Interferon Regulatory Factor 3 Exacerbates the Severity of COVID-19 in Mice by Wendy E. Walker, PhD, Luiz F. Garcia, MS, Pedro M. Palermo, PhD, Nawar Hakim, MD, Dinesh G. Goswami, PhD, Alok K. Dwivedi, PhD, Douglas M. Watts, PhD

“…There is still much to learn about the innate immune response to this virus. …”
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Computational image features of immune architecture is associated with clinical benefit and survival in gynecological cancers across treatment modalities by Pingfu Fu, Kaustav Bera, Anant Madabhushi, Haider Mahdi, Germán Corredor, Sepideh Azarianpour, Patrick Leo, Paula Toro, Amy Joehlin-Price, Mojgan Mokhtari

“…Background We present a computational approach (ArcTIL) for quantitative characterization of the architecture of tumor-infiltrating lymphocytes (TILs) and their interplay with cancer cells from digitized H&E-stained histology whole slide images and evaluate its prognostic role in three different gynecological cancer (GC) types and across three different treatment types (platinum, radiation and immunotherapy).Methods In this retrospective study, we included 926 patients with GC diagnosed with ovarian cancer (OC), cervical cancer, and endometrial cancer with available digitized diagnostic histology slides and survival outcome information. …”
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Pathways for Strengthening Lived Experience Leadership for Transformative Systems Change: Reflections on Research and Collective Change Strategies by Mark Loughhead, Ellie Hodges, Heather McIntyre, Nicholas Procter, Anne Barbara, Brooke Bickley, Lee Martinez, Leticia Albrecht, Lisa Huber

“…Methods The project invited a diverse range of self‐identified lived experience and other leaders to be involved in a PAR process featuring formal qualitative research (focus groups, surveys and interviews) as well as community development activities (leaders' summit meetings, consultations, training and community of practice meetings). …”
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Co-creating and disseminating substance use and vaping educational videos, question prompt lists, and other resources in partnership with community organizations and youth in Weste... by Betsy Sleath, Abena A. Adjei, Jeremy Lowery, Mckenna Knock, Bethany Beznos, Delesha M. Carpenter, Casey R. Tak, Kim James, Michelle Geiser, Nacire Garcia, Charles Lee

“…Objective: To co-design resources to empower youth to ask questions about vaping and substance use and to disseminate the developed materials in Western North Carolina. Methods: Two youth advisory boards were formed in Western North Carolina in partnership with two community organizations. …”
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Development and Delivery of an Integrated Digital Health Care Approach for Children With Juvenile Idiopathic Arthritis: Usability Study by Sonia Butler, Dean Sculley, Derek Santos, Xavier Gironès, Davinder Singh-Grewal, Andrea Coda

“…ObjectiveThis study aims to evaluate the usability of InteractiveClinics among children with JIA. MethodsAs part of this pediatric cross-sectional study, 12 children were asked to wear a smartwatch for 2 weeks, which was synchronized to the InteractiveClinics phone app and web-based platform. …”
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Implementation fidelity and client satisfaction in HIV testing and counseling services: perspectives from facilities and clients in Gondar city, Northwest Ethiopia by Bewuketu Terefe, Masresha Asmare Techane, Nega Tezera Assimamaw, Adane Kebede

“…Therefore, this study aimed to assess the current implementation status of VCT services and client satisfaction in public health facilities in Gondar City. Methods This cross-sectional study was conducted out from June to July 2022. …”
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The relationship between below average cognitive ability at age 5 years and the child’s experience of school at age 9 by Andrea K. Bowe, Mathias Urban, Anthony Staines, Deirdre M. Murray, Deirdre M. Murray

“…The aim of this study was to examine the causal association between below average cognitive ability at age 5 years and child-reported experience of school and self-concept, and teacher-reported class engagement and emotional-behavioural function at age 9 years.MethodsThis longitudinal cohort study used data from 7,392 children in the Growing Up in Ireland Infant Cohort, who had completed the Picture Similarities and Naming Vocabulary subtests of the British Abilities Scales at age 5. …”
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Evaluating the efficacy of mind maps and micro-videos in postoperative care education for lung cancer patients by Liang Feng, Wenjun Shen, Chen Zhang, Dandan Liu, Shunyi Huang, Xiaoxin Liu

“…Abstract Background Early health education is crucial for lung cancer patients and their families to learn self-monitoring and how to seek appropriate help for existing or upcoming issues. …”
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Cervicogenic Headache and Physiotherapy: A Systematic Review of Treatment Modalities by Manali Sanket Chitlange, Pallavi Harjpal

“…Aim: This article aims to provide a thorough overview of CGHs, covering a range of physical therapy treatments. Materials and Methods: In the present systematic review, a literature search was conducted to find pertinent studies and reviews on cervicogenic headache, using the PubMed database. …”
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The Clinical and Vascular Characteristics of RNF213 c.14576G>A Variant-Related Intracranial Major Artery Disease in China by Weiyang Cheng, Sufang Xue, Fang Wu, Xiaowei Song, Qiang Huang, Haiqing Song, Jian Wu

“…Moreover, we tried to explore the clinical significance of a testing variant in ICASO patients in China. Methods. Clinical material and routine image data were collected in 160 Chinese patients with ICASO, including 41 verified MMD and 119 non-MMD. …”
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CHANGE: A Multi-Country Cohort Project Exploring Child Malnutrition and Adult Non-Communicable Disease: Generating Evidence on Mechanistic Links to Inform Future Policy/Practice by Kimberley McKenzie, Natasha Lelijveld, Debbie Thompson, Kenneth Anujuo, Mubarek Abera, Marko Kerac

