Asperulosidic acid inhibits the PI3K/Akt/NF-κB pathway to suppress endotoxin-induced uveitis by Yong Du, Jing Lu, Lujia Feng, Long Zhao, Ping Wu, Yuxia He, Linbin Zhou, Xing Wang, Hui Peng

“…Asperulosidic Acid (ASPA), derived from Hedyotis diffusa, is known for its notable anti-inflammatory and antioxidant characteristics.MethodsThe present study explored the potential anti-inflammatory effects and the fundamental processes of ASPA by injecting it or a placebo into the vitreous of rats with endotoxin-induced uveitis (EIU). …”
Get full text

NLRP3: a key regulator of skin wound healing and macrophage-fibroblast interactions in mice by Jiamin Zhao, Shuangyi Zhang, Zhiguo Gong, Wei Mao, Wenhui Bao, Qianru Li, Yunjie Bai, Feifei Gao, Shuang Feng

“…Abstract Wound healing is a highly coordinated process driven by intricate molecular signaling and dynamic interactions between diverse cell types. …”
Get full text

The role of Latin America medicinal plants in wound healing by Mariana Sánchez-Ramos, Andrea Ruiz-Betancourt, Stephany Abigail Tadeo-Cuenca, Angélica Román-Guerrero, María Crystal Columba-Palomares, Araceli Guerrero-Alonso, Antonio Bernabé-Antonio, Deyanira Ojeda-Ramírez, Francisco Cruz-Sosa

“…Therefore, therapies have been developed to accelerate wound healing and have proven effective. However, factors such as diabetes mellitus limit the healing process because it causes alterations in microvascular dysfunction, as well as in the inflammatory response and greater oxidative stress. …”
Get full text

Whole systems approaches to diet and healthy weight: A scoping review of reviews. by Gavin Breslin, Olujoke Fakoya, Wendy Wills, Nigel Lloyd, Charis Bontoft, Amander Wellings, Sian Harding, John Jackson, Katherine Barrett, Adam P Wagner, Lisa Miners, Honey-Anne Greco, Katherine E Brown

“…<h4>Background</h4>Obesity is a global epidemic affecting all age groups, populations, and income levels across continents, though is known to disproportionately affect socioeconomically disadvantaged populations. …”
Get full text

Evaluasi Maturitas Teknologi Informasi Pada Proses Problem Management PT. XYZ Menggunakan Kerangka Kerja COBIT 5 by Muhammad Naufal Pratama, Andi Reza Perdanakusuma, Aditya Rachmadi

“…Based on the issues, it is necessary to conduct research that aims to determine the capability level of the problem management process implemented by the company using the COBIT 5 framework as a measuring tool for the Capability level in the Manage Problem sub-process (DSS03). …”
Get full text

Metformin for Treating Gestational Diabetes: What Have We Learned During the Last Two Decades? A Systematic Review by Angeliki Gerede, Ekaterini Domali, Christos Chatzakis, Chrysoula Margioula-Siarkou, Stamatios Petousis, Sofoklis Stavros, Konstantinos Nikolettos, Evanthia Gouveri, Sotirios Sotiriou, Panagiotis Tsikouras, Konstantinos Dinas, Nikolaos Nikolettos, Nikolaos Papanas, Dimitrios G. Goulis, Alexandros Sotiriadis

“…There has been accumulating evidence over the past two decades that metformin can be an effective treatment for gestational diabetes mellitus (GDM) in women whose diet and exercise fail to attain optimal glycemic control. …”
Get full text

Long-Lasting Anti-Inflammatory Activity of Human Microfragmented Adipose Tissue by Sara Nava, Valeria Sordi, Luisa Pascucci, Carlo Tremolada, Emilio Ciusani, Offer Zeira, Moris Cadei, Gianni Soldati, Augusto Pessina, Eugenio Parati, Mark Slevin, Giulio Alessandri

“…We conclude that MFAT is an effective preparation with a long-lasting anti-inflammatory activity probably mediated by a long-term survival of their MSC content that releases a combination of cytokines that affect several mechanisms involved in inflammation processes.…”
Get full text

Development of a Motion-Based Video Game for Postural Training: A Feasibility Study on Older Adults With Adult Degenerative Scoliosis by Frances K. W. Wan, Alex T. H. Mak, Claire W. Y. Chung, Joanne Y. W. Yip

“…Although this immediate effect only partially sustained after the 6-week program, the participants learned to adjust their shoulder and pelvis level for a better lateral alignment in standing. …”
Get full text

Examining of Impression Management of Academicians in Higher Education Institutions Providing Sports Education by Hakan Salim Çağlayan, İbrahim Bülent Fişekçioğlu, Tuncay Sarıipek

“…A research using a descriptive scanning method aimed at revealing the current situation; 51 Faculties of Sports Sciences participating in the data collection process[n=426], 13 School of Physical Education and Sports[n=72] and 2 at the Department of Physical Education and Sports Teaching Affiliated to the Faculties of Education[n=5] a total of 503 who served[male=404, female=99; professor=44, associate professor=99, dr.teachmember=122, teaching.see=133, Res.see=105] it was carried out on the sample of Acaemicians. …”
Get full text

Suppression of Proinflammatory Cytokines and Mediators in LPS-Induced RAW 264.7 Macrophages by Stem Extract of Alternanthera sessilis via the Inhibition of the NF-κB Pathway by Katyakyini Muniandy, Sivapragasam Gothai, Khaleel M. H. Badran, S. Suresh Kumar, Norhaizan Mohd Esa, Palanisamy Arulselvan

