A novel INDEL-based next-generation sequencing assay for monitoring donor-derived cell-free DNA in renal transplant recipients—from bedside to results: a UK pilot study by George E. Nita, Fotini Partheniou, Dan Ridgway, Sanjay Mehra, Matthew Howse, Abdul Hammad, Andrew R. Jones, Petra M. Goldsmith

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The Impact of Anabolic Androgenic Steroids on Organ Failure in Bodybuilders - a Review of Actual Literature by Julia Marcinkowska, Mateusz Szymon Muras, Tomasz Lorenc, Maciej Michalik, Krzysztof Marcinkowski, Jakub Mikszta, Natalia Mikszta

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Evaluation of Possible Nephrotoxic Potential of Gliricidia Sepium Aqueous Leaf Extract in Wistar rats by Taofeeq Oduola *, Muhammed Kabiru Dallatu , Aisha Aliyu , Abdurrasheed Ola Muhammed , Luqman Olayinka. Olatubosun , Ganiyat Busayo Oduola

“…Histology result of the kidney reveals normocytic normochromic cells. The present findings revealed that aqueous leaf extract of Gliricidia sepium is relatively safe and may not be nephrotoxic.…”
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Fabrication and characterization of inkjet-printed interdigitated electrodes for non-faradaic electrochemical detection of uromodulin in urine by Kunj Vora, Norbert Kordas, Karsten Seidl

“…We functionalized the passivated IDE with biotin-streptavidin complex and uromodulin antibody to detect uromodulin (6.75 μg/ml-100 μg/ml). …”
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Huaier Cream Protects against Adriamycin-Induced Nephropathy by Restoring Mitochondrial Function via PGC-1α Upregulation by Ruochen Che, Chunhua Zhu, Guixia Ding, Min Zhao, Mi Bai, Zhanjun Jia, Aihua Zhang, Songming Huang

“…The mechanism by which Huaier, a Chinese traditional medicine, protects podocytes remains unclear. We designed the present study to examine whether mitochondrial function restored by PGC-1α serves as the major target of Huaier cream in protecting ADR nephropathy. …”
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Association between serum neurofilament light chain levels and chronic kidney disease: a cross-sectional population-based study from the National Health and Nutrition Examination S... by Jian-De Lu, Kaisaierjiang Kadier, Diliyaer Dilixiati, Bingzhang Qiao, Renaguli Nuer, Abudureheman Zebibula, Mulati Rexiati, Kai Li, ShuiXue Li

“…Background The relationships of serum neurofilament light chain (NfL) levels with chronic kidney disease (CKD) and renal function indicators remain controversial, and comprehensive studies with large sample sizes are lacking.Methods In total, 2,051 participants aged 20 to 75 years were identified from the National Health and Nutrition Examination Survey (2013-2014 cycle). …”
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Application of the Liver Maximum Function Capacity Test in Acute Liver Failure: A Helpful Tool for Decision-Making in Liver Transplantation? by Florian Wolfgang Rudolf Vondran, Carsten Schumacher, Kai Johanning, Björn Hartleben, Wolfgang Knitsch, Olaf Wiesner, Elmar Jaeckel, Michael Peter Manns, Juergen Klempnauer, Hueseyin Bektas, Frank Lehner

“…Following LTx with a marginal donor organ (95% hepatosteatosis), uptake of liver function was demonstrated by postoperative increase of the LiMAx-value. …”
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Treatment decision-making and care among older adults with kidney failure: protocol for a multicentre, prospective observational cohort study with nested substudies and linked qual... by Martin Gallagher, Vasi Naganathan, Gian Luca Di Tanna, Celine Foote, Angela Makris, Chris Gianacas, Nicholas A Gray, Isaac Yeboah Addo, Amanda Siriwardana, Chenlei Kelly Li, Kenneth Yong, Yachna Mehta, Jannel Ramos, Sarah Roxburgh

“…Introduction Shared treatment decision-making and planning of care are fundamental in advanced chronic kidney disease (CKD) management. There are limited data on several key outcomes for the elderly population including survival, quality of life, symptom burden, changes in physical functioning and experienced burden of healthcare. …”
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Emerging role of the calcium-activated, small conductance, SK3 K+ channel in distal tubule function: regulation by TRPV4. by Jonathan Berrout, Mykola Mamenko, Oleg L Zaika, Lihe Chen, Wenzheng Zhang, Oleh Pochynyuk, Roger G O'Neil

“…The Ca2+-activated, maxi-K (BK) K+ channel, with low Ca2+-binding affinity, is expressed in the distal tubule of the nephron and contributes to flow-dependent K+ secretion. In the present study we demonstrate that the Ca2+-activated, SK3 (KCa2.3) K+ channel, with high Ca2+-binding affinity, is also expressed in the mouse kidney (RT-PCR, immunoblots). …”
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A novel fibrinogen-related protein with two coiled-coil regions from Chlamys farreri functions as immune recognition molecule by Meijia Li, Leilei Wang, Lingling Wang, Weilin Wang, Chuanyan Yang, Linsheng Song

