students for the workplace
Published 2025-03-01“…Abstract Generative artificial intelligence (Gen AI) has emerged as a transformative tool in higher education, widely adopted by both students and faculty for tasks ranging from writing to coding. Despite its growing usage, concerns over academic integrity and its long-term impact on learning persist. …”
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617
Paucity of optineurin gene variants in Indian juvenile open-angle glaucoma patients
Published 2025-08-01“…Genetic investigations like this may help in the understanding of disease pathogenesis and development of therapy for glaucoma management/treatment in the near future.…”
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618
Epigenetic mechanisms linking pregnancy complications to cardiovascular disease in offspring
Published 2024-11-01“…Additionally, dysregulation of microRNAs in response to complications like gestational diabetes may influence pathways related to insulin signaling and atherosclerosis. …”
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619
MicroRNA participates in embryo implantation by modulating endometrial tolerance in sows during peri-implantation period
Published 2025-08-01“…MicroRNAs (miRNAs) are a class of non-coding RNA. MiRNAs affect physiological processes by regulating messenger RNA (mRNA) translation of target genes. …”
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620
JC Polyomavirus Abundance and Distribution in Progressive Multifocal Leukoencephalopathy (PML) Brain Tissue Implicates Myelin Sheath in Intracerebral Dissemination of Infection.
Published 2016-01-01“…Our observations in this case, as well as in a case of PML-like disease in an immunocompromised rhesus macaque, suggest that long-range spread of polyomavirus and axonal destruction in PML might involve extracellular association between virus and the white matter myelin sheath.…”
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