Two-step consensus clustering approach to immune cell infiltration: An integrated exploration and validation of prognostic and immune implications in sarcomas by Ao-Yu Li, Jie Bu, Hui-Ni Xiao, Zi-Yue Zhao, Jia-Lin Zhang, Bin Yu, Hui Li, Jin-Ping Li, Tao Xiao

“…To conduct a comprehensive investigation of the sarcoma immune cell infiltration (ImmCI) patterns and tumoral microenvironment (TME). We utilized transcriptomic, clinical, and mutation data of sarcoma patients (training cohort) obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) server. …”
Get full text

Integrating single-cell RNA-Seq and bulk RNA-Seq data to explore the key role of fatty acid metabolism in hepatocellular carcinoma by Hua Dai, Xin Tao, Yuansen Shu, Fanrong Liu, Xiaoping Cheng, Xiushen Li, Bairui Shu, Hongcheng Luo, XuXiang Chen, Zhaorui Cheng

“…Subsequent to this, consensus clustering analysis was implemented to stratify patients into distinct subgroups, contingent upon the expression patterns of lipid metabolism genes. Further analytical procedures involved functional enrichment analysis, evaluation of immune infiltration, and examination of the mutation landscape.PTGES3 was identified as a pivotal gene associated with lipid metabolism. …”
Get full text

Un broche de cinturón tardoantiguo de la cueva de Lazaldai (Zuia, Álava/Araba) by José Ángel Hierro Gárate, Enrique Gutiérrez Cuenca, Leticia Tobalina Pulido, Diego Garate Maidagan, Iñaki Intxaurbe Alberdi, Antonio Torres Riesgo, Sergio Salazar Cañarte

“…Its surface is densely decorated with incised motifs, including a large central interlace pattern similar to a “Solomon’s knot” and bordered by a triple-line “wolf tooth” design. …”
Get full text

Heat Wave, Cone Crops, Forest-Floor Small Mammals, and Mustelid Predation in Coniferous Forests of Southern British Columbia by Thomas P. Sullivan, Druscilla S. Sullivan, Alan Vyse

“…We report a landscape-scale natural experiment that followed the abundance and demography of forest-floor small mammals and the activity of small mustelids over a 4-year period of an extreme heat wave and abundant coniferous cone crops. …”
Get full text

The roles of surface processes in porphyry copper deposit preservation by B. Hadler Boggiani, T. Salles, C. Mallard, N. Atwood

“…To do so, we rely on a global-scale numerical model (<i>goSPL</i>), which simulates landscape dynamics and associated erosion and deposition patterns over geological timescales. …”
Get full text

Metabolomic Profiling and Functional Characterization of Biochar from Vine Pruning Residues for Applications in Animal Feed by Serena Reggi, Sara Frazzini, Maria Claudia Torresani, Marianna Guagliano, Cinzia Cristiani, Salvatore Roberto Pilu, Martina Ghidoli, Luciana Rossi

Get full text

Building Greener Cities Together: Urban Afforestation Requires Multiple Skills to Address Social, Ecological, and Climate Challenges by Raffaello Resemini, Chiara Geroldi, Giulia Capotorti, Andrea De Toni, Francesco Parisi, Michele De Sanctis, Thomas Cabai, Micol Rossini, Luigi Vignali, Matteo Umberto Poli, Ermes Lo Piccolo, Barbara Mariotti, Andrea Arcidiacono, Paolo Biella, Erica Alghisi, Luciano Bani, Massino Bertini, Carlo Blasi, Francesca Buffi, Enrico Caprio, Stefano Castiglione, Patrizia Digiovinazzo, Olivia Dondina, Giuliano Fanelli, Francesco Ferrini, Valentina Fiorilli, Gianluca Gaiani, Daniela Gambino, Andrea Genre, Bruno Lasserre, Alberto Maltoni, Marco Marchetti, Chiara Montagnani, Marco Ottaviano, Cinzia Panigada, Silvia Ronchi, Stefano Salata, Fabio Salbitano, Enrico Simoni, Soraya Versace, Maria Chiara Pastore, Sandra Citterio, Massimo Labra, Rodolfo Gentili

“…Historical analyses of landscape patterns and ecological connectivity over the past 200 years, along with evaluations of afforestation projects from the last 70 years, have provided critical insights into the successes and challenges of previous interventions, serving as a guide for future efforts. …”
Get full text

Environmental spatial assessment at ranch scale: a tool for optimizing livestock management in Argentine forests by Santiago Agustín Varela, Noelia Cecilia Calamari, Fabio Daniel Trinco, Juan Pablo Diez, Mariana Weigandt, Flavia Romina Barzán, Lucrecia Lezana, Roxana Paola Eclesia, Dardo Rubén López, Rubén Darío Coria, Pablo Luís Peri, Fernando Javier Umaña, Fernando Raffo, Juan Ignacio Gazzotti, Carlos de la Peña, Marcelo Wilson, Emmanuel Gabioud, Hernán Hernández, Sonia Beatriz Canavelli

“…Ordinary kriging interpolated EHI values across the landscape, enabling spatial visualization of environmental health patterns and spatial variability. …”
Get full text

