Skatole Alleviates Osteoarthritis by Reprogramming Macrophage Polarization and Protecting Chondrocytes by Weiyun Wang, Yaru Chu, Yunkun Lu, Jie Xu, Weixuan Zhao, Zhuo Liang, Xueqiang Guo, Lingling Xi, Tao Han, Yaping Shen, Wenjuan Song, Yanhua Tang, Mengnan Wen, Zhuang Qian, Lei Wang, Zhenlin Fan, Guangdong Zhou, Wenjie Ren

“…The CUT&Tag assay results indicated that the downstream transcription factor p65 of NFκB can directly bind to gene loci related to inflammation, oxidative phosphorylation, and glutathione metabolism, thereby modulating gene expression. This regulatory process is inhibited by skatole. At the chondrocyte level, conditional medium from skatole-treated M1 macrophages balanced anabolism and catabolism in mouse chondrocytes and inhibited apoptosis. …”
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Peer support for adult social care in prisons in England and Wales: a mixed-methods rapid evaluation by Holly Walton, Efthalia Massou, Chris Sherlaw-Johnson, Donna Gipson, Lucy Wainwright, Paula Harriott, Pei Li Ng, Stephen Riley, Stephen Morris, Naomi J Fulop

“…No studies measured cost-effectiveness. Individual level factors, service level factors, and organisational factors influenced implementation of peer support schemes. …”
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How do physicians estimate cardiovascular risk in the el-derly using E-health - a pilot study by Sorina Maria Aurelian, Justin Aurelian, Simona Isabelle Stoica, Andreea Iulia Vlădulescu-Trandafir, Andreea Zamfirescu, Gelu Onose

“…These conditions can be effectively mitigated through the adoption of a healthy lifestyle. …”
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Systematic development of quality indicators for skin cancer management in primary care: a mixed-methods study protocol by Frances Rapport, Jeffrey Braithwaite, Anne E Cust, David Wilkinson, Andrea Smith, Bela Ines Laginha

“…Such incidence necessitates large-scale, effective skin cancer management practices. General practitioners (in mainstream practice and in skin cancer clinics) play an important role in skin cancer care provision, making decisions based on relevant evidence-based guidelines, protocols, experience and training. …”
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Research on optimisation of rural tourism development path in Henan province by Dou Yingying, Dzhylkychieva Zhyldyz, Liang Zongzheng, Zhang Shuolei, Liang Liuke

“…The analysis of the current state of this tourism industry in the region has identified the main problems and barriers faced by rural tourism in the process of its improvement. Therewith, it was established that investment difficulties, uneven infrastructure development, lack of qualified personnel in the field of tourism and the lack of effective programmes limit the potential of rural tourism in this region. …”
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Neuromorphic, physics-informed spiking neural network for molecular dynamics by Vuong Van Pham, Temoor Muther, Amirmasoud Kalantari Dahaghi

“…In recent years, Scientific Machine Learning (Sci-ML) in MD attracted significant attention and has become a new direction of scientific research. However, effectively integrating Sci-ML with MD simulations remains challenging. …”
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3D bioprinting lobule-like hepatorganoids with induced vascularization for orthotopic implantation by Jianing Yan, Zhichao Ye, Yiwei Lu, Yuyang Yuan, Xiaofeng Wang, Tingting Yan, Jun Yin, Yifan Wang

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Rehabilitation using virtual gaming for Hospital and hOMe-Based training for the Upper limb post Stroke (RHOMBUS II): protocol of a feasibility randomised controlled trial by Cherry Kilbride, Tom Butcher, Meriel Norris, Nana Anokye, Alyson Warland, Karen Baker, Dimitrios A Athanasiou, Guillem Singla-Buxarrais, Jennifer Ryan, Francesca Gowing, Carole Pound, Victoria Stewart, Basaam Aweid, Arul Samiyappan

“…Introduction Upper limb (UL) rehabilitation is most effective early after stroke, with higher doses leading to improved outcomes. …”
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Inducible engineering precursor metabolic flux for synthesizing hyaluronic acid of customized molecular weight in Streptococcus zooepidemicus by Rui Zhao, Jun Li, Yingtian Li, Xujuan Pei, Jingyi Di, Zhoujie Xie, Hao Liu, Weixia Gao

“…Streptococcus zooepidemicus, a prominent HA industrial producer, naturally synthetizes HA with high MW. Currently, few effective approaches exist for the direct and precise regulation of HA MW through a one-step fermentation process, and S. zooepidemicus lacks metabolic regulatory elements with varying intensities. …”
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End-to-End Mandarin Speech Reconstruction Based on Ultrasound Tongue Images Using Deep Learning by Fengji Li, Fei Shen, Ding Ma, Jie Zhou, Shaochuan Zhang, Li Wang, Fan Fan, Tao Liu, Xiaohong Chen, Tomoki Toda, Haijun Niu