“…Conclusions: Even though our cohorts are in low- and middle-income countries, there are lessons to be learned for other countries undergoing nutrition transition and disadvantaged/vulnerable populations in high-income countries.…”
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Creation of a Safe Educational Environment for Ukrainian Youth During War Conditions by Natalia Tverdokhliebova, Nataliіa Yevtushenko

“…They are in dire need of educational opportunities. Many people have to learn a language, identify an educational qualification, or undergo educational retraining. …”
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AI-ready rectal cancer MR imaging: a workflow for tumor detection and segmentation by Heather M. Selby, Yewon A. Son, Vipul R. Sheth, Todd H. Wagner, Erqi L. Pollom, Arden M. Morris

“…By combining the radiologist's clinical expertise with the data scientists’ imaging analysis skills, we sought to establish a foundation for future AI-driven approaches that streamline rectal tumor detection and segmentation, and optimize workflow efficiency. Methods A total of 37 patients with rectal cancer were included in this study. …”
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Acceptability of and experiences with menstrual hygiene cups among adolescent girls and young women aged 15–24 in two communities in Lusaka, Zambia: an exploratory study nested in... by Melleh Gondwe, Melvin Simuyaba, Mwelwa Phiri, Chisanga Mwansa, Albertus Schaap, Lucheka Sigande, Kwame Shanaube, Sian Floyd, Sarah Fidler, Helen Ayles, Musonda Simwinga, Bernadette Hensen

“…Methods Through community-based, peer-led spaces (hubs), AGYW could access menstrual products, including pads and menstrual cups. …”
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Co-Designing a User-Centered Digital Health Tool for Supportive Care Needs of Patients With Brain Tumors and Their Caregivers: Interview Analysis by Mahima Kalla, Ashleigh Bradford, Verena Schadewaldt, Kara Burns, Sarah C E Bray, Sarah Cain, Heidi McAlpine, Rana S Dhillon, Wendy Chapman, James R Whittle, Katharine J Drummond, Meinir Krishnasamy

“…ObjectiveThis study aims to generate ideas and concepts, through a co-design paradigm, to inform the development of a digital health tool to address the unmet needs of people affected by brain tumors. MethodsPatients with brain tumors, caregivers, and health professionals from 2 large public tertiary hospitals in Victoria, Australia, were invited to complete a qualitative interview discussing their unmet needs of care. …”
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Determinant factors influencing stunting prevention behaviors among working mothers in West Java Province, Indonesia: a cross-sectional study by Neti Juniarti, Ethar Alsharaydeh, Citra Windani Mambang Sari, Desy Indra Yani, Alison Hutton

“…This study aimed to identify the determinants of working mothers’ stunting prevention behavior, including individual factors, work-related stress, well-being, knowledge, and attitudes toward the behavior of working mothers in supporting the prevention of stunting in West Java Province, Indonesia. Methods This study used a cross-sectional design with a total sample of 225 working mothers in 78 offices mapped in Bandung city, Bekasi city, Bekasi Regency, Karawang Regency, West Bandung Regency, and Sumedang Regency in West Java Province, Indonesia. …”
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Establishing a Multicenter Active Adverse Events Following Immunization Sentinel Surveillance Network Across 22 Tertiary Care Hospitals in India: Protocol for a Prospective Observa... by Apoorva Sharan, Manoja Kumar Das, Akhil PM, Ramesh Poluru, Neeraj Kumar Kashyap, Christian Burri, Jan Bonhoeffer, Satinder Aneja, Deepak Polpakara, Narendra Kumar Arora

“…ObjectiveThis study describes the protocol for establishing a Multicenter Active Adverse Events Following Immunization Surveillance System (MAASS) network in India, which conducted prospective observational surveillance for 12 adverse pediatric outcomes between November 1, 2017, and March 20, 2020. MethodsA multistage site selection process was implemented, beginning with an initial screening survey followed by in-person visits to assess the suitability of potential tertiary care hospitals for inclusion in the network. …”
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Home-based digital counselling by frontline community workers for anxiety and depression symptoms in rural Sindh, Pakistan: the mPareshan intervention by Fauziah Rabbani, Javeria Nafis, Samina Akhtar, Amna Siddiqui, Zul Merali

“…Methods Using Generalized Anxiety Disorder-7 (GAD-7) and Patient Health Questionnaire-9 (PHQ-9), a baseline household survey was conducted by independent data collectors to measure anxiety and depression. …”
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Establishment of a clinical helpline for mpox: comparison of the 2022 and 2024 experience in the UK by Dr Helen Callaby, Dr Jane Osborne, Dr Catherine F Houlihan, Dr Tommy Rampling, Dr Amy Belfield, Dr Clare Warrell, Dr Christina Petridou, Dr Matthew Donati, Dr Nicola C Gordon

“…As part of the UK's preparedness activities, data from the 2022 helpline experience was reviewed to inform readiness for a helpline in the event of importation of cases into the UK. Methods: Telephone data were accessed for the initial outbreak period in 2022, and from the announcement of the PHEIC in 2024. …”
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Virtual Reality for the Prevention and Cessation of Nicotine Vaping in Youths: Protocol for a Randomized Controlled Trial by Belinda Borrelli, Daniel Weinstein, Romano Endrighi, Nikki Ling, Kathleen Koval, Lisa M Quintiliani, Kaitlyn Konieczny

“…ObjectiveThis randomized controlled trial aimed to evaluate the feasibility and preliminary efficacy of a virtual reality (VR) intervention for teens that targets both determinants of vaping (eg, mood and stress) and vaping prevention and cessation skills. MethodsThe participants are 150 students attending 1 of 2 racially and ethnically diverse Boston-area high schools. …”
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