Manufacturing Process Development for <i>Bison bison</i> Organ-Specific Lyophilized Extracts: Formulation and Benchmarking of Antioxidant Activities for Nutraceutical Preparations by Alexandre Porcello, Kim Girardet, Basste Hadjab, Kelly Lourenço, Corinne Scaletta, Philippe Abdel-Sayed, Nathalie Hirt-Burri, Lee Ann Applegate, Alexis E. Laurent

“…Overall, the present study provides an evidence-based technical/functional rationale for the preparation and control of American bison organ-specific lyophilized extracts to be included in nutraceutical preparations.…”
Get full text

Cordyceps cicadae ameliorates inflammatory responses, oxidative stress, and fibrosis by targeting the PI3K/mTOR‐mediated autophagy pathway in the renal of MRL/lpr mice by Feng Yang, Yanyan Zhang, Lei Dong, Zhichao Song

“…., CC group, n = 8) or an equal volume of saline (model group, n = 8), and MRL/MP mice were treated with an equal volume of saline (control group, n = 8). Renal function indices, renal pathology, inflammatory markers, oxidative stress markers, and renal interstitial fibrosis levels were evaluated after C. cicadae treatment. …”
Get full text

Subacute Inhalation Exposure of Mice to Ozone Induces Damage to Various Organs by Peiwen Wang, Yuan Lu, Kuikui Lu, Daxiao Xie, Min Ling, Luoding Lu, Weiyong Chen, Yu Wu, Qizhan Liu, Qian Bian, Tian Xiao

“…Body weights, pulmonary function, hematology, serum biochemistry, inflammatory factors, and injuries to various organs were assessed for O₃-exposed mice. …”
Get full text

Standards of specialized diabetes care. Edited by Dedov I.I., Shestakova M.V., Mayorov A.Yu. 9th edition by Ivan I. Dedov, Marina V. Shestakova, Aleksandr Y. Mayorov, Olga K. Vikulova, Gagik R. Galstyan, Tamara L. Kuraeva, Valentina A. Peterkova, Olga M. Smirnova, Elena G. Starostina, Elena V. Surkova, Olga Y. Sukhareva, Alla Y. Tokmakova, Minara S. Shamkhalova, Ivona Renata Jarek-Martynova, Ekaterina V. Artemova, Diana D. Beshlieva, Olga N. Bondarenko, Natalya N. Volevodz, Olga R. Grigoryan, Irina S. Gomova, Zera N. Dzhemilova, Roza M. Esayan, Liudmila I. Ibragimova, Viktor Y. Kalashnikov, Irina V. Kononenko, Dmitry N. Laptev, Dmitry V. Lipatov, Oleg G. Motovilin, Tatiana V. Nikonova, Roman V. Rozhivanov, Ekaterina A. Shestakova

“…Dear Colleagues! We are glad to present the 9th Edition (revised) of Standards of Diabetes Care. …”
Get full text

The acetylation GLI1 affects arsenical-induced renal fibrosis by mediating the Hedgehog signalling pathway by Pinya Liu, Yating Wang, Peiyu Jin, Qing Zhou, Liang Pei, Shuhua Xi

“…The results showed that the renal tubular structure was destroyed, renal function was impaired, and fibrosis occurred in renal tissue in arsenic-exposed F344 rats. …”
Get full text

Environmental Levels and Degradation Behavior of Pharmaceuticals and Personal Care Products (PPCPs) in the Water Environment by Zhaohe ZHANG, Dian CHEN, Wei ZHAO, Guoli YUAN, Jun LI, Xingchun JIAO

“…Long-term use will lead to liver and kidney damage and induce cancer[21], causing irreversible damage to human health.　　…”
Get full text

In-depth analysis of the safety of CAR-T cell therapy for solid tumors by Jiayi Dong, Jiayi Dong, Jiayi Dong, Jiayi Dong, Jiexiong Wu, Ye Jin, Ye Jin, Ye Jin, Ye Jin, Ye Jin, Zhu Zheng, Zhu Zheng, Zhu Zheng, Zhu Zheng, Zhu Zheng, Ting Su, Ting Su, Ting Su, Ting Su, Ting Su, Lijuan Shao, Lijuan Shao, Lijuan Shao, Lijuan Shao, Lijuan Shao, Jiaxin Bei, Jiaxin Bei, Jiaxin Bei, Jiaxin Bei, Size Chen, Size Chen, Size Chen, Size Chen, Size Chen