“…In clinical practice, most laryngectomees retain intact upper tract articulatory organs, emphasizing the significance of speech rehabilitation that utilizes articulatory motion information to effectively restore speech. This study proposed a deep learning-based end-to-end method for speech reconstruction using ultrasound tongue images. …”
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Integrating artificial Intelligence-Based metaheuristic optimization with Machine learning to enhance Nanomaterial-Containing latent heat thermal energy storage systems by Ali Basem, Hanaa Kadhim Abdulaali, As’ad Alizadeh, Pradeep Kumar Singh, Komal Parashar, Ali E. Anqi, Husam Rajab, Pancham Cajla, H. Maleki

“…Results showed a noticeable difference in the effectiveness of the GA and PSO algorithms in optimizing the structural and training parameters of various machine learning approaches. …”
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Novel image registration algorithm for scene-matching navigation by Hongrui YANG, Qiju ZHU, Peixian CAO, Hao GU, Dongdong ZHAO

“…It effectively extracts image features by delineating pixel characteristics of oriented gradients and uses a regional feature extraction strategy. …”
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PRACTICAL TRAINING OF OFFICERS OF THE STATE FIRE SERVICE THROUGH GAME-BASED LEARNING by V. V. Bulgakov, A. A. Lazarev, E. P. Konovalenko, T. A. Mochalova

“…It is common knowledge that lives and health of people as well as safe operation of various infrastructures depend on the high level of professionalism of the staff responsible for safety. …”
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Enhancing Spatial Allocation of Pediatric Medical Facilities for Reduced Travel-Related CO₂ Emissions: A Case Study in Tianjin, China by Hongjie Dong, He Zhang, Rui Wang, Yutong Zhang, Yuxue Zhang, Lisha Zhang

“…This study proposes enhancing the spatial allocation of pediatric medical facilities to effectively reduce travel-related CO₂ emissions. …”
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USING ARTIFICIAL INTELLIGENCE (AI) AND DEEP LEARNING TECHNIQUES IN FINANCIAL RISK MANAGEMENT by Joseph Olorunfemi AKANDE

“…Future research must prioritize developing models that can provide clear explanations of their decision-making processes, as well as ensuring that they do not disproportionately affect certain groups. …”
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USING ARTIFICIAL INTELLIGENCE (AI) AND DEEP LEARNING TECHNIQUES IN FINANCIAL RISK MANAGEMENT by Joseph Olorunfemi AKANDE

“…Future research must prioritize developing models that can provide clear explanations of their decision-making processes, as well as ensuring that they do not disproportionately affect certain groups. …”
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Modelo PEF de costes de la calidad como herramienta de gestión en empresas constructoras: una visión actual Quality costs PEF model as a management tool in construction firms: a pr... by Santos Gracia Villar, Luis A Dzul López

“…The objective of a quality costs system is to find the level of quality that minimizes total quality costs; this will give the security that the construction firm is working efficiently in relation to its processes and products…”
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Uso e ocupação do solo em São Paulo, alterações climáticas e os riscos ambientais contemporâneos by Jane Zilda dos Santos Ramires, Neli Aparecida de Mello-Théry

“…Climate change generates risks to all mankind, but it is the local level that its effects have greater magnitude because the world population is concentrated in large urban agglomerations and due to the characteristic pattern of urbanization intense soil sealing, removal of vegetation and occupation of vulnerable areas. …”
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Utilizing integrated bioinformatics and machine learning approaches to elucidate biomarkers linking sepsis to purine metabolism-associated genes by Fanqi Liang, Man Zheng, Jingjiu Lu, Peng Liu, Xinyu Chen

“…The diagnostic capability of these PMGs to effectively differentiate sepsis cases underscored their potential as biomarkers. …”
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Changes in Gene Expression of Whiteflies, Bemisia tabaci MED Feeding on Tomato Plants Infected by One of the Criniviruses, Tomato Chlorosis Virus through Transcriptome Analysis by Jing Zhao, Xiaoan Sun, Huijie Dai, Xianping Zhang, Dezhen Zhang, Xiaoping Zhu

“…The number of DEGs, degree of differential gene expressions, expression level of the same gene, involved biological processes, and metabolic functions in whiteflies post the 12 hours feeding, and viral acquisition were different from those from other three feeding treatments, which could be a significant finding suggesting an effective control of B. tabaci MED should be done less than 12 hours after whiteflies started feeding on ToCV-infected tomatoes. …”
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