The DJ-1-Binding Compound Exerts a Protective Effect in Both In Vitro and In Vivo Models of Sepsis-Induced Acute Kidney Injury by Réka Zrufkó, Csenge Pajtók, Beáta Szebeni, Apor Veres-Székely, Mária Bernáth, Csenge Szász, Péter Bokrossy, Attila J. Szabó, Ádám Vannay, Domonkos Pap

“…Our study revealed that compounds protecting DJ-1 functions may protect the kidney from LPS-induced damage, suggesting that DJ-1 could be a potential drug target for sepsis-induced AKI therapy.…”
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PRDM16 suppresses ferroptosis to protect against sepsis-associated acute kidney injury by targeting the NRF2/GPX4 axis by Qiang Zheng, Jihong Xing, Xiaozhou Li, Xianming Tang, Dongshan Zhang

“…This study reveals that lipopolysaccharide (LPS) and cecum ligation and puncture (CLP) instigated PRDM16 expression in Boston University mouse proximal tubule (BUMPT) cells and mouse kidneys, respectively. Functionally, PRDM16 curtailed LPS-induced ferroptosis. …”
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Dent’s disease: case series from a single center by Hilal Yaşar, Emre Leventoğlu, Bahar Büyükkaragöz, Kibriya Fidan, Sevcan A. Bakkaloğlu, Oğuz Söylemezoğlu

“…All patients were recommended oral hydration and a low-salt diet, and hydrochlorothiazide and enalapril were started. No deterioration in kidney function was observed in any patient. Conclusion. …”
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High-dose extended-release calcifediol successfully treated advanced secondary hyperparathyroidism in an end-stage kidney disease patient: a case report by Akhtar Ashfaq, John Choe, Samir Tabash, Stephen A. Strugnell, Laura L. Johnson, Charles W. Bishop

“…Abstract Background Hemodialysis (HD) patients lose renal CYP27B1 (cytochrome P450 25-hydroxyvitamin D-1α-hydroxylase) as kidney function declines causing low serum total 25-hydroxyvitamin D (25D) and 1,25-dihydroxyvitamin D (1,25D), and elevated intact parathyroid hormone (iPTH). …”
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CKD in Bardet-Biedl Syndrome: Evidence Supporting Multifactorial Etiology by Miriam Zacchia, Floriana Secondulfo, Andrea Melluso, Francesca Del Vecchio Blanco, Valentina Di Iorio, Anna Laura Torella, Giulio Piluso, Giovanna Capolongo, Francesco Trepiccione, Francesca Simonelli, Vincenzo Nigro, Alessandra Perna, Giovambattista Capasso

“…Early diagnosis and intervention are essential for improving patient outcomes. The present study analyzed kidney function in patients with BBS, with the aim to explore the impact of genetic variants and common risk factors for kidney disease. …”
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Apoptosis Inhibitor of Macrophages in Cats: A Potential Link Between an Exon 3 Variant Allele and Progression of Naturally Occurring Chronic Kidney Disease by Gabriela C. L. Evangelista, Julianne K. Hwang, Liam E. Broughton‐Neiswanger, Emily C. Carlo Reis, Michael H. Court, Katrina A. Mealey, Nicolas F. Villarino

“…ABSTRACT Background The protein apoptosis inhibitor of macrophages (AIM) is involved in kidney repair. An AIM (fAIM) genetic variant in cats resulting in a domain duplication might abrogate fAIM's protective effect on kidney function. …”
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First snapshot comparison of nephrotoxic potentials of four common organic UV filters in juvenile and adult zebrafish (Danio rerio) by Ba Reum Kwon, Gowoon Lee, Inae Lee, Ah-Reum Jo, Jeonghwan Lee, Na-Youn Park, Younglim Kho, Jung Pyo Lee, Kyungho Choi

“…Moreover, regardless of life stage, key genes (wt1a, podocin, nephrin, cdh17, sim1a, and kim-1) responsible for kidney structure and function showed transcriptional alterations that support nephrotoxic potentials of the test UVFs. …”
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Aortic Dissection a Day after Renal Transplantation by Abhijith Magal, Ganesh Srinivas Prasad, Aravind Patil, Ishtiaque Ahmed

“…We report the case of a 31-year-old male who developed a Stanford type B aortic dissection in the immediate postoperative period following a kidney transplant. Postoperatively, he presented with decreased urine output and accelerated hypertension. …”
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Renal denervation in secondary arterial hypertension therapy: clinical case by A. Yu. Orekhov, L. K. Karazhanova, A. A. Chinibaeva, A. B. Zhaksebergenova

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Protein carbamylation in atherosclerotic plaques correlates with uremia and disease progression, localizing predominantly to foam cells by Valeria Saar-Kovrov, Aleksandra Pawlowska, Adrien Guillot, Marion J. J. Gijbels, Marion J. J. Gijbels, Marion J. J. Gijbels, Judith C. Sluimer, Judith C. Sluimer, Lieve Temmerman, Pieter Goossens, Barend M. E. Mees, Frank Tacke, Vera Jankowski, Joachim Jankowski, Joachim Jankowski, Marjo M. P. C. Donners, Erik A. L. Biessen, Erik A. L. Biessen

“…IntroductionCarbamylation is a non-enzymatic post-translational protein modification common in patients with uremia that causes pro-atherogenic alterations in plasma proteins. It is abundantly present in late-stage atherosclerotic plaques; however, the pathogenic relevance and functional consequences of this accumulation are not known.MethodsHuman atherosclerotic plaque tissue samples were stratified by plaques’ stage and kidney function.ResultsImmunohistochemistry revealed a significantly higher carbamylated lysine (carb-lys) abundance in latestage hemorrhaged plaques of chronic kidney disease patients compared to early-stage plaques, and a significant negative correlation to glomerular filtration rate for the advanced plaques. …”
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Echinochrome pigment attenuates diabetic nephropathy in the models of type 1 and type 2 diabetes by Amel Mahmoud Soliman, Ayman Saber Mohamed, Mohamed-Assem Said Marie

