Localising loci underlying complex trait variation using Regional Genomic Relationship Mapping. by Yoshitaka Nagamine, Ricardo Pong-Wong, Pau Navarro, Veronique Vitart, Caroline Hayward, Igor Rudan, Harry Campbell, James Wilson, Sarah Wild, Andrew A Hicks, Peter P Pramstaller, Nicholas Hastie, Alan F Wright, Chris S Haley

“…We use genome-wide SNP array data to obtain both a genome-wide relationship matrix and regional relationship ("identity by state" or IBS) matrices for sequential regions across the genome. …”
Get full text

A Highly Sensitive Strain Sensor with Self-Assembled MXene/Multi-Walled Carbon Nanotube Sliding Networks for Gesture Recognition by Fei Wang, Hongchen Yu, Xingyu Ma, Xue Lv, Yijian Liu, Hanning Wang, Zhicheng Wang, Da Chen

“…The high performance enables good prospects in human detection, like human movement and pulse signals for healthcare. …”
Get full text

Hyphal penetration is the major pathway of translocation of Candida albicans across the blood-cerebrospinal fluid barrier by S. Schmidt, C. Schwerk, H. Schroten, H. Ishikawa, R. Schubert, T. Lehrnbecher, H. Rudolph

“…This is accomplished by the formation of a tunnel-like structure exploiting the actin cytoskeleton. …”
Get full text

Optimal integration of solar home systems and appliance scheduling for residential homes under severe national load shedding by Sakhile Twala, Xianming Ye, Xiaohua Xia, Lijun Zhang

“…In developing countries like South Africa, users experienced more than 1 030 hours of load shedding outages in just the first half of 2023 due to inadequate power supply from the national grid. …”
Get full text

Exploring the Inhibitory Efficacy of Resokaempferol and Tectochrysin on PI3Kα Protein by Combining DFT and Molecular Docking against Wild-Type and H1047R Mutant Forms by Cristina Paraschiv, Steluța Gosav, Catalina Mercedes Burlacu, Mirela Praisler

“…Further analysis of chemical potential and bioavailability confirmed the drug-like attributes of these flavonoids. Binding affinity and selectivity were rigorously assessed through self-docking and cross-docking against the PIK3CA PDB structures 7K71 and 8TS9. …”
Get full text

Arabidopsis TFL2/LHP1 specifically associates with genes marked by trimethylation of histone H3 lysine 27. by Franziska Turck, François Roudier, Sara Farrona, Marie-Laure Martin-Magniette, Elodie Guillaume, Nicolas Buisine, Séverine Gagnot, Robert A Martienssen, George Coupland, Vincent Colot

“…TERMINAL FLOWER 2/LIKE HETEROCHROMATIN PROTEIN 1 (TFL2/LHP1) is the only Arabidopsis protein with overall sequence similarity to the HETEROCHROMATIN PROTEIN 1 (HP1) family of metazoans and S. pombe. …”
Get full text

Grape by-products from the wine industry – an untapped sustainable resource for application in animal skin health preservation and treatment by Wanting Chen, Wanting Chen, Preeti Pandey, Zyta M. Ziora, Zyta M. Ziora, Anjana Jayasree, Anjana Jayasree, Harendra S. Parekh, Harendra S. Parekh

“…The all-wine industry is projected to generate over US$528 billion in sales globally by 2025, and like many mass-producing industries, it too generates significant waste and by-products, much of which ends up in landfill. …”
Get full text

IMT to Satellite Stochastic Interference Modeling and Coexistence Analysis of Upper 6 GHz-Band Service by Reza Aghazadeh Ayoubi, Dario Tagliaferri, Filippo Morandi, Luca Rinaldi, Laura Resteghini, Christian Mazzucco, Umberto Spagnolini

“…The surging capacity demands of 5G networks and the limited coverage distance of high frequencies like millimeter-wave (mmW) and sub-terahertz (THz) bands have led to consider the upper 6 GHz (U6G) spectrum for radio access. …”
Get full text

The role of Juniperus Macrocarpa extract as anti-inflammatory and antioxidant on methotrexate-induced acute liver injury in rat model [version 1; peer review: 1 approved, 2 approve... by Mohammed Qasim Yahya Malallah A. Al-Atrakji, Shahad Hassan Hadi

