An optimized caries model of Streptococcus mutans in rats and its application for evaluating prophylactic vaccines by Bowen Liu, Min Li, Xian Li, Jingyi Yang, Huimin Yan

“…However, owing to the lack of time to establish protective immunity ahead of challenge, the weaning rat model is suboptimal for assessing prophylactic vaccines against S. mutans infection. …”
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Mesosphere data assimilation based on the intelligent optimization of the uncertainty parameters in a theoretical model by Dexin Ren, Jiuhou Lei, Xuetao Chen, Tong Dang, Yu Liu

“…In this study, we conducted an intelligent optimization particle filtering algorithm to optimize the uncertainty parameters in a physics-based model, which was used to simulate the terrestrial mesosphere. …”
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Illumination in Museums: Four-Primary White LEDs to Optimize the Protective Effect and Color Quality by Rui Dang, Nan Wang, Gang Liu, Ye Yuan, Jie Liu, Huijiao Tan

“…Meanwhile, the color quality of light sources is also of great importance, and there is a lack of methodology for obtaining light sources with optimized spectra to simultaneously achieve the protective effect and ensure the color quality. …”
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Regional-scale intelligent optimization and topography impact in restoring global precipitation data gaps by Jiahan Wang, Jiaqi Chen, Peng Shen, Xiaoling Guan, Xiangmei Liu, Christian Massari, Zongzhi Wang, Mingming Feng, Qingxuan Wang, Youbei Lu, Ersa Wei, Yonghao Wang, Gulomjon Umirzakov, Bin Yong

“…However, over 60% of countries lack a complete surface-based rainfall gauge network, severely constraining the accuracy of global satellite precipitation retrievals. …”
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CORRECTION OF NUTRITIONAL STATE OF PREGNANT WOMEN USING OPTIMAL COMBINATION OF HEMATOPOIETIC MICRONUTRIENTS IN DIETS by E. V. Izvekova, L. S. Bolshakova, L. A. Ashikhina, E. G. Merkulova, O. L. Ladnova, А. V. Kuzina

“…It was carried out with optimal combination of hematopoietic trace elements and vitamins in the diets developed by the authors. …”
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A Small-Sample Scenario Optimization Scheduling Method Based on Multidimensional Data Expansion by Yaoxian Liu, Kaixin Zhang, Yue Sun, Jingwen Chen, Junshuo Chen

“…Currently, deep reinforcement learning has been widely applied to energy system optimization and scheduling, and the DRL method relies more heavily on historical data. …”
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In Silico strategies for drug discovery: optimizing natural compounds from foods for therapeutic applications by Romo-Hernández Aarón, Cortazar-Moya Sheila, González-Pérez Julio Emmanuel, Jiménez-González Oscar, López-Malo Aurelio, Morales-Camacho Jocksan Ismael

“…While several databases describe properties of natural products, their applicability and data accessibility are limited. Thus, the lack of accessible data represents a significant challenge in developing drugs based on natural compounds. …”
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Spatiotemporal profile of an optimal host response to virus infection in the primate central nervous system. by Olga A Maximova, Sarah L Anzick, Daniel E Sturdevant, Richard S Bennett, Lawrence J Faucette, Marisa St Claire, Stephen S Whitehead, Kishore Kanakabandi, Zong-Mei Sheng, Yongli Xiao, John C Kash, Jeffery K Taubenberger, Craig Martens, Jeffrey I Cohen

“…Viral infections of the central nervous system (CNS) are a major cause of morbidity largely due to lack of prevention and inadequate treatments. While mortality from viral CNS infections is significant, nearly two thirds of the patients survive. …”
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Optimizing Conservative Management of Groin Pain in Athletes: Insights from a Narrative Review by Roberto Tedeschi, Federica Giorgi, Daniela Platano, Lisa Berti, Danilo Donati

“…However, variability in methodologies, small sample sizes, and a lack of long-term follow-up limited the generalizability of the findings. …”
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Optimized Fermentation Conditions of Pulses Increase Scavenging Capacity and Markers of Anti-Diabetic Properties by Andrea Jimena Valdés-Alvarado, Erick Damián Castañeda-Reyes, Elvira Gonzalez de Mejia