“…Organ toxicity can also arise from CAR-T therapy, with potential damage affecting the gastrointestinal tract, kidneys, liver, and lungs, often tied to shared antigens found in both tumor and healthy tissues. …”
Get full text

A clinical case of late diagnosis of a chronic type I tyrosinemia by Natalia V. Chebotareva, Elvira D. Stafeeva, Olga А. Li, Agunda M. Kuchieva, Svetlana I. Polyakova, Jamal T. Abdurakhmanov, Sergey V. Moiseev

“…Tyrosinemia type 1 is a genetic disease mainly of the first months and years of life caused by a violation of normal tyrosine catabolism with the formation of final toxic metabolites that have a direct damaging effect on the liver and kidneys with the development of a characteristic clinical picture, represented mainly by functional and morphological disorders on a part of the liver that forms a cirrhosis clinic with a high probability of the latter's degeneration into hepatocellular carcinoma. …”
Get full text

Sodium-Dependent Glucose Transporter Type 2 Inhibitors as a Breakthrough in Neutropenia and Neutrophil Dysfunction Management in Patients with Glycogen Storage Disease Type Ib by Andrey N. Surkov, Leyla S. Namazova-Baranova, Anna L. Arakelyan, Evgeny E. Bessonov, Natalia V. Zhurkova

“…The condition is caused by pathogenic variants in the SLC37A4 gene leading to glucose metabolic disorder in the liver and kidneys, and as a result to severe organomegaly, hypoglycemia, and metabolic decompensation. …”
Get full text

LECTINS IN ANTI-CANCER STRATEGIES by M. V. Lakhtin, V. M. Lakhtin, V. A. Aleshkin, M. S. Afanasiev, S. S. Afanasiev

“…The list of mostly used communicative lectins (pattern recognition receptors, their soluble forms, other  soluble lectins possessing specificities of importance) involving in key intercellular cascades and pathway co-functioning is presented. The  regulation of resulting expression of distinct active lectins (available and hetero/di/oligomeric forms) and their interaction to  adequate glycoconjugate patterns as well as influence distribution of  co-functioning lectins and antigens CD between populations and  subpopulations of antigen-presented cells (dendritic cells cDC, mDC,  moDC, pDC; macrophages M2 and M1), mucosal M-cells, NK-cells  play key role for choice and development of anticancer complex  procedures increasing innate and innate-coupled immune responses.  …”
Get full text

Intestinal Barrier Damage and Growth Retardation Caused by Exposure to Polystyrene Nanoplastics Through Lactation Milk in Developing Mice by Chaoyu Zhou, Haiyan Wu, Lei Zhang, Xiao Xiao, Xiaodan Wang, Mingju Li, Runqiu Cai, Jia You, Qi Chen, Yifei Yang, Xinyuan Tian, Qianyu Bai, Yinzhu Chen, Huihui Bao, Tianlong Liu

“…The results show that PS-NP exposure during lactation and juvenile periods caused delayed weight gain and impaired organ development, particularly in the liver and kidneys, without causing functional abnormalities or toxic injuries. …”
Get full text

Intra-Abdominal Hypertension and Abdominal Compartment Syndrome. Literature Review by Sh. V. Timerbulatov, U. M. Abdullin, V. V. Viktorov, V. V. Plechev, A. R. Gafarova

“….), and the negative impact of increased IBP on the functions of the gastrointestinal, respiratory, cardiovascular systems, kidneys, central nervous system, timely diagnosis and treatment play an important role. …”
Get full text

Inhibition of Cerebral High-Mobility Group Box 1 Protein Attenuates Multiple Organ Damage and Improves T Cell-Mediated Immunity in Septic Rats by Chao Ren, Xiu-hua Li, Yao Wu, Ning Dong, Ya-lin Tong, Yong-ming Yao

