High level of soluble tumor necrosis factor receptors is associated with lower residual diuresis volume in patients on hemodialysis: An exploratory study. by Gabriele Teixeira Gonçalves, Luciana Martins de Mello Santos, Pedro Henrique Scheidt Figueiredo, Jaqueline de Paula Chaves Freitas, Jousielle Márcia Santos, Joyce Noelly Vitor Santos, Fidelis Antônio da Silva Junior, Frederico Lopes Alves, Vanessa Gomes Brandão, Emílio Henrique Barroso Maciel, Maria Cecília S M Prates, Borja Sañudo, Redha Taiar, Mario Bernardo-Filho, Danúbia da Cunha de Sá-Caputo, Vanessa Pereira Lima, Henrique Silveira, Victor Lacerda Gripp, Vanessa Amaral Mendonça, Ana Cristina Rodrigues Lacerda

“…<h4>Objective</h4>Patients on hemodialysis commonly present with elevated inflammatory markers. It is noteworthy, however, that higher levels of these markers may deteriorate residual renal function in in these individuals. …”
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Potential renoprotective effects and possible underlying mechanisms of angiotensin receptor-neprilysin inhibitors in cardiorenal syndrome by Md. Moshiur Rahman, Md. Moshiur Rahman, Asadur Rahman, Akira Nishiyama

“…Here, we gathered evidence on the impact of sacubitril/valsartan on the preservation of kidney function in patients with cardiorenal syndrome (CRS). …”
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Prevalence and characteristics of newly diagnosed heart failure in patients with shortness of breath after coronavirus infection by O. V. Masalkina, N. A. Koziolova, N. M. Syuzeva

“…Patients with shortness of breath after COVID-19 had more severe HF, both according to clinical tests and according to the blood concentration of N-terminal pro-brain natriuretic peptide (NT-proBNP), mainly with the preserved ejection fraction (EF) with a higher prevalence of left atrial (LA) enlargement in combination with a decrease in right ventricular (RV) systolic function and its dilatation. In patients after COVID-19 in the presence of chronic kidney disease, the RR for HF increased by 4,5 times; in the presence of C-reactive protein &gt;4 mg/l — by 1,6 times.Conclusion. …”
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An enigma of hypocalcaemia: unveiling the interaction between denosumab and intravenous iron when co-administered by Sabyasachi Roy, Anand Velusamy, Muhammed Russal Latheef

“…Background: Denosumab is a human monoclonal antibody that works by binding to and inhibiting receptor activator of nuclear factor-κB ligand (RANKL), a protein crucial for osteoclast activity, thereby preventing osteoclast formation, function and survival, ultimately reducing bone resorption.1 In doing so, it can cause hypocalcaemia, particularly in high-risk patients with chronic kidney disease (CKD), vitamin D deficiency or recent bisphosphonate therapy.2 Recent evidence suggests that intravenous iron therapy exacerbates this risk by inducing fibroblast growth factor 23 (FGF23)-mediated phosphate depletion and impaired calcium absorption.3 This case highlights a severe hypocalcaemia episode following denosumab and inrtravenous (IV) iron infusion, underscoring the importance of careful preparation before these infusions and proactive management. …”
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Polycystic liver disease in a third level hospital by Luis A. Torrez-Arias, Maria F. Higuera-De la Tijera

“…No weight loss in 92.8%. 25% with a family history of polycystic kidney and/or liver disease. The most frequent comorbidity was SAH in 44.6% followed by those who did not present comorbidities in 39.3%. …”
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Collapsing glomerulopathy associated with parvovirus B19 and systemic lupus erythematosus in a patient with APOL1 high-risk variant for nephropathy by Thaíza Passaglia Bernardes, Thalita Alvarenga Ferradosa Paula, Gabriel Teixeira Montezuma Sales, Patrícia Varela Calais, Renato Demarchi Foresto, Luiz Antonio Moura, Marcelino de Souza Durão Junior, João Bosco Pesquero, Gianna Mastroianni Kirsztajn

“…The patient was treated with prednisone and presented marked improvement of anemia and kidney function after a few weeks. …”
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Non-lethal sonodynamic therapy mitigates hypertensive renal fibrosis through the PI3K/AKT/mTORC1-autophagy pathway by DanDan Liu, Hui Wang, Jialong Li, Siqi Sheng, Shu Wang, Ye Tian

“…Autophagy activity is crucial for maintaining homeostasis, vitality, and physiological function of kidney cells, while also protecting the kidneys from fibrosis. …”
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Reversible Wenckebach Phenomenon in a Young Patient with Dengue Fever: A Case Report by Subash Mohan Thulasi, Yohidha Balamurugan, Sornavalli Valliappan, Visvesvaran Salitteeswaran, PK Ananthakumar

“…This article reports uncommon presentation of dengue-associated transient conduction disturbances without overt myocardial injury. …”
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Cutaneous Anthrax: What is the Hallmark? by Dhani Redhono Harioputro, Arie Kusumawardani, Iin Novita, Evi Nurhayatun, Rahajeng N Tunjungputri, Erni Juwita Nelwan