“…These models demonstrated strong predictive power (<i>p</i> < 0.01) and a non-significant lack of fit (<i>p</i> ≥ 0.05). Additionally, fermentation increased the soluble protein content (3–10 mg/mL) and significantly inhibited dipeptidyl peptidase-IV and α-glucosidase activities by 40–70% and 30–60%, respectively. …”
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Impact of ISTA and FISTA iterative optimization algorithms on electrical impedance tomography image reconstruction by Nguyen Diep Quoc Tuan, Huynh Hoang Nhut, Ven Huynh Thanh, Cao Dinh Minh Quan, Tran Anh Tu, Tran Trung Nghia

“…It focuses on enhancing the convergence and accuracy of EIT image reconstruction by evaluating the effectiveness of these optimization algorithms when applied to regularized inverse problems, using standard regularization techniques. …”
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Optimizing treatment sequencing in multiple myeloma: a novel model to predict survival outcomes by Maria Teresa Petrucci, Sara Bringhen, Cristina Entrala Cerezo, João Mendes, Patrizio Armeni

“…Furthermore, there is a lack of direct comparative clinical trial data to guide effective treatment sequencing. …”
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Optimized Flexible Microheater With Integrated Electrodes and Microchannel for On-Chip Bacterial Incubation and Electrochemical Detection by Sonal Fande, Khairunnisa Amreen, D. Sriram, Sanket Goel

“…Even though bacterial incubators play a vital role in providing optimal growth conditions for bacterial culture, they lack portability, which restricts their utility in real-time applications. …”
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Optimal planning and operation of energy community DERs considering local energy trading and uncertainties by Morsy Nour, José Pablo Chaves-Ávila, Matteo Troncia, Álvaro Sánchez-Miralles, Abdelfatah Ali

“…However, there is a noticeable lack of emphasis on optimizing the planning and integration of DERs within these ECs. …”
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Quasi‐Static Closed‐Loop Wind‐Farm Control for Combined Power and Fatigue Optimization by Ishaan Sood, Christophe del Fosse et d'Espierres, Johan Meyers

“…However, due to a lack of fast structural models, influence of wind‐farm flow control on turbine structural fatigue and loading is generally not considered. …”
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Febrile disease modeling and diagnosis system for optimizing medical decisions in resource-scarce settings by Daniel Asuquo, Kingsley Attai, Okure Obot, Moses Ekpenyong, Christie Akwaowo, Kiirya Arnold, Faith-Michael Uzoka

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Prescribers' perspectives: The impact of the controlled substance scheduling system on providing optimal patient care by Michael R. Barnes, Yijia Luo, Jonathon M. Parker, Brian M. Shepler

“…Results: Prescribers across all groups provided consistent responses suggesting an overall lack of understanding of controlled substance regulations, a negative attitude towards the controlled substance scheduling system, and a detrimental effect on providing optimal patient care. …”
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Spatial optimization of agricultural production from the perspective of “Greater Food Concept” in Yangzhou, China by Xin Li, Xin Xu, Ru Meng Yin

“…However, there is still a lack of an appropriate methodology to optimize the spatial agricultural production system under the concept of “greater food.” …”
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Optimization and benefit evaluation model of a cloud computing-based platform for power enterprises by Xueli Yin, Xuguang Zhang, Luyao Pei, Rong Hu, Kaihui Ye, Kangkang Cai

“…It responds to the current lack of systematic optimization mechanisms and evaluation methods in existing cloud computing applications. …”
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Dynamic niche technology based hybrid breeding optimization algorithm for multimodal feature selection by Ting Cai, Fan Ma, Zhiwei Ye, Wen Zhou, Mingwei Wang, Qiyi He, Hu Pan, Jun Shen

“…Nevertheless, most existing evolutionary algorithms suffered from a lack of diversity, making them insufficiently effective in finding multiple optimal solutions. …”
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