“…Inflammation is a natural process of the innate immune system, accompanied with the increase in the level of proinflammatory mediators, for example, nitric oxide (NO) and prostaglandin (PGE2); cytokines such as interleukin 6 (IL-6), interleukin 1β (IL-1β), and tumor necrosis factor alpha (TNFα); and enzymes including inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) via the activation and nuclear translocation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) subunit p65 due to the phosphorylation of inhibitory protein, IκBα. …”
Get full text

A Low Complexity Dual-Phase Alternating Scheme is Used With the PTS Method to Reduce PAPR for B5G Systems by Yung-Ping Tu, Chen-Wei Hsu

“…In the first stage, we use the partial transmission sequence (PTS) scheme to produce an acceptable PAPR threshold, which can be used as the initial upper bound level for the second stage. To reduce computational complexity, before entering the second stage, we employ the pre-process by Monte Carlo method to estimate the amount of subcarriers worth altering, denoted as <inline-formula> <tex-math notation="LaTeX">$\beta $ </tex-math></inline-formula>. …”
Get full text

The association between digital technology use and depression among older people in China: a moderated mediation model by Qinmei Wu, Wei He, Jinfu Wang, Litao Du, Xiangli Xue, Qiang He, Yang Pan, Si Chen, Xianliang Zhang

“…Various dimensions of digital technology use exerted direct effects on depression scores of 85.87% (DE, OR= -0.638, 95%CI: -1.036, -0.240), 86.09% (DD, OR= -0.526, 95%CI: -0.844, -0.208), and 87.82% (DP, OR= -0.173, 95%CI: -0.259, -0.087), respectively, and social participation mediated 14.13%, 13.91%, 12.18%. …”
Get full text

MEMBATIK SEBAGAI MEDIA DALAM MENURUNKAN PERILAKU AGRESIF ANAK by Nunuk Nur Shokiyah

“…Kata Kunci : Perilaku Agresif Anak, Metode eksperimen, Pelatihan Membatik   This study aims to examine the effect of batik training on children's aggressive behavior. …”
Get full text

Raw Cured Poultry Meat Fortified with Bee Pollen: Biomedical Research on Laboratory Animals by Maksim A. Sukhov, Tatiana M. Giro, Sergey V. Kozlov, Irina V. Ziruk

“…On day 14, the concentration of protein and its fractions in experimental group II reached the level of intact animals. In experimental groups II and III, the total protein was significantly higher due to the globulin fraction as a result of inflammatory and destructive processes in the liver. …”
Get full text

A network comparison on efficacy and safety profiling of PD-1/PD-L1 inhibitors in first-line treatment of advanced non-small cell lung cancer by Jie Fu, Jie Fu, Yi-Dan Yan, Xu Wan, Xiao-Fan Sun, Xiao-Fan Sun, Xiu-Mei Ma, Ying-Jie Su

“…Safety at the individual patient level must be a high priority in the decision-making process. …”
Get full text

Hydrogen Sulfide Promotes Functional Endometrium Recovery via Regulating Pyroptosis in Severe Endometrial Injury: A Prospective Laboratory Based Randomized Control Trial by Haiyan Shan, Mingyuan Xu, Jie Ni, Ling Zhou, Mengchun Xue, Jun Xue, Xiaohuan Yuan, Luyang Tao, Mingyang Zhang, Hong Zhang

“…In recent years, hydrogen sulfide (H2S), a gaseous signaling molecule, exerts significant regulatory effects on pyroptosis in diverse pathological processes. …”
Get full text

Baccaurea ramiflora fruit peel powder supplementation prevented inflammatory cell infiltration, oxidative stress, and fibrosis in carbon tetrachloride (CCl4) administered ovariecto... by Tahsin Zahan, Mirza Alimullah, Ishrat Jahan, Md. Borhan Uddin, Khondker Ayesha Akter, Md. Junaeid Rahman, Shahnaz Siddiqua, Kamrun Nahar Ela, Sakil Amin, Khondoker Shahin Ahmed, Hemayet Hossain, Ferdous Khan, Md Ashraful Alam, Nusrat Subhan

“…The results are comparable to the effects of silymarin therapy in rats that were administered CCl4. …”
Get full text

Neutrophil-to-lymphocyte, platelet-to-lymphocyte ratios and systemic immune-inflammation index in patients with post-traumatic stress disorder by Gözde Yontar, Elif Aktan Mutlu

“…Neutrophil and platelet levels of PTSD patients were significantly higher than controls although both groups’ values were in normal range. …”
Get full text

Six MicroRNA Prognostic Models for Overall Survival of Lung Adenocarcinoma by Juan Li, Xuyu Gu, Chanchan Gao, Jun Zhang

“…The purpose of this study is to screen for microRNAs (miRNAs) associated with the prognosis of lung adenocarcinoma (LUAD) and to explore its prognosis and effects on the tumor microenvironment in patients with LUAD. …”
Get full text

Three-Dimensional Aeroelastic Investigation of a Novel Convex Bladed H-Darrieus Wind Turbine Based on a Two-Way Coupled Computational Fluid Dynamics and Finite Element Analysis App... by Tarek Elbeji, Wael Ben Amira, Khaled Souaissa, Moncef Ghiss, Hatem Bentaher, Nabil Ben Fredj

Get full text