“…Echinochrome substance present in sea urchin shells and spines and possesses high antioxidant activity.Aim. is to evaluate the ability of Ech to suppress the progression of diabetic complication in kidney.Materials and methods. …”
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The Impact of Statins before High-Risk CABG on Postoperative Multiple Organ Function by Jiayang Wang, Wen Yuan, Kui Zhang, Nan Liu, Dong Liu, Yujie Zhou

“…The findings of this study might shed new light on questions of positive or negative effects of PST on multiple organ function after high-risk CABG, so as to ultimately improve high-risk patient in-hospital outcomes from CABG.…”
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The mitochondrial dysfunction regulated by JAK2/STAT3 pathway leads to the necroptosis in the renal cells under patulin exposure by Yun Liu, Ruhan Yi, Xu Zhang, Xiance Sun, Jing Li, Ningning Wang, Xiaofeng Yao, Cong Zhang, Haoyuan Deng, Shaopeng Wang, Guang Yang

“…Notably, the pharmacological protection of mitochondrial function by SS-31 significantly attenuated the onset of PAT-induced necroptosis. …”
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Long-term survival of a kidney transplant patient with advanced renal cancer after combination therapy: a case report and literature review by Chao Peng, Weihao Wang, Jiajun Chen, Shouhua Pan, Gang Xu, Mengyao Li, Lulu Zhang, Yulei Li, Keyuan Zhao, Jing Jin

“…After 2 years, the patient showed excellent graft function with no evidence of cancer progression. Despite subsequent graft failure, the disease remained controlled for more than 2 years and the patient survived for more than 3 years, which was significantly longer than the typical survival of 10 to 20 months in patients with advanced kidney cancer. …”
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A nuclear magnetic resonance spectroscopy metabolomic approach to renal dysfunction in canine leishmaniasis by Ángela Durán-Galea, José-Luis Ramiro-Alcobendas, FrancisoJavier Duque-Carrasco, Paloma Nicolás-Barceló, José-Ignacio Cristóbal-Verdejo, Patricia Ruíz-Tapia, Rafael Barrera-Chacón, Carlos F. Marcos

“…The kidneys are essential for numerous metabolic processes, and specific metabolites may serve as predictive biomarkers of kidney function. …”
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Homocysteine levels and cardiovascular disease risk factors in chronic kidney disease (CKD), hypertensive and healthy Nigerian adults: a comparative retrospective study by Hanady Hamdallah, Marvellous Adeoye, Abiodun Moshood Adeoye

“…A strong positive correlation between Hcy levels and FGF was identified across all groups (p<0.001).Conclusions The present study indicates that Hcy levels may not serve as a reliable predictor of CVD outcomes across populations with varying kidney function and CVD risk profiles.…”
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Immunological Avalanches in Renal Immune Diseases by Davide Viggiano, Pietro Iulianiello, Antonio Mancini, Candida Iacuzzo, Luca Apicella, Renata Angela Di Pietro, Sarah Hamzeh, Giovanna Cacciola, Eugenio Lippiello, Andrea Gigliotti, Carmine Secondulfo, Giancarlo Bilancio, Giuseppe Gigliotti

“…In a preliminary study on kidney transplant, all measured variables showed temporal instability. …”
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Immune Complex Mediated Glomerulonephritis with Acute Thrombotic Microangiopathy following Newly Detected Hepatitis B Virus Infection in a Kidney Transplant Recipient by Tracey Salter, Hannah Burton, Sam Douthwaite, William Newsholme, Catherine Horsfield, Rachel Hilton

“…Entecavir treatment resulted in an improvement in viral load and kidney function. HBV genotyping demonstrated a vaccine escape mutant, suggesting “past resolved” infection that reactivated with immunosuppression, though posttransplant acquisition cannot be excluded. …”
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Egyptian pediatric kidney transplantation: highlights on post-transplant follow-up and management of complications by the Egyptian Pediatric Clinical Practice Guidelines Committee... by Bahia Moustafa, Neveen A. Soliman, Ihab Shaheen, Ahmed Badr, Fatma M. Atia, Mohamed K. El Hatw, Engy Adel Mogahed, Mona EL-Ghamrawy, Khaled El Khashab, Noha Shaheen, Mohamad G. Shouman, Abeer Selim, Magdy El-Sharkawy, Tarek Abd El Azeem, Mohamad Esmat, Manal Salman, Bedeir Ali-El-Dein, Mona Abdel Rahim, Muhamed A. El-Hadedy, Moatasem Elsayed Ghoneim, Mai S. Korkor, Tarek E. I. Omar, Yasser Amer, Ashraf Abdel Baky, On Behalf of Egyptian Pediatric Clinical Practice Guideline Committee

“…Abstract Background Pediatric kidney transplantation is unique when compared to adults. …”
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hs-CRP/HDL-C can predict the risk of all cause mortality in cardiovascular-kidney-metabolic syndrome stage 1-4 patients by Fengjiao Han, Haiyang Guo, Hao Zhang, Yang Zheng

“…BackgroundThe precise function of the hs-CRP/HDL-C ratio in forecasting the long-term mortality risk of patients with stages 1-4 of Cardiovascular-Kidney-Metabolic (CKM) syndrome remains inadequately delineated. …”
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