Enhancement of CD8+T cell cytotoxicity activity by IFN-α implies alternative pathologic role in systemic lupus erythematosus by Chen-xing Zhang, You-ying Mao, Yu-pin Tan, Mei-yu Zhang, Kang Shao, Shu-jun Wang, Ping Ji, Jia-yuan Wang, Lei Yin, Ying Wang

“…Conclusion: In summary, elevated serum level of IFN-α was responsible for increased secretion of granzyme B and enhanced cytotoxicity of CD8+T cells in SLE and this process may be related to PI3K pathway. …”
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To construct and validate a risk score model of angiogenesis-related genes to predict the prognosis of hepatocellular carcinoma by Duangui Gao, Yuan Lu, Tianpeng Jiang, Qinghong Duan, Zhi Huang

“…Cox regression analysis, Kaplan Meier (KM) curve, ROC curve, and decision-curve analysis will be used to evaluate and examine the risk score prediction effect of the model. GSVA analysis was used to assess the variation of gene sets between groups, and ClBERSOFT, ESTIMATE, and TIMER databases were used to analyze the immune infiltration in the single-cell level analysis of gene expression differences between cells. …”
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Mathematical modeling in autoimmune diseases: from theory to clinical application by Yaroslav Ugolkov, Yaroslav Ugolkov, Yaroslav Ugolkov, Antonina Nikitich, Antonina Nikitich, Cristina Leon, Gabriel Helmlinger, Kirill Peskov, Kirill Peskov, Kirill Peskov, Kirill Peskov, Victor Sokolov, Victor Sokolov, Alina Volkova, Alina Volkova

“…Models differ in the spectra of quantitative data used in their development and mathematical methods, as well as in the level of “mechanistic granularity” chosen to describe the underlying biology. …”
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Non-thermal atmospheric pressure plasma-irradiated cysteine protects cardiac ischemia/reperfusion injury by preserving supersulfides by Akiyuki Nishimura, Tomohiro Tanaka, Kakeru Shimoda, Tomoaki Ida, Shota Sasaki, Keitaro Umezawa, Hiromi Imamura, Yasuteru Urano, Fumito Ichinose, Toshiro Kaneko, Takaaki Akaike, Motohiro Nishida

“…Non-thermal atmospheric pressure plasma irradiation therapy is attracted attention as it exerts beneficial effects by producing various reactive molecular species. …”
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Yoga programme for type-2 diabetes prevention (YOGA-DP) among high risk people in India: a multicentre feasibility randomised controlled trial protocol by Mark Hamer, Dorairaj Prabhakaran, Kavita Singh, Nikhil Tandon, Sanjay Kinra, Kaushik Chattopadhyay, Tess Harris, Pallavi Mishra, Sheila Margaret Greenfield, Sarah Anne Lewis, Nandi Krishnamurthy Manjunath, Rukamani Nair, Somnath Mukherjee, David Ross Harper

“…The exercise part is based on Yoga and includes Shithilikarana Vyayama (loosening exercises), Surya Namaskar (sun salutation exercises), Asana (Yogic poses), Pranayama (breathing practices) and Dhyana (meditation) and relaxation practices.Methods and analysis This is a multicentre, two-arm, parallel-group, feasibility RCT with blinded outcome assessment and integrated mixed-methods process evaluation. Eligible participants should be aged 18–74 years, at high risk of T2DM (fasting plasma glucose level 5.6–6.9 mmol/L) and safe to participate in physical activities. …”
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Characterizing tumor biology and immune microenvironment in high-grade serous ovarian cancer via single-cell RNA sequencing: insights for targeted and personalized immunotherapy st... by Fu Zhao, Fu Zhao, Xiaojing Jiang, Yumeng Li, Tianjiao Huang, Zhikai Xiahou, Wenyang Nie, Qian Li

“…Understanding the molecular mechanisms, immune landscape, and drug sensitivity of HGSOC is crucial for developing more effective and personalized therapies. This study integrates insights from cancer immunology, molecular profiling, and drug sensitivity analysis to identify novel therapeutic targets and improve treatment outcomes. …”
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Management of mangrove landscape and ecosystem for ecotourism by H.T. Silalahi, M. Basyuni, E.Y. Aritonang, B. Slamet, K.S. Hartini, A. Wee

“…Through thorough study and analysis of both human behavior and natural processes, effective management strategies can be developed to support ecotourism initiatives. …”
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Transcriptomic Analysis of Menstrual Blood-Derived Stem Cells Transplantation Combined with Exercise Training in Promoting Spinal Cord Injury Recovery in Rats by QI Longju, CHEN Shiyuan, LIAO Zehua, SHI Yuanhu, SUN Yuyu, WANG Qinghua

“…Furthermore, real-time quantitative PCR and Western blotting confirmed that brain-derived neurotrophic factor (BDNF) mRNA and protein expression levels in the CTMT group were significantly higher than those in the SCI group (P<0.001).ConclusionThe combined exercise training with MenSCs effectively promotes the recovery of motor function in SCI rats by upregulating BDNF expression, providing a novel strategy for SCI treatment.…”
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Insights into mungbean defense response to Cercospora leaf spot based on transcriptome analysis by Sukanya Inthaisong, Pakpoom Boonchuen, Tana Jaichopsanthia, Pongpan Songwattana, Apinya Khairum, Witsarut Chueakhunthod, Akkawat Tharapreuksapong, Panlada Tittabutr, Neung Teaumroong, Piyada Alisha Tantasawat