“…These findings collectively suggested that CfFREP functioned as a canonical immune recognition molecule in scallop, which offers fresh perspectives on the functions of mollusk FREPs.…”
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Intermittent Ureteropelvic Junction Obstruction Can Mimic Abdominal Migraine: A Case Report and Review of the Literature by Yasaman Daryabari, Parmida Sadat Pezeshki, Negar Mohammadi Ganjaroudi, Abdol‐Mohammad Kajbafzadeh

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Exploring the association of calbindin –D28K in renal dialysis with oral health: a comprehensive review by Mohamed Jaber, Mohamed Jaber, Mohamed Saleh Hamad Ingafou, Mohamed Saleh Hamad Ingafou, Nireeksha, Alexander Maniangat Luke, Alexander Maniangat Luke

“…Its relevance for both diagnosis and treatment of chronic kidney disease and associated diseases is highlighted by its involvement in renal function and neuroprotection.…”
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Considerations on the Development of Therapeutics in Vascular Calcification by Ana M. Valentin Cabrera, Sophie K. Ashbrook, Joshua D. Hutcheson

“…Vascular calcification can present as either medial or intimal calcification. …”
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Pregnancy outcomes in C3 glomerulopathy: a retrospective review by Lauren O. Fergus, Meryl Waldman, Monica D. Hall, Lynn Vining, Jillian Hall, Tina Liu, Yuzhou Zhang, Patrick J. Walker, Richard J. H. Smith, Carla M. Nester

“…Assessed data included clinical history, kidney function tests, and complement tests to identify genetic and/or acquired drivers of complement dysregulation. …”
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Comorbidities of Obesity in a Rural African Population Residing in Limpopo Province, South Africa: A Comparison between General and Central Obesity by Cairo B. Ntimana, Reneilwe G. Mashaba, Kagiso P. Seakamela, Eric Maimela, Matshane L. Masemola-Maphutha, Solomon S. R. Choma

“…Centrally obese participants were more likely to be diabetic, hypertensive, have dyslipidaemia, and exhibit reduced kidney function.…”
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Saroglitazar suppresses KIM-1 and type IV collagen in high fat diet and low-dose streptozotocin-induced diabetic nephropathy in Wistar rats by Rizwan Ahamad, Uma Bhandari, Sayima Nabi, Shweta Sharma

“…Histopathological results showed improvement in tubular degeneration, necrosis, and dilatation of Bowman’s space in kidney tissue. Conclusion: Saroglitazar attenuated renal injury by improving renal function in HFD+STZ-induced DN in Wistar rats.…”
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Allopurinol in the complex therapy of acute decompensation of heart failure by Laura H. Sarieva, Marina D. Muksinova, Svetlana N. Nasonova, Igor V. Zhirov, Sergey N. Tereshchenko

“…Materials and methods. We present the results of a 6-month follow-up for 72 patients with ADHF, hyperuricemia, and reduced filtration function of the kidneys, calculated using the CKD-EPI formula, divided equally into two groups: group 1 received standard of care for HF combined with a xanthine oxidase inhibitor – allopurinol, and group 2 received standard of care only. …”
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The prognostic and diagnostic value of fibroblast growth factor 23 in patients undergoing hemodialysis by Vladyslav Bardash, Tetiana Maksymets, Eugen Sklyarov

“…It exerts its effects on the kidneys, parathyroid glands, heart, and bones. FGF23 is a critical phosphaturic hormone that, alongside parathyroid hormone (PTH), regulates phosphate reabsorption and calcitriol (1,25(OH)₂D) synthesis in the kidneys. …”
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Hypoxia-Induced Differences in the Expression of Pyruvate Dehydrogenase Kinase 1-Related Factors in the Renal Tissues and Renal Interstitial Fibroblast-like Cells of Yak (Bos Grunn... by Manlin Zhou, Jun Wang, Ruirui Cao, Fan Zhang, Xuehui Luo, Yiyuan Liao, Weiji Chen, Haie Ding, Xiao Tan, Zilin Qiao, Kun Yang

“…We found that, at the tissue level, HIF-1α, PDK1, TGF-β1, Smad2, Smad3, and α-SMA were mainly distributed and expressed in tubular epithelial cells but were barely present in the renal mesenchymal fibroblasts of healthy cattle and yak kidneys. …”
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The effect of mannitol on postoperative renal function in patients undergoing coronary artery bypass surgery: A double-blinded randomized controlled trial by Masumeh Hemmati Maslakpak, Eisa Bilejani, Sohrab Negargar, Ahmadali Khalili, Vahid Alinejad, Amir Faravan

“…The study also found no statistically significant difference in the diuresis rate between the two groups (P=0.10). Conclusion: The present study has shown that adding mannitol to the prime has no effect on kidney function, length of time connected to mechanical ventilation, length of stay in the ICU, or 30-day mortality. …”
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