“…A dysregulated host immune response and multiple organ injury are major factors for the pathogenesis and progression of sepsis, which require specific mechanism and treatment. In the present study, we performed an intracerebroventricular (ICV) injection of BoxA, a specific antagonist of high-mobility group box 1 protein (HMGB1), in septic rats that were produced by cecal ligation and puncture surgery; we further assessed the functional changes of multiple organs and splenic T lymphocytes. …”
Get full text

NEW APPROACHES OF PREVENTIVE MAINTENANCE AND REHABILITATION, PATIENTS WITH UROLITHIASIS AFTER THE REMOTE LITHOTRIPSY WITH APPLICATION OF NEW VEGETATIVE GATHERING by I. R. Musin

“…The analysis of results of treatment has shown  that  application of phytogathering for patients with urolithic illness after a remote lithotripsy promotes a conclusion  of stones, there  is an early knocking  over of inflammatory changes, phytogathering doesn’t  break  a functional condition of kidneys.  At the  same  time under  the  influence of phytogathering there  was statistically authentic increase  in volume of urine, decrease in level of nitrogenous slags (a Creatinine, urea), the tendency to decrease in the raised concentration of uric acid in whey of blood and the maintenance in urine of oxalates and uric acid Besides, isn’ted.…”
Get full text

Advances in epigenetic mechanisms of lead toxicity by ZHANG Xinxin, YAN Chonghuai

“…It reveals how modifications in gene expression regulate cellular functions, leading to diverse cellular phenotypes and functions despite identical DNA sequences. …”
Get full text

Monogenic diseases associated with cardiomyopathy genes and their phenotypic manifestations by A. N. Kucher, M. S. Nazarenko

“…The aim of the present study was to summarize the data on the spectrum of genetic diseases and their phenotypic manifestations in case of structural and functional defects in 75 genes, pathogenic variants of which are associated with the formation of different types of cardiomyopathy (CMP). …”
Get full text

Achieving Permanent Male Infertility by Magnetic Nanoparticle Hyperthermia: A Breakthrough in Animal Fertility Management by Juliana Lis Mendes Brito, Vanessa Nicolau Lima, José Luiz P. R. Jivago, Aline R. M. Marangon, Marcus Vinícius-Araújo, Andris Figueiroa Bakuzis, Juliana dos Anjos Ribeiro dos Santos, Paulo E. N. Souza, Ricardo Bentes Azevedo, Carolina Madeira Lucci

“…The only two animals still displaying gonadal-like structures were azoospermic, and histopathology revealed the remaining tissue was non-functional. The procedure was well-tolerated and MNH-treated animals presented no long-term side effects. …”
Get full text

Levels of Mineral Elements in Different Organs of Dogs from the Ionian-Etnean Volcanic Area by Fabio Bruno, Anthea Miller, Giuseppe Bruschetta, Vincenzo Nava, Claudia Rifici, Sebastiano Zappalà, Patrizia Licata

Get full text

Patients with Papillary Renal Cancer and Germline Duplication of <i>MET</i> Exons 5-21 by Dmitry S. Mikhaylenko, Natalya B. Kuryakova, Fatima M. Bostanova, Viktoria V. Zabnenkova, Oksana P. Ryzhkova, Ilya V. Volodin, Dmitry V. Zaletaev, Dmitry V. Pustoshilov, Sergey I. Kutsev, Vladimir V. Strelnikov

“…Clinically, HPRC results in the development of multiple papillary renal cell carcinomas of the kidneys in young adults. HPRC is caused by point activating mutations in the <i>MET</i> gene encoding a transmembrane tyrosine kinase receptor. …”
Get full text

Molecular basis of the urate transporter URAT1 inhibition by gout drugs by Yang Suo, Justin G. Fedor, Han Zhang, Kalina Tsolova, Xiaoyu Shi, Kedar Sharma, Shweta Kumari, Mario Borgnia, Peng Zhan, Wonpil Im, Seok-Yong Lee

“…Together with functional experiments and molecular dynamics simulations, we reveal that these inhibitors bind selectively to URAT1 in inward-open states. …”
Get full text