“…Background Methotrexate (MTX) is an antifolate medication indicated to treat an array of tumors and autoinflammatory maladies. MTX may exhibit harmful impacts on multiple organs, especially liver injury and cirrhosis. …”
Get full text

Optimization of docetaxel-loaded cholesterol nanostructured lipid carriers for improving cancer treatment using Taguchi experimental design by Thanikodi Sathish, Jayant Giri, Saravanan Rathinasamy, Mohammad Kanan

“…This study used Taguchi's experimental design and analysis with the L16 orthogonal array. The design was utilised to analyse NLC particle size and zeta potential data. …”
Get full text

Expression patterns and subcellular localization of carbonic anhydrases are developmentally regulated during tooth formation. by Claes-Göran Reibring, Maha El Shahawy, Kristina Hallberg, Marie Kannius-Janson, Jeanette Nilsson, Seppo Parkkila, William S Sly, Abdul Waheed, Anders Linde, Amel Gritli-Linde

“…We uncovered that the latter form lace-like networks around incisors; hitherto these have been known to occur only in molars. …”
Get full text

Advances in cell-based biosensors: Transforming food flavor evaluation with novel approaches by Mahmoud Said Rashed, Esraa A. Abdelkarim, Tamer Elsamahy, Mabrouk Sobhy, Hany S. El-Mesery, Ali Salem

“…This review discusses the role of cell-based biosensors in flavor evaluation, showcasing their sensitivity, specificity, and rapid response. Using living cells like taste and olfactory cells, these biosensors surpass traditional approaches. …”
Get full text

Allergen challenge induces Ifng dependent GTPases in the lungs as part of a Th1 transcriptome response in a murine model of allergic asthma. by Nilesh Dharajiya, Swapnil Vaidya, Mala Sinha, Bruce Luxon, Istvan Boldogh, Sanjiv Sur

“…To identify these putative anti-inflammatory genes, we compared the gene expression profile in the lungs of ragweed-sensitized mice four hours after challenge with either PBS or ragweed extract (RWE) using a micro-array platform. Consistent with our hypothesis, RWE challenge concurrently upregulated Th1-associated early target genes of the Il12/Stat4 pathway, such as p47 and p65 GTPases (Iigp, Tgtp and Gbp1), Socs1, Cxcl9, Cxcl10 and Gadd45g with the Th2 genes Il4, Il5, Ccl2 and Ccl7. …”
Get full text

Development status and key technologies of deep-sea towing autonomous underwater vehicles by Guanyu LU, Tiedong ZHANG, Zhenglin LI, Dapeng JIANG, Ming LEI, Wanzhen LUO

“…Singapore used a digital thin-line towed array sonar on an AUV to invert seabed sediment characteristics. …”
Get full text

Zagociguat prevented stressor-induced neuromuscular dysfunction, improved mitochondrial physiology, and increased exercise capacity in diverse mitochondrial respiratory chain disea... by Leonard Burg, Heeyong Yoon, Min Peng, Peter Germano, Emily Reesey Gretzmacher, Rui Xiao, Vernon E. Anderson, Eiko Nakamaru-Ogiso, Eiko Nakamaru-Ogiso, Marni J. Falk, Marni J. Falk

“…BackgroundZagociguat (zag) is a CNS-penetrant, soluble guanylate cyclase (sGC) stimulator that has been evaluated in phase 2a, with phase 2b ongoing, clinical studies of primary mitochondrial disease (PMD) subjects with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes syndrome (MELAS). To explore its utility in a broader array of PMDs and secondary mitochondrial disorders, we performed prfeclinical modeling of zag across larval and adult zebrafish models with biochemical deficiencies in diverse respiratory chain (RC) complexes or dihydrolipoamide dehydrogenase (Dldh).MethodsZag was evaluated for tissue uptake, gross toxicity, protection from RC toxin-induced brain death, neuromuscular dysfunction, heartbeat loss, and biochemical dysfunction in transgenic or toxin-exposed zebrafish with mitochondrial enzyme deficiencies in complex I (ndufs2−/− or rotenone-exposed wild type (WT)), complex IV (surf1−/− or azide-exposed WT), multiple RC complexes (fbxl4−/−), or pyruvate dehydrogenase complex (dldh−/−). …”
Get full text