“…Moreover, SUPER5 was found to have higher β-1,3-glucanase and chitinase activity levels than CN84-1. Our findings contribute to an understanding of the CLS resistance mechanisms and may advocate the development of more effective disease management approaches.…”
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Geoconservation in Latin America and the Caribbean by Maria Da Gloria Motta Garcia, Marcos Antonio Leite Do Nascimento

“…This is a task achievable only through effective communication with society, which is the role of geoconservation. …”
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Facing migration under adverse conditions: challenges and resilience in the Colombo-Venezuelan border area by Gloria Omaira Bautista, Axel Kroeger, Nelly Rosero Castillo, Eduardo Gabriel Osorio Sanchez, Dianne Sofía Gonzales Escobar, Rafael Olarte, Sonia Diaz Monsalve

“…Following their arrival, irregular migrants had to go through a regulation (legalization) process in Colombia, with 48.1% having either initiated or completed this process. …”
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Management control for quality in a hospitality business using ARP curves and the multivariate geometric indicator - Control de gestión para la calidad en una empresa hotelera con... by Tomás José Fontalvo Herrera, Juan José Tous Ferrigno, Fabio Mejía Zambrano

“…Results: the premium and standard service lines achieved the highest Sigma Z levels, consistently exceeding 5. The analysis identified the required production units in each process to transition from an initial performance level (Z1) to a target level (Z2). …”
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Schnittstellen zwischen performance und Analyse von Popmusik. Performative Produktionsprozesse in Pink Floyds Album Wish You Were Here und Jordan Rudessʼ Coverversion von Genesisʼ... by Hubertus Dreyer, Pascal Horn

“…Both works belong to the prog rock tradition and display a similar level of musical complexity; the way in which these works are complex, however, differs and reflects different production styles: Pink Floydʼs album is the result of a quasi vegetative growth under strong psychological distress, leading to a dense network of musical cross-references throughout the album; Jordan Rudess, on the other hand, proceeds rationally and economically, and the artistic effect of the result owes much to the virtuosity of the musicians.…”
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Pengembangan Aplikasi Sistem Penilaian Praktik Pengalaman Lapangan pada Fakultas Ilmu Komputer Universitas Brawijaya Berbasis Web by Rizky Tri Sulistyo, Faizatul Amalia, Tri Afirianto

“…However, during the FEP implementation process all activities are still carried out offline. …”
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Design of an improved model using federated learning and LSTM autoencoders for secure and transparent blockchain network transactions by R. Vijay Anand, G. Magesh, I. Alagiri, Madala Guru Brahmam, Balamurugan Balusamy, Chithirai Pon Selvan, Haya Mesfer Alshahrani, Masresha Getahun, Ben Othman Soufiene

“…Our proposed framework is effective according to the interim outcomes where the aggregation of local models occurred without data leakage, detected anomalies very efficiently, managed models very transparently, with privacy of data at a very high level, and easily detected fraudulent transactions. …”
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Antioxidants in the Treatment of Chronic Diffuse Liver Diseases (the Results of the “MAXAR” Observational Program) by M. V. Mayevskaya, V. T. Ivashkin, V. D. Lunkov, S. P. Kryzhanovskiy, I. Yu. Pirogova, Ch. S. Pavlov, M. S. Zharkova, A. G. Beniashvili, M. A. Morozova

“…In the course of the treatment, no clinically significant side effects were documented.…”
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Lnc-EST885 promotes hepatocellular carcinoma metastasis through PI3K / AKT pathway by interaction with TRAF4 by Shaoliang Zhu, Gang Wang, Yuxuan Zhang, Mengjie Zou, Zhi Li, Shenhong Qu, Xiaosu Zou, Wenqian Nong, Weiwei Miao, Qicong Chen, Juanmei Mo, Huibing Chen, Lequn Li, Xiaofeng Dong, Honglin Luo

“…Methods: Cell experiments including FISH, western blot, flow cytometry and functional analysis were used to elucidate the effects of lnc-EST885 on cell proliferation, apoptosis, migration and EMT processes. …”
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How resistant is anammox biofilm against antibiotics: A special insight into anammox response towards fluoroquinolones by Faysal-Al Mamun, Rohit Kumar, Kelvin Ugochukwu Anwuta, Sovik Das, Madis Jaagura, Koit Herodes, Tetyana Kyrpel, Agnieszka Fiszka Borzyszkowska, Anna Zielińska-Jurek, Zane Vincevica-Gaile, Juris Burlakovs, Andrey E. Krauklis, Mohamad Nor Azra, Md Salauddin, Jiexi Zhong, Taavo Tenno, Kai Bester, Ivar Zekker

“…Evidently, at higher PhAC levels, the anammox process was active, and up to 75 % PhAC removal efficiency was obtained within 6 h of the batch cycle. …”
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Development and validation of the pain management competency scale for nurses and a nationwide survey of Chinese nurses by Yixue Wu, Xiang Pan, Lihui Gu, Yingge Tong, Siyi Chen, Ke Ni, Hangyan Du, Meng Yang, Jianyi Wang, Yi Chen, Yeling Wei, Lingling Luo, Wenqian Cheng

“…Abstract Background Nurses’ competency in pain management is essential for effectively alleviating patients' acute pain, controlling chronic pain, and promoting patient recovery. …”
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KiKli Fit: Investigating the Implementation of a Physical Activity Program in Pediatric Cancer by Lars Rehbein, Ann Christin Schneider, Christina Hillebrech, Christina Schindera, Amika Singh, Katharina Eva, Valentin Benzing

“…Children and their families expressed enthusiasm for engaging in structured PA, reporting perceived benefits such as reduced treatment-related side effects, increased PA levels, and improved self-esteem. …”
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