“…Blood tests revealed normal levels of hemoglobin, leukocyte, platelets, kidney and liver function. The anti-anthrax protective antigen (anti-PA) IgG level is found to be seropositive with a level of 85 U/ml. …”
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A race against time: A case report of fulminant myocarditis leading to cardiogenic shock by Martin Joseph, Tasnim Ahmed

“…Initial lab tests indicated significantly elevated troponin and lactate levels, along with increased inflammatory markers, a high white blood cell count, and abnormal kidney and liver function. Due to inadequate improvement with NIV, he was intubated and ventilated in the ED. …”
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Cutaneous Anthrax: What is the Hallmark? by Dhani Redhono Harioputro, Arie Kusumawardani, Iin Novita, Evi Nurhayatun, Rahajeng N Tunjungputri, Erni Juwita Nelwan

“…Blood tests revealed normal levels of hemoglobin, leukocyte, platelets, kidney and liver function. The anti-anthrax protective antigen (anti-PA) IgG level is found to be seropositive with a level of 85 U/ml. …”
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ADVANCEMENTS AND EMERGING PERSPECTIVES IN MICROSCOPIC IMAGING

“…Specific applications for this presentation includes: (i) visualization of cytoskeletal and functional organization in human, mouse, and zebrafish embryos and gametes,and human stem cells; (ii) structural imaging of whole organs such as the liver and kidney; and (iii) whole-organism imaging in zebrafish larvae and mouse fetuses, with particular emphasis on the methodologies employed to prepare and visualize such samples. …”
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Case report and literature review: IgG4-related tubulointerstitial nephritis coexistent with systemic lupus erythematosus by Xingfu Ji, Guilin Jing, Haoqi Sun, Xuan Li, Xuexun Chen

“…We present the case of a 68-year-old man with acute kidney injury that occurred following radiofrequency cardiac ablation. …”
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Basophil-derived exosomes exacerbate systemic lupus erythematosus by regulating B-cell proliferation via miR-24550 by Jiaxuan Chen, Shuzhen Liao, Jiaqi Lun, Xing Lu, Bitang Huang, Xiaoxian Liu, Xiaowei Xu, Lawei Yang, Fengbiao Guo, Liuyong You, Haiyan Xiao, Hua-Feng Liu, Qingjun Pan

“…In the lupus mouse model, basophil-derived exosomes accumulated primarily in the spleen and kidneys, inducing excessive immune cell proliferation and disrupting the plasma cell-plasmablast balance, which worsened kidney damage. …”
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Lung and Intestine: A Specific Link in an Ulcerative Colitis Rat Model by Yuan Liu, Xin-Yue Wang, Xue Yang, Shan Jing, Li Zhu, Si-Hua Gao

“…There were no significant changes in the liver and kidney function and histopathology. The colon and lung tissue iNOS, TXB2, P-selectin, ICAM-1, and VEGF-A expression of the model rats was significantly higher than the normal rats at both time points. …”
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α-GalCer-LNP ehanced mRNA delivery and activates natural killer T cells for superior tumor immunotherapy by Kexin Zhang, Zhen Xu, Zexiu Xiao, Fei Cao, Jing Wang, Yuandong Xu, Winson M.J. Ma, Sihui Long, Gao-Feng Zha

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Understanding Atherosclerotic Plaque Cellular Composition: Recent Advances Driven by Single Cell Omics by Esra Cetin, Anne-Catherine Raby

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Drug and siRNA screens identify ROCK2 as a therapeutic target for ciliopathies by Claire E. L. Smith, Andrew J. Streets, Alice V. R. Lake, Subaashini Natarajan, Sunayna K. Best, Katarzyna Szymanska, Magdalena Karwatka, Thomas Stevenson, Rachel Trowbridge, Gary Grant, Sushma N. Grellscheid, Richard Foster, Ciaran G. Morrison, Georgia Mavria, Jacquelyn Bond, Albert C. M. Ong, Colin A. Johnson

“…Currently, only one drug, Tolvaptan, is licensed to slow the decline of renal function for the ciliopathy polycystic kidney disease. …”
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Atypical Haemolytic Uraemic Syndrome Associated with Clostridium difficile Infection Successfully Treated with Eculizumab by Joshua M. Inglis, Jeffrey A. Barbara, Rajiv Juneja, Caroline Milton, George Passaris, Jordan Y. Z. Li

“…He developed an acute kidney injury with anaemia, thrombocytopaenia, raised lactate dehydrogenase, low haptoglobin, and red cell fragments. …”
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SALT CONSUMPTION. КIDNEYS AS THE TARGET ORGAN. РART IV by N. G. Poteshkina

“…The factors facilitating the transformation of normal hemodynamic profile into the hypertensive one are discussed. The author presents the results of experimental and clinical studies which confirm negative effects of excessive salt consumption on the morphology and function of kidneys as the key organ regulating blood pressure levels. …”
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