Pharmacokinetics and Pharmacodynamics of KT‐474, a Novel Selective Interleukin‐1 Receptor–Associated Kinase 4 (IRAK4) Degrader, in Healthy Adults by Sagar Agarwal, Alice A. McDonald, Veronica Campbell, Dapeng Chen, Jeff Davis, Haojing Rong, Aimee Mishkin, Anthony Slavin, Ashwin Gollerkeri, Jared A. Gollob

“…KT‐474 demonstrated robust IRAK4 degradation in blood, with mean reductions of up to 98% observed at the 50–200 mg QD doses, as well as inhibition of ex vivo induction of a broad array of cytokines and chemokines by stimulants lipopolysaccharides and R848. …”
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Functional heterogeneity of embryonic stem cells revealed through translational amplification of an early endodermal transcript. by Maurice A Canham, Alexei A Sharov, Minoru S H Ko, Joshua M Brickman

“…Here we use a transgenic allele designed to detect low level transcription in the primitive endoderm lineage as a tool to identify an immediate early endoderm-like ES cell state. This reporter employs a tandem array of internal ribosomal entry sites to drive translation of an enhanced Yellow Fluorescent Protein (Venus) from the transcript that normally encodes for the early endodermal marker Hex. …”
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Challenges and strategies for management and conservation of water resources and freshwater biodiversity in the Lake Victoria Basin by Frank O. Masese, Elizabeth W. Wanderi, Elizabeth W. Wanderi, Hyline N. Nyangweso, Hyline N. Nyangweso

“…The economies of the five countries in the LVB (Burundi, Kenya, Rwanda, Tanzania and Uganda) rely heavily on the rich array of natural resources and ecosystem services provided by the basin. …”
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Mechanisms of action and therapeutic potential of PCSK9-regulating drugs by Chenrui Qi, Daming Fan, Lei Wang, Lubo Guo, Huihui Jiang, Lu Wang

“…They mainly exert their effects by controlling PCSK9 gene transcription, influencing mRNA translation, and blocking the interaction between PCSK9 and LDL-R.Conclusions PCSK9-regulating drugs hold great promise for treating a diverse array of diseases. Future research should focus on optimizing their application in personalized therapies that target multiple pathways.…”
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Design of Radix-8 Unsigned Bit Pair Recoding Algorithm-Based Floating-Point Multiplier for Neural Network Computations by J. Jean Jenifer Nesam, S. Sankar Ganesh

“…The unsigned mantissa multiplication using partial product array reduction with the BPR technique uses 27.5% less area, 18% less power, and 33.33% improved speed for generating one partial product row than conventional Booth multipliers. …”
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A Monte Carlo Simulation study on the design and optimization of collimators for non-collinear cascade gamma-ray correlation emissions in medical imaging by Leonid Leopold Nkuba, Innocent Lugendo

“…Each block featured 105 parallel rectangular holes arranged in a 7 × 15 array, with a length of 10.0 mm, resulting in a ring-like collimator with a 41.0 mm outer radius. …”
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How the brain memorizes the world from others’ perspectives: investigating allocentric encoding of object features during perspective taking by Nanbo Wang, Shuo Huang, Junyang Cai, Ruiyi Huang, Haiyan Geng

“…Participants were instructed to memorize the target dimension features of a memory array from an avatar’s perspective while ignoring irrelevant dimension features. …”
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The Centre of Attention: A Powerful Radio Galaxy Pinpoints a Near-infrared-dark Protocluster at z ∼ 3.9 by A. J. Hedge, N. Seymour, J. W. Broderick, A. Gupta, J. Afonso, L. Ighina, M. Lehnert, G. Noirot, S. Shabala, D. Stern, R. J. Turner

“…We report the discovery of a z ∼ 3.9 protocluster identified from Atacama Large Millimeter/submillimeter Array Band 3 spectral scans of a bright radio source selected from the Galactic and Extragalactic All-sky Murchison Widefield Array (GLEAM) survey. …”
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Ultrafast dynamic contrast-enhanced breast MRI with quantitative perfusion parameters in differentiating breast cancer: a study focusing on triple-negative and HER2 positive breast... by Guo Haodong, Zhu Jianguo, Dmytro Pylypenko, Dou Weiqiang, Su Sheng, Xu Jie, Li Haige

“…DISCO is a more recent DCE MRI technique that has achieved high spatial and temporal resolution and minimized image artifacts in cases like malignant focal liver lesions, enhanced focal breast lesions, and intracranial aneurysms.ObjectiveTo employ the method mentioned above to differentiate between triple-negative and non-triple-negative as well as HER2 positive and HER2 negative cancer lesions, and to assess the value of quantitative and semi-quantitative parameters in molecularly typing breast cancer.MethodsAll participants were scanned with a 3.0-T MR scanner (GE SIGNA™ Premier) using a 16-channel phased-array body coil. …”
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Discovery and Timing of Four γ-Ray Millisecond Pulsars by M. Kerr, S. Johnston, C. J. Clark, F. Camilo, E. C. Ferrara, M. T. Wolff, S. M. Ransom, S. Dai, P. S. Ray, J. E. Reynolds, J. M. Sarkissian, E. D. Barr, M. K. Kramer, B. W. Stappers