Characterisation of the tumour microenvironment and PD-L1 granularity reveals the prognostic value of cancer-associated myofibroblasts in non-invasive bladder cancer by Carmen G. Cañizo, Félix Guerrero-Ramos, Mercedes Perez Escavy, Iris Lodewijk, Cristian Suárez-Cabrera, Lucía Morales, Sandra P. Nunes, Ester Munera-Maravilla, Carolina Rubio, Rebeca Sánchez, Marta Rodriguez-Izquierdo, Jaime Martínez de Villarreal, Francisco X. Real, Daniel Castellano, Cristina Martín-Arriscado, David Lora Pablos, Alfredo Rodríguez Antolín, Marta Dueñas, Jesús M. Paramio, Victor G. Martínez

“…Unbiased analysis revealed that myoCAF and M2-like macrophages are specifically enriched in high-grade NMIBC tumors. …”
Get full text

Discovery of a Pair of Galaxies with Both Hosting X-Ray Binary Candidates at z = 2.544 by Sijia Cai, Zheng Cai, Jianwei Lyu, Yunjing Wu, Xiaojing Lin, Mingyu Li, Junjie Mao, Jiayi Chen, Pengjun Lu

“…By combining multiwavelength observations from JWST/NIRSpec Micro-Shutter Assembly spectra, JWST/NIRCam and MIRI imaging, Chandra, Hubble Space Telescope, Very Large Telescope, Atacama Large Millimeter/submillimeter Array, and Very Large Array, we analyze the ionized emission lines, which are primarily driven by H II region–like processes. …”
Get full text

Neurofilament light chain plasma levels in major depressive disorder: a brief research report by Carlos Fernández-Pereira, Carlos Fernández-Pereira, Carlos Fernández-Pereira, María de los Ángeles Fernández-Ceballos, María de los Ángeles Fernández-Ceballos, María de los Ángeles Fernández-Ceballos, José Manuel Olivares, José M. Prieto-González, José M. Prieto-González, José M. Prieto-González, Roberto Carlos Agís-Balboa, Roberto Carlos Agís-Balboa, Roberto Carlos Agís-Balboa

“…However, there is still controversy of whether NfL peripheral levels might be altered in psychiatric disorders like major depressive disorder (MDD) when compared against a normal population.MethodsWe have measured NfL plasma levels by using single molecule array (SIMOA) technology in a Spanish small cohort of MDD patients (n = 15) and a HC group (n = 15). …”
Get full text

Epidemics In The 21st Century: A Multifaceted Challenge by Shawana Sharif

“…From the haunting reappearances of familiar adversaries like influenza to the unexpected onslaught of novel viruses such as SARS-CoV-2, this era has borne witness to a diverse array of health crises that have tested the resilience of societies worldwide. …”
Get full text

Exploring the Hemolymph of the Pill Millipede <i>Arthrosphaera lutescens</i> (Butler, 1872): Chemical Composition, Bioactive Properties, and Computational Studies by Priyanka Palakkaparambil, Veena Venugopal, Gouthami Vijayan, Mohammed Amjed Alsaegh, Varun Thachan Kundil, Arun Kumar Gangadharan, Ovungal Sabira, Aswathi, A. V. Raghu, Kodangattil Narayanan Jayaraj, Anthyalam Parambil Ajaykumar

“…Chemical characterization of hemolymph was performed using gas chromatography–mass spectrometry (GC-MS) and liquid chromatography–quadrupole time-of-flight mass spectrometry (LC-MS Q-TOF), revealing a complex array of over 200 compounds. The bioactive properties of hemolymph were determined by using radical scavenging capacity (DPPH assay); antibacterial activity against human pathogens like Escherichia coli (Migula, 1895) Castellani and Chalmers 1919, <i>Klebsiella pneumonia</i> (Schroeter, 1886) Trevisan 1887, and Staphylococcus aureus (Rosenbach, 1884); and cytotoxicity against Dalton’s lymphoma ascites (DLA) cells using the trypan blue assay. …”
Get full text