Assessing the prognostic and therapeutic value of cuproptosis-related genes in colon adenocarcinoma patients by Zhanhui Ye, Yixian Song, Mengqing Zhu, Fuying Zheng, Wenjie Qin, Wenjie Qin, Xue Li, Pei Wang, Zihua Li, Kequan Chen, Aimin Li

“…A novel prognostic risk model based on four CRGs (ORC1, PTTG1, DLAT, PDHB) was developed to stratify COAD patients into high-risk and low-risk groups, assessing overall survival, tumor microenvironment, and mutational landscape differences. We also evaluated the therapeutic effects of ferredoxin 1 (FDX1) and elesclomol in promoting cuproptosis in HCT116 and LoVo cell lines through various experiments, including cell proliferation, apoptosis assessment, mitochondrial membrane potential evaluation, and DLAT lipoylation detection via Western blot.ResultsCertain CRGs showed different expressions in COAD versus normal tissues. …”
Get full text

ADME gene-driven prognostic model for bladder cancer: a breakthrough in predicting survival and personalized treatment by Haojie Dai, Xi Zhang, You Zhao, Jun Nie, Zhenyu Hang, Xin Huang, Hongxiang Ma, Li Wang, Zihao Li, Ming Wu, Jun Fan, Ke Jiang, Weiping Luo, Chao Qin

“…Comprehensive studies established a strong correlation between the risk score and several key indicators: patterns of immune cell infiltration, reactions to immunotherapy, landscape of somatic mutation and profiles of drug sensitivity. …”
Get full text

Harnessing digital dividends: A systematic review of ICT initiatives for transformation in Tanzanian agriculture by Victor George

“…Key gaps identified in the literature reveal a limited understanding of ICT usage patterns among marginalized groups and highlight the need for further research into long-term impacts on livelihoods. …”
Get full text

Construction of Carbon Functional Zone in the Demonstration Zone of Green and Integrated Ecological Development of the Yangtze River Delta Based on Carbon Density Correction by Tian ZHANG, Zhen SHEN, Tingting SU, Daixin DAI

Get full text

Analysis and comparison of the trends in burden of low back pain in China and worldwide from 1990 to 2021 by Yongcun Wei, Yanchun Xie, Anwu Xuan, Hongwen Gu, Yi Lian, Zening Wang, Hongwei Wang, Hailong Yu

“…By benchmarking these trends against the worldwide disease burden, this research provides critical insights into how China’s experience aligns with or diverges from global patterns, offering valuable guidance for targeted public health strategies. …”
Get full text

Land Use Effects on the Space Use and Dispersal of an Apex Predator in an Ecotone Between Tropical Biodiversity Hotspots by Bernardo Brandão Niebuhr, Sandra M. C. Cavalcanti, Ermeson A. Vilalba, Vanessa V. Alberico, João Carlos Zecchini Gebin, Danilo da Costa Santos, Ananda de Barros Barban, Raphael de Oliveira, Eliezer Gurarie, Ronaldo G. Morato

“…Additionally, we evaluate the effect of animal translocations on dispersal and movement patterns. …”
Get full text

Criminal Law Challenged by Crossing into Virtual Reality by Mahdi Karimi

“…These characteristics make evaluating content or behavior in immersive virtual reality more challenging compared to real-world assessments. …”
Get full text

Field Scale Studies on the Spatial Variability of Soil Quality Indicators in Washington State, USA by Jeffrey L. Smith, Jonathan J. Halvorson

“…The distribution frequency of all parameters except respiration were normal although the spatial distribution across the landscape was highly variable. The biological parameters showed little correlation with each other when all data points were considered; however, when grouped in smaller sections, the correlations were more consistent with observed patterns across the field. …”
Get full text

Identification of biomarkers for Laryngeal squamous cell carcinoma through Mendelian randomization and integrated bioinformatics analysis by Pengjian Zhang, Weizhang Chen, Kai Chen, Yuanhang Ye, Weijun Wu

“…Risk scores were significantly correlated with clinical factors such as gender and N stage (extent of regional lymph node metastasis). Immune landscape analysis revealed distinct patterns of immune cell infiltration and functional scores between high-risk and low-risk groups, with significant differences in the infiltration of monocytes and neutrophils. …”
Get full text

A Comparative Analysis of Support Vector Machine and K-Nearest Neighbors Models for Network Attack Traffic Detection by Han Zhuoxi

“…The UNSW-NB15 dataset, which includes various attack types and normal traffic patterns, is used to evaluate the performance of these two models. …”
Get full text

Analysis of global stock market development-Integration of clustering, classification, and shapley values. by Marcin Stawarz

“…This study aims to analyze the development of global stock exchanges by integrating clustering, classification, and Shapley Values to identify growth patterns and understand the differences in market characteristics and dynamics. …”
Get full text

Water and Sheep: The Pronunciation and Geographical Distribution of Two Germanic Vowels in the Dialects Around the Former Zuiderzee Area by Floris Nijhuis, John L. A. Huisman, Roeland van Hout

“…Specifically, we tried to determine the dialectal landscape more thoroughly, find instances that illustrate cultural diffusion and migration, and evaluate the overall relationship between distance over water and vowel variations. …”
Get full text