“…PSR J0646–5455 has a strong, Vela-like γ -ray pulse profile and is suitable for inclusion in the γ -ray pulsar timing array. …”
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VLA FRAMEx. II. Radio Spectra of Nearby Active Galactic Nuclei at Subarcsecond Resolution by Andrew J. Sargent, Alexander J. van der Horst, Megan C. Johnson, Travis C. Fischer, Nathan J. Secrest, Phil J. Cigan, Onic I. Shuvo, Krista L. Smith

“…We present 4–12 GHz in-band spectral energy distributions with accompanying 6 GHz and 10 GHz imaging results for a volume-complete sample (<40 Mpc) of hard X-ray selected active galactic nuclei observed with the Karl G. Jansky Very Large Array (VLA) in its A-array configuration. Despite expectations, only 12 out of 25 of these targets have been detected by the Very Long Baseline Array (VLBA) at milliarcsecond resolution in our previous studies, and we aim to understand why the circumnuclear radio emission resolves away at the subparsec spatial scales. …”
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Characterization of jamun (Syzygium cumini Skeels) accessions for economic traits based on multivariate analysis by Prakash Chandra Tripathi, Anuradha Sane, Karunakaran Ganesan, Sankar Vadivel, Prakash Kumar, Kanupriya Chaturvedi, Ruchitha Thimmarayappa

“…Correlations unveiled positive relationships between pulp weight and attributes like leaf length, tree spread, and seed width, while a negative correlation was observed with total soluble solids. …”
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Sociocultural recursion in the context of actor-network interaction with generative artificial intelligence by V. A. Shelginskaya

“…The study reveals the actor structure of interaction with the GenAI as part of the composition of social and generative actors and data array mediating their connection. It is argued that the resulting nature of socio-generative interaction is determined by the social predestination of the data array, which we propose to distinguish in four variants. …”
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Distributed Acoustic Sensing for aftershock monitoring: the case of the 2019 Mw 4.9 Le Teil earthquake by Martijn van den Ende, Jean-Paul Ampuero, Françoise Courboulex, Bertrand Delouis, Maxime Godano, Christophe Larroque, Anthony Sladen

“…Through comparison with the local seismometer network, we assess the capabilities of the DAS array to detect and locate small-magnitude seismic events. …”
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Reprocessing from Highly Ionized Gas in the Soft Spectral State of V4641 Sgr with NuSTAR by Riley M. T. Connors, Joey Neilsen, Aarran W. Shaw, James F. Steiner, Federico Vincentelli, Javier A. García, Phil Uttley, Ronald A. Remillard, Guglielmo Mastroserio

“…We identify highly ionized Fe K emission lines—consistent with a combination of the near-neutral 6.4 keV Fe K α line and the H-like and He-like Fe K α and Fe K β transitions found at 6.7–7 keV and ∼8 keV—and find no evidence for strong relativistic broadening. …”
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Ta'u and Ofu/Olosega volcanoes: The “Twin Sisters” of Samoa, their P, T, X melting regime, and global implications by Stanley R. Hart, Matthew G. Jackson

“…Kinetic modeling shows melt re‐equilibration will be likely for ascent velocities (m/yr) less than 40/(conduit radius in cm)2. …”
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Detecting the Black Hole Candidate Population in M51’s Young Massive Star Clusters: Constraints on Accreting Intermediate-mass Black Holes by Kristen C. Dage, Evangelia Tremou, Bolivia Cuevas Otahola, Eric W. Koch, Kwangmin Oh, Richard M. Plotkin, Vivian L. Tang, Muhammad Ridha Aldhalemi, Zainab Bustani, Mariam Ismail Fawaz, Hans J. Harff, Amna Khalyleh, Timothy McBride, Jesse Mason, Anthony Preston, Cortney Rinehart, Ethan Vinson, Gemma Anderson, Edward M. Cackett, Shih Ching Fu, Sebastian Kamann, Teresa Panurach, Renuka Pechetti, Payaswini Saikia, Susmita Sett, Ryan Urquhart, Christopher Usher

“…However, more sensitive radio facilities, like the Square Kilometre Array and next-generation Very Large Array, may be able to provide evidence for IMBHs with masses down to  ~10 ^3 M _⊙ .…”
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Graphitic Carbon Nitride: A Novel Two-Dimensional Metal-Free Carbon-Based Polymer Material for Electrochemical Detection of Biomarkers by Ganesan Kausalya Sasikumar, Pitchai Utchimahali Muthu Raja, Peter Jerome, Rathinasamy Radhamani Shenthilkumar, Putrakumar Balla

“…It forms layered structures like graphite and demonstrates exciting and unusual physicochemical properties, making g-C₃N₄ widely used in nanoelectronic devices, spin electronics, energy storage, thermal conductivity materials, and many others. …”
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γδT cells, a key subset of T cell for cancer immunotherapy by Jianzhen Lv, Zheng Liu, Xiangting Ren, Siyuan Song, Yan Zhang, Yi Wang, Yi Wang

“…Unlike conventional αβT cells, γδT cells do not require major histocompatibility complex (MHC)-dependent antigen presentation for activation, enabling them to recognize and respond to a wide array of antigens, including phosphoantigens, stress-induced ligands, and tumor-associated antigens. …”
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Optimizing Niosomal Formulations for Enhanced Cellular Applications by Nilufer Cakir, Naile Ozturk, Asli Kara, Ali Zarrabi, Nur Mustafaoglu

“…We aimed to formulate and characterize a diverse array of niosomal nanoparticles, with particular emphasis on process-related parameters and physicochemical characteristics. …”
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